scholarly journals Septic arthritis in children 5 to 10 years old

2019 ◽  
Vol 1 (1) ◽  
pp. 27-36
Author(s):  
Rosa Viviana Tutasi Benitez ◽  
Enma María Guadamud Loren
Keyword(s):  
Staphylococcus Aureus ◽  
Septic Arthritis ◽  
Los Grupos

La artritis séptica es una patología infecciosa aguda que es la afectación de la cápsula articular frecuentemente por bacterias, siendo patógeno bacteriano más frecuente los grupos etarios es el Staphylococcus aureus, también puede ser causada por virus y hongos en menor proporción, en niños usualmente es por vía hematógena. Afecta más a hombres que a mujeres, teniendo una clínica muy inespecífica mayormente en lactantes. Sus síntomas clínicos se caracterizan por la negación a movilizar la articulación afectada, enrojecimiento y aumento de la temperatura local, acompañado en algunos casos de fiebre y síntomas sistémicos como taquicardia y aumento de frecuencia respiratoria. Usualmente su afectación es 90% monoarticular y10% poliarticular. La artritis séptica tiene las articulaciones como cadera, rodilla o codo. Como parte de los exámenes de laboratorio serán de gran utilidad biometría hemática completa, velocidad de eritrosedimentación y proteína creactiva. Debido a las complicaciones y secuelas incapacitantes que ocasiona, es considerada una urgencia médico-quirúrgico; su tratamiento debe ser precoz. Ante la confirmación mediante exámenes de laboratorio, es necesario eltratamiento farmacológico empírico intravenoso para obtener resultados del hemocultivo y cultivos de líquido sinovial que deben ser realizados antes del inicio con el tratamiento antibiótico. Su tratamiento será multidisciplinario. 

Matrix metalloproteinase-9 (gelatinase B) deficiency leads to increased severity of Staphylococcus aureus-triggered septic arthritis

2006 ◽  
Vol 8 (6) ◽  
pp. 1434-1439 ◽  
Author(s):  
Ann-Marie Calander ◽  
Sofie Starckx ◽  
Ghislain Opdenakker ◽  
Philip Bergin ◽  
Marianne Quiding-Järbrink ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Matrix Metalloproteinase ◽  
Septic Arthritis ◽  
Matrix Metalloproteinase 9 ◽  
Gelatinase B ◽  
Metalloproteinase 9

PVL Staphylococcus Aureus Osteomyelitis Complicating Septic Arthritis in a Uk Soldier Serving in Iraq

2009 ◽  
Vol 155 (3) ◽  
pp. 208-209 ◽  
Author(s):  
J. G. Penn-Barwell ◽  
S. Finnikin ◽  
I. Sargeant ◽  
K. Porter
Keyword(s):  
Staphylococcus Aureus ◽  
Septic Arthritis

scholarly journals 64-year-old male with septic arthritis of the pubic symphysis

2011 ◽  
Vol 1 (3) ◽  
pp. 76 ◽  
Author(s):  
Ewa Konik ◽  
Brent Bauer ◽  
Mark Lee
Keyword(s):  
Risk Factors ◽  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Septic Arthritis ◽  
Groin Pain ◽  
Pubic Symphysis ◽  
Pelvic Malignancy ◽  
Incontinence Surgery ◽  
Streptococcus Anginosus ◽  
Hip Motion

Septic arthritis of the pubic symphysis is a rare disease. Typical clinical features include fever, pubic or groin pain, pain with hip motion, and painful or waddling gait. Identified predisposing factors to develop an infection in pubic joint include female incontinence surgery or postpartum period; sports, especially soccer; pelvic malignancy; and intravenous drug abuse. The most often identified microorganisms were Staphylococcus aureus and Pseudomonas aeruginosa. Osteomyelitis complicates the majority of cases, and about half of the patients require surgical debridement along with a prolonged antibiotic treatment. We report a case of Streptococcus anginosus septic arthritis of the pubic symphysis. The patient did not have any of the above risk factors.

scholarly journals A potential key role for alpha-haemolysin ofStaphylococcus aureusin mediating chondrocyte death in septic arthritis

2018 ◽  
Vol 7 (7) ◽  
pp. 457-467 ◽  
Author(s):  
I. D. M. Smith ◽  
K. M. Milto ◽  
C. J. Doherty ◽  
S. G. B. Amyes ◽  
A. H. R. W. Simpson ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Septic Arthritis ◽  
Cartilage Damage ◽  
Laser Scanning Microscopy ◽  
Cartilage Explants ◽  
Confocal Laser ◽  
Dead Cell ◽  
Chondrocyte Viability ◽  
Chondrocyte Death ◽  
Bovine Cartilage

