scholarly journals Liquid biopsy as the universal DNA-based method for early cancer detection: problems, approaches, solutions

2021 ◽  
Vol 67 (5) ◽  
pp. 593-599
Author(s):  
Grigoriy Yanus ◽  
Tatiana Laidus ◽  
Aleksandr S Martianov ◽  
Svetlana Aleksakhina ◽  
Ekaterina Kuligina ◽  
...  
Keyword(s):  
Cancer Detection ◽  
Dna Sequences ◽  
Liquid Biopsy ◽  
Dna Analysis ◽  
Early Cancer ◽  
Biological Fluids ◽  
Risk Groups ◽  
Early Cancer Detection ◽  
Practical Implementation ◽  
Methylation Patterns

Until recently, the establishment of a universal test, allowing the early cancer detection by the analysis of blood, urine or other biological fluids seemed as realistic as the development of "Perpetuum mobile". There are numerous obstacles on this road: above all being the ultra-low concentrations of biomarkers shed by such tumors in the bloodstream. Meanwhile, in attempts to create such a test, the methodology of ultrasensitive DNA analysis has emerged, and stunning practical successes have been achieved in this field over the past few years. The performance of the CancerSEEK test has already reached the threshold for clinical utility of its practical implementation. Techniques based on the analysis of methylation patterns (Galleri test, cfMeDIP-seq) are also rapidly developing. A number of promising studies are based on quite unconventional approaches, for example, the analysis of tumor-associated viral or microbial DNA sequences circulating in plasma. In addition to universal tests aiming at the detection of any or many types of neoplasms in older people, the methods for early DNA-based detection of certain cancer types in selected high-risk groups are being developed. These advances finally make the prospects for introducing liquid biopsy into routine cancer screening look like a matter of the near future.

Abstract 2286: Liquid biopsy for early cancer detection

2019 ◽  
Author(s):  
Hyunji Kim ◽  
Fehmi Civitci ◽  
Josiah Wagner ◽  
Pavana Anur ◽  
Matthew Rames ◽  
...  
Keyword(s):  
Cancer Detection ◽  
Liquid Biopsy ◽  
Early Cancer ◽  
Early Cancer Detection

Abstract 2286: Liquid biopsy for early cancer detection

2019 ◽  
Author(s):  
Hyunji Kim ◽  
Fehmi Civitci ◽  
Josiah Wagner ◽  
Pavana Anur ◽  
Matthew Rames ◽  
...  
Keyword(s):  
Cancer Detection ◽  
Liquid Biopsy ◽  
Early Cancer ◽  
Early Cancer Detection

scholarly journals Determinants of Early Cancer Screening Behaviour in Nigeria

2018 ◽  
Vol 4 (Supplement 2) ◽  
pp. 54s-54s
Author(s):  
R.C.W. Chidebe ◽  
T.C. Orjiako ◽  
D.K. Atakere ◽  
O.O. Arowosegbe ◽  
D. Onu ◽  
...  
Keyword(s):  
Cancer Screening ◽  
Early Detection ◽  
Cancer Detection ◽  
Early Cancer ◽  
Specific Antigen ◽  
Risk Groups ◽  
Early Cancer Detection ◽  
Mortality And Morbidity ◽  
Clinical Breast ◽  
The Impact

