A patient with a severe form of atopic dermatitis, polyvalent allergy and an extreme elevation of IgE

2021 ◽  
Vol 15 (3) ◽  
pp. 155-159
Author(s):  
Zuzana Nevoralová
Keyword(s):  
Atopic Dermatitis ◽  
Severe Form

scholarly journals Severe form of atopic dermatitis - candidate for dupilumab therapy

2019 ◽  
Vol 13 (2) ◽  
pp. 80-82
Author(s):  
Spyridon Gkalpakiotis ◽  
Milena Tánczosová
Keyword(s):  
Atopic Dermatitis ◽  
Severe Form

scholarly journals The Effect of SARS-CoV-2 Virus Infection on the Course of Atopic Dermatitis in Patients

Medicina ◽  
2021 ◽  
Vol 57 (6) ◽  
pp. 521
Author(s):  
Martyna Miodońska ◽  
Agnieszka Bogacz ◽  
Magdalena Mróz ◽  
Szymon Mućka ◽  
Andrzej Bożek
Keyword(s):  
Atopic Dermatitis ◽  
Immunosuppressive Therapy ◽  
Systemic Treatment ◽  
Immunosuppressive Treatment ◽  
Skin Lesions ◽  
Skin Condition ◽  
Severe Form ◽  
Immune Mediated ◽  
Skin Symptoms ◽  
The Impact

Background and objectives: Atopic dermatitis (AD) is a disease with a complex pathophysiology involving immune-mediated reactions that lead to skin lesions that are typically localized and recurrent. Following the outbreak of the COVID-19 (coronavirus disease 2019) pandemic, attempting to assess the impact of SARS-CoV-2 infection on diseases caused by complex immune mechanisms has become important. The aim of this study was to assess the impact of SARS-CoV-2 infection on the course of AD, including immunosuppressive therapy, in patients with a severe form of the disease. Materials and methods: A retrospective analysis of 21 adults aged 18 to 52 years with AD diagnosed with COVID-19, including patients requiring hospitalization, was performed. Results: During SARS-CoV-2 infection, temporary exacerbation of skin lesions and/or skin pruritus was observed in nine (43%) patients but without the need for systemic treatment intervention. Patients with severe AD who received immunosuppressive therapy most often manifested mild exacerbation of skin symptoms. The skin condition improved in three patients. There was no significant effect of disease severity on the risk of severe COVID-19 (HR = 0.45; 95% CI: 0.32–0.65). Conclusions: The course of atopic dermatitis during SARS-CoV-2 infection may be different from the severity of its symptoms due to the lack of a significant influence. The immunosuppressive treatment used in patients with severe AD did not significantly affect the course of SARS-CoV-2 infection.

scholarly journals Atopic Dermatitis and Sensitisation to Molecular Components of Alternaria, Cladosporium, Penicillium, Aspergillus, and Malassezia—Results of Allergy Explorer ALEX 2

2021 ◽  
Vol 7 (3) ◽  
pp. 183
Author(s):  
Jarmila Celakovska ◽  
Radka Vankova ◽  
Josef Bukac ◽  
Eva Cermakova ◽  
Ctirad Andrys ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Bronchial Asthma ◽  
Specific Ige ◽  
Severe Form ◽  
Laboratory Diagnostics ◽  
Ige Mediated ◽  
High Level ◽  
Molecular Components ◽  
Very High

Progress in laboratory diagnostics of IgE-mediated allergies is being made through the use of component-resolved diagnosis. The aim of our study is to analyze the sensitization profile to allergen reagents in patients suffering from atopic dermatitis with the use of the ALEX 2–Allergy Explorer and especially to show the sensitization to molecular components of molds and yeast. The complete dermatological and allergological examination including the examination of the sensitization to allergen reagents with Allergy Explorer ALEX 2 testing was performed. The relation between the sensitization to molecular components of molds and yeast and the severity of atopic dermatitis, and the occurrence of bronchial asthma and allergic rhinitis was evaluated. Altogether, 100 atopic dermatitis patients were examined—48 men and 52 women, with an average age of 40.9 years. The sensitization to Mala s 6, Mala s 11, Sac c, Asp f 6, Cla h and Cla h 8 correlates to the severity of atopic dermatitis. The sensitization to Sac c, Alt a 6, Cla h, Cla h 8 was observed significantly more frequently in patients suffering from bronchial asthma to Mala s 6 in patients suffering from allergic rhinitis. In patients with severe form of atopic dermatitis (AD), a very high level of specific IgE was recorded to Mala s 11 (in 36%) and to Asp f 6 (in 12%).

