scholarly journals Role of transforming growth factor-beta signaling pathway in pathogenesis of benign biliary stricture

2008 ◽  
Vol 14 (31) ◽  
pp. 4949 ◽  
Author(s):  
Zhi-Min Geng ◽  
Jian-Bao Zheng ◽  
Xiao-Xue Zhang ◽  
Jie Tao ◽  
Lin Wang
Keyword(s):  
Growth Factor ◽  
Signaling Pathway ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Biliary Stricture ◽  
Benign Biliary Stricture ◽  
Growth Factor Beta

scholarly journals Axolotl as a Model to Study Scarless Wound Healing in Vertebrates: Role of the Transforming Growth Factor Beta Signaling Pathway

2013 ◽  
Vol 2 (5) ◽  
pp. 250-260 ◽  
Author(s):  
Jean-François Denis ◽  
Mathieu Lévesque ◽  
Simon D. Tran ◽  
Aldo-Joseph Camarda ◽  
Stéphane Roy
Keyword(s):  
Wound Healing ◽  
Growth Factor ◽  
Signaling Pathway ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Growth Factor Beta

Role of Transforming Growth Factor Beta in Human Cancer

2005 ◽  
Vol 23 (9) ◽  
pp. 2078-2093 ◽  
Author(s):  
Rebecca L. Elliott ◽  
Gerard C. Blobe
Keyword(s):  
Growth Factor ◽  
Signaling Pathway ◽  
Transforming Growth Factor Beta ◽  
Stromal Cells ◽  
Transforming Growth Factor ◽  
Human Cancer ◽  
Inhibition Of Proliferation ◽  
Human Cancers ◽  
Growth Factor Beta

Transforming growth factor beta (TGF-β) is a ubiquitous and essential regulator of cellular and physiologic processes including proliferation, differentiation, migration, cell survival, angiogenesis, and immunosurveillance. Alterations in the TGF-β signaling pathway, including mutation or deletion of members of the signaling pathway and resistance to TGF-β-mediated inhibition of proliferation are frequently observed in human cancers. Although these alterations define a tumor suppressor role for the TGF-β pathway in human cancer, TGF-β also mediates tumor-promoting effects, either through differential effects on tumor and stromal cells or through a fundamental alteration in the TGF-β responsiveness of the tumor cells themselves. TGF-β and members of the TGF-β signaling pathway are being evaluated as prognostic or predictive markers for cancer patients. Ongoing advances in understanding the TGF-β signaling pathway will enable targeting of this pathway for the chemoprevention and treatment of human cancers.

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