TYPE I DIABETES MELLITUS – DIAGNOSIS BASED ON COMPLICATIONS

We present you an atypical case of type 1 diabetes mellitus at onset, with multiple abscesses, diagnosis confirmed afterwards by laboratory tests. This report is of a 14 year-old girl, who presented with abscesses of thighs, hypogastric and inguinal area. The regular investigations performed pointed out hyperglycemia with glucose in the urine, accompanied by weight loss, polyuria and polydipsia. The abscesses were incised and drained. The pathological signs of the clinical examination were: influenced general status, decreased skin turgor, dry lips, multiple fistulized abscesses of the thighs and hypogastric area, hyperemic pharynx and tonsils. The blood tests revealed hyperglycemia (272 mg/dl), leukocytosis with granulocytosis, thrombocytosis, and increased values of hemoglobin. The clinical and paraclinical data were suggestive for type I diabetes mellitus, complicated with abscesses. The treatment consisted in substitutive treatment with insulin associated with antibiotics, antimycotics, analgesics, antipyretics, endo-venous perfusions for rehydration. The evolution of the case was favorable under treatment with insulin, the condition of the cutaneous abscesses improved very much after surgical treatment and administration of antibiotics, but they healed only after the equilibration of diabetes mellitus. In conclusion, even though in the specialty literature it is reported that there appear multiple cutaneous infections in patients with diabetes mellitus wrong treated, these are rarely diagnosed at the onset of this disorder in children, this fact being probably explained by the acute onset of the disease at this age.

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Clustering of Cases of Type 1 Diabetes Mellitus Occurring 2-4 Years After Vaccination is Consistent with Clustering After Infections and Progression to Type I Diabetes Mellitus in Autoantibody Positive Individuals

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem.2003.16.4.495 ◽

2003 ◽

Vol 16 (4) ◽

Cited By ~ 5

Author(s):

J.B. Classen ◽

D.C. Classen

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Type I Diabetes ◽

Type I Diabetes Mellitus ◽

Type I

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Acute Onset of Type I Diabetes Mellitus after Severe Echovirus 9 Infection: Putative Pathogenic Pathways

Clinical Infectious Diseases ◽

10.1086/318159 ◽

2000 ◽

Vol 31 (4) ◽

pp. 1025-1031 ◽

Cited By ~ 64

Author(s):

Gienke R. Vreugdenhil ◽

Nanette C. Schloot ◽

Anne Hoorens ◽

Ciska Rongen ◽

Daniel G. Pipeleers ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type I Diabetes ◽

Acute Onset ◽

Type I Diabetes Mellitus ◽

Type I

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Thyroid auto immune antibodies in children with Type-I Diabetes mellitus in relation to diabetes control

Pakistan Journal of Medical Sciences ◽

10.12669/pjms.35.4.192 ◽

2019 ◽

Vol 35 (4) ◽

Author(s):