scholarly journals Staphylococcal TSST-1 Association with Eczema Herpeticum in Humans

mSphere ◽  
2021 ◽  
Author(s):  
Patrick M. Schlievert ◽  
Richard J. Roller ◽  
Samuel H. Kilgore ◽  
Miguel Villarreal ◽  
Aloysius J. Klingelhutz ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Atopic Dermatitis ◽  
Toxic Shock Syndrome ◽  
Herpes Simplex Virus Infection ◽  
Severe Form ◽  
Toxic Shock ◽  
Content Type ◽  
Eczema Herpeticum ◽  
Toxic Shock Syndrome Toxin ◽  
Simplex Virus

Atopic dermatitis (eczema, AD) with concurrent herpes simplex virus infection (eczema herpeticum, ADEH) is a severe form of AD. We show that ADEH patients are colonized with Staphylococcus aureus that primarily produces the superantigen toxic shock syndrome toxin-1 (TSST-1); however, significantly but to a lesser extent the superantigens staphylococcal enterotoxins A, B, and C are also represented in ADEH.

scholarly journals The main aspects of the immunopathogenesis of atopic dermatitis in children

2021 ◽  
pp. 27-34
Author(s):  
Olga Olegovna Pobezhimova ◽  
Alexander Viktorovich Zhestkov
Keyword(s):  
Atopic Dermatitis ◽  
Rural Areas ◽  
Skin Diseases ◽  
Secondary Infection ◽  
Allergic Diseases ◽  
Developed Countries ◽  
Severe Form ◽  
Pathological Process ◽  
The Body ◽  
Social Adaptation

Research objective Atopic dermatitis (AtD) is the earliest and most frequent manifestation of the body’s hypersensitivity reaction to environmental allergens. Often manifested in severe form, affecting the skin, can occur in early infancy, childhood. The disease is genetically determined and is chronic. AtD is one of the most common skin diseases (from 20 to 40% in the structure of skin diseases), which occurs in all countries in people of both sexes. In recent years, there has been an increase in the incidence of AtD throughout the world. The disease is more common in highly developed countries and cities (less commonly in rural areas). AtD significantly reduces the quality of life of children, causing psychological discomfort and disrupting their social adaptation. AtD in children is a risk factor for the «atopic march» — the further sequential development of other allergic diseases: allergic rhinitis, pollinosis, allergic conjunctivitis, bronchial asthma. With a reduced immune response of the body, AtD in children can be complicated by the addition of a secondary infection (bacterial, viral, fungal). Such a high incidence rate, a debut in early childhood, a frequently recurring course of the pathological process, and a tendency towards an increase in the forms of the disease resistant to traditional therapy make the details of the pathogenesis of AtD particularly relevant. One of the main roles in the pathogenesis of AtD belongs to the cells of the immune system. The purpose of this article: to systematize the information available today on the immunopathogenesis of atopic dermatitis.

scholarly journals Severe atopic dermatitis in a boy with potato allergy

2020 ◽  
Vol 16 (3) ◽  
pp. 301-305
Author(s):  
Jędrzej Przekora ◽  
◽  
Agata Wawrzyniak ◽  
Anna Bujnowska ◽  
Agnieszka Rustecka ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Food Allergy ◽  
Dietary Intervention ◽  
Paediatric Population ◽  
Specific Ige ◽  
Primary Treatment ◽  
Elimination Diet ◽  
Severe Form ◽  
Severe Atopic Dermatitis ◽  
Skin Prick Tests

Food allergy is an important problem in the paediatric population. Food products that are most likely to induce allergic reactions include cow’s milk, wheat, peanuts, hen’s eggs, fish and seafood. Food-allergy-related diseases include, among other things, atopic dermatitis, urticaria and asthma. Anaphylactic shock is the most severe form of allergic reaction. Intramuscular adrenalin at a dose of 0.01 mg/kg body weight (maximum dose 0.3–0.5 mg) is the primary treatment for anaphylaxis. An elimination diet is the treatment of choice in food allergy. If symptoms persist despite dietary intervention, extended diagnosis using skin prick tests and/or specific IgE measurements should be performed. We present a clinical case of a 2.5-year-old boy with erythroderma secondary to atopic dermatitis, who was referred to our Department due to the lack of improvement after outpatient treatment. It was found during hospital stay that the symptoms were caused by potato allergens.

