Microbiological Etiology of Chronic Cough Associated with Acute Exacerbation of Chronic Obstructive Pulmonary Disease (COPD): A Study from Karachi, Pakistan

2020 ◽  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Acute Exacerbation ◽  
Tertiary Care ◽  
Environmental Pollutants ◽  
Sputum Culture ◽  
Chronic Obstructive ◽  
Care Hospital ◽  
Cross Sectional ◽  
Obstructive Pulmonary Disease

Background: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) worsens the respiratory symptoms that are usually triggered by infection with bacteria or viruses or by environmental pollutants. Therefore, the aim of this study was to determine the bacterial etiology from sputum culture in patients suffering from acute exacerbation of COPD, admitted in hospital. Methods: The study was cross sectional observational, where sputum bacterial cultures were analyzed from the patients with Acute exacerbation COPD treated in the ICU of a tertiary care hospital for pulmonary disease from January 2019 to December 2019. Two sputum samples were collected from each patient for bacterial examination. The results of sputum bacterial culture findings were expressed as frequency and percentage by using SPSS. Results: In the present study, there were 1296 patients, both males 749 (57.8%) and females 547 (42.2%). The mean age of patients was 57.39±19.74years. 470 (36.3%) showed negative culture reports. 440 (34.0%) patients had Moraxella infection, which was most common organism in all patients, and 149 (11.5%) patients had Pseudomonas infection, 157(12.1%) patients had Yeast Albicans and in only 1 (0.1%) patient Enterobacter infection were found. Other pathogens in low frequency identified were Haemophilus parainfluenzae, Streptococcus pneumoniae, Escherichia coli and Haemophilus influenzae. It was observed that the frequency of infections was linked with increasing age. Conclusion: With increasing age, people are prone to acquire pulmonary infections specifically COPD. It is therefore very important to perform sputum culture to identify the causative agents and treat the patients with appropriate antibiotic to reduce the episodes of AECOPD. Keywords: Bacteria; Sputum Culture; COPD; Antibiotic; Cough.

scholarly journals Cardiac troponin I as mortality predictor in acute exacerbation of chronic obstructive pulmonary disease

2017 ◽  
Vol 5 (6) ◽  
pp. 2669
Author(s):  
Seema Gupta ◽  
Varinder Saini ◽  
Jasbinder Kaur ◽  
Shivani Jaswal ◽  
Harjeet Kaur ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Acute Exacerbation ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Tertiary Care ◽  
Cardiac Troponin I ◽  
Chronic Obstructive ◽  
Care Hospital ◽  
Obstructive Pulmonary Disease

Background: Comorbidities are important determinants of outcome and quality of life of patients with chronic obstructive pulmonary disease (COPD). The risk of cardiovascular events in COPD patients is three to five-fold high. COPD is often associated with right ventricular hypertrophy and pulmonary hypertension. Various studies have associated levels of cardiac troponin I (cTnI) with severity and duration of acute exacerbation of COPD (AECOPD). The objective of the present study was to assess the usefulness of serum cTnI as mortality predictor in AECOPD patients.Methods: An observational, prospective and non interventional study was conducted in 50 patients with AECOPD admitted in the pulmonary medicine emergency or ward of a tertiary care hospital of Northern India. AECOPD was diagnosed according to Global Initiative for chronic obstructive lung disease guidelines. cTnI levels were estimated within 24 hours of admission by method based on chemiluminiscence along with routine investigations. Levels ≥ 0.01ng/ml were taken as positive. The patients were followed up for 30days for outcome in terms of mortality and morbidity. Data was entered and analyzed by SPSS package and two sided p values<0.05 were considered statistically significant.Results: The serum cTnI was found to be positive in 34% of patients with AECOPD. The in- hospital mortality was significantly low in patients having cTnI <0.01ng/ml as compared to patients with cTnI ≥0.01ng/ml. The patients with cTnI levels ≥0.01ng/ml had significantly higher mean PaCO2 levels and higher requirement for invasive or noninvasive ventilation during hospital stay as compared to patients having cTnI <0.01ng/ml (p=0.04 and 0.016 respectively).Conclusions: Levels of cTnI≥0.01ng/ml may be considered as a biomarker to predict mortality in AECOPD patients.

scholarly journals Anxiety and Depression Among Chronic Obstructive Pulmonary Disease Patients in A Tertiary Care Hospital, Nepal