Muneera Fadhil Ridha ◽

Munib Ahmed Al Zubaidi

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Glycemic Control ◽

Type I Diabetes ◽

Thyroid Autoimmunity ◽

Diabetic Control ◽

Type I Diabetes Mellitus ◽

Type I ◽

Thyroid Antibodies

Background & Objective: As an autoimmune disease, Type-1 diabetes mellitus (DM) may be associated with other autoimmune disorders, the presence of thyroid antibodies could be negatively impact the diabetic control. Our objective was to investigate thyroid autoimmunity in a cohort of children and adolescents with Type-1 diabetes and the Influence of the presence of thyroid autoimmune abnormalities on the control of diabetes in group of Iraqi pediatric patients with Type-I D.M. Methods: This study was conducted at the Medical City Complex, Children Welfare Hospital, Baghdad, Iraq. This study was carried out from the first of January 2016 till the end of September 2017. Data were analyzed from 150 patients with Type-1 diabetes, aged 1–18 years who were treated and are coming for regular follow up in the diabetic clinic. Thyroid functions tests, Antibodies to thyroglobulin (anti-TG) and thyroperoxidase (anti-TPO) were measured, documented and correlated with diabetic control according to glycated haemoglobin (HbA1c) level. Results: In the total of 150 patients, positive Antibodies to thyroglobulin (anti TG) were more in ≤3 years duration group of Diabetes mellitus( DM) and negative anti TG was less in the >3 years duration of DM group with statistically significant results (p=0.043), Regarding the distribution of thyroid antibodies (AB) according to HbA1c group, there was progressive positive anti thyroperoxidase (anti TPO) titer with glycemic status, good glycemic control had the lowest positive anti TPO titer and poor glycemic control group had the highest positive anti TPO titer and the result was statistically significant (p=0.048). Conclusions: Thyroid autoimmunity may be associated with poor diabetic control and elevated TSH levels, indicating subclinical hypothyroidism that my affect the diabetic control. doi: https://doi.org/10.12669/pjms.35.4.192 How to cite this:Ridha MF, Al-Zubaidi MA. Thyroid auto immune antibodies in children with type I Diabetes mellitus in relation to diabetes control. Pak J Med Sci. 2019;35(4):---------. doi: https://doi.org/10.12669/pjms.35.4.192 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Comparative assessment of changes in the incidence of type I diabetes mellitus in the regions with its high and low incidence

Medicni perspektivi (Medical perspectives) ◽

10.26641/2307-0404.2021.2.234732 ◽

2021 ◽

Vol 26 (2) ◽

pp. 180-187

Author(s):

Irada J. Aliyeva

Keyword(s):

Diabetes Mellitus ◽

Type I Diabetes ◽

Type I Diabetes Mellitus ◽

Morbidity Rate ◽

Type I ◽

High Incidence ◽

Low Incidence ◽

Adjusted Incidence ◽

Type 1 Dm

The purpose of this study was to determine dynamics of the levels of type I diabetes mellitus (DM) incidence in the regions with its different incidence. Material from the Azerbaijan Republican and Regional Registers of Diabetes Mellitus were used in this study. All cases of newly diagnosed type 1 DM and documented according to the clinical protocol in 2012-2016 were selected. At the first stage of the study, the rates of diabetes were identified in all administrative-territorial entities. Two groups from administrative-territorial entities were formed for further observation: the first group included regions with high (>80) incidence of type 1 DM, the second group included regions with low (<40) incidence of type 1 DM. At the next stages, changes in type 1 DM incidence were studied and a mean chronological incidence over five years (2012-2016) was determined. Morbidity rate in cities and regions of Azerbaijan in 2012 changed within a range from 5.4 to 294.8. The lowest incidence was observed in three districts: 5.4 in Agjabedi, 5.8 in Jalilabad, 6.1 in Masalli. Very high incidence was observed in Shamkir (294.8) and Khachmaz (278.7) districts. Data from Agdash (30.6) and NAR (32.2) were closer to data from the districts with low incidence. Incidence in Shirvan (81.9) and Yexlakh (171.7) districts was high, but lower than in Shamkir and Khachmaz districts. Type 1 DM incidence has significant interregional differences. Interregional differences in type 1 DM incidence do not depend on the age of the population; age-adjusted incidence of type 1 DM is within a range of 5.0-77.4.

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Characteristics and Outcomes of Children with Type-I Diabetes Mellitus Hospitalized for Ketoacidosis

Current Diabetes Reviews ◽

10.2174/1573399815666190906152125 ◽

2020 ◽

Vol 16 (7) ◽

pp. 779-786

Author(s):

