Collagenase-2- (MMP-8) as a Poimt - of- care Biomerker in Periodontal Disease in Patients with or Without Fixed Prosthesis Therapeutic Response to Doxycycline

Periodontal diseases ranges from simple gum inflammation to serious disease that consists in major damage to the soft tissue and bone teeth support. Periodontal diseases affects the marginal and apical periodontium and results from the interaction between bacterial biofilm and the host response. To determine the concentrations of MMP-8, as a disease marker, in saliva in prosthetic and nonprosthetic, aggressive (AP) and chronic (CP) periodontitis, doxycycline treated patients. 40 patients were distributed into 3 groups: 12 diagnosed with aggressive (AgP), 18 with chronic (CP) periodontitis. Each of these groups was subdivided into 2 subgroups with and without fixed prosthesis. 10 patients were in the normal group. Matrix metalloproteinase 8 (MMP-8) was evaluated before and after systemic doxycycline (Dox) treatment. mean MMP-8 value into the control group was 0.57 ng/mL with a standard deviation (STD) of 0,094 ng/mL. Highest MMP-8 value was established for the nonprosthesis AgP subgroup, before Dox treatment. The highest reduction in MMP-8 levels (40.8%) was between nonprosthesis AgP before Dox treatment and the same group after Doxycycline treamtent. MMP-8 saliva levels are lower than GCF levels, mostly through a dilution mechanism as previous studies had shown. Our study revealed that saliva MMP-8 level is relible marker for AgP but not for CP. Doxycycline treatment, in terms of lowering MMP-8 levels is most effective in patients that have AP and are also wearing fixed.

Download Full-text

Collagenase-2- (MMP-8) as a Poimt - of- care Biomerker in Periodontal Disease in Patients with or Without Fixed Prosthesis Therapeutic Response to Doxycycline

Revista de Chimie ◽

10.37358/rc.70.19.11.7703 ◽

2019 ◽

Vol 70 (11) ◽

pp. 4068-4072

Keyword(s):

Periodontal Disease ◽

Periodontal Diseases ◽

Bacterial Biofilm ◽

Control Group ◽

Disease Marker ◽

Doxycycline Treatment ◽

Group Matrix ◽

Before And After ◽

Fixed Prosthesis ◽

Serious Disease

Download Full-text

Optimization of antibacterial therapy in patients with endo-periodontal lesions

Biomedical Photonics ◽

10.24931/2413-9432-2021-10-1-17-24 ◽

2021 ◽

Vol 10 (1) ◽

pp. 17-24

Author(s):

R. A. Saleev ◽

S. L. Blashkova ◽

E. V. Krikun ◽

G. T. Saleeva ◽

J. V. Blashkova ◽

...

Keyword(s):

Diode Laser ◽

Periodontal Diseases ◽

Evaluation Criteria ◽

Qualitative Assessment ◽

Periodontal Pocket ◽

Control Group ◽

Root Canals ◽

Results Of Treatment ◽

Before And After ◽

Technological Effectiveness

To improve the quality and effectiveness of medical care for patients with inflammatory periodontal diseases, it is necessary to search for new approaches in both diagnosis and treatment. The aim of our study is to determine the effect of the diode laser on the pathogenic microflora of periodontal pockets and root canals in patients with endo-periodontal lesions (EPL). We carried out a comparative assessment of the bacterial contents of the root canals and periodontal pockets by polymerase chain reaction (PCR) before and after treatment with a diode laser (Doctor Smile Simpler, wavelength 980 nm) for 54 patients with EPL. The control group consisted of 56 patients who were treated according to the generally accepted method, including professional oral hygiene, endodontic treatment, and curettage of periodontal pockets. Evaluation criteria were a qualitative assessment of the content of periodontopathogens in the root canal and periodontal pocket before and after and treatment. As a result of our study, we found a statistically significant (p<0.01) reduction in the colonization of periodontal pockets and root canals in patients with EPL after laser decontamination. The high technological effectiveness of the methods used in combination with the low risk of complications at the stages of endodontic and periodontological treatment provides an antibacterial effect and reduces the duration of inflammation. The results of treatment of patients using a diode laser give reason to recommend their use in the dental practice.

Download Full-text

Neopterin Profile to Evaluate the Effectiveness of Treatment in Aggressive Periodontitis

Pteridines ◽

10.1515/pteridines.2003.14.3.77 ◽

2003 ◽

Vol 14 (3) ◽

pp. 77-81 ◽

Cited By ~ 4

Author(s):

Aysen Bodur ◽

Terken Baydar ◽

Nurdan Ozmeric ◽

Ayse Basak Engin ◽

Ahu Uraz ◽

...

