THE STUDY OF ORTHOPEDIA HOMEOBOX GENE EXPRESSION IN DIFFERENT TUMOR AND NORMAL HUMAN TISSUES

2017 ◽  
Vol 63 (1) ◽  
pp. 128-134
Author(s):  
Yuliya Karnaukhova ◽  
Dmitriy Polev ◽  
Larisa Krukovskaya ◽  
Andrey Kozlov
Keyword(s):  
Gene Expression ◽  
Homeobox Gene ◽  
Cancer Diagnostics ◽  
Human Tissues ◽  
Embryonic Tissues ◽  
Dna Strands ◽  
Normal Human ◽  
Testis Tissue ◽  
Gene Mrna ◽  
Cancer Testis

There was studied the OTP gene expression in different normal and tumor human tissues using PCR with specific primers. OTP gene is expressed in 23 of 29 tumor samples and intron fragment of OTP gene (sequence AI267901) is expressed in 49 of 59 tumor samples of different localization. Studied fragments of OTP gene are not transcribed in normal and embryonic tissues except for normal testis tissue, i.e. they can be classified as cancer-testis transcripts. According to preliminary data AI267901 RNA and OTP gene mRNA are transcribed from different DNA strands. Thus locus of OTP gene provides two independent tumor specific transcripts which are potential markers for the cancer diagnostics.

Uroplakin gene expression in normal human tissues and locally advanced bladder cancer

2002 ◽  
Vol 199 (1) ◽  
pp. 41-49 ◽  
Author(s):  
Jonathon Olsburgh ◽  
Patricia Harnden ◽  
Robert Weeks ◽  
Barbara Smith ◽  
Adrian Joyce ◽  
...  
Keyword(s):  
Gene Expression ◽  
Bladder Cancer ◽  
Locally Advanced ◽  
Human Tissues ◽  
Advanced Bladder Cancer ◽  
Normal Human

scholarly journals A compendium of gene expression in normal human tissues

2001 ◽  
Vol 7 (2) ◽  
pp. 97-104 ◽  
Author(s):  
LI-LI HSIAO ◽  
FERNANDO DANGOND ◽  
TAKUMI YOSHIDA ◽  
ROBERT HONG ◽  
RODERICK V. JENSEN ◽  
...  
Keyword(s):  
Gene Expression ◽  
Housekeeping Genes ◽  
Human Tissues ◽  
Biological Processes ◽  
Expression Index ◽  
Specific Expression ◽  
Future Studies ◽  
Biochemical Processes ◽  
Organ Systems ◽  
Normal Human

This study creates a compendium of gene expression in normal human tissues suitable as a reference for defining basic organ systems biology. Using oligonucleotide microarrays, we analyze 59 samples representing 19 distinct tissue types. Of ∼7,000 genes analyzed, 451 genes are expressed in all tissue types and designated as housekeeping genes. These genes display significant variation in expression levels among tissues and are sufficient for discerning tissue-specific expression signatures, indicative of fundamental differences in biochemical processes. In addition, subsets of tissue-selective genes are identified that define key biological processes characterizing each organ. This compendium highlights similarities and differences among organ systems and different individuals and also provides a publicly available resource (Human Gene Expression Index, the HuGE Index, http://www.hugeindex.org ) for future studies of pathophysiology.

Assessing gene expression variation in normal human tissues using GeneTag™, a novel, global, sensitive profiling method

2003 ◽  
Vol 101 (3) ◽  
pp. 199-217 ◽  
Author(s):  
Lily Y Wong ◽  
Andrea Hafeman ◽  
Victoria L Boyd ◽  
John Bodeau ◽  
Katherine D Lazaruk ◽  
...  
Keyword(s):  
Gene Expression ◽  
Human Tissues ◽  
Gene Expression Variation ◽  
Expression Variation ◽  
Normal Human
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