scholarly journals A RARE CASE OF EXTRADURAL THORACIC SPINAL CHORDOMA WITH MEDULLARY COMPRESSION AND LITERATURE REVIEW

2021 ◽  
Vol 20 (2) ◽  
pp. 237-240
Author(s):  
A. Ene ◽  
◽  
Iulia Elena Petre ◽  
A.N. Dabu ◽  
◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Back Pain ◽  
Thoracic Spine ◽  
Rare Case ◽  
English Literature ◽  
Lower Limbs ◽  
Spinal Tumors ◽  
Histopathological Study ◽  
Low Grade ◽  
Thoracic Spinal

Background. Chordomas are low-grade, slow-growing, but locally invasive and aggressive malignant tumors, arising from the remnants of the embryonic notochord. Given its origin, the distribution of chordomas is along the axial skeleton: 50% of cases in the sacral region, 35% skull base and 15% occur in the vertebral bodies of the spine, which most commonly involve cervical (particularly C2), followed by lumbar, and then the thoracic spine. Without a prompt and aggressive treatment the chances of metastasis are low, but the local recurrence rate is high (about 50%) with a 40% chance of 10-year survival. Objective. Our purpose is to present a rare case of an extradural thoracic chordoma, the importance of differential diagnosis and the management of this case for a better outcome. Case presentation. A 61-year-old man presented with a 1-month history of thoracic back pain, followed by rapidly progressive paraparesis and paresthesia in both lower limbs, and 24 hour urinary retention. MRI of the thoracic spine revealed an contrast-enhancing lesion arising from T5 to T6 vertebral level, with pre and paravertebral extension and medullary compression. The diagnosis of chordoma was made by tissue biopsy and histopathological study. There are few reports of chordomas with this localization in English literature. After surgery, the patient showed slightly good clinical outcome in terms of improvement of muscle strength in lower limbs and back pain decrease in intensity of back pain. Conclusions. Primary chordoma in the thoracic spine is extremely rare (less than 15% of the cases). This case highlights the importance of emergency surgery in the treatment of spinal tumors and the need to consider chordoma as a differential diagnosis for extradural spinal tumors. On the other hand the treatment is challenging because the current literature is lacking in evidence based guidelines due to low incidence.

Monostotic fibrous dysplasia of the thoracic spine: clinopathological description and follow up

2004 ◽  
Vol 100 (4) ◽  
pp. 378-381 ◽  
Author(s):  
Mehmet Arazi ◽  
Onder Guney ◽  
Mustafa Ozdemir ◽  
Omer Uluoglu ◽  
Nuket Uzum
Keyword(s):  
Fibrous Dysplasia ◽  
Thoracic Spine ◽  
Histopathological Examination ◽  
En Bloc Resection ◽  
Spinal Tumors ◽  
En Bloc ◽  
Content Type ◽  
Thoracic Spinal ◽  
Fine Print

✓ The authors report the case of a 53-year-old woman with monostotic fibrous dysplasia of the thoracic spine. The patient presented with a 1-month history of pain in the thoracic spinal region. En bloc resection of the lesion was successfully performed via a transthoracic approach, and a histopathological examination confirmed the diagnosis of fibrous dysplasia. At 24-month follow-up examination, pain and vertebral instability were absent. The findings in this case illustrate that, although very rare, monostotic fibrous dysplasia of the thoracic spine should be considered in the differential diagnosis of spinal tumors. Although a consensus for management of this disease has not been achieved, the authors recommend radical removal of all involved bone as well as internal fixation or bone graft—assisted fusion to achieve long-term stabilization.

scholarly journals Nevus of Ota with Rare Palatal Involvement: A Case Report with Emphasis on Differential Diagnosis

2011 ◽  
Vol 2011 ◽  
pp. 1-4
Author(s):  
Gaurav Sharma ◽  
Archna Nagpal
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Oral Cavity ◽  
Rare Case ◽  
Indian Subcontinent ◽  
English Literature ◽  
Melanocytic Nevus ◽  
Oral Manifestations ◽  
Nevus Of Ota ◽  
The Face

