“Central Giant Cell Granuloma of Maxilla- 
A Case Report”

Central giant Cell granuloma (CGCG) formerly called giant cell reparative granuloma is a benign bony lesion and etiology is unclear. It occurs most commonly in mandible and also occur in maxilla. 1%-7% of all benign lesions of jaws are central giant cell granuloma. It affects children and adults. it is usually a slow growing lesion, fast growing lesions also reported. The fast growing CGCG has an aggressive behavior mimicking a malignant lesion through it has the innocent histological appearance. CGCG sometimes resemble a wide variety of conditions that led to a misdiagnosis both on clinical and radiographic examination. Histological examination confirms as CGCG. The case described here involved maxilla which was treated with surgical curettage. The patient has been followed up for 11/2 years with no post operative complications and no recurrence. Keywords: Central giant cell granuloma, maxilla, benign, jaw

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Central Giant Cell Granuloma of Posterior Maxilla: First Expression of Primary Hyperparathyroidism

Case Reports in Endocrinology ◽

10.1155/2015/170412 ◽

2015 ◽

Vol 2015 ◽

pp. 1-7 ◽

Cited By ~ 1

Author(s):

Deepanshu Gulati ◽

Vishal Bansal ◽

Prajesh Dubey ◽

Sanjay Pandey ◽

Abhinav Agrawal

Keyword(s):

Primary Hyperparathyroidism ◽

Giant Cell ◽

Elevated Serum ◽

Cortical Plate ◽

Radiographic Examination ◽

Surgical Removal ◽

Giant Cell Granuloma ◽

Central Giant Cell Granuloma ◽

Posterior Maxilla ◽

Patient Reported

A case of 19-year-old male patient reported with the chief complaint of slowly growing diffuse painless swelling over the right part of the face from last 6 months. Intraoral examination revealed a swelling on right side of palate in relation to molar region with buccal cortical plate expansion. Radiographic examination (orthopantograph and 3DCT) showed large multilocular radiolucency in right maxilla with generalized loss of lamina dura. Incisional biopsy was done and specimen was sent for histopathological examination which showed multinucleated giant cells containing 15–30 nuclei. Based on clinical, radiological, and histopathological findings provisional diagnosis of central giant cell granuloma was made. Blood tests after histopathology demonstrated elevated serum calcium level and alkaline phosphatase level. Immunoassay of parathyroid hormone (PTH) level was found to be highly elevated. Radiographic examination of long bones like humerus and femur, mandible, and skull was also done which showed osteoclastic lesions. Considering the clinical, radiographic, histopathological, and blood investigation findings, final diagnosis of brown tumour of maxilla was made. The patient underwent partial parathyroidectomy under general anaesthesia to control primary hyperparathyroidism. Surgical removal of the bony lesion was done by curettage. The patient has been followed up for 1 year with no postoperative complications and the lesion healed uneventfully.

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A rare coexistence of central giant cell granuloma and parathyroid adenoma: Case report

IP Journal of Diagnostic Pathology and Oncology ◽

10.18231/j.jdpo.2021.034 ◽

2021 ◽

Vol 6 (2) ◽

pp. 155-158

Author(s):

Rohini Sebastian ◽

Meethu Rappai

Keyword(s):

Case Report ◽

Connective Tissue ◽

Parathyroid Adenoma ◽

Giant Cell ◽

Stromal Cells ◽

Giant Cells ◽

Giant Cell Granuloma ◽

Multinucleated Giant Cells ◽

Central Giant Cell Granuloma ◽

Bony Lesion

Central giant cell granuloma is a reparative bony lesion characterised by abundant multinucleated giant cells within a sea of spindle shaped mesenchymal stromal cells. Giant cells are scattered throughout the fibrovascular connective tissue stroma containing hemorrhage. Its coexistence with parathyroid adenoma is very rare. Brown tumour is a close differential in this scenario. Herein we present the case of a central giant cell granuloma of maxilla and parathyroid adenoma diagnosed almost during the same time in a 58 years old male.

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Central Giant Cell Granuloma

Dentistry and Oral Maxillofacial Surgery ◽

10.31579/2643-6612/010 ◽

2019 ◽

Vol 2 (1) ◽

pp. 01-04

Author(s):

Nilotpol Kashyap ◽

Manisha Upadhyay ◽

Rupam Tripathi ◽

Pallavi Pawar ◽

Ranjeet Kumar Prasad Sah ◽

...

