scholarly journals Comparison of BCL-2 Ecpression in Periocular Basal Cell Carcinoma Aggressive and Non-Aggressive Types in Mohammad Hoesin Hospital Palembang

2018 ◽  
Vol 1 (2) ◽  
pp. 18-36
Author(s):  
Fera Yunita Rodhiaty ◽  
Ika Kartika ◽  
Ibrahim
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Malignant Tumor ◽  
Histopathological Examination ◽  
Basal Layer ◽  
Growth Patterns ◽  
Bivariate Analysis ◽  
Fisher Exact Test ◽  
Cross Sectional

Abstract Background: Basal cell carcinoma (BCC) is a malignant tumor originating from non- keratinizing cells originating from the basal layer of the epidermis. Basal cell carcinoma is the most common malignant tumor, nearly 90% of all non-melanoma skin cancers. Clinically, BCC is difficult to distinguish, final diagnosis determined based on histopathological examination of complete tumor tissue. Based on histological growth patterns, BCC is divided into two, non- aggressive type (nodular and superficial) and aggressive type (infiltration, micronodular, fibroepithelial, basoskuamosa, keratotic, adnexal differentiation). The examination technique by analyzing the proteins or genes involved is related to the aggressiveness of basal cell carcinoma. Objective: This study was conducted to determine the comparison of expression of Bcl-2 in periocular basal type aggressive and non-aggressive carcinomas in dr. Mohammad Hoesin Palembang. Methodology: A cross sectional analytic study from 26 periocular basal cell carcinoma patients in RSUP dr. Mohammad Hoesin Palembang, January 2014- June 2018. Histopathologic features were examined with hematoxylin-eosine staining and imunohistochemical were examined with Bcl-2 monoclonal antibody. Data were analyzed by bivariate analysis, using chi-square test and fisher exact test. Results: Positive Bcl-2 expression was more common in periocular basal cell carcinoma (93.8%) than aggressive (50%), and nodular type (93.8%) compared to other types of histological differentiation. Positive Bcl-2 expression was also higher in female patients (90.9%) than males (66.7%). There is a significant relationship between expression of Bcl-2 and growth patterns, differentiation of cell histology and also sex of patients with basal cell carcinoma. Conclusion: In this study, there was a significant correlation between expression of Bcl-2 and aggressive and non-aggressive periocular basal cell carcinoma in RSUP dr. Mohammad Hoesin Palembang.

BOWENOID BASAL CELL CARCINOMA OF THE THUMB: A CASE REPORT AND REVIEW OF THE LITERATURE

Hand Surgery ◽  
2002 ◽  
Vol 07 (02) ◽  
pp. 295-298 ◽  
Author(s):  
M. Galeano ◽  
M. Colonna ◽  
M. Lentini ◽  
F. Stagno D'Alcontres
Keyword(s):  
Case Report ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Basal Layer ◽  
Rare Entity ◽  
Review Of The Literature ◽  
Skin Malignancy ◽  
Root Sheath ◽  
Common Skin

Basal cell carcinoma (BCC) is the most common skin malignancy arising from cells of the basal layer of the epithelium or from the external root sheath of the hair follicle. BCC of the digit is a rare entity. The article presents one such case of bowenoid BCC of the thumb which required amputation at the MP joint.

scholarly journals Large Basal Cell Carcinoma Defect Closure on The Lateral Cheek Using Multiple Advancement Flaps

2021 ◽  
pp. 1-7
Author(s):  
Siswanto Wahab ◽  
Khairuddin Djawad
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Histopathological Examination ◽  
Skin Flap ◽  
Reconstruction Procedure ◽  
The Face ◽  
Advancement Flaps ◽  
Substantial Morbidity

Basal cell carcinoma (BCC) is the most common type of nonmelanoma skin cancer (NMSC). It grows slowly and very rarely metastasizes but can cause substantial morbidity due to its tendency to relapse and locally invasive nature, especially when located on the face. Excision surgery is still the gold standard treatment for primary BCC and is usually followed by reconstruction procedure. Skin flap techniques vary widely, one of which is flap advancement technique. The main benefit of flap advancement technique is the ability to hide the excision line, thus resulting in an aesthetically sound outcome. We report a case of 72-year-old female with hyperpigmented plaque brownish lump on the left lateral cheek. A diagnosis of igmented basal cell carcinoma had been confirmed through histopathological examination. The patient was treated with wide excision surgery and the defect was closed by multiple advancement flaps. Follow-up after three months showed excellent cosmetic and functional outcome.