scholarly journals Sensitization to Molecular Components in 104 Atopic Dermatitis Patients in Relation to Subgroups of Patients Suffering from Bronchial Asthma and Allergic Rhinitis

2020 ◽  
Vol 63 (4) ◽  
pp. 164-175
Author(s):  
Radka Vaňková ◽  
Jarmila Čelakovská ◽  
Josef Bukač ◽  
Irena Krčmová ◽  
Jan Krejsek ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Bronchial Asthma ◽  
Specific Ige ◽  
Severe Form ◽  
Test Results ◽  
Atopic March ◽  
Specific Ige Antibodies ◽  
The Difference ◽  
Molecular Components

Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease. The progression from AD to bronchial asthma (AB) and allergic rhinitis (AR) is called atopic march. The aim of this study was to evaluate the difference in the sensitization to molecular components in patients suffering from AD in relation to subgroups of patients with AR and AB. Material and Methods: The complete dermatological and allergological examinations were performed. Specific IgE antibodies against 112 molecular components were measured with the multiplex ImmnoCAP ISAC test. Results: Altogether 104 atopic dermatitis patients (50 men, 54 women) at the average age 40.1 years were examined. The sensitization to molecular components was confirmed in 93.3% of patients. The sensitization to components of mites, grasses, trees, animals, moulds, and shrimps was significantly more frequent in patients with severe form of AD and the sensitization to components of grasses, trees, and moulds was significantly higher in subgroup of patients with AB. In subgroup of patients suffering from AR the higher occurrence of pollen-derived and pollen-food derived PR-10 proteins, grasses, mites, and animals was observed also. Conclusions: We have confirmed the significant differences in the sensitization to molecular components in patients suffering from severe form of AD, and in subgroups of patients suffering from AB and AR. These molecular components may play the important role in the consecutive development of different allergy pathologies called atopic march.

scholarly journals Severe form of atopic dermatitis

2021 ◽  
Vol 22 (3) ◽  
pp. 208-211
Author(s):  
Kristýna Škopková ◽  
Jan Potěšil
Keyword(s):  
Atopic Dermatitis ◽  
Severe Form

scholarly journals The patient's path to AD: a study of patients adherence to therapy

2020 ◽  
pp. 46-53
Author(s):  
L. S. Kruglova ◽  
N. V. Griazeva
Keyword(s):  
Atopic Dermatitis ◽  
Skin Diseases ◽  
Severe Form ◽  
Goal Measure ◽  
Treatment Regimens ◽  
The Past ◽  
Task Goal ◽  
Urgent Task ◽  
Common Skin ◽  
Information Requests

Introduction. Atopic dermatitis (AD) is one of the most common skin diseases. The prevalence of atopic dermatitis among children is up to 20%, among adults - 2-8%. According to the form, there are mild, moderate and severe AD. Over the past decades, there has been an increase in the incidence of AD, its course is becoming more complicated, and the outcome is becoming more difficult. In this regard, the search for new successful treatment methods, as well as a detailed analysis of the currently used treatment regimens, is an urgent task. Goal. Measure the distribution of patients with AD by type of course (mild, moderate, severe) with a description of the patient's path, including the most important moments of decision-making, drivers of switching, changes in therapy, the main groups of influence and identify the main information requests/needs of patients with AD.Materials and methods. The study involved 700 patients, including 96 patients with moderate to severe form and 116 with severe form. All patients were diagnosed with AD and had at least one exacerbation in the last year. The age of the patients was 18-60 years. Results. The data obtained show that patients with moderate to severe AD make up about 25% of all patients with AD, including patients with severe ad - about 5%. Antihistamines are most often used by patients with AD, and the drug in this category is most often referred to by patients as the “main” drug for AD. More than half of patients (60%) with moderate to severe AD have used systemic steroids and/or cyclosporins over the past year. Patients with severe AD are significantly more likely than other groups to use steroids and immunosuppressants. The recommendation of a doctor (most often - a dermatologist in a municipal clinic or a skin and venereal clinic) is the most significant factor determining the choice of a drug for the treatment of atopic dermatitis. Conclusions. The data obtained indicate the need to conduct special educational activities with patients such as “schools of atopic dermatitis”, informing patients about the features of lifestyle in AD, theoretical aspects of treatment and skin care.

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