scholarly journals Intraoperative imaging based on common-path time-domain reflectometry for brain tumor surgery

2020 ◽  
Vol 50 (2) ◽  
Author(s):  
Jae-Ho Han ◽  
Jaepyeong Cha
Keyword(s):  
Brain Tumor ◽  
Real Time ◽  
Time Domain ◽  
Near Infrared ◽  
Intraoperative Imaging ◽  
Tumor Resection ◽  
Time Domain Reflectometry ◽  
Optical Path ◽  
Fiber Probe ◽  
Common Path

Minimally invasive intraoperative imaging plays a crucial role in delicate microsurgeries for precise operation monitoring in which fiber optic imaging can be considered as an endoscopy and surgical proximity guidance tool due to its compactness. This paper presents a near-infrared time-domain reflectometric common-path optical coherence tomography imaging technique using a bare-fiber probe mounted directly on a scanning galvanometer. The common-path setup allows the use of a freely adjustable optical path length and a disposable fiber probe, as well as eliminating the need for an additional dedicated reference optical path. Experimental results demonstrate clear discrimination between the brain tumor tissue and the normal tissue for mouse brains with the images acquired in real-time over a wide area. The proposed method enables real-time and in situ visualization of tumor resection for intraoperative imaging, and this study demonstrates the feasibility of its application to microsurgical interventions.

Three-dimensional Force Perception of Robotic Bipolar Forceps for Brain Tumor Resection

2021 ◽  
Author(s):  
Xiu-Heng Zhang ◽  
Heng Zhang ◽  
Zhen Li ◽  
Gui-Bin Bian
Keyword(s):  
Brain Tumor ◽  
Real Time ◽  
Force Measurement ◽  
Measurement Techniques ◽  
Tumor Resection ◽  
Three Dimensional ◽  
Contact Forces ◽  
Surgical Instruments ◽  
Force Perception ◽  
Brain Tumor Resection

Abstract Three-dimensional force perception is critically important in the enhancement of human force perception to minimize brain injuries resulting from excessive forces applied by surgical instruments in robot-assisted brain tumor resection. And surgeons are not responsive enough to interpret tool-tissue interaction forces. In previous studies, various force measurement techniques have been published. In neurosurgical scenarios, there are still some drawbacks to these presented approaches to forces perception. Because of the narrow, and slim configuration of bipolar forceps, three-dimensional contact forces on forceps tips is not easy to be traced in real-time. Five fundamental acts of handling bipolar forceps are poking, opposing, pressing, opening, and closing. The first three acts independently correspond to the axial force of z, x, y. So, in this paper, typical interactions between bipolar forceps and brain tissues have been analyzed. A three-dimensional force perception technique to collect force data on bipolar forceps tips by installing three Fiber Bragg Grating Sensors (FBGs) on each prong of bipolar forceps in real-time is proposed. Experiments using a tele-neurosurgical robot were performed on an in-vitro pig brain. In the experiments, three-dimensional forces were tracked in real-time. It is possible to experience forces at a minimum of 0.01 N. The three-dimensional force perception range is 0-4 N. The calibrating resolution on x, y, and z, is 0.01, 0.03, 0.1 N, separately. According to our observation, the measurement accuracy precision is over 95%.

scholarly journals 3A1-B04 Real-time Simulation of Brain Tumor Resection Using GPGPU(Medical Robotics and Mechatronics (1))

2014 ◽  
Vol 2014 (0) ◽  
pp. _3A1-B04_1-_3A1-B04_4
Author(s):  
Kazuya SASE ◽  
Atsushi KONNO ◽  
Teppei TSUJITA ◽  
Akira FUKUHARA ◽  
XiaoShuai CHEN ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Real Time ◽  
Tumor Resection ◽  
Medical Robotics ◽  
Real Time Simulation ◽  
Time Simulation ◽  
Brain Tumor Resection

Near-Infrared Spectroscopy: A Tool for Monitoring Submerged Fermentation Processes Using an Immersion Optical-Fiber Probe

