scholarly journals Association between ABO and Rh Blood Groups and Risk of Preeclampsia: A Case-Control Study from Iran

2017 ◽  
Vol 5 (2) ◽  
pp. 173-176
Author(s):  
Firoozeh Aghasadeghi ◽  
Mostafa Saadat
Keyword(s):  
Blood Group ◽  
Case Control Study ◽  
Neonatal Morbidity ◽  
Case Control ◽  
Blood Groups ◽  
Iranian Population ◽  
Control Group ◽  
Abo Blood Groups ◽  
Control Study ◽  
Risk Of Preeclampsia

AIM: Preeclampsia (PE) is a major cause of maternal and neonatal morbidity and mortality. There is a genetic component in the development of PE with estimated heritability around 0.47. Several studies have investigated the association between maternal ABO blood groups (OMIM: 110300) and risk of PE, with contradictory results have emerged. Considering that there is no study in this filed from Iranian population, the present case-control study was carried out at Shiraz (south-west Iran).MATERIAL AND METHODS: In this study 331 women; 121 pregnant with PE and 210 normotensive pregnant women were included. Using blood group O (for ABO blood groups) or Rh+ (for Rh blood groups) as a reference, odds ratios (ORs) and its 95% confidence intervals (95% CI) of PE risk were estimated from logistic regression analysis.RESULTS: Although the A (OR = 0.67, 95% CI = 0.39-1.17, P = 0.165), B (OR = 0.86, 95% CI = 0.48-1.53, P = 0.615) and AB (OR = 1.14, 95% CI = 0.37-3.45, P = 0.812) phenotypes showed lower risks compared with the O blood group, statistical analysis indicated that there was no significant association between ABO phenotypes and risk of PE. The frequency of Rh- phenotype was higher among PE patients compared with the control group. However, the association was not significant (OR = 1.79, 95% CI = 0.69-4.65, P = 0.229). Adjusted ORs for age of participants and parity did not change the above-mentioned associations.CONCLUSION: Our present findings indicate that there is no association between ABO and Rh blood groups and risk of PE in Iranian population.

scholarly journals Is There a Relation between ABO Blood Groups and Clinical Outcome in Patients with Pemphigoid? A Case-Control Study

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Sedigheh Bakhtiari ◽  
Parviz Toosi ◽  
Somayyeh Azimi ◽  
Nafiseh Esmaili ◽  
Ali Montazami ◽  
...  
Keyword(s):  
Blood Group ◽  
Case Control Study ◽  
Case Control ◽  
Blood Groups ◽  
Control Group ◽  
Abo Blood Groups ◽  
Chi Square ◽  
Chi Square Test ◽  
Group B ◽  
Control Study

Background.Relationship between blood groups and dermatologic diseases remains controversial and was not yet fully elucidated nor explained clearly. The aim of this study was to examine if any relation exists between different types of pemphigoid diseases and ABO blood group.Methods.In this case-control study, 159 pemphigoid patients and 152 healthy matched-controls were evaluated. All blood group (including Rh status) data for the study was obtained from the hospital medical records. Statistical comparisons were completed with chi-square test and logistic regression.Results.Blood group “O” was found in 32.9% of patients and 38.2% of control group. Blood group “A” was found among 30.8% of patients and 34.2% of control group, while group “B” was reported in 27.4% of cases and 21.1% of controls and “AB” was identified among 8.9% of patients and 6.6% of control group. 84.9% of patients were Rh positive, while in the control group 86.2% of patients were Rh positive. No significant differences were found regarding ABO blood groups (P=0.46) or Rh (P=0.76) between pemphigoid patients and control group. Also, older females had the higher risk of developing bullous pemphigoid.Conclusion.We found no relationship between ABO blood groups and pemphigoid disease.

scholarly journals Relationship between blood group and gastric carcinoma in Erbil city: A case-control study