Nevus of Ota, a dermal melanocytic nevus, is rare in the Indian subcontinent. It presents as a brown, blue, or gray patch on the face and is within the distribution of the ophthalmic and maxillary branches of the trigeminal nerve. The oral cavity is infrequently involved in nevus of Ota. Only 11 cases have been documented in the English literature. We report a rare case of intraoral nevus of Ota in a 22-year-old male patient. This paper focuses on the differential diagnosis of oral manifestations of nevus of Ota to assist in proper followup to avert malignant transformation.

Low-grade myofibroblastic sarcoma of the thoracic spine: report of an extreme rare case

2016 ◽  
Vol 31 (6) ◽  
pp. 731-733 ◽  
Author(s):  
Georgios F. Hadjigeorgiou ◽  
Vasilios Samaras ◽  
Vasilios Varsos
Keyword(s):  
Thoracic Spine ◽  
Rare Case ◽  
Low Grade ◽  
Myofibroblastic Sarcoma

scholarly journals Methotrexate-related lymphoproliferative disorder of the lumbar spine origin presenting with severe low-back pain: case report

2018 ◽  
Vol 29 (5) ◽  
pp. 545-548 ◽  
Author(s):  
Naoya Kikuchi ◽  
Masafumi Uesugi ◽  
Masao Koda ◽  
Tomoaki Shimizu ◽  
Kohei Murakami ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Low Back Pain ◽  
Back Pain ◽  
Lumbar Spine ◽  
Lymphoproliferative Disorder ◽  
Rare Case ◽  
Tumor Regression ◽  
Spinal Tumors ◽  
Low Back ◽  
Spontaneous Tumor Regression

The use of methotrexate (MTX) to treat rheumatoid arthritis (RA) is increasing. Recently, MTX-associated lymphoproliferative disorder (MTX-LPD) has been frequently reported as lymphoma occurring during MTX therapy. The authors report their experience with a relatively rare case of MTX-LPD presenting in the lumbar spine. The patient, a 73-year-old woman who experienced low-back pain while receiving MTX therapy for RA, was suspected of having developed MTX-LPD based on her medical history, images of the L1 vertebra, and transpedicular biopsy results. One week after discontinuing MTX, the patient’s low-back pain reportedly improved. The woman was diagnosed with MTX-LPD based on histopathological findings. MTX discontinuation alone coincided with spontaneous tumor regression. Because MTX-LPD can occur in tissues other than lymph nodes, such as in bones and joints, it is a disease that should be considered when diagnosing spinal tumors in patients receiving MTX therapy.

scholarly journals Intramedullary Capillary Hemangioma of the Thoracic Spine: Case Report and Review of the Literature

Rare Tumors ◽  
2009 ◽  
Vol 1 (1) ◽  
pp. 4-6 ◽  
Author(s):  
Rahul Kasukurthi ◽  
Wilson Z. Ray ◽  
Spiros L. Blackburn ◽  
Eriks A. Lusis ◽  
Paul Santiago
Keyword(s):  
Spinal Cord ◽  
Case Report ◽  
Thoracic Spine ◽  
Rare Case ◽  
Capillary Hemangioma ◽  
Review Of The Literature ◽  
Thoracic Spinal Cord ◽  
Thoracic Spinal ◽  
Vascular Neoplasms ◽  
Spine Case

Capillary hemangiomas are benign vascular neoplasms. When associated with the spine, these growths frequently involve the vertebral body, but rarely have they been reported to occur as intradural lesions, while even more rarely occurring in a true intramedullary location. We report a rare case of an intramedullary capillary hemangioma of the thoracic spinal cord and a review of the literature.

scholarly journals Endometrial Stromal Sarcoma Arising in Colorectal Endometriosis: A Case Report and Review of the Literature

