In Vivo Intracellular Recording of Type-Identified Rat Spinal Motoneurons During Trans-Spinal Direct Current Stimulation

10.3791/61439 ◽  
2020 ◽  
Author(s):  
Marcin Bączyk ◽  
Piotr Krutki
Keyword(s):  
Direct Current ◽  
Intracellular Recording ◽  
Spinal Motoneurons ◽  
Direct Current Stimulation

scholarly journals In-vivo Imaging of Magnetic Fields Induced by Transcranial Direct Current Stimulation (tDCS) in Human Brain using MRI

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Mayank V. Jog ◽  
Robert X. Smith ◽  
Kay Jann ◽  
Walter Dunn ◽  
Belen Lafon ◽  
...  
Keyword(s):  
Magnetic Fields ◽  
Human Brain ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
In Vivo Imaging ◽  
Direct Current Stimulation

P285 Anodal direct current stimulation affects cortical blood flow and vascular permeability in vivo

2020 ◽  
Vol 131 (4) ◽  
pp. e176
Author(s):  
S. Frase ◽  
A.K. Gellner ◽  
J. Reis ◽  
B. Fritsch
Keyword(s):  
Blood Flow ◽  
Vascular Permeability ◽  
Direct Current ◽  
Cortical Blood Flow ◽  
Direct Current Stimulation

scholarly journals Direct Current Stimulation in Cell Culture Systems and Brain Slices—New Approaches for Mechanistic Evaluation of Neuronal Plasticity and Neuromodulation: State of the Art

Cells ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 3583
Author(s):  
Nadine Euskirchen ◽  
Michael A. Nitsche ◽  
Christoph van Thriel
Keyword(s):  
Cell Culture ◽  
Direct Current ◽  
Neuronal Plasticity ◽  
Intracellular Signaling ◽  
Ex Vivo ◽  
Brain Slices ◽  
Field Orientation ◽  
Direct Current Stimulation

Non-invasive direct current stimulation (DCS) of the human brain induces neuronal plasticity and alters plasticity-related cognition and behavior. Numerous basic animal research studies focusing on molecular and cellular targets of DCS have been published. In vivo, ex vivo, and in vitro models enhanced knowledge about mechanistic foundations of DCS effects. Our review identified 451 papers using a PRISMA-based search strategy. Only a minority of these papers used cell culture or brain slice experiments with DCS paradigms comparable to those applied in humans. Most of the studies were performed in brain slices (9 papers), whereas cell culture experiments (2 papers) were only rarely conducted. These ex vivo and in vitro approaches underline the importance of cell and electric field orientation, cell morphology, cell location within populations, stimulation duration (acute, prolonged, chronic), and molecular changes, such as Ca2+-dependent intracellular signaling pathways, for the effects of DC stimulation. The reviewed studies help to clarify and confirm basic mechanisms of this intervention. However, the potential of in vitro studies has not been fully exploited and a more systematic combination of rodent models, ex vivo, and cellular approaches might provide a better insight into the neurophysiological changes caused by tDCS.

scholarly journals Evidence of transcranial direct current stimulation-generated electric fields at subthalamic level in human brain in vivo

2018 ◽  
Vol 11 (4) ◽  
pp. 727-733 ◽  
Author(s):  
Pratik Y. Chhatbar ◽  
Steven A. Kautz ◽  
Istvan Takacs ◽  
Nathan C. Rowland ◽  
Gonzalo J. Revuelta ◽  
...  
Keyword(s):  
Human Brain ◽  
Electric Fields ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Direct Current Stimulation

Abstract WP139: Transcranial Direct Current Stimulation (tDCS) Generates Electric Fields (EF) at the Level of Deep Nuclei of the Human Brain in vivo

Stroke ◽  
2018 ◽  
Vol 49 (Suppl_1) ◽  
Author(s):  
Pratik Y Chhatbar ◽  
Steven A Kautz ◽  
Istvan Takacs ◽  
Nathan C Rowland ◽  
Gonzalo J Revuelta ◽  
...  
Keyword(s):  
Human Brain ◽  
Electric Fields ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Direct Current Stimulation

Polarity-dependent adaptations of motoneuron electrophysiological properties after 5-wk transcutaneous spinal direct current stimulation in rats

2020 ◽  
Vol 129 (4) ◽  
pp. 646-655
Author(s):  
Marcin Bączyk ◽  
Hanna Drzymała-Celichowska ◽  
Włodzimierz Mrówczyński ◽  
Piotr Krutki
Keyword(s):  
Direct Current ◽  
Repetitive Firing ◽  
Control Group ◽  
Spinal Motoneurons ◽  
Sham Control ◽  
Adaptive Changes ◽  
Electrophysiological Properties ◽  
Direct Current Stimulation ◽  
Anodal Polarization ◽  
Sham Control Group

Transcutaneous spinal direct current stimulation applied systematically for 5 wk evoked polarity-dependent adaptations in the electrophysiological properties of rat spinal motoneurons. After anodal polarization sessions, motoneurons became more excitable and could evoke higher maximum discharge frequencies during repetitive firing than motoneurons in the sham polarization group. However, no significant adaptive changes of motoneuron properties were observed after repeated cathodal polarization in comparison with the sham control group.

Effect of transcranial direct current stimulation on in-vivo assessed neuro-metabolites through magnetic resonance spectroscopy: a systematic review

2021 ◽  
pp. 1-48
Author(s):  
Harleen Chhabra ◽  
Vani Holebasavanahalli Thimmashetty ◽  
Venkataram Shivakumar ◽  
Ganesan Venkatasubramanian ◽  
Janardhanan C Narayanswamy
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Psychiatric Disorders ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Psychiatric Patients ◽  
Relevant Literature ◽  
Resonance Spectroscopy ◽  
Direct Current Stimulation

Abstract Objective: Previous studies have examined the effect of transcranial direct current stimulation (tDCS) on the in-vivo concentrations of neuro-metabolites assessed through magnetic resonance spectroscopy (MRS) in neurological and psychiatry disorders. This review aims to systematically evaluate the data on the effect of tDCS on MRS findings and thereby attempt to understand the potential mechanism of tDCS on neuro-metabolites. Methods: The relevant literature was obtained through PubMed and cross-reference (search till June 2020). Thirty-four studies were reviewed of which, 22 reported results from healthy controls and 12 were from patients with neurological and psychiatric disorders. Results: The evidence converges to highlight that tDCS modulates the neuro-metabolite levels at the site of stimulation, which, in turn, translates into alterations in the behavioural outcome. It also shows that the baseline level of these neuro-metabolites can, to a certain extent, predict the outcome after tDCS. However, even though tDCS has shown promising effects in alleviating symptoms of various psychiatric disorders, there are limited studies that have reported the effect of tDCS on neuro-metabolite levels. Conclusions: There is a compelling need for more systematic studies examining patients with psychiatric/neurological disorders with larger samples and harmonised tDCS protocols. More studies will potentially help us to understand the tDCS mechanism of action pertinent to neuro-metabolite levels modulation. Further, studies should be conducted in psychiatric patients to understand the neurological changes in this population and potentially unravel the neuro-metabolite X tDCS interaction effect that can be translated into individualised treatment.

Sign in / Sign up

Export Citation Format

Share Document