Bestimmung von Alkanolaminen in der Luft an Arbeitsplätzen – Eine Vergleichsstudie zur Etablierung der Messverfahren/Determination of alkanolamines in workplace atmospheres: A comparative study for establishment of the measurement methods

Gefahrstoffe ◽  
2020 ◽  
Vol 80 (07-08) ◽  
pp. 267-271
Author(s):  
M. Blaskowitz ◽  
P. Ansari Eshlaghi ◽  
S. Svabenicky ◽  
D. Breuer
Keyword(s):  
Comparative Study ◽  
Measurement Methods ◽  
Ca 50

Alkanolamine sind Verbindungen, die an vielen Arbeitsplätzen auftreten. Sie werden z. B. in Reinigern oder Kühlschmierstoffen eingesetzt. Das Institut für Arbeitsschutz der Deutschen Gesetzlichen Unfallversicherung (IFA) und die Allgemeine Unfallversicherungsanstalt (AUVA) in Österreich haben in den vergangenen Jahren jeweils Messverfahren zur Bestimmung von Alkanolaminen in der Luft am Arbeitsplatz entwickelt. Beide Verfahren beruhen auf der Erfassung dampfförmiger und partikulärer Alkanolamine, um die Arbeitsplatzgrenzwerte (AGW) sowie die Werte der maximalen Arbeitsplatzkonzentrationen (MAK) zu ermitteln. Zur Validierung der Verfahren wurden zunächst Laborvergleichsuntersuchungen und abschließend Parallelmessungen an Arbeitsplätzen vorgenommen. Die Ergebnisse sind gut vergleichbar. In einem Metall bearbeitenden Betrieb wurden Konzentrationen von 1,4 bis 2,1 mg/m³ gemessen, was ca. 50 % des in Deutschland geltenden AGW entspricht.

Determination of Pyridostigmine Bromide in Presence of its Related Impurities by Four Modified Classical Least Square Based Models: A Comparative Study

2020 ◽  
Vol 17 (1) ◽  
pp. 87-94
Author(s):  
Ibrahim A. Naguib ◽  
Fatma F. Abdallah ◽  
Aml A. Emam ◽  
Eglal A. Abdelaleem
Keyword(s):  
Comparative Study ◽  
Least Squares ◽  
Orthogonal Projection ◽  
Predictive Ability ◽  
Least Square ◽  
Projection To Latent Structures ◽  
Preprocessing Method ◽  
Spectral Residual ◽  
Latent Structures

: Quantitative determination of pyridostigmine bromide in the presence of its two related substances; impurity A and impurity B was considered as a case study to construct the comparison. Introduction: Novel manipulations of the well-known classical least squares multivariate calibration model were explained in detail as a comparative analytical study in this research work. In addition to the application of plain classical least squares model, two preprocessing steps were tried, where prior to modeling with classical least squares, first derivatization and orthogonal projection to latent structures were applied to produce two novel manipulations of the classical least square-based model. Moreover, spectral residual augmented classical least squares model is included in the present comparative study. Methods: 3 factor 4 level design was implemented constructing a training set of 16 mixtures with different concentrations of the studied components. To investigate the predictive ability of the studied models; a test set consisting of 9 mixtures was constructed. Results: The key performance indicator of this comparative study was the root mean square error of prediction for the independent test set mixtures, where it was found 1.367 when classical least squares applied with no preprocessing method, 1.352 when first derivative data was implemented, 0.2100 when orthogonal projection to latent structures preprocessing method was applied and 0.2747 when spectral residual augmented classical least squares was performed. Conclusion: Coupling of classical least squares model with orthogonal projection to latent structures preprocessing method produced significant improvement of the predictive ability of it.

Tumor Markers and Lung Cancer: Correlation between Serum and Bronchial Secretion Levels of Cea, Tpa, Canag Ca-50, Nse and Ferritin

1987 ◽  
Vol 2 (3) ◽  
pp. 151-156 ◽  
Author(s):  
Vincenzo Macchia ◽  
Angela Mariano ◽  
Mariarita Cavalcanti ◽  
Anna Coppa ◽  
Ciriaco Cecere ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Carcinoma ◽  
Simultaneous Determination ◽  
Neuron Specific Enolase ◽  
Bronchial Secretion ◽  
Lung Malignancy ◽  
Ca 50 ◽  
Oat Cell Carcinoma ◽  
Diagnosis Of Lung Cancer

The levels of carcinoembryonic antigeny (CEA), tissue polypeptide antigeny (TPA), CanAg 50, neuron specific enolase (NSE) and ferritin were determined in bronchial secretion and serum of patients with neoplastic and non-neoplastic lung diseases. Simultaneous determination of two or three markers in the serum and in bronchoalveolar lavage (BAL) may be clinically useful for the diagnosis of lung cancer and even for the type of tumor. The positivity of CEA determined simultaneously in serum and in BAL of patients with lung cancer is higher than 80% whereas in patients with benign lung disease it is lower than 40%. The simultaneous assay of TP A in serum and in BAL showed 100% positivity in patients with oat-cell carcinoma, the frequencies of positivity were similar in patients with non-oat-cell carcinoma. For NSE and CanAg CA-50 patients with oat-cell carinoma showed 100% positivity. Simultaneous assay of ferritin in serum and in BAL gave 85% positivity in patients with oat-cell carcinoma and only 23% in patients with non-oat-cell carcinoma. We conclude that the simultaneous determination of CEA and CanAg CA-50 or NSE in serum and in BAL is a useful aid in the diagnosis of lung malignancy.

scholarly journals Comparative study of two immunoassays used for the determination of serum vitamin D

2021 ◽  
pp. e00242
Author(s):  
Raquel Lahoz ◽  
Juan Pelegrín Sánchez ◽  
Silvia Górriz ◽  
Pilar Calmarza
Keyword(s):  
Vitamin D ◽  
Comparative Study ◽  
Serum Vitamin ◽  
Serum Vitamin D
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