Anticholinergic, Antioxidant Activity and LC-MS/MS analysis of Ethanol Extract from Salvia officinalis L.

Antioxidant phytochemicals play a key role in oxidative stress control and in the prevention of related disorders, such as premature aging, degenerative diseases, diabetes, and cancer. The aim of this study was to investigate the potential antioxidant activity and the phytochemical profile of Senecio clivicolus Wedd., a perennial shrub, belonging to the Asteraceae family. Despite the wide interest of this family, this specie has not been investigated yet. S. clivicolus aerial parts were extracted with 96% ethanol. Then, the ethanol extract was fractionated by liquid/liquid extraction using an increasing solvents polarity. Total polyphenol and terpenoid contents were measured. Moreover, the antioxidant activity was evaluated by six different complementary in vitro assays. The Relative Antioxidant Capacity Index (RACI) was used to compare data obtained by different tests. The sample showing the highest RACI was subjected to characterization and quantitation of its phenolic composition using LC-MS/MS analysis. The ethyl acetate fraction, investigated by LC-MS/MS analysis, showed 30 compounds, most of them are chlorogenic acid and flavonoid derivatives. To the best of our knowledge, this is the first report about the evaluation of antioxidant activity and phytochemical profile of S. clivicolus, underlying the importance of this species as a source of health-promoting phytochemicals.

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Formulation of sage essential oil (Salvia officinalis, L.) monoterpenes into chitosan hydrogels and permeation study with GC-MS analysis

Drug Development and Industrial Pharmacy ◽

10.3109/03639045.2014.927480 ◽

2014 ◽

Vol 41 (7) ◽

pp. 1080-1088 ◽

Cited By ~ 4

Author(s):

Alexandra Kodadová ◽

Zuzana Vitková ◽

Petra Herdová ◽

Anton Ťažký ◽

Jarmila Oremusová ◽

...

Keyword(s):

Essential Oil ◽

Salvia Officinalis ◽

Ms Analysis ◽

Permeation Study ◽

Salvia Officinalis L ◽

Chitosan Hydrogels

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Investigation the application of niosome as a nanocarrier for sage (Salvia officinalis L.) extract by spectroscopy and chemometrics

Revista del Cuerpo Médico del HNAAA ◽

10.35434/rcmhnaaa.2021.142.1044 ◽

2021 ◽

Vol 14 (2) ◽

pp. 155-162

Author(s):

Seyedeh Somayeh Samaei ◽

Mohammadreza Khanmohammadi Khorrami ◽

Amir Bagheri Garmarudi

Keyword(s):

Thin Film ◽

Zeta Potential ◽

Ethanol Extract ◽

Salvia Officinalis ◽

Loading Capacity ◽

Hydrophilic Extract ◽

Ft Ir ◽

Salvia Officinalis L ◽

Field Imaging ◽

Scanning Electron

Objetive: Investigation the application of niosome as a nanocarrier for sage (Salvia officinalis L.) extract by spectroscopy and chemometrics. Material and Method: In this study,niosome nanoparticles containing cholesterol and without cholesterol were prepared by thin film hydration method. Ethanol extract of sage was extracted by microwave and loaded inside the niosome nanoparticles. The size of the nanoparticles was determined by field imaging scanning electron microscopy (FE-SEM). The zeta potential of the niosomes was determined by Dynamic light scattering (DLS). to investigate the type of interactions between surfactants and cholesterol used in the niosome structure, Fourier transform infrared spectroscopy (FT-IR) was used. Drug release was investigated for 5 consecutive days in phosphate buffer salin (PBS) 0/01 M with pH=7.4 at T=370C. Results:The zeta potential of the niosomes with cholesterol and without cholesterol was -24/1&-15/6 mv . The loading capacity of the drug in the concentration range (1-3% w / w of niosum) for both types of niosome was between 61% and 93%. Conclusion: This results show that the release rate of niosme with cholesterol is significantly more regular and lower than of niosome without cholesterol. In general, it can be concluded that niosome can be a suitable nano-carrier for delivery of hydrophilic extract of the sage.

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