2021 ◽  
Vol 25 (3) ◽  
pp. 633-637
Author(s):  
Abdullah Ibrahim
Keyword(s):  
Gastric Carcinoma ◽  
Blood Group ◽  
Case Control Study ◽  
Case Control ◽  
Blood Groups ◽  
Abo Blood Group ◽  
Abo Blood Groups ◽  
Group A ◽  
And Control ◽  
Control Study

Background and objective: Gastric carcinoma can be caused by the interaction between environmental factors and genetic variations. The relationship between ABO blood groups and carcinogenesis or progression of human tumors has been reported by many investigations. This study aimed to understand the correlation between ABO blood groups and the risk of developing gastric carcinoma. Methods: This case-control study included the ABO blood group and rhesus system of 92 patients diagnosed with gastric carcinoma at Erbil city from 2017 to 2019. Informed consent was obtained from all patients. As a control, the blood group from 260 healthy blood donors was collected from Erbil blood bank. Results: Of 92 patients, 58.7% were males, and 41.3% were females. The mean age was 62 (28 - 97) years. Regarding the type of gastric carcinoma, 58.7% were intestinal, and 41.3% were diffuse type. Blood group and rhesus system of patients and control were compared. Blood group O was 47.8% in cases versus 40.8% in control and 42.6% in all participants, followed by blood group A (31.5% of gastric carcinoma patients and 26.5% of control with a total of 27.8% of all participants). Regarding the Rhesus system, 92.4% of cases were Rh+, and 7.6% were Rh- compared with 92.9% Rh+and 7.1% Rh- in control. None of them was statistically significant. Conclusion: There was no statistically significant association between blood groups and gastric carcinoma, although blood group O was more common, followed by A. Keywords: Gastric carcinoma; ABO blood group; Erbil.

scholarly journals Susceptibility to the novel coronavirus disease (COVID-19) is associated with ABO and Rh blood groups: a case-control study from Afghanistan

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Khyber Saify ◽  
Mohammad Sarwar Alborz ◽  
Mostafa Saadat
Keyword(s):  
Blood Group ◽  
Case Control Study ◽  
Statistical Significance ◽  
Case Control ◽  
Blood Groups ◽  
Control Group ◽  
North East ◽  
Group A ◽  
Novel Coronavirus ◽  
Control Study

Abstract Background There are preliminary studies about the association between COVID-19 and ABO phenotypes and the results are controversial. There are only two studies which investigated the association of Rh blood groups in addition to ABO with COVID-19; however, in the statistical analysis ABO and Rh blood groups have been considered separately. Therefore, the present case-control study was performed to determine the association of COVID-19 with ABO blood groups considering the Rh blood groups simultaneously. The study was conducted in Kunduz COVID-19 treatment specific center, Spin-Zar Hospital (Kunduz Province, North East Afghanistan). A total of 301 confirmed COVID-19 cases and 1039 healthy blood donors as control group were included in the study. Results The Rh− phenotype strongly increased the risk of COVID-19 (OR = 2.97, 95% CI 1.86–3.89, P < 0.001). Although blood group A increased the risk of developing COVID-19, the association did not reach statistical significance. In analysis of the combination phenotypes, the A− blood group remarkably increased the risk of COVID-19 (OR = 7.24, 95% CI 3.62–14.4, P < 0.001). Multivariate analysis revealed that the interaction of Rh and ABO is significant (P < 0.013). Conclusion These findings indicate that susceptibility to COVID-19 is strongly associated with A− blood group.

A Case-Control Study on the p73 G4A Gene Polymorphism and Susceptibility to Breast Cancer in an Iranian Population

2020 ◽  
Author(s):  
Zeinab TAVAKKOL AFSHARI ◽  
Zahra GHOLIZADEH ◽  
Amin Reza NIKPOOR ◽  
Jalil TAVAKKOL AFSHARI ◽  
Rashin GANJALI ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Case Control Study ◽  
Case Control ◽  
Iranian Population ◽  
Control Group ◽  
Case Group ◽  
Medical Sciences ◽  
Control Groups ◽  
And Control ◽  
Control Study

