Outcome of Single Dose Prophylactic Antibiotic in Carpal Tunnel Release Surgery

Study Objective ◽

Postoperative Wound ◽

Compressive Neuropathy ◽

Carpal Tunnel Release Surgery

Background: It has been well documented that administering a prophylactic antibiotic brings down the rate of postoperative wound infection very strikingly in carpal tunnel release (CTR) surgery. Carpal tunnel syndrome (CTS) is definitely a compressive neuropathy of the upper limbs, which is both benign and frequent. The study objective was to determine the postoperative wound infection rate in carpal tunnel release surgery after having administered a single dose of a prophylactic antibiotic. Methods: This cross-sectional study was carried out at the department of Neurosurgery, Dammam Medical Complex-Saudi Arabia. The study was based on 122 patients who were operated for carpal tunnel release procedures at the centre. Pre-operatively all patients were subjected to nerve conduction studies (NCS) to document CTS as the definitive diagnosis. As a routine, every patient was administered intravenous loading dose of cefuroxime (1.5g) at least 1 hour prior to surgery. All patients were treated as day care cases and were discharged after a few hours of surgery. On discharge, no further antibiotics were administered. Their wounds were examined. Results: Superficial redness over the site of incision was noted in three of the patients and wound infection in two others. These two patients improved with oral antibiotics. Not a single patient needed re-exploration. Conclusion: The current study showed that this is an efficacious and a very safe protocol to follow. Assuming the fact that the incidence of surgical site infection (SSI) in CTR surgery is low, the results were not different when compared to the results from other centres.

Deep postoperative wound infection after carpal tunnel release

The Journal Of Hand Surgery ◽

10.1016/s0363-5023(89)80093-0 ◽

1989 ◽

Vol 14 (5) ◽

pp. 869-873 ◽

Cited By ~ 55

Author(s):

Arlen D. Hanssen ◽

Peter C. Amadio, ◽

Stephen P. DeSilva ◽

Duane M. Ilstrup

Keyword(s):

Wound Infection ◽

Carpal Tunnel ◽

Carpal Tunnel Release ◽

Prospective study of preincisional intraparietal single-dose ceftriaxone in reducing postoperative wound infection in type I and II diabetic patients

Acta Diabetologica ◽

10.1007/s005920050160 ◽

1999 ◽

Vol 36 (3) ◽

pp. 159-162 ◽

Cited By ~ 4

Author(s):

I. Petrakis ◽

C. Gonianakis ◽

N. Vrachassotakis ◽

A. Tsatsakis ◽

I.S. Vallilakis ◽

...

Keyword(s):

Single Dose ◽

Prospective Study ◽

Wound Infection ◽

Diabetic Patients ◽

Type I ◽

Results of using the infection avoidance Protocol for postoperative wounds in spinal surgery

Russian journal of neurosurgery ◽

10.17650/1683-3295-2020-22-3-51-56 ◽

2020 ◽

Vol 22 (3) ◽

pp. 51-56

Author(s):

A. A. Grin ◽

A. K. Kaykov ◽

A. Yu. Kordonskiy ◽

V. A. Karanadze ◽

O. A. Levina ◽

...

Keyword(s):

Risk Factors ◽

Cohort Study ◽

Wound Infection ◽

Spinal Surgery ◽

Retrospective Cohort ◽

Subcutaneous Fat ◽

Control Group ◽

Study Objective ◽

Background. We developed a Protocol based on the results of a previous study of risk factors for infection of a postoperative wound: do not use monopolar coagulation on the skin and subcutaneous fat; remove hemostatic material from the wound; relax the established wound expander every 65 minutes; refuse to suture the muscles in the area of laminectomy, refuse to use an intradermal suture.The study objective is a verification of the received Protocol.Materials and methods. A comprehensive retrospective cohort study evaluated the results of surgical treatment of 575 spinal patients who were under the authors’ supervision in 2014–2016. Patients were divided into groups: operated in the period from 2014 to 2016 (control group), operated in 2017, in the treatment of which the Protocol for reducing complications was applied (main group).Results. It was found that after the introduction of the Protocol, the percentage of patients with postoperative wound infection decreased from 6.0 to 1.3 %.Conclusion. The resulting Protocol is an effective tool for reducing wound infection and can be recommended for prevention of the postoperative wound infection in patients with spinal with diseases and injuries.

