CD34 EXPRESSION AS A SURROGATE MARKER FOR DIAGNOSIS OF INVASIVE DUCTAL CARCINOMA OF BREAST.

2021 ◽  
pp. 28-30
Author(s):  
Ritika Bharti
Keyword(s):  
Invasive Ductal Carcinoma ◽  
Internal Control ◽  
Ductal Carcinoma ◽  
Surrogate Marker ◽  
Normal Breast ◽  
Axillary Lymph Node Metastasis ◽  
Axillary Lymph ◽  
Malignant Breast ◽  
Breast Lumps ◽  
Cd34 Expression

Background : The normal stroma of breast has enormous numbers of CD34+ brocytes therefore loss of CD34 expression in mesenchymal cells has been considered as signicant in malignant transformation and as such thought to be conclusive proof in IDC. This hypothesis leads to the identication of a new marker to diagnose cases of IDC. This study is aimed to establish the role of CD34 in diagnosis of IDC of breast. AIM: To establish the CD34 stromal expression as signicant immunohistochemical marker and to establish its efcacy as diagnostic tool to diagnose IDC. Result: A total of 50 cases of already diagnosed invasive ductal carcinoma of breast were selected and CD34 staining was performed on parafn section of all specimens. Most of the patients were in age group 35-50 years who presented with breast lumps. 50 cases of invasive ductal carcinoma were seen with 22 cases shows Lymphovascular and perineural involvement and 26 cases showed nipple areola involvement and 38 showed axillary lymph node metastasis. On histological grading of 50 malignant cases 06 cases were grade - III, 26 cases were grade- II and 18 were grade - I. Normal breast tissue was taken as internal control which show diffuse CD34 expression in stroma while there is loss of expression of CD34 in stroma in inltrating ductal carcinoma. Thereby conrms the loss of cell molecules adhesive property and signal transduction. Conclusion: There is obvious absence of expression of CD34 in malignant breast lesions. Therefore in this study we conclude that CD34 has potential to be used as surrogate diagnostic marker and management of IDC.

scholarly journals Unusual Occurrence of Rare Lipid-Rich Carcinoma and Conventional Invasive Ductal Carcinoma in the One Breast: Case Report

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Katarina Machalekova ◽  
Karol Kajo ◽  
Marian Bencat
Keyword(s):  
Lymph Nodes ◽  
Invasive Ductal Carcinoma ◽  
Ductal Carcinoma ◽  
Frozen Section ◽  
Histological Grade ◽  
Resection Margins ◽  
Axillary Lymph Nodes ◽  
Positive Staining ◽  
Axillary Lymph ◽  
Palpable Mass

A 56-year-old woman noticed a palpable mass in her left breast during self-examination. Patient was admitted to our hospital and malignant bifocal tumour was diagnosed by ultrasonography, digital mammography, magnetic resonance, and core-cut biopsy. The patient underwent planned conservative surgery (biquadrantectomy) with a sentinel node examination, but after results of the frozen section with positive resection margins and positive sentinel lymph nodes subsequent mastectomy with axillary lymph node dissection were realized. Histology in the resection specimen revealed two isolated and distinct tumours. One of the lesions represented conventional invasive ductal carcinoma of histological grade 3, and the second tumour was evaluated as invasive lipid-rich carcinoma, containing tumour cells with clear and foamy cytoplasm. Lipids in neoplastic cells were detected by Oil Red O staining and ultrastructural examination. Immunohistochemical analysis of both carcinomas was almost identical with negative steroid receptors, positive staining of HER-2, and p53 and with high proliferation activity (Ki-67). Mastectomy specimen contained residual foci of invasive ductal carcinoma and dissected axillary lymph nodes were free of metastasis. Patient underwent first cycles of chemotherapy with paclitaxel and Herceptin together with local radiotherapy and two month after surgery is without any evidence of the disease.

scholarly journals Histopathological Study of Malignant Neoplasm of Breast of Different Age and Sex Groups In a Tertiary Care Hospital