Background: The tumor protein p73 (TP73) is a homolog of TP53 family. Ectopic p73 overexpression largely mimics p53 activities as a tumor suppressor and activates the transcription of p53-responsive genes and as a result induce apoptosis. This study aimed to investigate the association between p73 G4A polymorphism and the risk of breast cancer in a northeastern Iranian population. Methods: This case-control study was performed on 105 patients who admitted in educational hospitals of Mashhad University of Medical Sciences, Iran during 2013-2015, with breast cancer as case group and 120 healthy women as the control group. PCR-CTPP method was used to investigate the relationship between the p73 G4A polymorphism and the risk of breast cancer. Results: There was no significant association between the AA genotype of the p73 G4A polymorphism and breast cancer in case and control groups. Although G allele frequency was higher in the case group, the abundance of this allele between case and control groups was not statistically meaningful and, as a result, not associated with the risk of breast cancer in this study group. Conclusion: There was no association between G4A p73 polymorphism and the risk of breast cancer in a northeastern Iranian population.  

scholarly journals ASSOCIATION OF ABO AND RH BLOOD GROUPS WITH COVID-19 PCR POSITIVE STATUS: A CASE CONTROL STUDY

2021 ◽  
Vol 71 (3) ◽  
pp. 801-04
Author(s):  
Shabana Asif ◽  
Aashi Ahmed ◽  
Aliya Batool ◽  
Bushra Anwar ◽  
Ambreen Gul ◽  
...  
Keyword(s):  
Blood Group ◽  
Case Control Study ◽  
Case Control ◽  
Blood Groups ◽  
Categorical Variables ◽  
P Value ◽  
Rt Pcr ◽  
Odds Ratios ◽  
Hospital Data ◽  
Control Study

Objective: To determine association of ABO and Rh blood groups with COVID-19 RT-PCR positive status. Study Design: Case control study. Place and Duration of the Study: Department of Pathology, Margalla Hospital Taxila, from Apr 2020 to Dec 2020. Methodology: The sample comprised of 436 cases and 500 controls. Out of 3936 RT-PCR done during the study duration, 436 RT-PCR positives were enrolled in study as cases. 500 age and gender matched controls were selected from same population. Study variables (age, gender, blood groups, RT-PCR result) were obtained from Hospital data (HIMS). Data was analyzed using SPSS version 25. Mean and SD was calculated for age. Frequencies were calculated for categorical variables. p-value calculated applying chi square test. Odds ratios calculated to determine association. Results: The mean age of cases was 37.3 ± 16.3. Statistically significant association was observed between age, gender and COVID-19 RT-PCR positive status. B+ blood group was most frequent both among cases (35.4%) and controls (36.2%), followed by O+ and A+. However, no significant association was observed between blood groups and COVID-19 RTPCR positivity. Odds ratios calculated for blood group O and non - O (OR=0.95), A antigen (OR=0.97) and Rh factor (OR 0.93) among cases and controls showed week negative association. Whereas a weak positive association of B antigen + and B antigen - with PCR positivity (1.07) was observed between cases and controls. Conclusion: Susceptibility to acquire COVID-19 infection is not associated with ABO and Rh blood groups according to this study.

scholarly journals Predictors of Preeclampsia Based on a 10-Year Case-Control Study

2019 ◽  
Author(s):  
Arezoo Shayan ◽  
Hadis Sourinejad ◽  
Mansoureh Refaei ◽  
Seyedeh Zahra Masoumi ◽  
Leili Tapak ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Group ◽  
Case Control Study ◽  
Case Control ◽  
Control Group ◽  
Case Group ◽  
Retrospective Case ◽  
Low Education ◽  
High Age ◽  
Control Study

