scholarly journals VENOUS BLOOD INDICES AFTER CAVAPLICATION IN PATIENTS WITH THROMBOSIS OF THE VENA CAVA INFERIOR

2020 ◽  
pp. 143-147
Author(s):  
V. I. Rusin ◽  
Ya. M. Popovich
Keyword(s):  
Blood Flow ◽  
Inferior Vena Cava ◽  
Inferior Vena ◽  
Venous Blood ◽  
Vena Cava ◽  
Volume Index ◽  
Venous Blood Flow ◽  
Vena Cava Inferior ◽  
Systolic Volume ◽  
Before And After

Summary. Despite reports of plication with inferior vena cava thrombosis, the venous hemodynamics before and after hardware cavaplication has been not evaluated. The aim of research. Estimate the changes of the venous blood flow indices after complication in patients with vena cava inferior thrombosis. Materials and methods. Quantitative assessment of venous blood flow was performed in 34 patients with inferior vena cava thrombosis before and after incomplete hardware cavaplication. Cavaplication was performed in 11 (32.4 %) patients with non-tumor and in 23 (67.6 %) patients with tumors of the vena cava inferior. For selecting the site of cavaplication, the infrarenal branch of the vena cava inferior directly below the renal veins was prevailed – in 29 (85.3 %) patients, the plication of vena cava inferior lower or higher hepatic veins in 4 (11.8 %) and 1 (2.9 %) patients were performed respectively. Results. Increases of following indices of central and regional hemodynamics after hardware cavaplication were observed, in particular, volume (by 56.5 %) and the linear rate of blood flow (by 40.4 %), minute volume of blood flow (by 16.2 %), cardiac index (by 8.8 %), systolic volume (by 6 %), end-systolic volume index (by 4.5 %), end-diastolic volume index (by 3.9 %) and ejection fraction (by 2.1 %). Instead, the pressure in the inferior vena cava (by 18.2 %) and stroke volume (by 8.9 %) decreased, which, however, was also considered as a positive result of thrombectomy from the vena cava inferior and hardware cavaplication. Conclusions. Within a year after inferior vena plication, indicators of central and peripheral hemodynamics were within the physiological norm and collateral pathways during radioisotope phleboscintigraphy weren`t determined. At the same time, the lumen of the vena cava inferior was completely restored, after 12-18 months, in all cases after plication.

Die Aplasie der Vena cava inferior als Ursache rezidivierender Bein- und Beckenvenenthrombosen

VASA ◽  
1999 ◽  
Vol 28 (4) ◽  
pp. 289-292 ◽  
Author(s):  
Tiesenhausen ◽  
Amann ◽  
Thalhammer ◽  
Aschauer
Keyword(s):  
Inferior Vena Cava ◽  
Inferior Vena ◽  
Heart Defects ◽  
Vena Cava ◽  
Clinical Signs ◽  
Vena Cava Inferior ◽  
Caval Vein ◽  
Rare Finding ◽  
Thrombotic Complications ◽  
Asplenia Syndrome

Congenital anomalies of the caval vein are often associated with other abnormities such as heart defects, situs inversus or a polysplenia-asplenia-syndrome. An isolated, congenital malformation like aplasia of the inferior vena cava is a rare finding. A review of the embryology and abnormities, diagnostics, clinical signs and treatment is given together with the histories of two patients having thrombosis of the lower extremities and pelvic veins, caused by aplasia of the inferior vena cava. After thrombotic complications caused by vena cava aplasia there is high risk of recurrence. Those patients should be anticoagulated for lifetime.

