A Case-Control Study on the p73 G4A Gene Polymorphism and Susceptibility to Breast Cancer in an Iranian Population

Background: The tumor protein p73 (TP73) is a homolog of TP53 family. Ectopic p73 overexpression largely mimics p53 activities as a tumor suppressor and activates the transcription of p53-responsive genes and as a result induce apoptosis. This study aimed to investigate the association between p73 G4A polymorphism and the risk of breast cancer in a northeastern Iranian population. Methods: This case-control study was performed on 105 patients who admitted in educational hospitals of Mashhad University of Medical Sciences, Iran during 2013-2015, with breast cancer as case group and 120 healthy women as the control group. PCR-CTPP method was used to investigate the relationship between the p73 G4A polymorphism and the risk of breast cancer. Results: There was no significant association between the AA genotype of the p73 G4A polymorphism and breast cancer in case and control groups. Although G allele frequency was higher in the case group, the abundance of this allele between case and control groups was not statistically meaningful and, as a result, not associated with the risk of breast cancer in this study group. Conclusion: There was no association between G4A p73 polymorphism and the risk of breast cancer in a northeastern Iranian population.

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LIFEStyle, Prevention and Risk of Acute PaNcreatitis (LIFESPAN): protocol of a multicentre and multinational observational case–control study

BMJ Open ◽

10.1136/bmjopen-2019-029660 ◽

2020 ◽

Vol 10 (1) ◽

pp. e029660 ◽

Cited By ~ 1

Author(s):

Balázs Koncz ◽

Erika Darvasi ◽

Dalma Erdősi ◽

Andrea Szentesi ◽

Katalin Márta ◽

...

Keyword(s):

Acute Pancreatitis ◽

Case Control Study ◽

Dietary Habits ◽

Case Control ◽

Medical Community ◽

Control Group ◽

Case Group ◽

Control Groups ◽

Link Type ◽

Control Study

IntroductionAcute pancreatitis (AP) is a life-threatening inflammatory disease of the exocrine pancreas which needs acute hospitalisation. Despite its importance, we have significant lack of knowledge whether the lifestyle factors elevate or decrease the risk of AP or influence the disease outcome. So far, no synthetising study has been carried out examining associations between socioeconomic factors, dietary habits, physical activity, chronic stress, sleep quality and AP. Accordingly, LIFESPAN identifies risk factors of acute pancreatitis and helps to prepare preventive recommendations for lifestyle elements.Methods and analysisLIFESPAN is an observational, multicentre international case–control study. Participating subjects will create case and control groups. The study protocol was designed according to the SPIRIT guideline. Patients in the case group (n=1700) have suffered from AP (alcohol-induced, n=500; biliary, n=500; hypertriglyceridemiainduced, n=200; other, n=500); the control group subjects have no AP in their medical history. Our study will have three major control groups (n=2200): hospital-based (n=500), population-based (n=500) and aetiology-based (alcohol, n=500; biliary, n=500 and hypertriglyceridemia, n=200). All of them will be matched to the case group individually by gender, age and location of residence. Aggregately, 3900 subjects will be enrolled into the study. The study participants will complete a complex questionnaire with the help of a clinical research administrator/study nurse. Analysis methods include analysis of the continuous and categorical values.Ethics and disseminationThe study has obtained the relevant ethical approval (54175-2/2018/EKU) and also internationally registered (ISRCTN25940508). After obtaining the final conclusions, we will publish the data to the medical community and will also disseminate our results via open access.Trial registration numberISRCTN25940508; Pre-results.

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ASSESSMENT OF QUALITY OF LIFE IN PRIMARY OPEN ANGLE GLAUCOMA PATIENTS: A CASE-CONTROL STUDY.