2018 ◽  
Vol 5 (2) ◽  
pp. 42-44
Author(s):  
Nazmun Nahar ◽  
Mohammed Iqbal ◽  
Kazi Md Shahidur Rahman ◽  
Md Abdullah Yusuf ◽  
Shahed Iqbal ◽  
...  
Keyword(s):  
Invasive Ductal Carcinoma ◽  
Breast Neoplasm ◽  
Ductal Carcinoma ◽  
Tertiary Care ◽  
Malignant Neoplasm ◽  
Care Hospital ◽  
Age Group ◽  
Breast Lump ◽  
Malignant Breast ◽  
Age And Sex

Background: Various types of female breast cancer associated with rapidly increasing age incidence. Objective: The purpose of the present study was to find out the frequency of different types of malignant neoplasm of breast in different age and sex.Methodology: This cross-sectional study was carried out at the Department of Pathology, Chittagong Medical College, Chittagong, Bangladesh from May 2005 to June 2006. Patients presented with breast lump of different age and sex were subjected to this study. Details gross examination was done followed by H & E staining for histopathological study.Result: A total number of 48 samples were selected after fulfilling the inclusion and exclusion criteria. This present study conducted in 27 specimens out of 48 breast lump. Among these benign and malignant were 21 and 27, respectively. Majority of the malignancy found in age group 41-50 years. Histopathologically Invasive ductal carcinoma was common 81.5%.There was significant association between different age group and type of neoplasm. In relation to sex malignant breast neoplasm was more common in female.Conclusion: In conclusion invasive ductal carcinoma was the commonest lesion of breast. In relation to sex malignant breast neoplasm was more common in female.Journal of Current and Advance Medical Research 2018;5(2):42-44

IS TUMOUR SIZE AN INDEPENDENT PREDICTOR FOR AXILLARY LYMPH NODE METASTASIS IN INFILTRATING DUCT CARCINOMA BREAST IN T2 AND T3 TUMOURS : PROSPECTIVE REVIEW OF 256 CASES

2021 ◽  
pp. 12-14
Author(s):  
Nimisha C. R. ◽  
Ravindran Chirukandath ◽  
Sharath K Krishnan ◽  
Sancia Roy Fernandez ◽  
Remani Remani ◽  
...  
Keyword(s):  
Lymph Node ◽  
Tumor Size ◽  
Axillary Lymph Node ◽  
Ductal Carcinoma ◽  
Tumour Size ◽  
Axillary Lymph Node Metastasis ◽  
Nodal Status ◽  
Axillary Lymph ◽  
Duct Carcinoma ◽  
Node Metastasis

Background: As breast cancer remains a major fraction of cancer cases worldwide, the options for minimalizing postoperative morbidity and mortality remain an area for ardent research and improvement. The ability to identify patients at low risk of axillary metastases, would be of great value in limiting extensive axillary dissection which causes signicant morbidity, thereby improving the postoperative quality of life amongst patients. We conducted a study to identify characteristics of primary tumors highly associated with axillary lymph node metastases by comparing various demographic and tumor characteristics against nodal status. Methodology: 288 cases of the axillary dissection specimens of all inltrating duct carcinoma cases who underwent MRM in Government Medical College, Thrissur for 5 consecutive years were studied (n=256). Pathology was interpreted by a select group of Pathologists and then reanalyzed by another set to avoid bias. Various other aspects were studied including age distribution, histology, tumour size and nodal status. Analysis was done using SPSS 26 software. Results: The mean age of the study population was 50.58 years. The most common histopathological type encountered was Invasive ductal carcinoma – NOS (89.58%). Most of the patients (78.29%) belonged to T2 stage, with most patients (76.39%) having 1- 3 nodes involved. On analysis, a signicant association between T status ( T2 ,T3 ) and N status (p = 0.001) was found. However, there was no signicant correlation between age against tumor size or nodal status (p = 0.528, and p = 0.614 respectively). Conclusions: This study found that while tumor size is independently can predict the amount of axillary lymph node metastasis especially in T2 and T3 tumors , there is no signicant predictor value for age in predicting the nodal status or tumor size in invasive ductal carcinoma. However, the factors which modifying tumor behavior like the grade, ER status, Her2 neu status and Cerb 2 will have an inuence on the prediction of Axillary Lymph node involvement that offers further scope of prospective research

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