scholarly journals Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies

10.3791/52801 ◽  
2015 ◽  
Author(s):  
Enza Lonardo ◽  
Michele Cioffi ◽  
Patricia Sancho ◽  
Shanthini Crusz ◽  
Christopher Heeschen
Keyword(s):  
Pancreatic Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Treatment Strategies ◽  
New Treatment

scholarly journals “Empowering” Cardiac Cells via Stem Cell Derived Mitochondrial Transplantation- Does Age Matter?

2021 ◽  
Vol 22 (4) ◽  
pp. 1824
Author(s):  
Matthias Mietsch ◽  
Rabea Hinkel
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Treatment Strategies ◽  
Cardiac Cells ◽  
Aging Effects ◽  
Beneficial Effects ◽  
Micro Rnas ◽  
New Treatment

With cardiovascular diseases affecting millions of patients, new treatment strategies are urgently needed. The use of stem cell based approaches has been investigated during the last decades and promising effects have been achieved. However, the beneficial effect of stem cells has been found to being partly due to paracrine functions by alterations of their microenvironment and so an interesting field of research, the “stem- less” approaches has emerged over the last years using or altering the microenvironment, for example, via deletion of senescent cells, application of micro RNAs or by modifying the cellular energy metabolism via targeting mitochondria. Using autologous muscle-derived mitochondria for transplantations into the affected tissues has resulted in promising reports of improvements of cardiac functions in vitro and in vivo. However, since the targeted treatment group represents mainly elderly or otherwise sick patients, it is unclear whether and to what extent autologous mitochondria would exert their beneficial effects in these cases. Stem cells might represent better sources for mitochondria and could enhance the effect of mitochondrial transplantations. Therefore in this review we aim to provide an overview on aging effects of stem cells and mitochondria which might be important for mitochondrial transplantation and to give an overview on the current state in this field together with considerations worthwhile for further investigations.

scholarly journals Chemosensitization and inhibition of pancreatic cancer stem cell proliferation by overexpression of microRNA-205

2017 ◽  
Vol 402 ◽  
pp. 1-8 ◽  
Author(s):  
Amit Kumar Chaudhary ◽  
Goutam Mondal ◽  
Virender Kumar ◽  
Krishna Kattel ◽  
Ram I. Mahato
Keyword(s):  
Pancreatic Cancer ◽  
Cell Proliferation ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Stem Cell Proliferation

658 CD44, Pancreatic Cancer Stem Cell Marker, Positive Cells Are Responsible for the Acquiring Gemcitabine Induced Chemoresistance In Vitro

2008 ◽  
Vol 134 (4) ◽  
pp. A-96
Author(s):  
Sung Pil Hong ◽  
Jeong Youp Park ◽  
Jing Wen ◽  
Jin Wook Yoon ◽  
Kyung Hwa Park ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Stem Cell Marker ◽  
Cancer Stem Cell Marker ◽  
Cell Marker

scholarly journals A direct pancreatic cancer xenograft model as a platform for cancer stem cell therapeutic development

2009 ◽  
Vol 8 (2) ◽  
pp. 310-314 ◽  
Author(s):  
Antonio Jimeno ◽  
Georg Feldmann ◽  
Ana Suárez-Gauthier ◽  
Zeshaan Rasheed ◽  
Anna Solomon ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Xenograft Model ◽  
Therapeutic Development

Evolving Concepts for Use of Stem Cells and Tissue Engineering for Cardiac Regeneration

2016 ◽  
pp. 279-313
Author(s):  
Jahnavi Sarvepalli ◽  
Rajalakshmi Santhakumar ◽  
Rama Shanker Verma
Keyword(s):  
Tissue Engineering ◽  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Treatment Options ◽  
Treatment Strategies ◽  
Basic Research ◽  
Underlying Mechanism ◽  
Repair Mechanisms ◽  
New Treatment

The incidence of cardiovascular disease (CVD) in adults are increasing worldwide with impaired repair mechanisms, leading to tissue and organ failure. With the current advancements, life expectancy has improved and has led to search for new treatment strategies that improves tissue regeneration. Recently, stem cell therapy and tissue engineering has captured the attention of clinicians, scientists, and patients as alternative treatment options. The overall clinical experience of these suggests that they can be safely used in the right clinical setting. Ultimately, large outcome trials will have to be conducted to assess their efficacy. Clinical trials have to be carefully designed and patient safety must remain the key concern. At the same time, continued basic research is required to understand the underlying mechanism of cell-based therapies and cell tissue interactions. This chapter reviews the evolving paradigm of stem cell therapy and tissue engineering approaches for clinical application and explores its implications.

scholarly journals NAF-1 Inhibition by Resveratrol Suppresses Cancer Stem Cell-Like Properties and the Invasion of Pancreatic Cancer

2020 ◽  
Vol 10 ◽  
Author(s):  
Tao Qin ◽  
Liang Cheng ◽  
Ying Xiao ◽  
Weikun Qian ◽  
Jie Li ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell

scholarly journals FAM83A is amplified and promotes cancer stem cell-like traits and chemoresistance in pancreatic cancer

Oncogenesis ◽  
2017 ◽  
Vol 6 (3) ◽  
pp. e300-e300 ◽  
Author(s):  
S Chen ◽  
J Huang ◽  
Z Liu ◽  
Q Liang ◽  
N Zhang ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell
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