scholarly journals Acute hepatitis: a rare complication of Epstein-Barr virus (EBV) infection

2010 ◽  
Vol 4 (10) ◽  
pp. 668-673 ◽  
Author(s):  
Mehmet Uluğ ◽  
Mustafa Kemal Çelen ◽  
Celal Ayaz ◽  
Mehmet Faruk Geyik ◽  
Salih Hoşoğlu
Keyword(s):  
Liver Function ◽  
Acute Hepatitis ◽  
Epstein Barr Virus ◽  
Acute Infection ◽  
Healthy Woman ◽  
Liver Function Tests ◽  
Barr Virus ◽  
Ebv Infection ◽  
Function Tests ◽  
Epstein Barr

Infectious Mononucleosis (IM), a benign lymphoproliferative disease, is the best known clinical syndrome caused by Epstein-Barr Virus (EBV). It usually resolves over a period of weeks or months without sequelae but may occasionally be complicated by a wide variety of neurologic, hematologic, hepatic, respiratory, and psychological complications. In this report we describe a patient with acute hepatitis following EBV-IM in a previously healthy woman. A 26-year-old woman who presented with fever, generalized weakness, nausea, sore throat, yellowing of skin, and a generalized skin rash was admitted to our clinic. Tonsillar enlargement, pharyngeal erythema, palatal petechiae, lymphadenopathy, and jaundice were noted. Significant atypical lymphocytes ( > 10%) were seen on the peripheral blood smear. Liver function tests such as ALT: 303 U/L, AST: 172 U/L, ALP: 193 U/L and total bilirubin: 7.3 mg/dl were elevated. Serological tests for EBV infection were consistent with acute infection (EBV virus capsid antigen was reactive with IgM and IgG antibodies). The Monospot test was also positive. On the seventh day, liver function tests and bilirubin had risen to peak level and platelets were decreased. The patient was managed supportively and her critical condition improved and was finally stabilized. Although the prognosis for IM is very favorable, a variety of acute complications may occur.

Epstein–Barr virus and regulatory T cells in Egyptian paediatric patients with acute B lymphoblastic leukaemia

2016 ◽  
Vol 70 (2) ◽  
pp. 120-125 ◽  
Author(s):  
Mohamed E Ateyah ◽  
Mona E Hashem ◽  
Mohamed Abdelsalam
Keyword(s):  
Lymphoblastic Leukaemia ◽  
Epstein Barr Virus ◽  
Acute Infection ◽  
Treg Cells ◽  
Control Group ◽  
Healthy Children ◽  
Barr Virus ◽  
Ebv Infection ◽  
High Incidence ◽  
Epstein Barr

ObjectiveAcute B lymphoblastic leukaemia (B-ALL) is the most common type of childhood malignancy worldwide but little is known of its origin. Recently, many studies showed both a high incidence of Epstein–Barr virus (EBV) infection and high levels of CD4+CD25+Foxp3+(Treg cells) in children with B-ALL. In our study, we investigated the possible relationship between EBV infection and the onset of B-ALL, and its relation to expression of CD4+, CD25high+Foxp3+ T regulatory cells.Subject and methodsWe analysed expression and mean fluorescence intensity (MFI) of Treg cells in peripheral blood of 45 children with B-ALL and in 40 apparently healthy children as a control, using flow cytometry. Serum anti-EBV viral capsid antigen (VCA) IgG, anti-EBV nuclear antigen (EBNA) IgG (for latent infection) and anti-EBV VCA IgM (for acute infection) were investigated using ELISA.ResultsAnalysis of the Treg cells population in patients and controls revealed that expression of CD4+ CD25high+ T lymphocytes was higher in patients than in controls (mean±SD 15.7±4.1 and 10.61±2.6 in patients and controls, respectively, and MFI of Foxp3 was 30.1±7.1 and 16.7±3.7 in patients and controls, respectively (p<0.001)). There was a high incidence of latent EBV infection in patients (31%) compared with controls (10%) while the incidence of acute infection was 12% in patients and 0% in the control group. To study the role of latent EBV infection in the pathogenesis of acute B-ALL, OR was calculated (OR=4.06, coefficient index 1.2–13.6).ConclusionsThese findings suggest a possible role for Treg cells and EBV in the pathogenesis of B-ALL. Further studies are needed on the possible mechanisms of tumour genesis related to Treg cells and EBV in children with B-ALL.

scholarly journals Epstein–Barr Virus-Induced Mononucleosis as an Imitator of Severe Preeclampsia

2017 ◽  
Vol 07 (01) ◽  
pp. e5-e7
Author(s):  
S. Staley ◽  
Marcela Smid ◽  
Sarah Dotters-Katz ◽  
Elizabeth Stringer
Keyword(s):  
Differential Diagnosis ◽  
Epstein Barr Virus ◽  
Liver Enzymes ◽  
Acute Infection ◽  
Supportive Treatment ◽  
Barr Virus ◽  
Ebv Infection ◽  
Elevated Liver Enzymes ◽  
Epstein Barr ◽  
In Pregnancy

Background In pregnancy, conditions presenting with hematologic abnormalities, transaminitis, and proteinuria pose diagnostic challenges in pregnancy. Case We present the case of an 18-year-old woman, G1P0, at 33 weeks' gestation with fever of unknown cause, who developed progressively elevated liver enzymes, proteinuria, and thrombocytopenia, due to Epstein–Barr virus (EBV) infection. Conclusion Acute infection with EBV should be included in the differential diagnosis of preeclampsia with severe features, particularly in the setting of fever. Supportive treatment and observation may prevent iatrogenic preterm birth.

