scholarly journals CONSIDERATIONS ON THE USE OF HUMULUS LUPULUS L. AS AN ESTROGENIC AGENT

2017 ◽  
Vol 12 (4) ◽  
pp. 198-203
Author(s):  
Anca Daniela RAICIU ◽  
◽  
Daniel CORD ◽  
Alin FOCŞA ◽  
◽  
...  
Keyword(s):  
Bone Resorption ◽  
Estrogen Receptors ◽  
Sodium Methoxide ◽  
Biological Properties ◽  
Humulus Lupulus ◽  
Raw Material ◽  
Osteoclastic Bone Resorption ◽  
Humulus Lupulus L ◽  
Sodium Methoxide Solution ◽  
Initial Method

Introduction. Hops (Humulus lupulus L.) is used as a raw material for the production of beer but has also biological properties. Phytoestrogens present in the hops have an antioxidant, anti-inflammatory and probiotic role, while having an effect on the diseases of osteoporosis, diabetes and vasomotor effects (calf) during menopause. Material and method. 8-prenilnaringenine was prepared according to a modification of the initial method. To a cooled solution of naringenin was added a methanolic sodium methoxide solution and prenyl bromide. Results and discussions. The estrogenic effect has been attributed to substances such as β-acids, β-sitosterol, xanthohumol and desmethylxanthohumol. Further investigations have shown that 8-prenylnaringenine is a major hops estrogen. 8-prenilnaringenin acts on estrogen receptors that mediate bone osteoblastic formation and inhibit osteoclastic bone resorption.

scholarly journals Composition and In Vitro Effects of Cultivars of Humulus lupulus L. Hops on Cholinesterase Activity and Microbial Growth

Nutrients ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 1377 ◽  
Author(s):  
Joanna Kobus-Cisowska ◽  
Daria Szymanowska-Powałowska ◽  
Oskar Szczepaniak ◽  
Dominik Kmiecik ◽  
Monika Przeor ◽  
...  
Keyword(s):  
Phenolic Acids ◽  
Ethanol Extract ◽  
Humulus Lupulus ◽  
Raw Material ◽  
In Vitro Tests ◽  
Humulus Lupulus L ◽  
Health Promoting ◽  
In Vitro Effects ◽  
Ethanol Extracts

Common hop (Humulus lupulus L.) has significant health-promoting properties. Hop cones contain resins, essential oils, proteins, polyphenols, lipids, waxes, and cellulose. Hop extracts include bioactive compounds such as polyphenolic compounds (phenolic acids, and flavonols), and chlorophylls. The aim of this study was to compare the pro-health potential of hop cone extracts obtained from three cultivars (Magnum, Lubelski, and Marynka). The results showed that the cones of Magnum cultivar demonstrated the highest biological activity. The sum of phenolic acids and flavonols in ethanol extract was the highest for this variety and was equal 4903.5 µg/g dw. Ethanol extracts of Magnum cultivars showed the highest degree of iron ion chelation (55.43–88.76%) as well as the activity against 1,1-diphenyl-2-picrylhydrazyl radical (4.75 mmol Tx/g dw). Hop cone extracts as cholinesterase inhibitors showed high potential for aqueous variants. In terms of antimicrobial activity, all investigated extracts demonstrated strong inhibition against Staphylococcus aureus and Staphylococcus epidermidis, with the Magnum cultivar showing the strongest inhibition. Owing to the biofunctional features of hop cone, it can be concluded that it is an attractive raw material with pro-health potential that can be used much more widely in food technology. However, it should be noted that toxicological tests and in vitro tests must be carried out before the raw material is used in food production.

scholarly journals FLAVONOLS HPLC ANALYSIS, IN VITRO BIOLOGICAL ACTIVITIES IN SELECTED HUMULUS LUPULUS L. GENOTYPES

2013 ◽  
Vol 12 (2) ◽  
pp. 129-140
Author(s):  
Maria Maliarova ◽  
Tibor Maliar ◽  
Jana Girmanova ◽  
Jozef Lehotay ◽  
Jan Kraic
Keyword(s):  
Biological Activities ◽  
Humulus Lupulus ◽  
Point Of View ◽  
Raw Material ◽  
Humulus Lupulus L ◽  
Bitter Acids ◽  
High Level ◽  
Beer Production ◽  
Structural Classes

