scholarly journals NEUTROPHIL TO LYMPHOCYTE RATIO AS A MARKER OF ACUTE EXACERBATION AND DISEASE SEVERITY IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE

2020 ◽  
pp. 46-47
Author(s):  
A. Yogalakshmee ◽  
P. Manimekalai ◽  
Priyanka Priyanka
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Acute Exacerbation ◽  
Disease Severity ◽  
Chronic Obstructive ◽  
Exclusion Criteria ◽  
Obstructive Pulmonary Disease ◽  
Lymphocyte Ratio ◽  
Medical College ◽  
One Year

The study is conducted on patients attending Sree Balaji Medical College and Hospital, Chennai during the study period . A sum total of 100 patients with Chronic Obstructive Pulmonary Disease attending Sree Balaji Medical College and Hospital was included in the study, based on the inclusion and exclusion criteria. The study is done after getting informed signed consent from the patients participated in the same. Duration of study was one year.

scholarly journals Papel da relação neutrófilo-linfócito no valor prognóstico para exacerbação e mortalidade entre indivíduos com Doença Pulmonar Obstrutiva Crônica: revisão integrativa da literatura

2021 ◽  
Vol 10 (12) ◽  
pp. e86101220080
Author(s):  
Barbara Rocha Alves Araújo ◽  
Clara Alvina Davi Coelho ◽  
Júlia Oliveira Santos ◽  
Marcella Luciano de Oliveira ◽  
Rita de Cássia Medeiros Queiroz ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Acute Exacerbation ◽  
Neutrophil To Lymphocyte Ratio ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Lymphocyte Ratio ◽  
Para Determinar

A DPOC é uma doença caracterizada por restrição do fluxo aéreo, inflamação sistêmica e a períodos de exacerbação aguda. Recentemente, demonstrou-se que a relação neutrófilo-linfócito (RNL) é preditor sensível de exacerbação aguda e do prognóstico do paciente com DPOC. Objetivou-se discutir a conformidade entre a RNL na exacerbação da DPOC, apresentando informações que correlacionam a alteração leucocitária com o agravamento dos sintomas e do desfecho do paciente com DPOC. Assim, foi realizada revisão Integrativa da literatura na base de dados PubMed das produções dos últimos 10 anos. Os descritores utilizados foram: “Neutrophil to Lymphocyte Ratio”, “Chronic Obstructive Pulmonary Disease” e “Acute Exacerbation”, os quais foram conjugados para delimitação da busca. Foram selecionados 10 artigos ao final das buscas, sendo os anos de 2015, 2018 e 2020 os mais prevalentes com 20% das publicações cada um. Os estudos tiveram origem na Turquia, responsável por 40% deles, 30% das publicações foram realizadas na China, e Irã, Israel e Japão, cada país com 10%. Encontrou-se níveis mais altos de RNL em pacientes que tiveram morte intra-hospitalar (≥ 4) e admissão hospitalar (≥ 2,7). Todavia, alguns estudos demonstraram que a RNL não é útil para determinar o fenótipo eosinofílico da DPOC exacerbada, e que marcadores inflamatórios se elevam distintamente de acordo com o endotipo de exacerbação. Portanto, a RNL é parâmetro simples e custo efetivo para predição, acompanhamento e prognóstico da exacerbação aguda de DPOC, inclusive nos pacientes estáveis, evidenciando associação positiva entre exacerbação aguda e relações celulares nos pacientes portadores de DPOC.

scholarly journals Influence of disease severity, smoking status and therapy regimes on leukocyte subsets and their ratios in stable chronic obstructive pulmonary disease

2020 ◽  
Author(s):  
Iva Hlapčić ◽  
Andrea Vukić Dugac ◽  
Sanja Popović-Grle ◽  
Ivona Markelić ◽  
Ivana Rako ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Disease Severity ◽  
Blood Cells ◽  
Smoking Status ◽  
White Blood Cells ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Lymphocyte Ratio ◽  
Copd Patients

IntroductionBlood cells are involved in systemic inflammation in chronic obstructive pulmonary disease (COPD). We aimed to assess differences in leukocyte subsets and their ratios between COPD patients and healthy individuals as well as their association with disease severity, smoking status and therapy in COPD.Material and methodsOne hundred and nine patients in the stable phase of COPD and 95 controls participated in the study. After blood sampling, white blood cells (WBC), neutrophils (NEUTRO), monocytes (MO), lymphocytes (LY) and basophils (BA) were determined on a Sysmex XN-1000 analyser, and ratios were calculated afterwards.ResultsWhite blood cells, NEUTRO, MO and BA were higher in COPD patients than in controls. Also, COPD patients had increased neutrophil to lymphocyte ratio (NLR), derived NLR (dNLR), monocyte to lymphocyte ratio (MLR), basophil to lymphocyte ratio (BLR), basophil to monocyte ratio (BMR) and monocyte/granulocyte to lymphocyte ratio (M/GLR). Smoking has an impact on leukocyte counts, with BA, BLR and BMR being higher in COPD smokers vs. ex-smokers. Patients with very severe COPD were distinguished from moderate COPD by NLR, dNLR and M/GLR. In addition, those parameters were associated with lung function and dyspnoea, and NLR and dNLR also with multicomponent COPD indices BODCAT and DOSE. Great potential of dNLR, NLR and M/GLR in identifying COPD patients was observed regarding their odds ratios (OR) of 5.07, 2.86, 2.60, respectively (p < 0.001). Common COPD therapy did not affect any of the parameters investigated.ConclusionsLeukocyte subsets and their ratios could be implemented in COPD assessment, especially in evaluating disease severity and prediction.

scholarly journals Predictive Value of Novel Inflammation-Based Biomarkers for Pulmonary Hypertension in the Acute Exacerbation of Chronic Obstructive Pulmonary Disease

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Huanhuan Zuo ◽  
Xiaochen Xie ◽  
Jiahuan Peng ◽  
Lixin Wang ◽  
Rong Zhu
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Hypertension ◽  
Pulmonary Disease ◽  
Acute Exacerbation ◽  
Univariate Analysis ◽  
Systolic Pressure ◽  
Control Group ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Lymphocyte Ratio

Recently, there has been an increasing interest in the potential clinical use of several inflammatory indexes, namely, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic-immune-inflammation index (SII). This study aimed at assessing whether these markers could be early indicators of pulmonary hypertension (PH) in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). A total of 185 patients were enrolled in our retrospective study from January 2017 to January 2019. Receiver operating characteristic curve (ROC) and area under the curve (AUC) were used to evaluate the clinical significance of these biomarkers to predict PH in patients with AECOPD. According to the diagnostic criterion for PH by Doppler echocardiography, the patients were stratified into two groups. The study group consisted of 101 patients complicated with PH, and the control group had 84 patients. The NLR, PLR, and SII values of the PH group were significantly higher than those of the AECOPD one (p<0.05). The blood biomarker levels were positively correlated with NT-proBNP levels, while they had no significant correlation with the estimated pulmonary arterial systolic pressure (PASP) other than PLR. NLR, PLR, and SII values were all associated with PH (p<0.05) in the univariate analysis, but not in the multivariate analysis. The AUC of NLR used for predicting PH was 0.701 and was higher than PLR and SII. Using 4.659 as the cut-off value of NLR, the sensitivity was 81.2%, and the specificity was 59.5%. In conclusion, these simple markers may be useful in the prediction of PH in patients with AECOPD.

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