scholarly journals Sever hepatitis induced by Epstein-Barr virus: case series

2018 ◽  
Vol 31 (1) ◽  
pp. 44-46
Author(s):  
Mohammad Reza Hasanjani Roushan ◽  
Mostafa Javanian ◽  
Zahra Aliramaji ◽  
Soheil Ebrahimpour
Keyword(s):  
Epstein Barr Virus ◽  
Case Series ◽  
Liver Function Tests ◽  
Case Histories ◽  
Respiratory Complications ◽  
Serological Tests ◽  
Barr Virus ◽  
Ebv Infection ◽  
Epstein Barr ◽  
Current Report

AbstractEpstein-Barr virus (EBV) is a causative agent of infectious mononucleosis syndrome. This infection often resolves over a period of several months without outcomes, but may occasionally be complicated by a great variety of neurologic, hepatic, hematologic and respiratory complications. In the current report, we present the case histories of three patients with acute hepatitis following EBV infection when previously healthy. The patients showed fever, nausea, weakness, as well as yellowing of the skin, and then in the course of examination, sore throat. They were managed supportively and their clinical condition improved. Liver function tests such as ALT, AST, ALP, were undertaken and bilirubin were elevated. The serological tests for EBV infection were consistent with the acute phase of infection. The monospot test was also positive. The patients were managed supportively, and their critical condition was improved.

scholarly journals Epstein-Barr Virus-induced Jaundice

2020 ◽  
Vol 4 (1) ◽  
pp. 69-71
Author(s):  
Jessica Herold ◽  
Felipe Grimaldo
Keyword(s):  
Biliary Obstruction ◽  
Epstein Barr Virus ◽  
Rare Complication ◽  
Liver Function Tests ◽  
Advanced Imaging ◽  
Barr Virus ◽  
Ebv Infection ◽  
Common Diagnosis ◽  
Epstein Barr ◽  
Made In

Infectious mononucleosis is primarily caused by Epstein-Barr virus (EBV) and is a common diagnosis made in emergency departments worldwide. Subclinical and transient transaminase elevations are a well-established sequela of EBV. However, acute cholestatic hepatitis is a rare complication. EBV infection should be considered as part of the differential diagnosis in patients with an obstructive pattern on liver function tests without evidence of biliary obstruction demonstrated on advanced imaging.

scholarly journals Autoimmune hepatitis following Epstein-Barr virus infection: a diagnostic dilemma

2019 ◽  
Vol 12 (7) ◽  
pp. e229615 ◽  
Author(s):  
Haoran Peng ◽  
Tanna Lim ◽  
Jae Nam ◽  
Jin Lee
Keyword(s):  
Autoimmune Hepatitis ◽  
Epstein Barr Virus ◽  
Case Reports ◽  
Acute Infection ◽  
Epstein Barr Virus Infection ◽  
Diagnostic Dilemma ◽  
Barr Virus ◽  
Ebv Infection ◽  
Epstein Barr ◽  
Barr Virus Infection

Epstein-Barr virus (EBV) infections frequently affect the liver and cause hepatitis. EBV is a well-known trigger of certain autoimmune diseases. There are few case reports showing the evidence of autoimmune hepatitis (AIH) following EBV infection. However, the diagnosis of AIH is very challenging in the setting of an acute infection. Here, we demonstrate a case of AIH following EBV infection in a patient ultimately recovered after receiving treatment for AIH.

scholarly journals Acute hepatitis due to infectious mononucleosis

2019 ◽  
Vol 12 (8) ◽  
pp. e229679
Author(s):  
Robin G Manappallil ◽  
Neena Mampilly ◽  
Blessy Josphine
Keyword(s):  
Acute Hepatitis ◽  
Infectious Mononucleosis ◽  
Epstein Barr Virus ◽  
Liver Enzymes ◽  
Barr Virus ◽  
Ebv Infection ◽  
Elevated Liver Enzymes ◽  
Epstein Barr

The syndrome of infectious mononucleosis is commonly seen with Epstein-Barr virus (EBV) infection. It may cause acute hepatitis, which is usually self-limiting and characterised by mildly elevated liver enzymes, but rarely jaundice. The patient being reported showcases EBV infection with jaundice, which is an uncommon scenario.

Epstein–Barr virus infection in primary immunodeficiency

2018 ◽  
Vol 5 (3) ◽  
pp. 65-85 ◽  
Author(s):  
Adi Ovadia ◽  
Ilan Dalal
Keyword(s):  
Primary Immunodeficiency ◽  
Epstein Barr Virus ◽  
Current Knowledge ◽  
Acute Infection ◽  
Epstein Barr Virus Infection ◽  
Barr Virus ◽  
Ebv Infection ◽  
Increased Risk ◽  
Abnormal Response ◽  
Epstein Barr

Primary immunodeficiency (PID) is a group of genetic disorders which affects immune cell development, differentiation, and function. The affected individuals are highly susceptible to infection by a diverse array of pathogens. Epstein–Barr virus (EBV) infection is ubiquitous in humans and usually involves an asymptomatic or self-limiting clinical course. In rare cases, EBV can cause not only an acute infection but also a severe exaggerated immune response and lymphoproliferative disease. Furthermore, EBV infection in patients with PID can lead to immune dysregulation and increased risk of malignancies, in addition to the severe course of the acute infection. Recognition of the different genetic defects and their effect on immunological pathways provide us with fundamental insights into the pathophysiology of EBV infection and associated disease, and may lead to developing better targeted therapies in the future. Here, we review all of PIDs with an abnormal response to EBV disease. Statement of novelty: Here we provide a review of the current knowledge of all PIDs reported to be associated with abnormal response to EBV infection and associated disease, such as hemophagocytic lymphohistiocytosis.

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