The development and evaluation of a continuous flow process for the lipase-mediated oxidation of alkenes
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We report the use of an immobilised form of Candida antarctica lipase B, Novozym® 435, in a preliminary investigation into the development of a continuous flow reactor capable of performing the chemo-enzymatic oxidation of alkenes in high yield and purity, utilising the commercially available oxidant hydrogen peroxide (100 volumes). Initial investigations focussed on the lipase-mediated oxidation of 1-methylcyclohexene, with the optimised reaction conditions subsequently employed for the epoxidation of an array of aromatic and aliphatic alkenes in 97.6 to 99.5% yield and quantitative purity.
2019 ◽
Vol 7
(30)
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pp. 9167-9174
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2006 ◽
Vol 45
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pp. 652-659
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2020 ◽
Vol 8
(35)
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pp. 13195-13205
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2019 ◽
Vol 18
(2)
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pp. 314-318
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2020 ◽
Vol 295
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pp. 122291
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2017 ◽
Vol 115
(3)
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pp. 606-616
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2006 ◽
Vol 691
(24-25)
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pp. 5197-5203
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