scholarly journals No metabolites impact in allergic inflammation regulation and their contribution to remodelling bronchi mucous in bronchial asthma patients

2009 ◽  
Vol 6 (5) ◽  
pp. 11-17
Author(s):  
L M Ogorodova ◽  
O V Kozina ◽  
E A Gereng ◽  
L M Ogorodova ◽  
O V Kozina ◽  
...  
Keyword(s):  
Bronchial Asthma ◽  
Clinical Signs ◽  
Allergic Inflammation ◽  
Nitrite Concentration ◽  
Tnf Α ◽  
Th2 Inflammation ◽  
Exhaled Air ◽  
Asthma Patients ◽  
Inflammation Cytokines

Background. To study the role of NO metabolites in allergic inflammation regulation and remodelling in BA patients. Material and methods. Morphological and morphometrical methods of investigation of bronchi mucous of 39 BA patients were used, IL-4, TNF-α, INF-g, IL-8, nitrite, 3-nitrotyrosine, nitrosoglutathion levels in bronchoalveolar washout were investigated, nitrite concentration in condensate of the exhaled air was measured. Results. The increased level of IL-4, TNF-α, INF-g, IL-8 in bronchoalveolar washout is associated with persistent Th2-inflammation. The BA severity correlate with highest IL-8, TNF-a, INF-g, nitrite and 3-nitrotyrosine level but with nitrosoglutathion deficit and in general is associated with structured architectonics bronchi mucous abnormalities. Conclusion. The association of toxic NO metabolites, pro-inflammation cytokines levels, bronchi mucous path-omorphological abnormalities with clinical signs of BA confirms the role of toxic NO metabolites in development of Th2-inflammations.

The role of physical rehabilitation in the treatment of bronchial asthma patients

2021 ◽  
Author(s):  
Mykola Ostrovskyy ◽  
Kostiantyn Shvets ◽  
Kseniia Ostrovska ◽  
Iryna Savelikhina ◽  
Oleksandr Varunkiv ◽  
...  
Keyword(s):  
Bronchial Asthma ◽  
Physical Rehabilitation ◽  
Asthma Patients

scholarly journals Increased particle flow rate from airways precedes clinical signs of ARDS in a porcine model of LPS-induced acute lung injury

2020 ◽  
Vol 318 (3) ◽  
pp. L510-L517
Author(s):  
Martin Stenlo ◽  
Snejana Hyllén ◽  
Iran A. N. Silva ◽  
Deniz A. Bölükbas ◽  
Leif Pierre ◽  
...  
Keyword(s):  
Flow Rate ◽  
Distress Syndrome ◽  
Porcine Model ◽  
Clinical Signs ◽  
Particle Flow ◽  
Tnf Α ◽  
Cytokine Levels ◽  
Exhaled Air ◽  
Saline Administration ◽  
Invasive Diagnostics

Acute respiratory distress syndrome (ARDS) is a common cause of death in the intensive care unit, with mortality rates of ~30–40%. To reduce invasive diagnostics such as bronchoalveolar lavage and time-consuming in-hospital transports for imaging diagnostics, we hypothesized that particle flow rate (PFR) pattern from the airways could be an early detection method and contribute to improving diagnostics and optimizing personalized therapies. Porcine models were ventilated mechanically. Lipopolysaccharide (LPS) was administered endotracheally and in the pulmonary artery to induce ARDS. PFR was measured using a customized particles in exhaled air (PExA 2.0) device. In contrast to control animals undergoing mechanical ventilation and receiving saline administration, animals who received LPS developed ARDS according to clinical guidelines and histologic assessment. Plasma levels of TNF-α and IL-6 increased significantly compared with baseline after 120 and 180 min, respectively. On the other hand, the PFR significantly increased and peaked 60 min after LPS administration, i.e., ~30 min before any ARDS stage was observed with other well-established outcome measurements such as hypoxemia, increased inspiratory pressure, and lower tidal volumes or plasma cytokine levels. The present results imply that PFR could be used to detect early biomarkers or as a clinical indicator for the onset of ARDS.

scholarly journals Airway epithelial integrin β4 suppresses allergic inflammation by decreasing CCL17 production

2020 ◽  
Vol 134 (13) ◽  
pp. 1735-1749 ◽  
Author(s):  
Lin Yuan ◽  
Xun Zhang ◽  
Ming Yang ◽  
Xizi Du ◽  
Leyuan Wang ◽  
...  
Keyword(s):  
Molecular Mechanisms ◽  
Allergic Inflammation ◽  
Airway Epithelial Cells ◽  
Airway Epithelial ◽  
Th2 Response ◽  
Integrin Β4 ◽  
Dust Mite ◽  
Asthma Patients ◽  
Deficient Mice