Keyword(s):

Periodontal Disease ◽

Periodontal Diseases ◽

Aggressive Periodontitis ◽

Periodontal Treatment ◽

Control Group ◽

Non Invasive ◽

Neopterin Concentration ◽

Significant Difference ◽

Before And After ◽

Pre Treatment

Abstract Periodontal disease results from the interaction of the host defence mechanisms with the microbial dental plaque. Analysis of gingival crevicular Huid (GCF) provides a non-invasive means of evaluating the role of the host response in periodontal disease. Based on our previous study, demonstrating increased levels of neopterin in GCF and saliva from patients with aggressive periodontitis (AgP), the aim of this study was to evaluate the effect of periodontal treatment on the levels of neopterin in GCF, saliva and urine of patients with AgP.Pre-treatment values of neopterin in GCF were 4.04 ± 0.86 nmol/ml for the AgP group (n=8) and 2.68 ± 0.90 nmol/ml fyr the control group (n=8; difference not significant). After periodontal treatment, the level of ncoptei in was found 2.38 ± 0.72 nmol/ml in the patient group which did not differ f r om pre-treatment levels. The salivary neopterin concentration was higher in both AgP groups (14.14 ± 2.85 nmol/1 and 8.02 ± 3.12 nmol/1, before and after periodontal treatment) than in controls (2.58 ± 0.3 nmol/1; both p<0.05). No significant difference in salivary neopterin level was observed in patients before and after periodontal treatment.Concentrations of urine neopterin in patients before treatment were 188.5 ± 30.98 μηιοί neopterin/mol creatinine and 168.1 + 20.21 μηιοί in controls (difference not significant). Following periodontal treatment, the urinary neopterin levels (310.1 ± 39.82 μηιοί neopterin/mol creatinine) were higher when compared to the baseline levels and to controls (p<0.05).Our results suggest that neopterin in saliva and GCF might be associated with the periodontal diseases process.

Download Full-text

Thermography of periodontal tissues in patients with partial tooth loss before and after orthopedic treatment

Medical alphabet ◽

10.33667/2078-5631-2020-3-22-24 ◽

2020 ◽

pp. 22-24

Author(s):

E. N. Zhulev ◽

E. P. Arkhangelskaya

Keyword(s):

Tooth Loss ◽

Periodontal Diseases ◽

Study Data ◽

Ease Of Use ◽

Control Group ◽

Orthopedic Treatment ◽

Partial Loss ◽

Periodontal Tissues ◽

Non Invasive ◽

Before And After

The article is devoted to the study of the condition of periodontal tissues in patients with diagnoses of ‘defect of hard tissue of teeth’ and ‘partial loss of teeth’ before and after orthopedic treatment using the method of thermography. The method of infrared thermography has such qualities as high information content, non-invasive research, ease of use, objectivity and complete safety. 50 patients were examined before and after prosthetics with fixed prostheses and 30 subjects of the control group with an intact periodontium. As a result of the study, data were obtained that led to the conclusion that orthopedic treatment of patients with periodontal diseases favorably affects the state of periodontal tissues, reducing inflammation, as evidenced by a decrease in thermography values after treatment.

Download Full-text

Effects of a 6-Week Straw Phonation in Water Exercise Program on the Aging Voice

Journal of Speech Language and Hearing Research ◽

10.1044/2020_jslhr-19-00124 ◽

2020 ◽

Vol 63 (4) ◽

pp. 1018-1032

Author(s):

Chia-Hsin Wu ◽

Roger W. Chan

Keyword(s):

Acoustic Analysis ◽

Vocal Tract ◽

Exercise Program ◽

Analysis Of Covariance ◽

Elderly Subjects ◽

Control Group ◽

Perceptual Evaluation ◽

Positive Effects ◽

Aging Voice ◽

Before And After

Purpose Semi-occluded vocal tract (SOVT) exercises with tubes or straws have been widely used for a variety of voice disorders. Yet, the effects of longer periods of SOVT exercises (lasting for weeks) on the aging voice are not well understood. This study investigated the effects of a 6-week straw phonation in water (SPW) exercise program. Method Thirty-seven elderly subjects with self-perceived voice problems were assigned into two groups: (a) SPW exercises with six weekly sessions and home practice (experimental group) and (b) vocal hygiene education (control group). Before and after intervention (2 weeks after the completion of the exercise program), acoustic analysis, auditory–perceptual evaluation, and self-assessment of vocal impairment were conducted. Results Analysis of covariance revealed significant differences between the two groups in smoothed cepstral peak prominence measures, harmonics-to-noise ratio, the auditory–perceptual parameter of breathiness, and Voice Handicap Index-10 scores postintervention. No significant differences between the two groups were found for other measures. Conclusions Our results supported the positive effects of SOVT exercises for the aging voice, with a 6-week SPW exercise program being a clinical option. Future studies should involve long-term follow-up and additional outcome measures to better understand the efficacy of SOVT exercises, particularly SPW exercises, for the aging voice.