2018 ◽  
Vol 6 (4) ◽  
pp. 129-135
Author(s):  
Tara Roka ◽  
Nirmala Aryal ◽  
Anjana Ghimire ◽  
Subhadra Pradhan ◽  
Krishna Kumar Aryal
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Depression Scale ◽  
Anxiety And Depression ◽  
Chronic Obstructive ◽  
Care Hospital ◽  
Cross Sectional ◽  
Obstructive Pulmonary Disease

Background: Psychiatric co-morbidities such as anxiety and depression among patients with chronic obstructive pulmonary disease exacerbate the disease, prolong the hospital stay, increase the disease symptoms and deter the quality of life.Objective: To assess the proportion of anxiety or depression among patients with chronic obstructive pulmonary disease in a tertiary care hospital.Methodology: We carried out a cross sectional study interviewing 307 patients from a tertiary care hospital using sequential sampling technique. We used structured questionnaire and included hospital anxiety and depression scale to measure anxiety and depression. We considered a summed score of

scholarly journals Anemia in Patients with Chronic Obstructive Pulmonary Disease in a Tertiary Care Hospital in Bangladesh

2014 ◽  
Vol 4 (3) ◽  
pp. 151-155
Author(s):  
Naser Ahmed ◽  
Rukhsana Parvin ◽  
Md Abul Kalam Azad
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Smoking Habit ◽  
Tertiary Care ◽  
Chronic Obstructive ◽  
Care Hospital ◽  
Anemia Of Chronic Disease ◽  
Cross Sectional ◽  
Obstructive Pulmonary Disease ◽  
Copd Patients

Background: Chronic obstructive pulmonary disease (COPD) is usually associated with polycythemia. It is assumed that systemic inflammatory components of COPD can interfere with erythropoietin and can result in anemia of chronic disease which will impair the functional capacity of these patients and also increase morbidity and mortality. Objective: To evaluate anemia status in COPD patients. Materials and Methods: This cross-sectional study was conducted in clinically stable 50 COPD patients in the outpatient department of Medicine in Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka during the period of July to December 2011. The demographic characteristics, smoking habit, duration of disease, types and severity of anemia, BMI and results of 6-minute walk test were recorded. Results: Out of 50 COPD patients, 76% were male and 24% were female. Among them 32% patients were anemic, 20% were polycythemic and 48% patients had normal hemoglobin. Among the anemic patients with COPD, 87% were male and 13% were female,75% were mildly anemic and 4% moderately anemic, 62.5% had normocytic and 37.5% had microcytic anemia. Conclusion: Anemia in COPD patients is often overlooked and underestimated. Clinicians should be aware of the presence of anemia in patients with COPD so that appropriate treatment could be initiated to improve the quality of life and prognosis DOI: http://dx.doi.org/10.3329/jemc.v4i3.20943 J Enam Med Col 2014; 4(3): 151-155

scholarly journals Metabolic Syndrome in Patients with Chronic Obstructive Pulmonary Disease in Medicine Department of a Tertiary Care Hospital: A Descriptive Cross-sectional Study

2021 ◽  
Vol 59 (236) ◽  
Author(s):  
Niraj Kumar Singh ◽  
Lochan Karki
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Metabolic Syndrome ◽  
Pulmonary Disease ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Chronic Obstructive ◽  
Care Hospital ◽  
Cross Sectional ◽  
Obstructive Pulmonary Disease ◽  
Medicine Department

Introduction: The best recognized systemic manifestations of chronic obstructive pulmonary disease include, cardiovascular co-morbidities, cachexia and muscle dysfunction, osteoporosis, anemia, and clinical depression and anxiety. This study was undertaken to find the prevalence of the metabolic syndrome in chronic obstructive pulmonary disease patients who were admitted in the medicine department of a tertiary care hospital. Methods: A descriptive cross-sectional study was carried out in the medicine department of Nepal Medical College and teaching hospital between October 2009 and January 2010. Ethical approval was taken from the Intitutional Review Committee. Convenience sampling technique was used. All chronic obstructive pulmonary disease patients were included. Descriptive statistics were used to evaluate baseline characteristics. Point estimate at 90% Confidence Interval was calculated along with frequency and proportion for binary data. Results: Out of 84 patients, the period prevalence of metabolic syndrome is 30 (35.71%) (29.80-40.20 at 90% Confidence Interval) as per the definition by International Diabetes Federation 2006 for South Asians. Among them, 35 (41.67%) were male and 49 (58.33% ) were female. Eight (9.5%) were of age between 40-49 years, 11 (13.1%) between 50-59 years, 27 (32.1%) between 60-69 years and 38 (45.2%) of 70 years and above. Conclusions: The study showed that the prevalence of metabolic syndrome was found to be lower than the previous study done in similar settings.

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