2003 ◽  
Vol 57 (2) ◽  
pp. 132-138 ◽  
Author(s):  
E. Tamburini ◽  
G. Vaccari ◽  
S. Tosi ◽  
A. Trilli
Keyword(s):  
Optical Fiber ◽  
Real Time ◽  
Gas Flow ◽  
Near Infrared ◽  
Nir Spectroscopy ◽  
Real Time Monitoring ◽  
Difference Spectra ◽  
Fiber Probe ◽  
Selective Determination ◽  
Optical Fiber Probe

Near-infrared (NIR) spectroscopy has been developed as a noninvasive tool for the direct, real-time monitoring of glucose, lactic acid, acetic acid, and biomass in liquid cultures of microrganisms of the genera Lactobacillus and Staphylococcus. This was achieved employing a steam-sterilizable optical-fiber probe immersed in the culture (In-line Interactance System®). Second-derivative spectra obtained were subjected to partial least-squares (PLS) regression and the results were used to build predictive models for each analyte of interest. Multivariate regression was carried out on two different sets of spectra, namely whole broth minus the spectral subtraction of water, and raw spectra. A comparison of the two models showed that the first cannot be properly applied to real-time monitoring, so this work suggests calibration based on non-difference spectra, demonstrating it to be sufficiently reliable to allow the selective determination of the analytes with satisfactory levels of prediction (standard error of prediction (SEP) < 10%). Direct interfacing of the NIR system to the bioreactor control system allowed the implementation of completely automated monitoring of different cultivation strategies (continuous, repeated batch). The validity of the in-line analyses carried out was found to depend crucially on maintaining constant hydrodynamic conditions of the stirred cultures because both gas flow and stirring speed variations were found to markedly influence the spectral signal.

scholarly journals Simultaneous Assessment of Luminal Integrity and Vascular Perfusion of the Gastrointestinal Tract Using Dual-Channel Near-Infrared Fluorescence

2012 ◽  
Vol 11 (4) ◽  
pp. 7290.2011.00048 ◽  
Author(s):  
Yoshitomo Ashitate ◽  
Carrie S. Vooght ◽  
Merlijn Hutteman ◽  
Rafiou Oketokoun ◽  
Hak Soo Choi ◽  
...  
Keyword(s):  
Real Time ◽  
Vascular Function ◽  
Near Infrared ◽  
Imaging System ◽  
Intraoperative Imaging ◽  
Blood Perfusion ◽  
Herbal Supplement ◽  
Gi Tract ◽  
Vascular Perfusion ◽  
Dual Channel

Anastomotic complications such as stenosis and leakage in the gastrointestinal (GI) tract can cause high patient morbidity and mortality. To identify the potential preconditions of these complications intraoperatively, we explored the use of two 700 nm near-infrared (NIR) fluorophores administered intraluminally: (1) chlorella, an over-the-counter herbal supplement containing high concentrations of chlorophyll, and (2) methylene blue (MB). In parallel, we administered the 800 nm NIR fluorophore indocyanine green (ICG) intravenously to assess vascular function. Dual-channel, real-time intraoperative imaging and quantitation of the contrast to background ratio (CBR) were performed under normal conditions or after anastomosis or leakage of the stomach and intestines in 35 kg Yorkshire pigs using the Fluorescence-Assisted Resection and Exploration (FLARE) imaging system. Luminal integrity could be assessed with relatively high sensitivity with either chlorella or MB, although chlorella provided significantly higher CBR. ICG angiography provided assessment of blood perfusion of normal, ischemic, and anastomotic areas of the GI tract. Used simultaneously, 700 nm (chlorella or MB) and 800 nm (ICG) NIR fluorescence permitted independent assessment of luminal integrity and vascular perfusion of the GI tract intraoperatively and in real time. This technology has the potential to identify critical complications, such as anastomotic leakage, intraoperatively, when correction is still possible.

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