ObjectivesStaphylococcus aureus (S. aureus) is the most commonly implicated organism in septic arthritis, a condition that may be highly destructive to articular cartilage. Previous studies investigating laboratory and clinical strains of S. aureus have demonstrated that potent toxins induced significant chondrocyte death, although the precise toxin or toxins that were involved was unknown. In this study, we used isogenic S. aureus mutants to assess the influence of alpha (Hla)-, beta (Hlb)-, and gamma (Hlg)-haemolysins, toxins considered important for the destruction of host tissue, on in situ bovine chondrocyte viability.MethodsBovine cartilage explants were cultured with isogenic S. aureus mutants and/or their culture supernatants. Chondrocyte viability was then assessed within defined regions of interest in the axial and coronal plane following live- and dead-cell imaging using the fluorescent probes 5-chloromethylfluorescein diacetate and propidium iodide, respectively, and confocal laser-scanning microscopy.ResultsHla-producing mutants caused substantial chondrocyte death compared with the toxin-deficient control (Hla-Hlb-Hlg-), whilst mutants producing Hlb and Hlg in the absence of Hla induced minimal chondrocyte death. Coronal studies established that Hla-induced chondrocyte death started in the superficial zone of cartilage and spread to deeper layers, whereas Hlb and Hlg toxins were without significant effect.ConclusionThis study identified Hla as a highly potent S. aureus toxin that caused rapid chondrocyte death in bovine cartilage, with other toxins or metabolic products produced by the bacteria playing a minor role. The identification of Hla in mediating chondrocyte death may assist in the development of therapeutic strategies aimed at reducing the extent of cartilage damage during and after an episode of septic arthritis. Cite this article: I. D. M. Smith, K. M. Milto, C. J. Doherty, S. G. B. Amyes, A. H. R. W. Simpson, A. C. Hall. A potential key role for alpha-haemolysin of Staphylococcus aureus in mediating chondrocyte death in septic arthritis. Bone Joint Res 2018;7:457–467. DOI: 10.1302/2046-3758.77.BJR-2017-0165.R1.

scholarly journals 393. Changing Trends, Risk Factors, and Treatment Challenges in Staphylococcus aureus Septic Arthritis

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S202-S202
Author(s):  
Valerie Gobao ◽  
Mostafa Alfishawy ◽  
Neel Shah ◽  
Karin Byers ◽  
Mohamed Yassin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Staphylococcus Aureus ◽  
Drug Use ◽  
Positive Result ◽  
Septic Arthritis ◽  
Intravenous Drug ◽  
Intravenous Drug Use ◽  
Retrospective Case ◽  
Factors Associated ◽  
Rule Out

Abstract Background Staphylococcus aureus is a common organism in native septic arthritis. It is traditionally believed to be self-limited with rapid and aggressive debridement and appropriate antibiotic selection. The incidence of S. aureus septic arthritis is increasing, and further characterization is needed to improve diagnosis and treatment. For patients presenting with native S. aureus septic arthritis, we evaluated the reliability of methicillin-resistant S. aureus (MRSA) screening as a predictor to rule out MRSA septic arthritis, the risk factors associated with this disease, and the treatment and surgical outcomes. Methods A retrospective case–control study of patients diagnosed with septic arthritis in the UPMC health system (Pittsburgh, PA) between 2012 and 2016 was completed. The primary outcomes of interest were surgical intervention and the need to alter antibiotic treatment. Patient demographics, characteristics, and outcomes were recorded. Results A total of 215 cases of septic arthritis were identified, and 64% (n = 138) had S. aureus cultured. In this set, 36% (50/138) of these patients were identified with MRSA. Of the patients diagnosed with MRSA septic arthritis, 50% screened prior to admission had a positive result (8/16) and 48% screened during admission had a positive result (14/29). Compared with septic arthritis with other organisms, risk factors associated with S. aureus included history of intravenous drug use (OR: 4.3, CI: 1.7 to 10.8, P = 0.002) and being immunocompetent (OR: 0.3, CI: 0.1 to 0.6, P = 0.002). These infections were associated with concurrent infections of the spine (OR: 5.7, CI: 2.1 to 15.1, P = 0.0005). As compared with other organisms, there was a high probability of switching antibiotics during treatment (OR: 3.7, CI: 1.1 to 13.0, P = 0.04) and relapse of infection (OR: 4.2, CI: 1.2 to 14.6, P = 0.02). Conclusion S. aureus septic arthritis is associated with intravenous drug use, and not with immunosuppression. A negative MRSA screen does not rule out this organism. Concurrent spine infections are common. There is a high likelihood of infection relapse and that antibiotics will need to be altered during treatment. With the opioid epidemic, the incidence is likely to increase further. More work is needed to improve diagnosis and overcome treatment challenges. Disclosures All authors: No reported disclosures.