Abstract Airway epithelial cells (AECs) play a key role in asthma susceptibility and severity. Integrin β4 (ITGB4) is a structural adhesion molecule that is down-regulated in the airway epithelium of asthma patients. Although a few studies hint toward the role of ITGB4 in asthmatic inflammation pathogenesis, their specific resultant effects remain unexplored. In the present study, we determined the role of ITGB4 of AECs in the regulation of Th2 response and identified the underpinning molecular mechanisms. We found that ITGB4 deficiency led to exaggerated lung inflammation and AHR with higher production of CCL17 in house dust mite (HDM)-treated mice. ITGB4 regulated CCL17 production in AECs through EGFR, ERK and NF-κB pathways. EFGR-antagonist treatment or the neutralization of CCL17 both inhibited exaggerated pathological marks in HDM-challenged ITGB4-deficient mice. Together, these results demonstrated the involvement of ITGB4 deficiency in the development of Th2 responses of allergic asthma by down-regulation of EGFR and CCL17 pathway in AECs.

scholarly journals ROLE OF NITRIC OXIDE IN EXHALED AIR IN BRONCHIALASTHMA

2010 ◽  
Vol 7 (1) ◽  
pp. 26-31
Author(s):  
N M Nenasheva ◽  
N M Nenasheva
Keyword(s):  
Nitric Oxide ◽  
Bronchial Asthma ◽  
Human Body ◽  
Physiological Effects ◽  
Exhaled Air

In this review the main physiological effects of nitric oxide in the human body have been considered, as well as its pathophysiologic role in bronchial asthma. Methods for determination of nitric oxide in exhaled air have been described. The importance of determining the level of nitric oxide in patients with bronchial asthma has been analyzed.

scholarly journals Nonlymphocyte-Derived Tumor Necrosis Factor Is Required for Induction of Colitis in Recombination Activating Gene (Rag)2−/− Mice upon Transfer of Cd4+Cd45rbhi T Cells

1999 ◽  
Vol 190 (10) ◽  
pp. 1479-1492 ◽  
Author(s):  
Nadia Corazza ◽  
Susanne Eichenberger ◽  
Hans-Pietro Eugster ◽  
Christoph Mueller
Keyword(s):  
T Cells ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Colonic Mucosa ◽  
Clinical Signs ◽  
Interferon Γ ◽  
Tnf Α ◽  
Recombination Activating Gene ◽  
Necrosis Factor

In this study, we addressed the role of tumor necrosis factor (TNF)-α and lymphotoxin (LT)-α in the development of colitis and defined the cellular sources (T cells versus non-T cells) of TNF (TNF-α and LT-α) relevant to disease development. After adoptive transfer of TNF+/+ CD4+CD45RBhi splenocytes into TNF+/+ recombination activating gene (RAG)2−/− mice, the recipients develop massive inflammation of the large intestinal mucosa concurrent with massive weight loss. In contrast, clinical signs of disease are completely absent in TNF−/−RAG2−/− recipients of TNF−/− CD4+CD45RBhi T cells, although elevated numbers of interferon-γ–producing cells are present in the colonic mucosa. Surprisingly, upon transfer of TNF−/−CD4+CD45RBhi T cells into TNF+/+RAG2−/− recipients, colitis develops with kinetics similar to those upon transfer of TNF+/+CD4+CD45RBhi donor cells. In contrast, no clinical signs of colitis are observed in TNF−/−RAG2−/− recipients of TNF+/+CD4+CD45RBhi T cells. This protection from colitis is not a consequence of the absence of LT-α, as TNF-α−/−RAG2−/− recipients of TNF-α−/− CD4+CD45RBhi T cells are also protected from colitis induction. These results demonstrate the importance of TNF production by non-T cells of the colonic mucosa in the pathogenesis of colitis and provide direct evidence for a nonredundant role of TNF-α in this mouse model of colitis.

scholarly journals CHANGES IN BRONCHIAL ASTHMA CONTROL AND INFLAMMATION BIOMARKERS DURING THE ALLERGEN-SPECIFIC IMMUNOTHERAPY AND ACCOMPANYINGTREATMENT