A Novel Parameter Derived From Photoplethysmographic Pulse Wave to Predict Risk of Postreperfusion Syndrome

2020 ◽  
Author(s):  
Hai-ying Kong ◽  
Xian Zhao ◽  
Su-Qin Huang
Keyword(s):  
Liver Transplantation ◽  
Inferior Vena Cava ◽  
Inferior Vena ◽  
Pulse Wave ◽  
Surgical Stress ◽  
Vena Cava ◽  
Stress Index ◽  
Increased Risk ◽  
Sympathetic Modulation ◽  
Before And After

Abstract BackgroundPostreperfusion syndrome (PRS), observed after reperfusion of the grafted liver, was associated with poor outcome. The end-stage liver disease (ESLD) with autonomic dysfunction in the cardiovascular system has greater risk of developing of PRS, due to the poor ability in sympathetic vasoconstriction. Surgical Stress Index (SSI) is a novel parameter derived from photoplethysmographic pulse wave to assess central sympathetic modulation in awake volunteers. In this study, we determined the relationship between SSI values and the risk of developing of PRS during orthotopic liver transplantation.MethodsWe retrospectively studied 163 patients who had undergone OLT, and divided the patients into PRS group and non-PRS group. SSI and related parameters were determined 5min before and after clamping of the inferior vena cava, the occurrence of PRS were recorded during reperfusion.ResultsThe clamping of the inferior vena cava modified the SSI significantly, accompanied with significant hemodynamic response. The SSI increased significantly after clamping (47.0 (43.0-49.0 ) vs.81.0(69.5-89.0), p<0.001). The SSI increased by 45.3% at 5min after clamping of the inferior vena cava in the PRS group, as opposed to 81.7% in the non-PRS group (P = 0.037). PRS occurred in only 19.4% of patients in whom the SSI increased by more than 50%. Based on a multivariate analysis, percentage of the variation in the SSI was associated with a significant increased risk in developing the PRS (OR 2.49, 95% CI 1.15-5.02; P=0.021).ConclusionsSSI can sensitively indicate the central sympathetic modulation function during liver transplantation procedure. SSI might be a sensitive marker of risk of developing PRS.

Mechanism of hemodynamic responses to occlusion of the descending thoracic aorta

1980 ◽  
Vol 238 (4) ◽  
pp. H423-H429 ◽  
Author(s):  
O. Stokland ◽  
M. M. Miller ◽  
A. Ilebekk ◽  
F. Kiil
Keyword(s):  
Inferior Vena Cava ◽  
Superior Vena Cava ◽  
Inferior Vena ◽  
Superior Vena ◽  
Vena Cava ◽  
Spinal Column ◽  
Left Ventricular Pressure ◽  
Left Ventricular ◽  
Aortic Occlusion ◽  
Systolic Volume

To examine left ventricular responses to aortic occlusion, changes in end-diastolic volume (EDV) and end-systolic volume (ESV) were estimated by ultrasonic recordings of myocardial distances in atropinized open-chest dogs. During aortic occlusion EDV and ESV increased equally, systolic left ventricular pressure (LVP) rose by 86 +/- 8 mmHg, and blood flow more than doubled in the superior vena cava and fell by 90% in the inferior vena cava. During combined occlusion of aorta and inferior vena cava, systolic LVP and superior vena cava flow did not rise above control and EDV declined. By infusing 25 +/- 2 ml/kg body wt of blood during combined occlusion, the effects of aortic occlusion could be reproduced; control values before blood infusion were reestablished by withdrawal of only one-third of the infused volume, indicating a shunt line along the spinal column. Thus during aortic occlusion, transfer of blood accounts for the rise in EDV and increased activation of the Frank-Starling mechanism; increased afterload raises ESV as much as EDV in anesthetized dogs not subjected to sympathetic stimulation. Consequently, stroke volume is maintained and systolic LVP increased.

