scholarly journals Evaluation of Molecularly Imprinted Polymer Pearls for Selective Isolation of Hypericins

2017 ◽  
Vol 54 (3) ◽  
pp. 495-501 ◽  
Author(s):  
Ana Mihaela Florea ◽  
Tanta Verona Iordache ◽  
Anamaria Zaharia ◽  
Bianca Georgescu ◽  
Andreea Elena Voicu ◽  
...  
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Phase Inversion ◽  
Hypericum Perforatum ◽  
Thermal Analyses ◽  
Selective Isolation ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Wet Phase Inversion ◽  
Hypericum Perforatum L

This article describes the evaluation of molecularly imprinted polymers (MIPs) obtained by wet phase inversion for facile separation of hypericins from Hypericum perforatum L. (or Saint John�s Wort, SJW). In this respect, concentrated extracts containing hypericin and pseudohypericin were used as �phyto-templates� for creating selective cavities into the pearl shaped MIPs. The obtained MIPs were characterized by infrared and by thermal analyses. Chromatographic evaluation of the MIPs was performed relative to blank samples and it was concluded that the pearls can retain selectively the hypericins from SJW extracts.

scholarly journals Molecularly Imprinted Polymer Pearls Obtained by Phase Inversion for the Selective Recognition of Hypericin

2019 ◽  
Vol 56 (2) ◽  
pp. 315-320
Author(s):  
Ana-Mihaela(Florea) Gavrila ◽  
Tanta-Verona Iordache ◽  
Teodor Sandu ◽  
Anamaria Zaharia ◽  
Anita-Laura Radu ◽  
...  
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Phase Inversion ◽  
High Performance ◽  
Extraction Procedure ◽  
Inversion Method ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Wet Phase Inversion ◽  
Uv Visible ◽  
Phase Inversion Method

A facile and inexpensive approach was established to prepare spherical molecularly imprinted polymers with hypericin (H-MIPs) via the wet-phase inversion method. The H-MIPs were characterized by infrared spectroscopy and thermogravimetric analysis. High-performance liquid chromatography combined with UV-Visible spectroscopy were used to assess the efficiency of the extraction procedure and, furthermore, to investigate the recognition properties of the H-MIPs. Obtaining an imprinting factor of 3.38 for hypericin strongly indicated a successful formation of molecularly imprinted cavities onto the H-MIPs. A fair selectivity towards hypericin was tested in comparison to the interfering molecule pseudohypericin.

Recent developments in molecularly imprinted polymer nanofibers and their applications

2015 ◽  
Vol 7 (18) ◽  
pp. 7406-7415 ◽  
Author(s):  
Shabi Abbas Zaidi
Keyword(s):  
Molecularly Imprinted Polymer ◽  
Molecularly Imprinted Polymers ◽  
Imprinted Polymer ◽  
Polymer Nanofibers ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Recent Developments ◽  
Analyte Detection

Molecularly imprinted polymers (MIPs) have been potential and versatile candidates for analyte detection.

Simple and selective detection of quercetin in extracts of plants and food samples by dispersive-micro-solid phase extraction based on core–shell magnetic molecularly imprinted polymers

2018 ◽  
Vol 42 (19) ◽  
pp. 16144-16153 ◽  
Author(s):  
Arash Asfaram ◽  
Maryam Arabi ◽  
Abbas Ostovan ◽  
Hossein Sadeghi ◽  
Mehrorang Ghaedi
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Solid Phase ◽  
Food Samples ◽  
Selective Detection ◽  
Phase Extraction ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Magnetic Molecularly Imprinted Polymer ◽  
Magnetic Molecularly Imprinted Polymers

In the present study, a D-μ-SPE clean-up method was established for the analysis of quercetin in extracts of plants and food samples using a magnetic molecularly imprinted polymer as the sorbent by HPLC-UV detection.

scholarly journals Determination of sialic acid in serum samples by dispersive solid-phase extraction based on boronate-affinity magnetic hollow molecularly imprinted polymer sorbent

RSC Advances ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. 5394-5401 ◽  
Author(s):  
Wei Huang ◽  
Xingyu Hou ◽  
Yukui Tong ◽  
Miaomiao Tian
Keyword(s):  
Sialic Acid ◽  
Molecularly Imprinted Polymers ◽  
Solid Phase ◽  
Phase Extraction ◽  
Dispersive Solid Phase Extraction ◽  
Imprinted Polymer ◽  
Serum Samples ◽  
Molecularly Imprinted ◽  
Imprinted Polymers