Keyword(s):

Giant Cell ◽

Fibrous Tissue ◽

Giant Cells ◽

World Health ◽

Giant Cell Granuloma ◽

Central Giant Cell Granuloma ◽

Bony Lesion ◽

Benign Tumours ◽

Health Organization ◽

Intraosseous Lesion

Central giant cell granuloma (central giant cell granuloma) is an uncommon benign bony lesion that occurs in the mandible and maxilla and accounts for approximately 7% of all benign tumours of the jaws [1]. The World Health Organization (WHO) has defined central giant cell granuloma as an intraosseous lesion consisting of cellular fibrous tissue that contains multiple foci of haemorrhage, aggregations of multinucleated giant cells and occasional trabeculae of woven bone [2]. Central giant cell granuloma occurs predominantly in children or young adults, with approximately 75%of cases presenting before 30 years of age although presentation can occur at any age [3]. Females are affected more frequently than males, with a ratio of 2:1

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Aggressive Central Giant Cell Granuloma in the Posterior Region of Mandible – A Case Report

International Journal of Health Sciences and Research ◽

10.52403/ijhsr.20210416 ◽

2021 ◽

Vol 11 (4) ◽

pp. 118-121

Author(s):

Ajay Sutare ◽

Ajay Pratap Singh Parihar ◽

Varsha A.C.

Keyword(s):

Case Report ◽

Key Words ◽

Giant Cell ◽

Root Resorption ◽

Osteolytic Lesion ◽

Giant Cell Granuloma ◽

Central Giant Cell Granuloma ◽

Mandibular Molar ◽

Bony Lesion ◽

Molar Region

Central giant cell granuloma (CGCG) is an uncommon, benign, intraosseous bony lesion of the mandible and maxilla which is variably aggressive in nature. The incidence of an aggressive and recurrence nature is greatest in a female with a ratio of 2:1. Based on the clinical and radiographic features, Central giant cell granuloma can be classified as aggressive and non-aggressive lesions. Here we report a case of central giant cell granuloma in the posterior mandibular molar region which was aggressive in nature. The clinically and radiographically swelling was evaluated with displaced tooth, pain, cortical expansion, and root resorption. The treatment varies according to the nature of the lesion, this case was treated by conservative excision with continuity of the mandible. Key words: Aggressive, central giant cell granuloma, osteolytic lesion.

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A Conservative Surgical Approach Towards Central Giant Cell Granuloma: A Case Report

Journal of the Bahrain Medical Society ◽

10.26715/jbms.3_18112018 ◽

2018 ◽

Vol 30 (3) ◽

pp. 1-4

Author(s):

Ahmed Al-Qattan

Keyword(s):

Case Report ◽

Giant Cell ◽

Surgical Approach ◽

Pyogenic Granuloma ◽

Histopathological Analysis ◽

Giant Cell Granuloma ◽

Case Presentation ◽

Central Giant Cell Granuloma ◽

History Of ◽

Bony Lesion

Central giant cell granuloma (CGCG) is an infrequent benign bony lesion of unpredictably aggressive behavior. The precise lesion character is debatable and remains inconclusive. However, three main theories were proposed: a sensitive lesion, a kind of neoplasm, or a developmental anomaly. This is a case presentation of a 16-year-old boy with a dental history of extraction of the lower right first molar, presented to hospital with two months history of swelling in the aforementioned area after the procedure. First biopsy of the swelling was performed outside the Kingdom of Bahrain. As per histopathological findings, the swelling was described as pyogenic granuloma. Second biopsy with necessary workup was conducted in the Kingdom of Bahrain and was confirmed as central giant cell granuloma through histopathological analysis; it was removed surgically.

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Central giant cell granuloma: a case report

Journal of Oral Medicine and Oral Surgery ◽

10.1051/mbcb/2017024 ◽

2018 ◽

Vol 24 (1) ◽

pp. 24-28

Author(s):

Antoine Butel ◽

Gemma Di Bernardo ◽

Beatrice Louvet

Keyword(s):

Giant Cell ◽

Root Resorption ◽

Surgical Excision ◽

Normal Mucosa ◽

Giant Cell Granuloma ◽

Surgical Specimen ◽

Central Giant Cell Granuloma ◽

Bony Lesion ◽

Radiolucent Lesion

Introduction: Central giant cell granuloma (CGCG) is an uncommon benign bony lesion that occurs in the mandible and maxilla. Observation: A 30-year-old woman was evaluated for a radiolucent lesion of the mandible, which was discovered by chance. This image was associated with a painless swelling covered by normal mucosa. No symptoms were associated. After surgical excision, histological examination of the surgical specimen concluded a CGCG. Surgical follow-up was simple, and the first radiological test performed 3 months after confirming the onset of bone healing. Comments: The clinical behavior of CGCG ranges from a slow-growing asymptomatic swelling to an aggressive lesion with pain, local osteolysis, root resorption and tooth displacement. Therapeutic options have greatly varied in recent years. Nonsurgical treatments with alpha-interferon, calcitonin, and corticosteroids have been described and their benefits may be worthy of consideration. Conclusion: A surgical approach is considered as the traditional treatment and is still the most accepted one. However, in some publications, authors disagree on the type of surgery that should be performed.

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