Splanchnic and systemic absorption of intraperitoneal insulin using a new double-tracer method

1994 ◽  
Vol 266 (5) ◽  
pp. E750-E759 ◽  
Author(s):  
J. Radziuk ◽  
S. Pye ◽  
D. E. Seigler ◽  
J. S. Skyler ◽  
R. Offord ◽  
...  
Keyword(s):  
Inferior Vena Cava ◽  
Portal Vein ◽  
Inferior Vena ◽  
Vena Cava ◽  
Systemic Absorption ◽  
Tracer Method ◽  
Total Recovery ◽  
Before And After ◽  
Intraperitoneal Insulin ◽  
Serial Samples

The absorption of a bolus of intraperitoneal insulin into the splanchnic and peripheral circulations was separately assessed in dogs using an infusion of two insulin tracers (A1-[3H]insulin and B1-[3H]insulin). One tracer was infused into the superior mesenteric artery and the second into the jugular vein. Serial samples were taken before and after an injection of insulin (1 U/kg ip). Sampling was from the portal vein and the inferior vena cava. By using the principle of equivalent entry of tracer and unlabeled material, we developed two simultaneous equations for the rate of splanchnic and peripheral insulin absorption at each time point. These were solved to yield the two rates. Mean concentrations in the portal vein were approximately 25% higher than in the inferior vena cava, reflecting the splanchnic absorption. This rate accounted for almost half (51 +/- 9%) of the insulin absorbed. The remainder of the absorption was peripheral. The total recovery of intraperitoneal insulin, absorbed by either route, was 88 +/- 11%. Portal absorption peaked earlier than peripheral. Absorption by both routes was 90% complete within approximately 2 h (131 +/- 16 min). In summary, therefore, intraperitoneal insulin is rapidly and almost completely absorbed, with absorption split between the splanchnic and peripheral routes of entry.

A Rare Case of Recurrent Lower Extremity Ulcer

2019 ◽  
Vol 18 (4) ◽  
pp. 389-392 ◽  
Author(s):  
Wei Zhu ◽  
Huapei Song
Keyword(s):  
Inferior Vena Cava ◽  
Lower Extremity ◽  
Inferior Vena ◽  
Vena Cava ◽  
Venous Blood Flow ◽  
Leg Ulcers ◽  
Budd Chiari Syndrome ◽  
Pressure Therapy ◽  
Venous Leg Ulcers ◽  
Chiari Syndrome

Venous leg ulcers are a manifestation of lower extremity chronic venous disorder. Venous hypertension caused by abnormal venous blood flow is considered to be the primary mechanism of venous ulcers. The etiology of lower extremity venous ulcer is complicated, and it is difficult to be treated. At present, it has achieved a certain effect for venous leg ulcers through the combination of drugs, pressure therapy, and surgical treatment. Budd-Chiari syndrome is a rare syndrome characterized by portal hypertension and/or inferior vena cava syndrome. Treatment of Budd-Chiari syndrome includes anticoagulation, thrombolysis, angioplasty, stenting, transjugular intrahepatic portosystemic shunt, and liver transplantation. This article reports an elderly female patient with recurrent ulceration of both lower extremities that healed poorly after long-term dressing and skin grafting. During further examination, she was found to have Budd-Chiari syndrome. Through multidisciplinary treatment, which includes removing the inferior vena cava stenosis and implanting the ulcer wound, the ulcer wounds then healed.

Dose-dependent thrombus resolution due to oral plasminogen activator inhibitor (PAI)-1 inhibition with tiplaxtinin in a rat stenosis model of venous thrombosis

2008 ◽  
Vol 99 (04) ◽  
pp. 749-758 ◽  
Author(s):  
Sanjiv Baxi ◽  
David Crandall ◽  
Thomas Meier ◽  
Shirley Wrobleski ◽  
Angela Hawley ◽  
...  
Keyword(s):  
Blood Flow ◽  
Inferior Vena Cava ◽  
Venous Thrombosis ◽  
Inferior Vena ◽  
Phase 1 ◽  
Vena Cava ◽  
Phase 2 ◽  
Oral Gavage ◽  
Dose Dependent ◽  
Pai 1