scholarly journals Septic Arthritis and the Opioid Epidemic: 1465 Cases of Culture-Positive Native Joint Septic Arthritis From 1990–2018

2020 ◽  
Vol 7 (3) ◽  
Author(s):  
John J Ross ◽  
Kevin L Ard ◽  
Narath Carlile
Keyword(s):  
Staphylococcus Aureus ◽  
Drug Use ◽  
Synovial Fluid ◽  
Septic Arthritis ◽  
Injection Drug Use ◽  
Injection Drug ◽  
Facet Joints ◽  
Cell Counts ◽  
Culture Positive ◽  
Fluid Cell

Abstract Background The clinical spectrum of septic arthritis in the era of the opioid crisis is ill-defined. Methods This is a retrospective chart review of 1465 cases of culture-positive native joint septic arthritis at Boston teaching hospitals between 1990 and 2018. Results Between 1990–2008 and 2009–2018, the proportion of septic arthritis cases involving people who inject drugs (PWID) rose from 10.3% to 20% (P < .0000005). Overall, methicillin-sensitive Staphylococcus aureus (MSSA) caused 41.5% of cases, and methicillin-resistant Staphylococcus aureus (MRSA) caused 17.9%. Gram-negative rods caused only 6.2% of cases. Predictors of MRSA septic arthritis included injection drug use (P < .001), bacteremia (P < .001), health care exposure (P < .001), and advancing age (P = .01). Infections with MSSA were more common in PWID (56.3% vs 38.8%; P < .00001), as were infections with MRSA (24% vs 16.8%; P = .01) and Serratia sp. (4% vs 0.4%; P = .002). Septic arthritis in the setting of injection drug use was significantly more likely to involve the sacroiliac, acromioclavicular, and facet joints; 36.8% of patients had initial synovial fluid cell counts of <50 000 cells/mm3. Conclusions Injection drug use has become the most common risk factor for septic arthritis in our patient population. Septic arthritis in PWID is more often caused by MRSA, MSSA, and Serratia sp., and is more prone to involve the sacroiliac, acromioclavicular, sternoclavicular, and facet joints. Synovial fluid cell counts of <50 000 cells/mm3 are common in culture-positive septic arthritis.

scholarly journals A case of Lemierre-like Syndrome: internal jugular vein thrombosis secondary to Staphylococcus aureus sternoclavicular joint septic arthritis

2019 ◽  
Vol 2019 (7) ◽  
Author(s):  
Chaozer Er ◽  
Vanessa Hwee Ting Tey ◽  
Navin Kuthiah ◽  
Veeraraghavan Meyyur Aravamudan
Keyword(s):  
Staphylococcus Aureus ◽  
Septic Arthritis ◽  
Internal Jugular Vein ◽  
Jugular Vein ◽  
Sternoclavicular Joint ◽  
Jugular Vein Thrombosis ◽  
Lemierre Syndrome ◽  
Vein Thrombosis ◽  
Oropharyngeal Infection ◽  
Responsible Pathogen

Abstract Lemierre syndrome is the internal jugular vein (IJV) suppurative thrombophlebitis, usually secondary to oropharyngeal infection. Staphylococcus aureus is an emerging responsible pathogen. We report a unique case of IJV thrombosis secondary to methicillin-susceptible S. aureus sternoclavicular joint septic arthritis. We review the existing literature on Lemierre syndrome: its various manifestations, causative pathogens, treatment and management.

scholarly journals A Rare Case of Septic Arthritis of Lumbar Facet Joint with Epidural Abscess, and Bacterial Meningitis Caused by Methicillin-Sensitive Staphylococcus aureus

2018 ◽  
Vol 07 (02) ◽  
pp. 139-141
Author(s):  
Miguel Maldonado-Morán ◽  
Juan Muñoz ◽  
Javier Matta ◽  
Victor Arrieta ◽  
Oscar Bernal ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Septic Arthritis ◽  
Epidural Abscess ◽  
Facet Joint ◽  
Rare Condition ◽  
Lumbar Facet Joint ◽  
Cerebrospinal Fluid Analysis ◽  
Fluid Analysis ◽  
Lower Back ◽  
Lumbar Facet

AbstractSeptic arthritis of the facet joint is an extremely rare condition, even more in young immunocompetent patients. There have been approximately only 40 cases of this entity reported worldwide. Here, the authors present a 16-year-old male patient with lower back pain, fever, and cephalea. Blood cultures and cerebrospinal fluid analysis confirmed methicillin-sensitive Staphylococcus aureus infection, and magnetic resonance imaging showed septic arthritis of the lumbar left facet joint L3 and epidural abscess. Intravenous oxacillin was administered, and the patient improved. No other treatment was required.

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