Abstract The Humulus lupulus L. is well known as necessary raw material for beer production. The main structural classes of chemical compounds identified from hop cones include terpenes, bitter acids, prenylated chalcones, and flavonol glycosides. They were subjects of presented work. The content of quercetin was found in the range 490 - 1092 μg/g and that of kaempferol from 218 to 568 μg/g of the dry hop cones. The content of isorhamnetin was very low in all varieties. From biological activities in vitro point of view, relative high level of inhibition activity was observed for six hop genotypes - Zlatan, Lučan, and the Oswald's clones 31, 70, 71, 72, 114 on both enzymes thrombin and urokinase, but without correlation to analyzed flavonols content. In spite of this, antioxidant activity, measured by both the BCLM and HPE methods, was found high and seem to be in correlation with content of analyzed flavonols. Particularly the Oswald's clone 114 expressed very potent biological activities. In general, obtained results indicate that hop cones are valuable material also for other application others than beer production.

scholarly journals Hops (Humulus lupulus L.) as a Novel Multipurpose Crop for the Mediterranean Region of Europe: Challenges and Opportunities of Their Cultivation

Agriculture ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 484
Author(s):  
Francesco Rossini ◽  
Giuseppe Virga ◽  
Paolo Loreti ◽  
Nicolò Iacuzzi ◽  
Roberto Ruggeri ◽  
...  
Keyword(s):  
Humulus Lupulus ◽  
Specific Reference ◽  
Research Activity ◽  
Plant Parts ◽  
Craft Beer ◽  
Recent Success ◽  
Natural Medicine ◽  
Humulus Lupulus L ◽  
Challenges And Opportunities ◽  
Almost All

The common hop (Humulus lupulus L.) is a dioecious perennial climbing plant, mainly known for the use of its female inflorescences (cones or, simply, “hops”) in the brewing industry. However, the very first interest towards hops was due to its medicinal properties. Actually, the variety of compounds present in almost all plant parts were (and still are) used to treat or prevent several ailments and metabolic disorders, from insomnia to menopausal symptoms as well as obesity and even cancer. Although hops are predominantly grown for hopping beer, the increasing interest in natural medicine is widening new interesting perspectives for this crop. Moreover, the recent success of the craft beer sector all over the world, made the cultivated hop come out from its traditional growing areas. Particularly, in Europe this resulted in a movement towards southern countries such as Italy, which added itself to the already existing hop industry in Portugal and Spain. In these relatively new environments, a complete knowledge and expertise of hop growing practices is lacking. Overall, while many studies were conducted globally on phytochemistry, bioactivity, and the genetics of hops, results from public research activity on basic hop agronomy are very few and discontinuous as well. The objective of this article is to provide an overview of possible uses, phenology, and agronomic aspects of hops, with specific reference to the difficulties and opportunities this crop is experiencing in the new growing areas, under both conventional and organic farming. The present review aims to fill a void still existing for this topic in the literature and to give directions for farmers that want to face the cultivation of such a challenging crop.

Bioactive compounds and antioxidant activities of Brazilian hop ( Humulus lupulus L.) extracts

2019 ◽  
Vol 55 (1) ◽  
pp. 340-347 ◽  
Author(s):  
Aline da Rosa Almeida ◽  
Matheus Vinícius de Oliveira Brisol Maciel ◽  
Michelle Heck Machado ◽  
Giovana Carolina Bazzo ◽  
Rafael Dutra Armas ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
Antioxidant Activities ◽  
Humulus Lupulus ◽  
Humulus Lupulus L

Characterization of a Cell Line Derived From a Human Giant Cell Tumor That Stimulates Osteoclastic Bone Resorption

1993 ◽  
Vol &NA; (296) ◽  
pp. 229???241 ◽  
Author(s):  
RICHARD O. C. OREFFO ◽  
G. JUNE MARSHALL ◽  
MARY KIRCHEN ◽  
CARLOS GARCIA ◽  
WOLF E. GALLWITZ ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Giant Cell Tumor ◽  
Cell Line ◽  
Giant Cell ◽  
Cell Tumor ◽  
Osteoclastic Bone Resorption ◽  
A Cell
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