scholarly journals Contextual and Cued Fear Conditioning Test Using a Video Analyzing System in Mice

10.3791/50871 ◽  
2014 ◽  
Author(s):  
Hirotaka Shoji ◽  
Keizo Takao ◽  
Satoko Hattori ◽  
Tsuyoshi Miyakawa
Keyword(s):  
Fear Conditioning ◽  
Fear Conditioning Test

Targeted invalidation of CCK2 receptor gene induces anxiolytic-like action in light–dark exploration, but not in fear conditioning test

2005 ◽  
Vol 181 (2) ◽  
pp. 347-357 ◽  
Author(s):  
Sirli Raud ◽  
Jürgen Innos ◽  
Urho Abramov ◽  
Ain Reimets ◽  
Sulev Kõks ◽  
...  
Keyword(s):  
Fear Conditioning ◽  
Receptor Gene ◽  
Cck2 Receptor ◽  
Fear Conditioning Test

scholarly journals Visually cued fear conditioning test for memory impairment related to cortical function

2020 ◽  
Vol 40 (4) ◽  
pp. 371-375
Author(s):  
Kazuya Kuboyama ◽  
Yuki Shirakawa ◽  
Koji Kawada ◽  
Naoki Fujii ◽  
Daiki Ojima ◽  
...  
Keyword(s):  
Fear Conditioning ◽  
Memory Impairment ◽  
Cortical Function ◽  
Fear Conditioning Test

scholarly journals piRNAs in the Olfactory Bulb Related to Fear Conditioning can Migrate from the Brain to the Germline

2021 ◽  
Vol 3 (5) ◽  
pp. 132-136
Author(s):  
Sicong Chen
Keyword(s):  
Olfactory Bulb ◽  
Fear Conditioning ◽  
Small Rnas ◽  
Memory Formation ◽  
Virus Vector ◽  
Single Nucleotide ◽  
The Brain ◽  
Fear Conditioning Test

Small RNAs have been shown to be crucial in the mechanisms of transgenerational memory. Precisely, piRNAs have previously been thought to only exist in the germline and are related to transgenerational memory. To determine if the offspring inherits memory due to piRNA transmission, we conducted odor fear-conditioning tests and identified a piRNA that increased in abundance. That piRNA is thought to be involved in memory formation of the fear-conditioning test. We then used a virus vector to manipulate a single nucleotide of that piRNA sequence to see if it can migrate from the olfactory bulb to the germline. The data should theoretically indicate whether the mutant piRNA has migrated from the olfactory bulb to the germline of the mice.

Effects of an Anxiety-Specific Psychometric Factor on Fear Conditioning and Fear Generalization

2017 ◽  
Vol 225 (3) ◽  
pp. 200-213 ◽  
Author(s):  
Christian Baumann ◽  
Miriam A. Schiele ◽  
Martin J. Herrmann ◽  
Tina B. Lonsdorf ◽  
Peter Zwanzger ◽  
...  
Keyword(s):  
Risk Factor ◽  
Anxiety Disorders ◽  
Fear Conditioning ◽  
Longitudinal Design ◽  
Principal Component ◽  
Anxiety And Depression ◽  
Specific Factor ◽  
High Anxious ◽  
Two Factors ◽  
Fear Generalization

Abstract. Conditioning and generalization of fear are assumed to play central roles in the pathogenesis of anxiety disorders. Here we investigate the influence of a psychometric anxiety-specific factor on these two processes, thus try to identify a potential risk factor for the development of anxiety disorders. To this end, 126 healthy participants were examined with questionnaires assessing symptoms of anxiety and depression and with a fear conditioning and generalization paradigm. A principal component analysis of the questionnaire data identified two factors representing the constructs anxiety and depression. Variations in fear conditioning and fear generalization were solely associated with the anxiety factor characterized by anxiety sensitivity and agoraphobic cognitions; high-anxious individuals exhibited stronger fear responses (arousal) during conditioning and stronger generalization effects for valence and UCS-expectancy ratings. Thus, the revealed psychometric factor “anxiety” was associated with enhanced fear generalization, an assumed risk factor for anxiety disorders. These results ask for replication with a longitudinal design allowing to examine their predictive validity.

Challenges of Fear Conditioning Research in the Age of RDoC

2017 ◽  
Vol 225 (3) ◽  
pp. 189-199 ◽  
Author(s):  
Tina B. Lonsdorf ◽  
Jan Richter
Keyword(s):  
Fear Conditioning ◽  
Clinical Diagnosis ◽  
Research Domain Criteria ◽  
Major Focus ◽  
The Future ◽  
Definition Of ◽  
Methodological Considerations ◽  
Research Domain

Abstract. As the criticism of the definition of the phenotype (i.e., clinical diagnosis) represents the major focus of the Research Domain Criteria (RDoC) initiative, it is somewhat surprising that discussions have not yet focused more on specific conceptual and procedural considerations of the suggested RDoC constructs, sub-constructs, and associated paradigms. We argue that we need more precise thinking as well as a conceptual and methodological discussion of RDoC domains and constructs, their interrelationships as well as their experimental operationalization and nomenclature. The present work is intended to start such a debate using fear conditioning as an example. Thereby, we aim to provide thought-provoking impulses on the role of fear conditioning in the age of RDoC as well as conceptual and methodological considerations and suggestions to guide RDoC-based fear conditioning research in the future.

Effects of β-Adrenoreceptor Blockade During Chronic Exercise on Contextual Fear Conditioning and mRNA for Galanin and Brain-Derived Neurotrophic Factor.

2004 ◽  
Vol 118 (6) ◽  
pp. 1378-1390 ◽  
Author(s):  
Jacqueline D. Van Hoomissen ◽  
Philip V. Holmes ◽  
Andrew S. Zellner ◽  
Adeline Poudevigne ◽  
Rod K. Dishman
Keyword(s):  
Fear Conditioning ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Contextual Fear Conditioning ◽  
Chronic Exercise ◽  
Contextual Fear
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