Download Full-text

Effect of Emotions in a Lexical Decision Task

Swiss Journal of Psychology ◽

10.1024/1421-0185/a000193 ◽

2017 ◽

Vol 76 (2) ◽

pp. 71-79 ◽

Cited By ~ 1

Author(s):

Hélène Maire ◽

Renaud Brochard ◽

Jean-Luc Kop ◽

Vivien Dioux ◽

Daniel Zagar

Keyword(s):

Lexical Decision ◽

Lexical Decision Task ◽

Emotional State ◽

Control Group ◽

Decision Task ◽

Attentional Orienting ◽

Emotional States ◽

Sequence Effect ◽

Emotion Induction ◽

Before And After

Abstract. This study measured the effect of emotional states on lexical decision task performance and investigated which underlying components (physiological, attentional orienting, executive, lexical, and/or strategic) are affected. We did this by assessing participants’ performance on a lexical decision task, which they completed before and after an emotional state induction task. The sequence effect, usually produced when participants repeat a task, was significantly smaller in participants who had received one of the three emotion inductions (happiness, sadness, embarrassment) than in control group participants (neutral induction). Using the diffusion model ( Ratcliff, 1978 ) to resolve the data into meaningful parameters that correspond to specific psychological components, we found that emotion induction only modulated the parameter reflecting the physiological and/or attentional orienting components, whereas the executive, lexical, and strategic components were not altered. These results suggest that emotional states have an impact on the low-level mechanisms underlying mental chronometric tasks.

Download Full-text

Changes in Platelet Aggregability after Ovariectomy

Thrombosis and Haemostasis ◽

10.1055/s-0038-1657029 ◽

1979 ◽

Vol 42 (04) ◽

pp. 1332-1339 ◽

Cited By ~ 7

Author(s):

Hiroh Yamazaki ◽

Takeshi Motomiya ◽

Minoru Sonoda ◽

Noboru Miyagawa

Keyword(s):

Platelet Count ◽

Platelet Activation ◽

Ovarian Hormones ◽

Control Group ◽

Platelet Aggregability ◽

Appearance Rate ◽

Before And After ◽

The Difference ◽

Induced Aggregation ◽

Observation Period

SummaryChanges in platelets in 48 patients with uterine myoma before and after hysterectomy with and without ovariectomy were examined. Bilateral ovariectomy in 25 cases (ovariec-tomized group) and unilateral or non-ovariectomy in 23 cases (control group) were performed at the hysterectomy. Platelet count and an appearance rate of secondary aggregation decreased at one day after and increased at one week after the operation, similarly in both the ovariectomized and the control group. The appearance rate of secondary aggregation was reflected in an intensity of aggregation at 5 min after the addition of reagent to PRP. At one month after the operation, the appearance rate of secondary aggregation induced by 3 μM ADP showed a statistically significant decrease in comparison with the preoperation value (P <0.05) and the enhancement of 5-min aggregation was still observed in the control group, while ceased in the ovariectomized group. The difference between the two groups was significant (P < 0.05). There was almost no change in the speed and intensity of primary and secondary aggregation during the observation period. No significant differences in collagen-induced aggregation were noted between the two groups. The results suggest that ovarian hormones, mainly estrogen, facilitate platelet activation which is mediated by the so-called secondary aggregation.

Download Full-text

PENGARUH TERAPI TERTAWA TERHADAP PENURUNAN TEKANAN DARAH LANSIA DI UPT PANTI WREDHA BUDHI DHARMA YOGYAKARTA

Surya Medika: Jurnal Ilmiah Ilmu Keperawatan dan Ilmu Kesehatan Masyarakat ◽

10.32504/sm.v13i1.99 ◽

2019 ◽

Vol 13 (1) ◽

Author(s):

Niken Setyaningrum ◽

Andri Setyorini ◽

Fachruddin Tri Fitrianta

Keyword(s):