Background: Early detection and improvements/advancements in medicine have contributed to an overall decrease in mortality and morbidity rates resulting from cancer diagnoses. Despite this improvement in national and global health status, Nigerians continue to be diagnosed at a later stage, with a more aggressive disease state. This is an important observation given the impact cancer has on the abilities of individuals to function physically, psychologically, and socially within the context of their environment. It is important therefore to identify and target specific groups that may be less willing to present for early cancer screening. Aim: To understand the characteristics of people who are likely or not likely to present for early cancer screening among Nigerians, and to address the use of mechanisms by which to ensure a timely diagnosis of preventable cancers among Nigerians. Methods: Adult Nigerians (N=144), 18-71 years of age who presented for clinical breast exam (CBE), visual inspection with acetic acid (VIA) and prostate specific antigen test (PSA) screenings after an awareness exercise; completed survey forms which included a personality inventory, early cancer detection behavior scale and a demography profile. Multiple regression and ANOVA were used to examine predictive patterns as well as differences between and within groups. Results: Results showed income ( b = 0.18, P < .05) to be a significant determinant of early cancer detection behavior, such that higher income earners were more likely to go for screening. There were also significant gender differences in current cancer detection behavior between males (M = 0.15, SD = 0.51) and females (M= 0.47, SD = 0.80); males are less likely to engage in early detection behavior ( F(1,145) = 4.76, P = .03). Data further show differences between older (≥ 41) and younger (≤ 40) participants in intention to screen for cancer, with older participants reporting more willingness to engage in cancer screening. Conclusion: Our finding enhances our understanding of the profile of the groups who are less likely to screen for cancer. Also, it suggests that awareness campaign and free screening exercises should target these at-risk groups in Nigeria.

scholarly journals Using methylation signatures on cell-free DNA for early cancer detection: a new era in liquid biopsy?

2020 ◽  
Vol 31 (6) ◽  
pp. 665-667 ◽  
Author(s):  
C. Bailleux ◽  
L. Lacroix ◽  
E. Barranger ◽  
S. Delaloge
Keyword(s):  
Cancer Detection ◽  
Liquid Biopsy ◽  
Early Cancer ◽  
Early Cancer Detection ◽  
Cell Free Dna ◽  
New Era ◽  
Free Dna

scholarly journals Small-area data on socioeconomic status and immigrant groups for evaluating equity of early cancer detection and care

2021 ◽  
pp. 1-6
Author(s):  
Ulf Strömberg ◽  
Brandon L. Parkes ◽  
Amir Baigi ◽  
Carl Bonander ◽  
Anders Holmén ◽  
...  
Keyword(s):  
Socioeconomic Status ◽  
Cancer Detection ◽  
Small Area ◽  
Early Cancer ◽  
Early Cancer Detection ◽  
Area Data

Dying To Be Men: Masculinity and Early Cancer Detection Among Nigerian Men

2021 ◽  
pp. 0272684X2110049
Author(s):  
Darlingtina Esiaka ◽  
Candidus Nwakasi ◽  
Kelsey Brodie ◽  
Aaron Philip ◽  
Kalu Ogba
Keyword(s):  
Public Health ◽  
Cancer Detection ◽  
Attachment Styles ◽  
Early Cancer ◽  
Sub Saharan Africa ◽  
Early Cancer Detection ◽  
Anxious Attachment ◽  
Incidence And Mortality ◽  
Nigerian Men ◽  
Sub Saharan

Cancer incidence and mortality in Nigeria are increasing at an alarming rate, especially among Nigerian men. Despite the numerous public health campaigns and education on the importance of early cancer detection in Nigeria, there exist high rate of fatal/advanced stage cancer diagnoses among Nigerian men, even among affluent Nigerian men. However, there is limited information on patterns of cancer screening and psychosocial predictors of early cancer detection behaviors among Nigerian men. In this cross-sectional study, we examined demographic and psychosocial factors influencing early cancer detection behaviors among Nigerian men. Participants (N = 143; Mage = 44.73) responded to survey assessing: masculinity, attachment styles, current and future cancer detection behaviors, and sociodemographic characteristics. We found that among the participants studied, education, masculinity and anxious attachment were significantly associated with current cancer detection behaviors. Additionally, education and anxious attachment were significantly associated with future cancer detection behaviors. Our finding is best served for clinicians and public health professionals, especially those in the field of oncology in Sub-Saharan Africa. Also, the study may be used as a groundwork for future research and health intervention programs targeting men in Sub-Saharan Africa.

Sign in / Sign up

Export Citation Format

Share Document