scholarly journals ROLE OF NITRIC OXIDE IN EXHALED AIR IN BRONCHIALASTHMA

2010 ◽  
Vol 7 (1) ◽  
pp. 26-31
Author(s):  
N M Nenasheva ◽  
N M Nenasheva
Keyword(s):  
Nitric Oxide ◽  
Bronchial Asthma ◽  
Human Body ◽  
Physiological Effects ◽  
Exhaled Air

In this review the main physiological effects of nitric oxide in the human body have been considered, as well as its pathophysiologic role in bronchial asthma. Methods for determination of nitric oxide in exhaled air have been described. The importance of determining the level of nitric oxide in patients with bronchial asthma has been analyzed.

scholarly journals Nitric Oxide and Biological Mediators in Pediatric Chronic Rhinosinusitis and Asthma

2019 ◽  
Vol 8 (11) ◽  
pp. 1783 ◽  
Author(s):  
Valentina Agnese Ferraro ◽  
Stefania Zanconato ◽  
Eugenio Baraldi ◽  
Silvia Carraro
Keyword(s):  
Nitric Oxide ◽  
Chronic Rhinosinusitis ◽  
Exhaled Breath Condensate ◽  
Main Body ◽  
Exhaled Breath ◽  
Non Invasive ◽  
Volatile Organic ◽  
Exhaled Air ◽  
Breath Condensate

Background: In the context of the so-called unified airway theory, chronic rhinosinusitis (CRS) and asthma may coexist. The inflammation underlying these conditions can be studied through the aid of biomarkers. Main body: We described the main biological mediators that have been studied in pediatric CRS and asthma, and, according to the available literature, we reported their potential role in the diagnosis and management of these conditions. As for CRS, we discussed the studies that investigated nasal nitric oxide (nNO), pendrin, and periostin. As for asthma, we discussed the role of fractional exhaled nitric oxide (feNO), the role of periostin, and that of biological mediators measured in exhaled breath condensate (EBC) and exhaled air (volatile organic compounds, VOCs). Conclusion: Among non-invasive biomarkers, nNO seems the most informative in CRS and feNO in asthma. Other biological mediators seem promising, but further studies are needed before they can be applied in clinical practice.

scholarly journals Determination of motor activity and anxiety-related behaviour in rodents: methodological aspects and role of nitric oxide

2013 ◽  
Vol 6 (3) ◽  
pp. 126-135 ◽  
Author(s):  
Natalia Sestakova ◽  
Angelika Puzserova ◽  
Michal Kluknavsky ◽  
Iveta Bernatova
Keyword(s):  
Nitric Oxide ◽  
Motor Activity ◽  
Psychological Research ◽  
Black And White ◽  
Plus Maze ◽  
Experimental Subjects ◽  
Behavioural Tests ◽  
Methodological Aspects

ABSTRACT In various areas of the bio-medical, pharmacological and psychological research a multitude of behavioural tests have been used to investigate the effects of environmental, genetic and epi-genetic factors as well as pharmacological substances or diseased states on behaviour and thus on the physiological and psycho-social status of experimental subjects. This article is reviewing the most frequently used behavioural tests in animal research (open field, elevated plus maze, zero maze, and black and white box). It provides a summary of common characteristics as well as differences in the methods used in various studies to determine motor activity, anxiety and emotionality. Additionally to methodological aspects, strain, sex and stress-related differences as well as the involvement of nitric oxide in modulation of motor activity and anxiety of rodents were briefly reviewed.

scholarly journals THE STUDY OF THE ELECTROMAGNETIC COMPONENT OF THE HUMAN BODY AS A DIAGNOSTIC INDICATOR IN THE EXAMINATION OF PATIENTS WITH NON-COMMUNICABLE DISEASES: PROBLEM STATEMENT

2020 ◽  
Vol 73 (6) ◽  
pp. 1279-1283
Author(s):  
Ozar P. Mintser ◽  
Valery V. Semenets ◽  
Maksim М. Potiazhenko ◽  
Peter М. Podpruzhnykov ◽  
Ganna V. Nevoit
Keyword(s):  
Human Body ◽  
Rapid Assessment ◽  
Conceptual System ◽  
Body Tissues ◽  
Instrumental Methods ◽  
Diagnostic Indicator ◽  
Electromagnetic Component

The aim of the publication is to substantiate a conceptual system of views on the role of internal electromagnetic fields and the scientific feasibility of studying the direction of their possible use as a diagnostic indicator in the examination of patients with NCDs. Materials and methods: The of the presented data was carried out during a search study of methods for the rapid assessment of valeological status, prenosological early diagnosis of NCDs, analysis of existing methods for studying the electromagnetic phenomena of the human body. Review: The authors systematized the existing technical capabilities and instrumental methods in the framework of systemic medicine. The article proposes a working classification of methods, justifies the choice of methods for further research. Conclusions: 1) The study of the electromagnetic component of the human body as a diagnostic indicator in the examination of patients with NCDs is a relevant and promising scientific direction at the present stage. 2) Methods for assessing heart rate variability in a short recording, computerized hardware segmental diagnostics, a computerized digital study of Gas-discharge Electrophotonic Analysis, determination of the PBS-activity of body tissues were selected to further examine the value of their diagnostic parameters in examining patients with NCDs in the first and second levels of therapeutic care.

scholarly journals No metabolites impact in allergic inflammation regulation and their contribution to remodelling bronchi mucous in bronchial asthma patients

2009 ◽  
Vol 6 (5) ◽  
pp. 11-17
Author(s):  
L M Ogorodova ◽  
O V Kozina ◽  
E A Gereng ◽  
L M Ogorodova ◽  
O V Kozina ◽  
...  
Keyword(s):  
Bronchial Asthma ◽  
Clinical Signs ◽  
Allergic Inflammation ◽  
Nitrite Concentration ◽  
Tnf Α ◽  
Th2 Inflammation ◽  
Exhaled Air ◽  
Asthma Patients ◽  
Inflammation Cytokines

Background. To study the role of NO metabolites in allergic inflammation regulation and remodelling in BA patients. Material and methods. Morphological and morphometrical methods of investigation of bronchi mucous of 39 BA patients were used, IL-4, TNF-α, INF-g, IL-8, nitrite, 3-nitrotyrosine, nitrosoglutathion levels in bronchoalveolar washout were investigated, nitrite concentration in condensate of the exhaled air was measured. Results. The increased level of IL-4, TNF-α, INF-g, IL-8 in bronchoalveolar washout is associated with persistent Th2-inflammation. The BA severity correlate with highest IL-8, TNF-a, INF-g, nitrite and 3-nitrotyrosine level but with nitrosoglutathion deficit and in general is associated with structured architectonics bronchi mucous abnormalities. Conclusion. The association of toxic NO metabolites, pro-inflammation cytokines levels, bronchi mucous path-omorphological abnormalities with clinical signs of BA confirms the role of toxic NO metabolites in development of Th2-inflammations.

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