Blood Pressure ◽

Data Analysis ◽

The Elderly ◽

Control Group ◽

Group Comparison ◽

Control Blood Pressure ◽

Men And Women ◽

Treatment Of Hypertension ◽

Before And After ◽

The Difference

ABSTRACTBackground: Hypertension is one of the most common diseases, because this disease is suffered byboth men and women, as well as adults and young people. Treatment of hypertension does not onlyrely on medications from the doctor or regulate diet alone, but it is also important to make our bodyalways relaxed. Laughter can help to control blood pressure by reducing endocrine stress andcreating a relaxed condition to deal with relaxation.Objective: The general objective of the study was to determine the effect of laughter therapy ondecreasing elderly blood pressure in UPT Panti Wredha Budhi Dharma Yogyakarta.Methods: The design used in this study is a pre-experimental design study with one group pre-posttestresearch design where there is no control group (comparison). The population in this study wereelderly aged over> 60 years at 55 UPT Panti Wredha Budhi Dharma Yogyakarta. The method oftaking in this study uses total sampling. The sample in this study were 55 elderly. Data analysis wasused to determine the difference in blood pressure before and after laughing therapy with a ratio datascale that was using Pairs T-TestResult: There is an effect of laughing therapy on blood pressure in the elderly at UPT Panti WredhaBudhi Dharma Yogyakarta marked with a significant value of 0.000 (P <0.05)

Download Full-text

FRACTIONAL DETERMINATIONS OF URINARY 17-KETOSTEROIDS IN HYPEREMESIS GRAVIDARUM

Acta Endocrinologica ◽

10.1530/acta.0.0410123 ◽

1962 ◽

Vol 41 (1) ◽

pp. 123-128 ◽

Cited By ~ 6

Author(s):

Pentti A. Järvinen ◽

Sykkö Pesonen ◽

Pirkko Väänänen

Keyword(s):

Hyperemesis Gravidarum ◽

First Trimester ◽

Control Group ◽

Before And After ◽

Daily Urine ◽

First Trimester Of Pregnancy ◽

The Difference

ABSTRACT The fractional determination of 17-ketosteroids in the daily urine was performed in nine cases of hyperemesis gravidarum and in four control cases, in the first trimester of pregnancy both before and after corticotrophin administration. The excretion of total 17-KS is similar in the two groups. Only in the hyperemesis group does the excretion of total 17-KS increase significantly after corticotrophin administration. The fractional determination reveals no difference between the two groups of patients with regard to the values of the fractions U (unidentified 17-KS), A (androsterone) and Rest (11-oxygenated 17-KS). The excretion of dehydroepiandrosterone is significantly higher in the hyperemesis group than in the control group. The excretion of androstanolone seems to be lower in the hyperemesis group than in the control group, but the difference is not statistically significant. The differences in the correlation between dehydroepiandrosterone and androstanolone in the two groups is significant. The high excretion of dehydroepiandrosterone and low excretion of androstanolone in cases of hyperemesis gravidarum is a sign of adrenal dysfunction.

Download Full-text

Clinical and microbiological aspects of vaginal microbiota at pregnant with threat of late miscarriages during treatment with vaginal gestagens forms

HEALTH OF WOMAN ◽

10.15574/hw.2017.117.68 ◽

2017 ◽

pp. 68-73

Author(s):

I.P. Polishchuk ◽

Keyword(s):

Pregnant Women ◽

Therapeutic Effect ◽

Local Treatment ◽

Vaginal Microbiota ◽

Control Group ◽

Before And After ◽

Low Efficiency ◽

Late Miscarriage ◽

Microbiological Aspects ◽

Micronized Progesterone

The objective: was to examine the effectiveness of treatment of late miscarriage threat by micronized form of progesterone for 100 mg – 3 times a day in the form of gelatin pills and vaginal tablets with lactose. Patients and methods. Under our supervision there were 70 pregnant women with normocenosis of vagina (NCV) without extragenital pathology, which were not performed systemic or local treatment with antibacterial drugs in the last 4 weeks. Among them 25 pregnant women with TLSM treated by gelatin tablets of micronized progesterone (GTP) (group 1); 25 pregnant women with TLSM, treated by vaginal micronized progesterone tablets (VPT) (2nd group) and 20 healthy women with physiological pregnancy – PV (control group). The distribution of women in the group adhered to the principles of randomization. The age of examined women ranged from 19 to 32 years, most pregnant women were aged under 30 years (89.02%). General clinical examination was carried out according to the standard scheme according to the Order MH of Ukraine № 620. Results. During the research we have determined the colpocytologcal dynamics and state of vaginal microbiota in pregnant women with threatened late miscarriage with initial vaginal normocenosis before and after treatment whit vaginal forms of progesterone. Conclusion. The received results showed low efficiency of micronized progesterone gelatin dragee at threat of the late miscarriage that at small therapeutic effect has led to the development of vaginal dysbiosis in all surveyed. In contrast, the use of micronized progesterone vaginal tablets – the maximally rapid therapeutic effect without disturbance of vaginal normocenosis. Key words: the threat of a late miscarriage, vaginal micronized forms of progesterone.

Download Full-text