Objective: To investigate the predictors of preeclampsia based on a 10-years case-control study. Materials and methods: The present retrospective, case-control study was carried out in a referral Hospital in Hamadan, Iran, during 2005-2015. Using a hospital information system (HIS), all the available information on hospitalized preeclamptic patients during 10-years period was collected and all preeclamptic women were qualified for the study as the case group (729 subjects) and the same number of non-preeclamptic women were assigned to the control group. The required data were collected using the researcher-made questionnaire and analyzed using descriptive statistics, chi-square test, independent t-test and logistic regression. Results: The results show that high age (OR = 1.04), low education (diploma compared to illiterate OR = 0.51 and middle school education compared to illiterate OR = 0.55), blood group O (AB: OR = 0.32; B: OR = 0.36; A: OR = 0.26) and fertilization during autumn (spring: OR = 0.41; summer: OR = 0.26; autumn: OR = 1.13) could raise the risk of preeclampsia. Conclusion: High age, low education, blood group O and fertilization in cold seasons could be the risk factors of preeclampsia.  Recognizing the risk factors of preeclampsia could help the determination of high risk cases and designing of effective interventions.

scholarly journals ABO Blood Groups in Oral Cancer: A First Case-Control Study in a Defined Group of Iranian Patients

2014 ◽  
Vol 15 (3) ◽  
pp. 1415-1418 ◽  
Author(s):  
Hamed Mortazavi ◽  
Shima Hajian ◽  
Elnaz Fadavi ◽  
Siamak Sabour ◽  
Maryam Baharvand ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Case Control Study ◽  
Case Control ◽  
Blood Groups ◽  
Abo Blood Groups ◽  
First Case ◽  
Control Study ◽  
Iranian Patients

scholarly journals O Blood Group as Risk Factor for Preeclampsia among Sudanese Women

2016 ◽  
Vol 4 (4) ◽  
pp. 603-606 ◽  
Author(s):  
Abdelmageed Elmugabil ◽  
Duria A. Rayis ◽  
Mohamed A. Ahmed ◽  
Ishag Adam ◽  
Gasim I. Gasim
Keyword(s):  
Risk Factors ◽  
Pregnant Women ◽  
Blood Group ◽  
Informal Education ◽  
Case Control Study ◽  
Binary Logistic Regression ◽  
Case Control ◽  
The Other ◽  
Control Study ◽  
Risk Of Preeclampsia

AIM: To investigate blood groups and the other possible risk factors for preeclampsia among Sudanese women.MATERIAL AND METHODS: A case – control study was conducted at Saad Abualila Hospital, Khartoum, Sudan during the period of July 2013 through December 2014. The cases were women with preeclampsia and healthy pregnant women were the controls.RESULTS: Two hundred eighty pregnant women were enrolled (140 in each arm of the study). Around one-quarter of all women (280) were primiparae (74.0, 26.4%), the majority were housewives (201, 71.7%). Seventy-nine (28.2%) were illiterate or had no informal education. Around half of the women (130, 46.4%) had O blood group. Binary logistic regression showed association between preeclampsia and lack of antenatal care (OR = 2.75, 95% CI = 1.172─6.494, P = 0.020) as well as O blood group (OR = 1.78, 95% CI = 1.088─2.934, P=0.022).CONCLUSION: The current study showed that women with blood group O were at higher risk of preeclampsia.

Relationship between Blood Groups (ABO) and Varicose Veins of the Lower Limbs. A Case-Control Study

1989 ◽  
Vol 4 (1) ◽  
pp. 37-40 ◽  
Author(s):  
André Cornu-Thenard ◽  
William Dab ◽  
Isabelle de Vicenzi ◽  
Jean Valty
Keyword(s):  
Venous Thrombosis ◽  
Case Control Study ◽  
Varicose Veins ◽  
Vascular Diseases ◽  
Case Control ◽  
Blood Groups ◽  
Lower Limbs ◽  
Abo Blood Groups ◽  
Group A ◽  
Control Study

Numerous studies have already shown the existence of a relationship between blood groups of the ABO system and certain vascular diseases: group A and atheromatous disease1,4,5,7,9,12; group A and deep venous thrombosis of the lower limbs6,11,13. However, no study has reported an association between varicose veins and the ABO blood groups. The aim of this study was to investigate the possible existence of such an association.

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