2011 ◽  
Vol 8 (2) ◽  
pp. 44-50
Author(s):  
T I Eliseeva ◽  
Yu S Kul'gina ◽  
I I Balabolkin ◽  
T I Eliseeva ◽  
U S Kulgina ◽  
...  
Keyword(s):  
Asthma Control ◽  
Bronchial Asthma ◽  
Specific Immunotherapy ◽  
Inhaled Corticosteroids ◽  
Total Concentration ◽  
Allergic Inflammation ◽  
Exhaled Breath ◽  
Allergen Specific Immunotherapy ◽  
Exhaled Air ◽  
Ic Treatment

Background. The work is devoted to the studying of the correspondence between the symptoms dynamics and the concentrations of the nitrogen oxide (NO) methabolites in the exhaled breath air condensate in patients with bronchial asthma (BA) during allergenospecific immunotherapy (ASIT) and accompanying treatment. Methods. The symptoms of BA were estimated using the Asthma Control Questionaire (ACQ). The inflammation biomarkers level (NO methabolites in the exhaled air condensate) was measured by the spectrofluorometric method of Griess. Results. During ASIT and accompanying treatment (cetirizine or levocetirizine with basis BA therapy corresponding to the observed BA severity with allergens eliminated), the symptoms reduction (decrease in the total ACQ scores) was observed along with decrease of the total concentration of NO metabolites in blood. This was observed both for the steroid- naive patients and for the patients taking the inhaled corticosteroids (IC) treatment. Conclusion: In patients with mild BA, combination of ASIT and non-steroid accompanying therapy on the basis of cetirizine or levocetirizine results in the improvement of the BA control and reduction of the allergic inflammation in airways comaparable to the analogous processes in patients with moderate BA taking the analogous therapy but with IC included.

scholarly journals NEUTROPHILS AND RESPIRATORY TRACT BACTERIAL INFECTIONS IN PATIENTS WITH BRONCHIAL ASTHMA AND COPD

2011 ◽  
Vol 8 (2) ◽  
pp. 34-43
Author(s):  
Gleb Borisovich Fedoseev ◽  
B I Trofimov ◽  
N N Rogacheva ◽  
T S Razumovskaya ◽  
G B Fedoseev ◽  
...  
Keyword(s):  
Respiratory Tract ◽  
Allergic Asthma ◽  
Bronchial Asthma ◽  
Respiratory System ◽  
Functional Activity ◽  
Bacterial Infections ◽  
Clinical Investigations ◽  
Copd Patients ◽  
Asthma Patients

The article concerns the role of respiratory tract bacterial infections in development of bronchial asthma and COPD. Analysis is based on current publications and results of clinical investigations. Ability of neutrophils to protect the respiratory system from bacterial agents is underlined. The results obtained during investigation of 132 bronchial asthma and 33 COPD patients showed that in allergic asthma patients high percentage of sputum neutrophils is associated with normal FEV1% and mild course of the disease. In COPD patients high percentage of sputum neutrophils is usually associated with low FEV1%. It is proposed, that in these patients functional activity of neutrophils is associated with predominant injury of respiratory structures.

The Effect of Interleukin 38 on Inflammation-induced Corneal Neovascularization

2019 ◽  
Vol 19 (8) ◽  
pp. 589-596
Author(s):  
Jiangli Zhu ◽  
Jing Zhang ◽  
Yan Wang ◽  
Jianping Chen ◽  
Xiaopeng Li ◽  
...  
Keyword(s):  
Inflammatory Responses ◽  
Interleukin 1 ◽  
Topical Administration ◽  
Corneal Neovascularization ◽  
Tube Formation ◽  
Retinal Endothelial Cells ◽  
Tnf Α ◽  
Inflammation Cytokines

Background: Angiogenesis is tightly linked to inflammation. Cytokines of interleukin 1 (IL-1) family are key mediators in modulating inflammatory responses. Methods: In this study, we examined the role of IL-38, a member of the IL-1 family, in mediating inflammation-induced angiogenesis. Results: The results showed that the angiogenesis was attenuated by topical administration of IL-38 to the injured corneas in a mouse model of alkali-induced corneal neovascularization (CNV). Further study showed that the expression of inflammatory cytokines TNF-α, IL-6, IL-8 and IL-1β was decreased in the IL-38-treated corneas. Moreover, the angiogenic activities including the proliferation, migration and tube formation of human retinal endothelial cells were reduced by IL-38 treatment in vitro. Conclusion: The data indicate that IL-38 modulates inflammation-induced angiogenesis.

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