Pengaruh Pemberian Antibiotik Profilaksis Sefazolin, Seftriakson dan Antibiotik Seftriakson Sebelum dan Sesudah Operasi Terhadap Infeksi Luka Pasca Operasi

JOURNAL OBGIN EMAS ◽

10.25077/aoj.4.1.77-86.2020 ◽

2020 ◽

Vol 4 (1) ◽

pp. 77-86

Author(s):

Herti Marni ◽

Dovy Djanas ◽

Hafni Bachtiar

Keyword(s):

Wound Infection ◽

Univariate Analysis ◽

Prophylactic Antibiotic ◽

Prophylactic Antibiotics ◽

Bivariate Analysis ◽

Control Group ◽

Control Group Design ◽

Postoperative Wound ◽

Before And After

Objective : To determine the effect of giving prophylactic antibiotic ceftriaxone and cefazolin and giving ceftriaxone before and after surgery to the risk of postoperative wound infection in postoperative patients.Method: This study was an experimental study with a post test control group design that looked at the differences in the effect of administration of ceftriaxone, cefazolin, and ceftriaxone before and after surgery on the risk of postoperative wound infection. The population in this study were patients planned for surgery in the Obstetric and Gynelologic Departement of Dr. M. Djamil General Hopital, Padang. The number of samples used by 30 people with a group of 10 people each group. The study began in August until the number of samples was fulfilled. Univariate analysis was used to see the frequency, percentage, mean, and standard deviation. Bivariate analysis using Chi-square test with 95% CI (α <0.05) was used to see differences in the effect of the three antibiotic procedures.Results: There were no cases of postoperative wound infection based on the three procedures used. There was no difference in the effect of prophylactic antibiotics in postoperative infections. Conclusion: There was no difference in the effect of the three procedures for prophylactic antibiotics in postoperative infections.Keywords: Prophylactic Antibiotics, Surgical Wound Infections, Cefazolin, Ceftriaxone, Superficial incisional SSI

Prophylactic parenteral antibiotics in clean neurosurgical procedures: a review

Journal of Neurosurgery ◽

10.3171/jns.1988.69.1.0052 ◽

1988 ◽

Vol 69 (1) ◽

pp. 52-57 ◽

Cited By ~ 52

Author(s):

Robert Dempsey ◽

Robert P. Rapp ◽

Byron Young ◽

Sarah Johnston ◽

Phillip Tibbs

Keyword(s):

Wound Infection ◽

First Generation ◽

Prophylactic Antibiotic ◽

Neurosurgical Procedures ◽

Gram Positive ◽

Content Type ◽

Postoperative Wound ◽

The Cost ◽

Antibiotic Agents

✓ Clean surgical procedures carry a risk of postoperative wound infection that is less than 5% in most hospitals. The use of prophylactic antibiotic agents in clean neurosurgical cases is controversial, and the neurosurgical literature through 1980 contains no controlled clinical trials to study its effectiveness in such cases. A report of 1732 consecutive procedures without a single postoperative wound infection in patients receiving systemic gentamicin, vancomycin, and streptomycin irrigation fluids is often quoted by neurosurgeons; however, these results have not yet been duplicated by others. Since 1980, there have been several controlled trials that support the use in clean neurosurgical cases of prophylactic antibiotics, including the vancomycin/gentamicin/streptomycin regimen and the first-generation cephalosporins. A report in 1986 of 1602 cases without a primary wound infection supports the use of a single perioperative dose of cefazolin. A review of causative organisms in postoperative wound infections demonstrates the preponderance of Gram-positive pathogens. Therefore, when antibiotic prophylaxis is indicated, adequate Gram-positive bacterial coverage, including protection against Staphylococcus infection, is required. With consideration of the present data, the cost of antibiotic therapy, and the danger of drug toxicity, a short perioperative regimen of cefazolin as prophylaxis is preferred in clean neurosurgical cases.

A randomised controlled trial comparing the efficacy of single dose prophylactic ceftriaxone versus post-operative ciprofloxacin and metronidazole combination in reducing post-operative wound infection after clean surgeries

International Surgery Journal ◽

10.18203/2349-2902.isj20184704 ◽

2018 ◽

Vol 5 (12) ◽

pp. 3864

Author(s):

S. Vasu ◽

Kshir Sagar

Keyword(s):

Single Dose ◽

Side Effects ◽

Wound Infection ◽

Medical Science ◽

Research Centre ◽

Control Group ◽

Routine Practice ◽

Study Group ◽

Background: Surgical site infections were considered to be the major contributor to increased morbidity and mortality in clean surgeries. Many studies prove that single dose prophylaxis is more effective than multiple dosing. No data currently exist about comparative efficacy of single dose prophylactic ceftriaxone with postoperative ciprofloxacin and metronidazole combination in reducing postoperative wound infection after clean surgeries. Hence the present study was done to compare their efficacy in terms rate of incidence of wound infection and side effects.Methods: This prospective study was done on 120 patients who were selected for clean surgeries at Sapthagiri Institute of Medical Science and Research Centre, Bengaluru during the period from April 2015 and March 2016. 60 patients received single dose of ceftriaxone prophylactically and considered as study group and other 60 patients received combination of ciprofloxacin and metronidazole postoperatively for 5-7 days and considered as control group. The efficacy of drugs was estimated in terms of reducing the incidence of wound infection.Results: The wound infection rate was 13.33% in the study group and 28.33% in control. Staphylococcus aureus was the most common organism isolated from wound discharge. However, gram negative organism accounted for majority of infections. There were no major side effects encountered in either of the groups.Conclusions: The study concludes that single dose ceftriaxone can be widely applied in the routine practice in clean surgeries. The single dose ceftriaxone showed many advantages over the control group in terms of Reduced the incidence of postoperative wound infection with no major side effects.