scholarly journals Schneiderian Carcinoma

2020 ◽  
Vol 7 (2) ◽  
pp. 476-480
Author(s):  
Ledisda Apriana ◽  
Udadi Sadhana ◽  
Indra Wijaya ◽  
Vega Karlowee
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Malignant Transformation ◽  
Squamous Cell ◽  
Malignant Tumours ◽  
Schneiderian Papilloma ◽  
Fibrous Stroma ◽  
Eosinophilic Cytoplasm ◽  
Nonkeratinizing Squamous Cell Carcinoma ◽  
Epidemiological Characteristics

Latar Belakang: Squamous Cell Carcinoma (SCC) adalah keganasan paling umum dari kepala dan leher (sekitar 3%), tetapi hanya <1% dari seluruh jenis keganasan (insidensi jarang), yang dibagi menjadi jenis keratinizing dan non-keratinizing. Nonkeratinizing squamous cell carcinoma mempunyai berbagai nama lain, salah satunya Schneiderian carcinoma. Dahulu, Schneiderian carcinoma disebut sebagai Carcinoma Ex-Schneiderian Papilloma (malignant transformation). Atas kelangkaan dan keberagaman penamaan kasus ini, maka penulis tertarik untuk menyajikan kasus ini. Laporan Kasus: Seorang laki-laki 68 tahun datang dengan keluhan utama benjolan di leher kanan. Dilakukan tindakan wide eksisi dan rekontruksi, kemudian dikirimkan sampel untuk pemeriksaan histopatologi, didapatkan gambaran kelompok-kelompok sel epithelial ganas, dengan inti bulat oval, pleomorfik, hiperkromatik, berkromatin kasar, sitoplasma eosinofilik, mitosis dapat ditemukan, tumbuh papilifer, infiltratif diantara dalam stroma jaringan ikat fibrous. Dilakukan pemeriksaan lanjutan dengan pengecatan imunohistokimia yang memberikan hasil: CK5/6 positif, P63 positif, dan Ki67 positif > 80%. Diskusi: Ciri dan gejala pada pasien ini sesuai dengan kekhasan epidemiologi berdasarkan literatur. Berdasarkan pemeriksaan histopatologis dan pulasan imunohistokimia menyokong diagnosis Squamous cell carcinoma, transisional differenteated (Schneiderian carcinoma) regio colli sisi dekstra. Kesimpulan: Pemeriksaan histopatologi dan imunohistokimia pada kasus Schneiderian carcinoma ini menjadi penting serta harus dibedakan dengan jenis lainnya karena masing-masing manajemen dan prognosisnya pun berbeda. Kata Kunci: Schneiderian carcinoma, nonkeratinizing squamous cell carcinoma, transisional differenteated, Carcinoma Ex-Schneiderian Papilloma.    Background: Squamous Cell Carcinoma (SCC) is rare, accounting for <1% of malignant tumours and only about 3% of malignancies of the head and neck, that includes a keratinizing and a non keratinizing type. Nonkeratinizing squamous cell carcinoma has various other names, which one is Schneiderian carcinoma. In the past, Schneiderian carcinoma was referred to as Carcinoma Ex Schneiderian Papilloma (Malignant Transformation). Based on the scarcity and diversity of naming these cases, the authors are interested to presenting this case. Case Description: A 68-year-old man comes with a complaint of a lump in the right neck. Wide excision and reconstruction were carried out, then samples were sent for histopathology, a description of malignant epithelial cell groups, with oval, pleomorphic, hyperchromatic, coarse chromatin nuclei, eosinophilic cytoplasm, mitosis can be found, papilliferous growth, infiltrative within the tissue fibrous stroma. Follow-up examination with immunohistochemical staining that gave results: CK5/6 positive, P63 positive, and Ki67 >80%. Discussion: Characteristics and symptoms in these patients are consistent with epidemiological characteristics based on literature. Based on histopathological and immunohistochemical examination support to diagnosis Squamous cell carcinoma, transitional differenteated (Schneiderian carcinoma) in colli region right side. Conclusion: Histopathology and immunohistochemistry examination in the case of Schneiderian carcinoma are important and must be distinguished from other types because each management and prognosis are different. Keywords: Schneiderian carcinoma, nonkeratinizing squamous cell carcinoma, transisional differenteated, Carcinoma Ex-Schneiderian Papilloma.