2015 ◽  
Vol 2015 ◽  
pp. 1-4
Author(s):  
Qiao Wang ◽  
Xia Zhao ◽  
Ping Han
Keyword(s):  
Differential Diagnosis ◽  
English Literature ◽  
Tumor Resection ◽  
Endometrial Stromal Sarcoma ◽  
Low Grade ◽  
Review Of The Literature ◽  
Primary Tumors ◽  
Colorectal Endometriosis ◽  
Stromal Sarcoma ◽  
History Of

Extrauterine endometrial stromal sarcoma (ESS) arising in endometriosis is extremely rare, particularly in the colorectum. It should always be included in the differential diagnosis of primary tumors originating from gastrointestinal tract in females, given that preoperative endoscopical biopsy may reveal no specific changes. We reported a case of ESS arising in colorectal endometriosis and reviewed the previous 7 cases reported in the English literature. Our patient, who was unavailable for tumor resection and refused further adjuvant therapy, played a role in representing the natural history of low-grade extragenital ESS. This case was the only death from ESS arising in colorectal endometriosis.

scholarly journals Recurrent spondylodiscitis secondary to hallux osteomyelitis

2019 ◽  
Vol 19 (1) ◽  
pp. 63-65
Author(s):  
Aleksandra Staniszewska ◽  
Elizabeth Ballingall ◽  
Peter Schnatterbeck ◽  
Christopher R Lattimer ◽  
Amit Amin ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Differential Diagnosis ◽  
Back Pain ◽  
Thoracic Spine ◽  
Diabetic Foot ◽  
Diabetic Foot Infection ◽  
Local Disease ◽  
Severe Back Pain

Foot infections are the commonest complication of diabetes mellitus requiring hospitalisation. Despite local osteomyelitis being the most frequent sequel of a diabetic foot infection, there is emerging evidence to suggest that local disease may lead to distant infections. In this report we present a case of recurrent thoracic spine spondylodiscitis due to left hallux osteomyelitis in a man with type 2 diabetes. This case illustrates the importance of considering spondylodiscitis as a differential diagnosis in patients presenting with diabetic foot infection and complaining of acute severe back pain.

scholarly journals Uncommon Progression of an Extradural Spinal Meningioma

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Atef Ben Nsir ◽  
Mohamed Boughamoura ◽  
Houda Mahmoudi ◽  
Mohamed Kilani ◽  
Nejib Hattab
Keyword(s):  
Differential Diagnosis ◽  
Thoracic Spine ◽  
Rare Case ◽  
Relevant Literature ◽  
Malignant Neoplasms ◽  
Spinal Meningioma ◽  
Spinal Meningiomas

Extradural spinal meningiomas are rare. Our understanding of purely extradural spinal meningiomas is still incomplete and they may be easily confused with malignant neoplasms, much more common in this location. We report a rare case of a purely extradural thoracic spine meningioma in a 70-year-old man, with an unusual progression. In addition we discuss the pathogenesis of these tumors and the potential pitfalls in differential diagnosis and review the relevant literature concerning their treatment and outcome.

Nummular Eczema: An Updated Review

2020 ◽  
Vol 14 ◽  
Author(s):  
Alexander K.C. Leung ◽  
Joseph M. Lam ◽  
Kin Fon Leong ◽  
Amy A.M. Leung ◽  
Alex H.C. Wong ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
English Literature ◽  
Contact Allergy ◽  
Correct Diagnosis ◽  
Hot Water ◽  
Lower Limbs ◽  
Pubmed Search ◽  
Annular Lesions ◽  
Key Terms ◽  
Nummular Eczema