Staged excision of primary periocular basal cell carcinoma: absence of residual tumour in re-excised specimens: a 10-year series

2018 ◽  
Vol 103 (7) ◽  
pp. 976-979 ◽  
Author(s):  
Lindsay A McGrath ◽  
Adam Meeney ◽  
Zanna I Currie ◽  
Hardeep Singh Mudhar ◽  
Jennifer H Tan
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Significant Proportion ◽  
Surgical Excision ◽  
Lower Eyelid ◽  
Growth Patterns ◽  
Residual Tumour ◽  
Tumour Characteristics

AimsThe aim is to study staged periocular basal cell carcinoma (BCC) excision in a tertiary oculoplastic referral centre in Sheffield, UK. In particular, we examined patients with close or positive margins and no tumour seen on re-excision to identify demographics and tumour characteristics in this population.MethodsA retrospective review of medical records of 437 cases of staged periocular BCC excisions over a 10-year period (2007–2017) was carried out. Patients had surgical excision with 3 mm clinically clear margins. Staged excision was performed for all cases included in this study. Standard reconstruction techniques were employed. Histopathology was analysed for tumour type, subtype and stage.ResultsOver the 10-year period, of the 437 periocular BCCs, 156 had close or involved margins. Residual tumour was found in 29 (18.6%), whereas in 122 eyelids of 120 patients (78.2%) no residual tumour was identified on histological examination. Micronodular (54.1%) and nodular (23.7%) growth patterns of BCC, as well as lower eyelid location (72.1%), were the most prevalent in this population. Two patients (1.6%) had recurrence of BCC over a mean follow-up of 57 months (range 1–125 months).ConclusionsA significant proportion of BCCs transected on initial excision show no residual tumour in the re-excision specimens. In the interval between initial excision and re-excision, there may be eradication of the residual tumour. The exact mechanisms for this are unclear, however, and re-excision remains the appropriate recommended course in the presence of involved surgical margins of periocular BCC, particularly when high-risk tumour subtypes are encountered.

scholarly journals Differences in Rate of Complete Excision of Basal Cell Carcinoma by Dermatologists, Plastic Surgeons and General Practitioners: A Large Cross-Sectional Study

Dermatology ◽  
2018 ◽  
Vol 234 (3-4) ◽  
pp. 86-91 ◽  
Author(s):  
Kirtie Ramdas ◽  
Charlotte van Lee ◽  
Samuel Beck ◽  
Patrick Bindels ◽  
Vincent Noordhoek Hegt ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
General Practitioners ◽  
Basal Cell ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Complete Excision ◽  
Cross Sectional

scholarly journals Molecular detection of Merkel cell polyomavirus in basal cell carcinoma and perilesional tissue: a cross-sectional study

2020 ◽  
Vol 95 (4) ◽  
pp. 527-528
Author(s):  
Marianna Tavares Venceslau Gonçalves ◽  
Rafael Brandão Varella ◽  
Núbia Karla de Oliveira Almeida ◽  
Maria Angelica Arpon Marandino Guimarães ◽  
Flávio Barbosa Luz
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Molecular Detection ◽  
Cross Sectional Study ◽  
Merkel Cell Polyomavirus ◽  
Merkel Cell ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Concurrent primary and secondary myiasis on basal cell carcinoma