FIRST REPORT OF SQUAMOUS CELL CARCINOMA IN AN OVINE HOOF

2019 ◽  
Vol 45 (04) ◽  
pp. 141-144
Author(s):  
Aida Davari
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Inflammatory Cells ◽  
Large Tumor ◽  
Fibrous Stroma ◽  
Eosinophilic Cytoplasm ◽  
Uncommon Case ◽  
Mitotic Figures ◽  
First Time

This paper describes, for the first time, the clinical and histopathological characteristics of squamous cell carcinoma (SCC) in the hoof of a two-year-old female native Iranian sheep. Physical examination of this uncommon case revealed a large, irregularly-shaped, dark-brown-to-blackish, cauliflower-like ulcerated mass in the coronary band of the hoof which had caused lameness and bleeding. On cut-section, a dark red ulcerated stiff mass was observed. In the histopathological investigation, the moderately-differentiated SCC revealed keratin pearls accumulated moderately in cytoplasm, as well as acellular ones, and a relatively dense fibrous stroma. The large tumor cells contained a small amount of eosinophilic cytoplasm and vesicular nuclei, and in some cases, they were slightly hyperchromatic. As well, in some areas, mitotic figures as well as diverse inflammatory cells infiltration were observed. To the best of our knowledge, this is the first paper reporting an incidence of SCC in an ovine hoof.

scholarly journals Osteoclastic Giant Cell Rich Squamous Cell Carcinoma of the Uterine Cervix: A Case Report and Review of the Literature

2014 ◽  
Vol 2014 ◽  
pp. 1-4
Author(s):  
Lucía Alemán-Meza ◽  
Gabriela Sofía Gómez-Macías ◽  
Oralia Barboza-Quintana ◽  
Raquel Garza-Guajardo ◽  
Abelardo Loya-Solis
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Giant Cell ◽  
Squamous Cell ◽  
Uterine Cervix ◽  
Female Genital Tract ◽  
Giant Cells ◽  
Eosinophilic Cytoplasm ◽  
Nonkeratinizing Squamous Cell Carcinoma ◽  
Common Malignancy

Cervical carcinoma is the most common malignancy of the female genital tract and represents the second most common malignancy in women worldwide. Histologically 85 to 90% of cervical cancers are squamous cell carcinoma. Osteoclastic giant cell rich squamous cell carcinoma is an unusual histological variant of which only 4 cases have been reported. We present the case of a 49-year-old woman with a 6-month history of irregular vaginal bleeding. Examination revealed a 2.7 cm polypoid mass in the anterior lip of the uterine cervix. The patient underwent hysterectomy with bilateral salpingo-oophorectomy. Microscopically the tumor was composed of infiltrative nests of poorly differentiated nonkeratinizing squamous cell carcinoma. Interspersed in between these tumor cells were numerous osteoclastic giant cells with abundant eosinophilic cytoplasm devoid of nuclear atypia, hyperchromatism, or mitotic activity. Immunohistochemistry was performed; CK and P63 were strongly positive in the squamous component and negative in the osteoclastic giant cells, while CD68 and Vimentin were strongly positive in the giant cell population and negative in the squamous component. The patient received chemo- and radiotherapy for recurrent disease identified 3 months later on a follow-up CT scan; 7 months after the surgical procedure the patient is clinically and radiologically disease-free.

scholarly journals Clinical analysis of 12 cases of ovarian cystic mature teratoma with malignant transformation into squamous cell carcinoma

2021 ◽  
Vol 49 (2) ◽  
pp. 030006052098154
Author(s):  
Xiangyu Wang ◽  
Wenjing Li ◽  
Yan Kong ◽  
Xiangyu Liu ◽  
Zhumei Cui
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Malignant Transformation ◽  
Squamous Cell ◽  
Tumor Size ◽  
Treatment Guidelines ◽  
Mature Teratoma ◽  
Cystic Teratoma ◽  
Clinical Analysis ◽  
Palpable Mass