Boronate-affinity magnetic hollow molecularly imprinted polymers were prepared with sialic acid (SA) as a template to selectively extract SA from serum samples coupled with HPLC-UV.

scholarly journals Reusable molecularly imprinted polymeric nanospheres for diclofenac removal from water samples

2020 ◽  
pp. 174751982092599
Author(s):  
Noha Amaly ◽  
Georges Istamboulie ◽  
Ahmed Y El-Moghazy ◽  
Thierry Noguer
Keyword(s):  
Molecularly Imprinted Polymer ◽  
Molecularly Imprinted Polymers ◽  
Water Samples ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Residue Removal ◽  
Pharmaceutical Pollutants ◽  
Polymer Nanospheres ◽  
Average Size

The preparation of efficient molecularly imprinted polymers materials (MIPs) for pharmaceutical residue removal is still a challenging task. Herein, we design uniformly molecularly imprinted polymer nanospheres via a precipitation polymerization method using methacrylic acid (MAA) as functional monomer and N,N-methylenebis(acrylamide) (MBAA) as a crosslinker for removal of diclofenac (DFC) as a model for pharmaceutical pollutants. Nanospheres with average size 200 nm were prepared with MAA:MBAA at a ratio of 1:7 and acetonitrile/toluene (1:1) as a porogenic solvent. The successful synthesis is evidenced by Fourier transform infrared spectroscopy, scanning electron microscopy, and with a particle size analyzer. The rebinding experiments confirmed that the more introduction of the carboxyl groups from MAA could remarkably improve the imprinting effect with a significantly increased imprinting factor and specific rebinding capacity reached 450 mg/g after 15 min. Furthermore, the adsorption capacity of the molecularly imprinted polymers is maintained above 85% after seven regeneration cycles, indicating that the molecularly imprinted polymers can be used multiple times. Moreover, the developed molecularly imprinted polymers show promising DFC removal efficiency from real water samples, which suggests that the prepared molecularly imprinted polymer nanospheres are promising in DFC separation.

scholarly journals MOLECULARLY IMPRINTED POLYMER NANOPARTICLES (MIP-NPs) APPLICATIONS IN ELECTROCHEMICAL SENSORS

2019 ◽  
pp. 1-6
Author(s):  
DIANE FAUZI ◽  
FEBRINA AMELIA SAPUTRI
Keyword(s):  
Molecularly Imprinted Polymers ◽  
High Stability ◽  
Electrochemical Sensors ◽  
Specific Binding ◽  
Environmental Contaminants ◽  
Polymer Nanoparticles ◽  
Selective Recognition ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Imprinted Polymers

Molecularly Imprinted Polymers (MIPs) is a polymer that binds together to form a specific binding site that is selective for certain analytes. Its high stability, its synthesize simplicity, and it can ease costs significantly make it was applied widely as a receptor instead of antibodies or enzymes. MIPs can be re-developed into MIPs nanoparticles (MIP-NPs) which have greater potential. MIPs use in electrochemical sensors have relevant applications in daily life and have been tested in human samples. Electrochemical sensors have been successfully functioned with MIP-NPs leading to real-time monitoring of drugs, pesticides, environmental contaminants, and secondary metabolites, as well as molecules with biological relevance. The aim of this review is to summarize the developments and applications of MIP-NPs as a selective recognition component in electrochemical sensors with special emphasis on their analytical applications.

Molecularly Imprinted Polymer and Computational Study of (E)-4-(2- cyano-3-(dimethylamino)acryloyl)benzoic Acid from Poly(ethylene terephthalate) Plastic Waste

2020 ◽  
Vol 16 (2) ◽  
pp. 119-137 ◽  
Author(s):  
Asmaa M. Fahim ◽  
Bartłomiej Wasiniak ◽  
Jerzy P. Łukaszewicz
Keyword(s):  
Benzoic Acid ◽  
Molecularly Imprinted Polymer ◽  
Molecularly Imprinted Polymers ◽  
Ethylene Terephthalate ◽  
Computational Study ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Poly Ethylene Terephthalate ◽  
Poly Ethylene

