scholarly journals Green coffee bean extract attenuates gentamicin induced acute nephrotoxicity in rats

2022 ◽  
Vol 21 (2) ◽  
pp. 256-268
Author(s):  
Amina Unis ◽  
◽  
Amany Abdelbary ◽  
Keyword(s):  
Renal Damage ◽  
Potential Role ◽  
Great Effort ◽  
Coffee Bean ◽  
Green Coffee ◽  
Stress Markers ◽  
Significant Amelioration ◽  
Green Coffee Bean Extract ◽  
Green Coffee Bean ◽  
Daily Intraperitoneal Injection

Gentamicin induced acute nephrotoxicity (GIAN) is considered as one of the important causes of acute renal failure. In recent years’ great effort has been focused on the introduction of herbal medicine as a novel therapeutic agent for prevention of GIAN. Hence, the current study was designed to investigate the effect of green coffee bean extract (GCBE) on GIAN in rats. Results of the present study showed that rat groups that received oral GCBE for 7 days after induction of GIAN (by a daily intraperitoneal injection of gentamicin for 7days), reported a significant improvement in renal functions tests when compared to the GIAN model groups. Moreover, there was significant amelioration in renal oxidative stress markers (renal malondialdehyde, renal superoxide dismutase) and renal histopathological changes in the GCBE-treated groups when compared to GIAN model group. These results indicate that GCBE has a potential role in ameliorating renal damage involved in GIAN.

scholarly journals Acute and sub-chronic toxicity evaluation of a standardized green coffee bean extract (CGA-7™) in Wistar albino rats

2021 ◽  
Vol 9 ◽  
pp. 205031212098488
Author(s):  
Venkatakrishna K ◽  
Sudeep HV ◽  
Shyamprasad K
Keyword(s):  
Oral Dose ◽  
Chronic Toxicity ◽  
Clinical Signs ◽  
Albino Rats ◽  
Coffee Bean ◽  
Green Coffee ◽  
Toxicological Assessment ◽  
Limit Test ◽  
Green Coffee Bean Extract ◽  
Green Coffee Bean

Objective: Despite having numerous physiological benefits, toxicological assessment of green coffee beans is sparce. Here, we document the oral acute and sub-chronic toxicity of a standardized decaffeinated green coffee bean extract containing 50% chlorogenic acids (CGA-7™) in rats. Methods: We have performed a limit test at single oral dose of 2000 mg/kg to evaluate the acute toxicity in female Wistar rats. Furthermore, repeated dose 90-day toxicity study was conducted to assess the risk of long-term use of CGA-7. Result: A 14-day observation revealed no clinical signs of toxicity or mortality in animals at 2000 mg/kg acute oral dose of CGA-7. The administration of 250, 500, and 1000 mg/kg CGA-7 showed significant alterations in some parameters such as food consumption, relative organ weights of brain and spleen, haematological and biochemical parameters compared to control. These changes were not consistent and dose-dependent throughout the study. Furthermore, the changes were within the physiological range and toxicologically insignificant. CGA-7 did not affect the normal metabolism and physiology of the animals up to 1000 mg/kg dose. Macroscopic and histological examination of organs did not reveal any organ toxicity. Conclusion: Finally, the findings from this study suggest the safety of green coffee bean extract.

scholarly journals Decaffeinated Green Coffee Bean Extract Attenuates Diet-Induced Obesity and Insulin Resistance in Mice

2014 ◽  
Vol 2014 ◽  
pp. 1-14 ◽  
Author(s):  
Su Jin Song ◽  
Sena Choi ◽  
Taesun Park
Keyword(s):  
Insulin Resistance ◽  
Adipose Tissue ◽  
Plasma Lipids ◽  
Body Weight Gain ◽  
Chow Diet ◽  
Coffee Bean ◽  
Green Coffee ◽  
Visceral Adipose ◽  
Green Coffee Bean Extract ◽  
Green Coffee Bean

This study investigated whether decaffeinated green coffee bean extract prevents obesity and improves insulin resistance and elucidated its mechanism of action. Male C57BL/6N mice(N=48)were divided into six dietary groups: chow diet, HFD, HFD-supplemented with 0.1%, 0.3%, and 0.9% decaffeinated green coffee bean extract, and 0.15% 5-caffeoylquinic acid. Based on the reduction in HFD-induced body weight gain and increments in plasma lipids, glucose, and insulin levels, the minimum effective dose of green coffee bean extract appears to be 0.3%. Green coffee bean extract resulted in downregulation of genes involved in WNT10b- and galanin-mediated adipogenesis and TLR4-mediated proinflammatory pathway and stimulation of GLUT4 translocation to the plasma membrane in white adipose tissue. Taken together, decaffeinated green coffee bean extract appeared to reverse HFD-induced fat accumulation and insulin resistance by downregulating the genes involved in adipogenesis and inflammation in visceral adipose tissue.

scholarly journals Efficacy of a novel green coffee bean extract (GCB‐70) in weight management (1107.2)

2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
Anand Swaroop ◽  
Manashi Bagchi ◽  
Pawan Kumar ◽  
Debasis Bagchi
Keyword(s):  
Weight Management ◽  
Coffee Bean ◽  
Green Coffee ◽  
Green Coffee Bean Extract ◽  
Green Coffee Bean
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