Roza Zinab Ababulgu ◽

Behailu Terefe Tesfaye

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Diabetic Ketoacidosis ◽

Type I Diabetes ◽

Type I Diabetes Mellitus ◽

Type I ◽

Newly Diagnosed ◽

Family History Of Diabetes ◽

Diabetes Patients

Background: Type 1 diabetes mellitus is a common autoimmune disorder that often presents in children. In these patients, diabetic ketoacidosis is one of the most common and serious acute complications associated with significant morbidity and mortality. Nevertheless, limited studies are conducted in Ethiopia. Objective: The aim of this study was to assess patient-related characteristics and outcomes of diabetic ketoacidosis, and their relative difference among children with newly diagnosed and previously known type-I diabetes mellitus. Methods: This is a retrospective cross-sectional study of 63 type-1 diabetes patients admitted for ketoacidosis at Jimma university medical center, a tertiary hospital. Data was collected using a checklist, and entered into Epidata 4.2.0.0 and analyzed using STATA 13.0. Descriptive statistics was performed; Mann-Whitney and Chi-square test statistics were employed for comparison. Result: Of the total, 39 were newly diagnosed type-I diabetes patients. Polydipsia and Polyuria (each in 74.6%) were the predominant symptoms at presentation. ketoacidosis precipitants were undocumented in the majority of the patients (53.97%). Mean (±SD) Random blood sugar was 434.05 (±117.62)mg/dl. Ketoacidosis was mild in severity in 63.49%. Family history of diabetes, unknown precipitants and the first episode of ketoacidosis were significantly different among the new and known type-I diabetes patients. No mortality was documented. Conclusion: The observed patient characteristics are typical of those reported in many studies and standard resources. Despite no mortality was documented, the need for early diagnosis and management should not be overlooked. Further study, with large sample size, is recommended to point-out the real characteristics difference among new and known type-I diabetes mellitus patients admitted for ketoacidosis.

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Transient Global Amnesia in a Collegiate Baseball Player with Type I Diabetes Mellitus: A Case Report

Journal of Athletic Training ◽

10.4085/1062-6050-46.3.319 ◽

2011 ◽

Vol 46 (3) ◽

pp. 319-321 ◽

Cited By ~ 5

Author(s):

Jocelyn R. Gravlee ◽

John J. Barrett

Keyword(s):

Diabetes Mellitus ◽

Blood Glucose ◽

Type I Diabetes ◽

Transient Global Amnesia ◽

Acute Onset ◽

Type I Diabetes Mellitus ◽

Type I ◽

Benign Condition ◽

Memory Disturbance ◽

Global Amnesia

Objective: To present the case of a collegiate pitcher with type I diabetes mellitus who developed transient global amnesia and to characterize the acute onset of symptoms and clinical diagnosis of this rarely reported neurologic condition in the student-athlete population. Background: A 21-year-old collegiate pitcher with type I diabetes mellitus was found by his roommate to have acute-onset memory loss. The athletic trainer identified normal blood glucose levels and normal vital signs but profound amnesia. The patient was evaluated by his team physician and referred to the local emergency department for acute-onset memory disturbance. Differential Diagnosis: Hypoglycemia, ketoacidosis, adverse drug reaction, infectious disease, transient epileptic amnesia, transient ischemic attack, acute confusional state, complex partial seizure, psychogenic amnesia, migraine, intracerebral hemorrhage, traumatic brain injury, tumor, and transient global amnesia. Treatment: Diagnostic studies included computed tomography of the head, urine and serum toxicology, urinalysis, blood glucose level, electrolytes, blood urea nitrogen level, creatinine level, complete blood count, and electroencephalography. The patient was admitted overnight to the neurology service. The next morning, electroencephalography was repeated, and magnetic resonance imaging of the head with contrast was performed. The patient was discharged with the diagnosis of transient global amnesia. Uniqueness: Transient global amnesia is considered a benign condition characterized by an acute episode of memory disturbance involving the inability to form new memories and recall recent events. It is rare in young people, with only 3 case reports involving young athletes published in the literature. Conclusions: Transient global amnesia is a rarely diagnosed neurologic disturbance that may present acutely in student–athletes, although most reported cases affect older adults. Un-familiarity with the symptoms may cause anxiety for the athlete and bystanders. Transient global amnesia does not result in long-term neurologic deficit, and neurologic function will return to baseline.

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