scholarly journals MYASTHENIA GRAVIS IN PREGNANCY: A RARE ASSOCIATION WITH AN UNPREDICTABLE EVOLUTION – THREE CASES PRESENTATION

2021 ◽  
Vol 20 (2) ◽  
pp. 241-245
Author(s):  
Benjilany Aboubakr ◽  
◽  
Kouach Jaouad ◽  
Keyword(s):  
Sex Ratio ◽  
Myasthenia Gravis ◽  
Prenatal Period ◽  
Striated Muscles ◽  
Rare Association ◽  
Optimal Monitoring ◽  
Mother And Child ◽  
Synaptic Receptors ◽  
Two Peaks ◽  
In Pregnancy

Myasthenia gravis is a neuro-immunological disease due to the blockage of motor plate post-synaptic receptors by antiacetylcholine receptors antibodies, causing excessive fatigability of skeletal striated muscles. Thus, vital prognosis is engaged by swallowing disorders and respiratory distress related to pharyngeal striated and intercostal muscles damage. Myasthenia evolves by flare-ups, with two peaks of prevalence: first one, between 20 and 30 years-old with femal predominance. Then after 40 years-old, sex ratio evens out. Therefore, association of myasthenia and pregnancy is not exceptional, hence the interest in knowing particularities of these pregnancies, to ensure optimal monitoring for both mother and child. Indeed, mother’s risk is myasthenia decompensation, while child’s risk is neonatal myasthenia gravis. We report three myasthenia and pregnancy cases, from prenatal period to pueripartum, then we discuss in literature light, myasthenia gravis bidirectional influence on pregnancy, as well as impact of anti-myasthenic treatments on pregnancy.

scholarly journals Treatment and therapeutic strategies for pituitary apoplexy in pregnancy: a case series

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Yuya Kato ◽  
Yoshikazu Ogawa ◽  
Teiji Tominaga
Keyword(s):  
Pituitary Apoplexy ◽  
Clinical Symptoms ◽  
Case Series ◽  
Optimal Timing ◽  
Presenting Symptoms ◽  
Pathological Evaluation ◽  
Mother And Child ◽  
Life Threatening ◽  
In Pregnancy

Abstract Background Pregnancy is a known risk factor for pituitary apoplexy, which is life threatening for both mother and child. However, very few clinical interventions have been proposed for managing pituitary apoplexy in pregnancy. Case presentation We describe the management of three cases of pituitary apoplexy during pregnancy and review available literature. Presenting symptoms in our case series were headache and/or visual disturbances, and the etiology in all cases was hemorrhage. Conservative therapy was followed until 34 weeks of gestation, after which babies were delivered by cesarean section with prophylactic bolus hydrocortisone supplementation. Tumor removal was only electively performed after delivery using the transsphenoidal approach. All three patients and their babies had a good clinical course, and postoperative pathological evaluation revealed that all tumors were functional and that they secreted prolactin. Conclusions Although the mechanism of pituitary apoplexy occurrence remains unknown, the most important treatment strategy for pituitary apoplexy in pregnancy remains adequate hydrocortisone supplementation and frequent hormonal investigation. Radiological follow-up should be performed only if clinical symptoms deteriorate, and optimal timing for surgical resection should be discussed by a multidisciplinary team that includes obstetricians and neonatologists.

scholarly journals Myasthenia Gravis and Large Granular Lymphocytic Leukemia: a rare association

2020 ◽  
Vol 14 ◽  
pp. 100226
Author(s):  
Yumeng Zhang ◽  
Christa Varnadoe ◽  
Ankita Tandon ◽  
Peter Forsyth ◽  
Rami Komrokji ◽  
...  
Keyword(s):  
Myasthenia Gravis ◽  
Lymphocytic Leukemia ◽  
Rare Association ◽  
Large Granular Lymphocytic Leukemia

scholarly journals Rare association of thymoma, myasthenia gravis and sarcoidosis : a case report

2008 ◽  
Vol 2 (1) ◽  
Author(s):  
Mohankumar Kurukumbi ◽  
Roger L Weir ◽  
Janaki Kalyanam ◽  
Mansoor Nasim ◽  
Annapurni Jayam-Trouth
Keyword(s):  
Case Report ◽  
Myasthenia Gravis ◽  
Rare Association

scholarly journals Sleep Disorders in Pregnancy

2021 ◽  
Author(s):  
Patrizia Moretti ◽  
Giulia Menculini ◽  
Lucia Gonfia
Keyword(s):  
Risk Factors ◽  
Circadian Rhythms ◽  
Pregnant Women ◽  
Sleep Disorders ◽  
Sleep Disturbances ◽  
Pharmacological Treatments ◽  
Mother And Child ◽  
Physiological Sleep ◽  
In Pregnancy