SummaryThis study aimed to evaluate a small-molecule PAI-1 inhibitor (PAI-039; tiplaxtinin) in a rodent stenosis model of venous thrombosis in a two-phase experiment. Phase 1 determined the efficacy of tiplaxtinin against Lovenox (LOV), while phase 2 determined the dose-dependent efficacy. For both phases, drug treatment began 24 hours after surgically induced venous thrombosis and continued for four days. Phase 1 animals (n = 24) receiving low-dose (LD; 1 mg/kg oral gavage) PAI-1 inhibitor demonstrated a 52% decrease in thrombus weight (TW) versus controls (p < 0.05) with significant reductions in active plasma PAI-1, while the high-dose (HD; 10 mg/kg oral gavage) group demonstrated a 23% reduction in TW versus controls. Animals treated subcutaneously with LOV (3 mg/kg) showed a 39% decrease in TW versus controls (p < 0.05). Coagulation tests (aPTT and TCT) were significantly different in LOV compared to PAI-1 inhibitor groups. PAI-039 treatment was also associated with significantly increased return of inferior vena cava blood flow four days post-thrombosis versus controls (p < 0.05). In phase 2 (n = 30), TW was reduced from the 0.5 mg/kg to 5 mg/ kg experimental groups, with the 10 mg/kg group demonstrating a paradoxical increase. The 5 mg/kg group showed statistically significant decreases in TW versus controls after four treatment days (p < 0.05). This is the first study to demonstrate dose related effects of PAI-039 on increasing thrombus resolution and inferior vena cava blood flow without adverse effects on anti-coagulation in a rat stenosis model of venous thrombosis.

scholarly journals Effect of spontaneous breathing on umbilical venous blood flow and placental transfusion during delayed cord clamping in preterm lambs

2019 ◽  
Vol 105 (1) ◽  
pp. 26-32 ◽  
Author(s):  
Emma Brouwer ◽  
Arjan B te Pas ◽  
Graeme R Polglase ◽  
Erin V McGillick ◽  
Stefan Böhringer ◽  
...  
Keyword(s):  
Blood Flow ◽  
Body Weight ◽  
Spontaneous Breathing ◽  
Venous Blood ◽  
Vena Cava ◽  
Venous Blood Flow ◽  
Delayed Cord Clamping ◽  
Venous Flow ◽  
Cord Clamping ◽  
Pregnant Sheep

IntroductionDuring delayed umbilical cord clamping, the factors underpinning placental transfusion remain unknown. We hypothesised that reductions in thoracic pressure during inspiration would enhance placental transfusion in spontaneously breathing preterm lambs.ObjectiveInvestigate the effect of spontaneous breathing on umbilical venous flow and body weight in preterm lambs.MethodsPregnant sheep were instrumented at 132–133 days gestational age to measure fetal common umbilical venous, pulmonary and cerebral blood flows as well as arterial and intrapleural (IP) pressures. At delivery, doxapram and caffeine were administered to promote breathing. Lamb body weights were measured continuously and breathing was assessed by IP pressure changes.ResultsIn 6 lambs, 491 out of 1117 breaths were analysed for change in body weight. Weight increased in 46.6% and decreased in 47.5% of breaths. An overall mean increase of 0.02±2.5 g per breath was calculated, and no net placental transfusion was observed prior to cord clamping (median difference in body weight 52.3 [−54.9–166.1] g, p=0.418). Umbilical venous (UV) flow transiently decreased with each inspiration, and in some cases ceased, before UV flow normalised during expiration. The reduction in UV flow was positively correlated with the standardised reduction in (IP) pressure, increasing by 109 mL/min for every SD reduction in IP pressure. Thus, the reduction in UV flow was closely related to inspiratory depth.ConclusionsSpontaneous breathing had no net effect on body weight in preterm lambs at birth. UV blood flow decreased as inspiratory effort increased, possibly due to constriction of the inferior vena cava caused by diaphragmatic contraction, as previously observed in human fetuses.

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