Objective This study aimed to examine the clinicopathological characteristics, treatment, and prognostic factors in 12 cases of malignant transformation of mature cystic teratoma of the ovary (MCTO). Methods We performed a retrospective study of 12 patients with malignant transformation of MCTO who were admitted to the Affiliated Hospital of Qingdao University from 2003 to 2019. We examined case records, clinical parameters, and biological assessments. Results The median age of the patients was 56.5 years and seven of them were postmenopausal. The average tumor size was 18.5 cm. All patients had pelvic masses at their first hospital visit. Nine of the patients had discomfort in the lower abdomen, two presented with a lower abdominal palpable mass, and three were complicated by fever. The median follow-up time was 73 months (12‒193 months). Ten patients survived with a disease-free status and two died. Conclusions There is a low incidence of malignant transformation of MCTO, and its most common histological type is squamous cell carcinoma. Age and tumor size are important factors in malignant transformation of teratomas. While there is a lack of treatment guidelines for malignant transformation of MCTO, early diagnosis and treatment may be beneficial for these patients.

scholarly journals Ureteral urothelial carcinoma with squamous cell carcinoma and sarcomatoid carcinoma differentiation: a case report

BMC Surgery ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Shangqing Ren ◽  
Hualin Feng ◽  
Yige Bao ◽  
Yi Wei ◽  
Yong Ou ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Urinary Tract ◽  
Urothelial Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Standard Treatment ◽  
Clinical Manifestations ◽  
Sarcomatoid Carcinoma ◽  
Upper Urinary Tract ◽  
Malignant Tumours

Abstract Background Upper urinary tract urothelial carcinoma (UTUC) with multiple pathological types is extremely rare in the clinic, but the recurrence rate and mortality these patients are high. At present, there is no standard treatment for such cases. Case presentation We reported a case of ureteral urothelial carcinoma with squamous cell carcinoma and sarcomatoid carcinoma differentiation and rapid ileal metastasis and reviewed the literature related to different pathological types of upper urinary tract tumours to explore the diagnosis, treatment and prognosis characteristics of the disease, enhance our understanding of its clinical manifestations and history of evolution and provide guidance for avoiding missed diagnosis and misdiagnosis. Conclusion There is no standard treatment for urinary malignant tumours with multiple pathological types; radical surgery is considered a suitable choice. Chemotherapy, targeted drug therapy and immunotherapy may be beneficial to the survival of patients. In short, these patients have a high risk of recurrence and metastasis and a poor prognosis.

scholarly journals Squamous cell carcinoma in mature cystic teratoma of the ovary

2012 ◽  
Vol 65 (9-10) ◽  
pp. 429-431 ◽  
Author(s):  
Jelena Amidzic ◽  
Matilda Djolai ◽  
Mihaela Mocko-Kacanski ◽  
Aleksandar Gluhovic ◽  
Jelena Ilic ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Malignant Transformation ◽  
Squamous Cell ◽  
Rare Complication ◽  
Cystic Teratoma ◽  
Internal Surface ◽  
Cystic Mass ◽  
Mature Cystic Teratoma ◽  
Well Differentiated

Introduction. Malignant transformation is a rare complication of mature cystic teratoma, with squamous cell carcinoma as the most common malignancy (in 75% of cases). In this article we present a case of a well-differentiated squamous cell carcinoma arising in a mature cystic teratoma and discuss the morphological and clinico-pathological features of malignant transformation in teratoma. Case Report. An 80-year-old woman with symptoms of acute abdomen underwent left salpingo-oophorectomy. Gross examination showed a cystic mass measuring 20 cm in diameter, with papillary formation on its internal surface. Histology revealed a well-differentiated squamous cell carcinoma arising in mature cystic teratoma. Squamous epithelium surrounding the tumor was dysplastic. Conclusion. Squamous cell carcinoma in mature cystic teratoma is a rare pathologic event and in most cases it is an accidental pathohistological finding.

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