Background: Nummular eczema may mimic diseases that present with annular configuration and the differential diagnosis is broad. Objective: This article aimed to provide an update on the evaluation, diagnosis, and treatment of nummular eczema. Methods: A PubMed search was performed in Clinical Queries using the key terms “nummular eczema”, “discoid eczema”, OR “nummular dermatitis”. The search strategy included meta-analyses, randomized controlled trials, clinical trials, observational studies, and reviews. The search was restricted to the English literature. The information retrieved from the above search was used in the compilation of the present article. Patents were searched using the key terms “nummular eczema”, “discoid eczema”, OR “nummular dermatitis” in www.google.com/patents and www.freepatentsonline.com. Results: Nummular eczema is characterized by sharply defined, oval or coin-shaped, erythematous, eczematous plaques. Typically, the size of the lesion varies from 1 to 10 cm in diameter. The lesions are usually multiple and symmetrically distributed. Sites of predilection include the lower limbs followed by the upper limbs. The lesions are usually intensely pruritic. The diagnosis is mainly clinical based on the characteristic round to oval erythematous plaques in a patient with diffusely dry skin. Nummular eczema should be distinguished from other annular lesions. Dermoscopy can reveal additional features that can be valuable for correct diagnosis. Biopsy or laboratory tests are generally not necessary. However, a potassium hydroxide wet-mount examination of skin scrapings should be performed if tinea corporis is suspected. Because contact allergy is common with nummular eczema, patch testing should be considered in patients with chronic, recalcitrant nummular eczema. Avoidance of precipitating factors, optimal skin care, and high or ultra-high potency topical corticosteroids are the mainstay of therapy. Recent patents related to the management of nummular eczema are also discussed. Conclusion: With proper treatment, nummular eczema can be cleared over a few weeks, although the course can be chronic and characterized by relapses and remissions. Moisturizing of the skin and avoidance of identifiable exacerbating factors such as hot water baths and harsh soaps may reduce the frequency of recurrence. Diseases that present with annular lesions may mimic nummular eczema and the differential diagnosis is broad. As such, physicians must be familiar with this condition so that an accurate diagnosis can be made, and appropriate treatment initiated.

Primary Appendiceal Gastrointestinal Stromal Tumor: A Case of an Incidental Tumor

2020 ◽  
Vol 154 (Supplement_1) ◽  
pp. S72-S72
Author(s):  
L Balikani
Keyword(s):  
Differential Diagnosis ◽  
Gastrointestinal Stromal Tumor ◽  
Mitotic Activity ◽  
English Literature ◽  
Low Risk ◽  
Stromal Tumor ◽  
Thick Wall ◽  
Low Grade ◽  
Stromal Tumors ◽  
Mesenchymal Neoplasm

Abstract Introduction/Objective Gastrointestinal stromal tumors (GISTs) are rare with an approximate prevalence of 2%. Though rare, they are the most common mesenchymal neoplasm of the gastrointestinal tract. They commonly occur in the stomach (50-60%), small intestine (20-30%), large intestine and esophagus (<10%). GISTs arising in the appendix are very rare, with less than 20 cases reported in the English literature to date. The clinical presentation varies from appendicitis-like symptoms to incidental findings on imaging, during surgery for other diseases or at autopsy. The differential diagnosis of GIST from other stromal tumors is often difficult on hematoxylin and eosin (H&E) examination alone. The use of immunohistochemistry (IHC) plays a key role in confirming the diagnosis. GISTs can be graded based on a four-tier risk stratification system, including high, intermediate, low and very low risk, taking size tumor and mitotic activity into consideration. Most of the previously reported cases of primary appendiceal GIST were low or very low risk but one case of malignant GIST arising in the appendix has been reported. Methods We present the case of a 65-year-old male with a slightly thickened appendix and fluid in the distal aspect incidentally found on computer tomography (CT) scan for diverticulitis workup. An appendectomy with adequate was performed. The gross specimen revealed a 0.2-0.4 cm thick wall with no gross perforations or masses. Histologically, the tumor measured 0.8 cm and was composed of spindle cells with no nuclear atypia and absent to low mitotic activity. The IHC profile of the tumor was positive for CD117, DOG1 and CD34. A diagnosis of Gastrointestinal stromal tumor, low grade was rendered. Conclusion We endeavor to highlight the importance of considering GIST in the differential diagnosis in patients with nonspecific symptoms and/or atypical image findings of the appendix especially in ruling out a possible malignant GIST.

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