2012 ◽  
Vol 87 (2) ◽  
pp. 292-295 ◽  
Author(s):  
Adriana Andrade Raposo ◽  
Antônio Pedro Mendes Schettini ◽  
Cesare Massone
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Histopathological Examination ◽  
Traumatic Injury ◽  
Skin Condition ◽  
Healthy Patient ◽  
Dorsal Region ◽  
Skin Cancers ◽  
Fly Larvae

Myiasis is a disease caused by infestation of fly larvae in human and other vertebrate tissues. It is a skin condition common in tropical and subtropical countries and its predisposing factors are: chronic diseases, immunodeficiency, poor hygiene, senility, psychiatric disorders, skin cancers and ulcerated mucosae. We report the case of a healthy patient who after traumatic injury of a preexisting lesion showed a tumor on the dorsal region parasitized by fly larvae. The histopathological examination performed for the diagnosis of skin neoplasm surprisingly revealed the presence of a partially degenerated larva with characteristics of Dermatobia hominis, suggesting an association of primary and secondary myiasis on basal cell carcinoma.

Excision of Head and Neck Basal Cell Carcinoma With a Rapid, Cross-sectional, Frozen-Section Technique

2002 ◽  
Vol 4 (2) ◽  
pp. 114-119 ◽  
Author(s):  
Stuart H. Bentkover ◽  
Donald M. Grande ◽  
Henry Soto ◽  
Beth A. Kozlicak ◽  
Donna Guillaume ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Basal Cell ◽  
Frozen Section ◽  
Cross Sectional ◽  
Section Technique

scholarly journals Pigmented Paraaxillary Located "Complex" Basal Cell Carcinoma Imitating clinically irritated Melanocytic Lesion - Succesfull Surgical Approach in Bulgarian Patient

2017 ◽  
Vol 5 (4) ◽  
pp. 497-500
Author(s):  
Cristiana Voicu ◽  
Mara Mihai ◽  
Mihai Lupu ◽  
James W. Patterson ◽  
Nely Koleva ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Histopathological Examination ◽  
Surgical Excision ◽  
Melanocytic Lesion ◽  
Complete Surgical Excision ◽  
Axillary Region ◽  
The Right ◽  
Clinical Subtype

BACKGROUND: Basal cell carcinoma (BCC) is the most frequently encountered neoplasm worldwide. While nodular BCC is the most frequent clinical subtype, other forms of BCC, such as superficial, cystic, morpheiform, infiltrative, and pigmented may also be encountered.CASE PRESENTATION: We present the case of a 67-year-old male with a relatively well-defined infiltrative, pigmented plaque with multiple colours and peripheral growth situated in the right axillary region. The histopathologic examination performed after complete surgical excision of the tumour revealed a complex pigmented BCC with macronodular, fibroepithelioma-like, cystic, focally infiltrative and basosquamous features.CONCLUSION: Uncommon locations of BCCs in sun-protected areas such as the axillary region require a higher degree of suspicion for diagnosis. The complex histology of the presented case, including subtypes with differing biologic attributes, emphasises the importance of histopathological examination in the diagnosis and therapeutic management of BCC.

scholarly journals Spontaneous Regression of Annular Basal Cell Carcinoma: A Case Report

2019 ◽  
Vol 11 (2) ◽  
pp. 145-149
Author(s):  
Usho Go ◽  
Kazunori Miyata ◽  
Masaru Fujita ◽  
Takashi Ohide ◽  
Tsuyoshi Mitsuishi
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Spontaneous Regression ◽  
Histopathological Examination ◽  
Sweat Glands ◽  
Temporal Region ◽  
Japanese Male ◽  
Old Japanese ◽  
The Right

We herein present a case of annular basal cell carcinoma (BCC) with spontaneous regression on the right temporal region of a 56-year-old Japanese male. Histopathological examination revealed that the central section had no tumor cells. The sweat glands, follicles, and other cutaneous appendages were also absent. This pattern of spontaneous regression is quite uncommon, and understanding the histopathology may be important for future approaches to BCC.

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