Sleep disturbances and changes in circadian rhythms are commonly observed in pregnant women. These disorders can result from anatomical, physiological, psychological, and hormonal alterations that can influence sleeping during this phase. Sleep disorders during pregnancy can be responsible for detrimental effects on both mother and foetus. In this chapter we will focus on the epidemiology of sleep disorders, physiological sleep mechanisms and their alterations during pregnancy, as well as on risk factors for sleep disorders in pregnancy. We will then focus of the most frequent sleep disorders during pregnancy, also considering eventual adverse implications for both mother and child, prognosis, and possible pharmacological and non-pharmacological treatments.

scholarly journals Seronegative Myasthenia Gravis and a Biermer’s Anemia: A Rare Association

2017 ◽  
Vol 07 (04) ◽  
pp. 160-164
Author(s):  
Boundia Djiba ◽  
Baïdy Sy Kane ◽  
Awa Cheikh Ndao ◽  
Michel Assane Ndour ◽  
Nafissatou Diagne ◽  
...  
Keyword(s):  
Myasthenia Gravis ◽  
Rare Association ◽  
Seronegative Myasthenia Gravis

scholarly journals Myasthenia gravis and paroxysmal nocturnal hemoglobinuria after thymectomy: A rare association

eJHaem ◽  
2021 ◽  
Author(s):  
Jean Galtier ◽  
Fanny Duval ◽  
Irène Machelart ◽  
Carine Greib ◽  
Estibaliz Lazaro ◽  
...  
Keyword(s):  
Myasthenia Gravis ◽  
Paroxysmal Nocturnal Hemoglobinuria ◽  
Rare Association

Stillbirth as the primary manifestation of disseminated tuberculosis in a young immunocompetent mother with multiple perforations of the ileum

2021 ◽  
Vol 14 (2) ◽  
pp. e239386
Author(s):  
Deepak Rajput ◽  
Amit Gupta ◽  
Ravi Roshan ◽  
Arvind Kumar
Keyword(s):  
Weight Loss ◽  
Pregnancy Loss ◽  
Clinical Presentation ◽  
Delayed Presentation ◽  
Female Reproductive System ◽  
Middle Income ◽  
Middle Income Countries ◽  
Low Middle Income Countries ◽  
Mother And Child ◽  
In Pregnancy

Tuberculosis (TB), a significant cause of morbidity and mortality worldwide, is particularly relevant in low/middle-income countries like India, where the disease is endemic. The female reproductive system is very vulnerable to this infection with, the clinical presentation being utterly silent in most patients. Symptoms of TB in pregnancy may initially be attributed to the gravidity itself besides temporary concealment of associated weight loss by the normally occurring weight gain during the pregnancy. Untreated TB may cause pregnancy loss by either placental damage or direct harm to both the mother and child. We report a case of latent disseminated TB in a young immunocompetent female that was revealed in the postpartum state (after full-term stillbirth delivery at home) as 20 ileal perforations secondary to intestinal TB. Due to ongoing sepsis and delayed presentation to the hospital, the patient could not be salvaged despite the best possible efforts.

scholarly journals Hyperthyroidism During Pregnancy: Etiology, Diagnosis and Management

2005 ◽  
Vol 1 (1) ◽  
pp. 97-104
Author(s):  
John H Lazarus
Keyword(s):  
Radioiodine Therapy ◽  
Hyperemesis Gravidarum ◽  
Thyroid Stimulating Hormone ◽  
Postpartum Women ◽  
Reference Ranges ◽  
Second Trimester ◽  
Autoimmune Thyroid ◽  
Mother And Child ◽  
Neonatal Hyperthyroidism ◽  
In Pregnancy

Pregnancy has marked effects on thyroid physiology and autoimmune thyroid disease tends to ameliorate through gestation due to the general immunosuppression seen in pregnancy. There is a need for trimester-specific thyroid hormone reference ranges. Hyperthyroidism in pregnancy – usually due to Graves' disease – is not common but, if the patient is compliant, a good outcome can be expected for both mother and child if treatment with anti-thyroid drugs (propylthiouracil is preferred) is instituted. Thyroid-stimulating hormone receptor antibody should be measured at 36 weeks in such patients in order to predict the possibility of neonatal hyperthyroidism. Transient gestational hyperthyroidism is often associated with hyperemesis gravidarum and thyroid function should be checked in patients severely affected by this condition. Radioiodine therapy is contraindicated in pregnancy but thyroid surgery may be performed safely in the second trimester. Autoimmune thyroiditis and Graves’ hyperthyroidism occur quite commonly in postpartum women.

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