Background: Molecularly imprinted polymers (MIPs) are utilized in the separation of a pure compound from complex matrices. A stable template-monomer complex generates MIPs with the highest affinity and selectivity for the template. In this investigation, degradation of Poly(ethylene terephthalate) PET afforded the (E)-4-(2-cyano-3-(dimethylamino) acryloyl) benzoic acid (4) (TAM) which used TAM as template which interacts with Methacrylic Acid (MAA) monomer, in the presence of CH3CN as progen. The TAM-MMA complex interactions are dependent on stable hydrogen bonding interaction between the carboxylic acid group of TAM and the hydroxyl group of MMA with minimal interference of porogen CH3CN. The DFT/B3LYP/6-31+G model chemistry was used to optimize their structures and frequency calculations. The binding energies between TAM with different monomers showed the most stable molar ratio of 1:4 which was confirmed through experimental analysis. Methods: The present work describes the synthesis of (E)-4-(2-cyano-3-(dimethylamino) acryloyl) benzoic acid (4) (TAM) from PET waste and formation of molecularly imprinted polymer from TAM with the methacrylic acid monomer. The optimization of molecular imprinted was stimulated via DFT/B3LYP/6-31G (d). The imprinted polymer film was characterized via thermal analysis, pore size, FT-IR and scanning electron microscopy. Results: The most stable molecularly imprinted polymers (MIPs) showed binding energy of TAM(MMA4)=-2063.456 KJ/mol with a small value of mesopores (10-100 Å). Also, the sorption capability of TAM-MIPs showed 6.57 mg/g using STP-MIP-9VC. Moreover, the average pore size ranged between 0.2-1 nm with the BET surface about 300 m2/g. Conclusion: The proposed TAM exhibited a high degree of selectivity for MMA in comparison with other different monomers through hydrogen bond interaction, which was thermally stable, good reproducibility and excellent regeneration capacity and elucidated in the computational study and analytical analysis.

Influences of Preparative Conditions on Properties of Erythromycin-Molecularly Imprinted Membrane

2009 ◽  
Vol 87-88 ◽  
pp. 119-124
Author(s):  
Ping Guan ◽  
Xiao Ling Hu ◽  
Ya Mei Zhao
Keyword(s):  
Ethyl Alcohol ◽  
Phase Inversion ◽  
Extraction Time ◽  
Cross Linking ◽  
Functional Monomer ◽  
Absolute Ethyl Alcohol ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Wet Phase Inversion ◽  
Molecularly Imprinted Membrane

Erythromycin molecularly imprinted membranes (EM-MIMs) were prepared by wet phase inversion from imprinted polymers which were prepared by MAA as functional monomer, AN as membrane monomer and EDMA as crosslinker in the presence of erythromycin as template. The influences of the proportion of EM and MAA, cross-linking use level, different initiators and use level as well as extraction time on the imprinted sites and specific separation of EM-MIMs for EM were investigated. The results show that EM-MIMs were provided with more imprinted sites and more excellent separation properties for EM when adding MAA 0.0461mol, EM 0.724mmol, AIBN and (NH4)2S2O8 each 0.12g as initiators, and the mole ratio of EDMA and MAA at 5:1. The extraction of templates was carried out by using absolute ethyl alcohol as eluant and ultrasonic oscillating for 40min.

Synthesis and Evaluation of a Molecularly Imprinted Polymer Selective to 2,4,6-Trichlorophenol

2004 ◽  
Vol 57 (8) ◽  
pp. 759 ◽  
Author(s):  
Lachlan Schwarz ◽  
Clovia I. Holdsworth ◽  
Adam McCluskey ◽  
Michael C. Bowyer
Keyword(s):  
Molecularly Imprinted Polymer ◽  
Molecularly Imprinted Polymers ◽  
Competitive Binding ◽  
Imprinted Polymer ◽  
Binding Studies ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Target Molecule ◽  
High Preference ◽  
Structural Analogues

Molecularly imprinted polymers (MIPs) selective for the phenolic contaminant 2,4,6-trichlorophenol (2,4,6-TCP) were prepared and evaluated in three porogens of differing character (hexane, acetonitrile, dichloromethane). Rebinding of 2,4,6-TCP was found to be most effective in dichloromethane (imprinting factor: 13.2). Competitive binding studies performed against a range of close structural analogues showed a high preference for the target molecule, although partial recognition towards 2,4-dichlorophenol was also observed. Specificity was found to be dependent upon the presence of ring chlorine on the target, which suggested that these atoms participate in secondary binding interactions that are essential for successful recognition in the polymer cavity.

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