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v4i4.1198 ◽

2020 ◽

Vol 4 (4) ◽

Author(s):

Archana Kumari ◽

Sony Sinha

Keyword(s):

Quality Of Life ◽

Case Control Study ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Case Control ◽

Control Group ◽

Case Group ◽

And Control ◽

Control Study

Aim: to evaluate quality of life in primary open angle glaucoma patients using a standard questionnaire. Material and methods: The present prospective case-control study was conducted in the department of Ophthalmology, Patna Medical College and Hospital, Patna, Bihar, India. The study included 200 subjects who were divided into (case group n=100) and (control group n=100). Quality of life was assessed using Glaucoma Quality Of Life-15 Questionnaire (GQOL-15). Results: Mean age of patients in case group (n=100) and control group (n=100) was 57.97 years, and 57.84 years respectively. Overall QOL score was significantly between the two groups (p<0001). QOL score increases as the Glaucoma Severity score increases. Conclusion: QOL of patients with glaucoma was found poor as compared to control group. It showed a clear trend of worsening QOL scores with increasing severity of disease. Keywords: Glaucoma, Quality of life, QOL-15

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FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN KEJADIAN PEDICULOSIS CAPITIS DI SMP DARUL HIJRAH PUTRI MARTAPURA: CASE CONTROL STUDY

Dunia Keperawatan ◽

10.20527/dk.v4i2.2516 ◽

2017 ◽

Vol 4 (2) ◽

pp. 124

Author(s):

Sovia Yunida ◽

Kurnia Rachmawati ◽

Musafaah Musafaah

Keyword(s):

Case Control Study ◽

Head Louse ◽

Case Control ◽

Control Group ◽

Case Group ◽

Pediculosis Capitis ◽

Sleep Habit ◽

Pediculus Humanus ◽

And Control ◽

Control Study

ABSTRAKPediculosis capitis adalah infestasi yang disebabkan oleh pediculus humanus var. capitis dan merupakan masalah kesehatan anak-anak yang tinggal di asrama. Sampai saat ini penelitian tentang hal yang menyebabkan kutu kepala masih terbatas. Tujuan penelitian untuk mengetahui faktor-faktor yang berhubungan dengan kejadian pediculosis capitis pada anak-anak yang tinggal di asrama. Metode penelitian ini menggunakan studi kasus kontrol, pada siswi SMP pondok pesantren dan dilakukan tanggal 09 Desember 2015. Responden dibagi dalam 2 kelompok yaitu kelompok kasus (n=48) dan kelompok kontrol (n=48). Pemeriksaan kutu kepala dilakukan menggunakan sisir bergigi rapat dan respon pasien dicatat dalam lembar checklist. Hasil penelitian tidak terdapat hubungan antara faktor-faktor risiko yaitu panjang rambut (p=0,321), frekuensi mencuci rambut dalam seminggu (p=0,117), berbagi sisir (p=0,301), berbagi handuk (p=1,000), berbagi penutup kepala (kerudung) (p=0,323), kebiasaan tidur atau penggunaan tempat tidur bersama (p=0,784), dan frekuensi mengganti sprei tempat tidur sekali seminggu (p=0,268), dengan kejadian pediculosis capitis. kesimpulan pada penelitian tidak terdapat hubungan antara faktor-faktor dengan kejadian pediculosis capitis, hal ini mungkin disebabkan oleh faktor lain yaitu kepadatan hunian.Kata-kata kunci: pediculosis capitis, kutu kepala, faktor risiko.ABSTRACTPediculosis capitis is an infestation caused by pediculus humanus var. capitis and it is one of health problem on children who lived in a dormitory. Unfortunately, recent research about things caused head louse is still limited. The objective was to determine the factors which had correlation with pediculosis capitis incident in children who lived in dormitory. The method of this research used case control study, performed to girl students in SMP Pondok Pesantren on 09 December 2015. Respondents were divided into 2 groups, case group (n=48) and control group (n=48). The examination of head louse was performed using tight-brush comb and patient’s response has written in checklist paper. The result there was no correlation between hair long (p=0,321), frequency of hair washing in a week (p=0,117), shared comb (p=0,301), shared towel (p=1,000), shared head cover (jilbab) (p=0,323), sleep habit or shared bed (p=0,784), and frequency of changing bed cover once a week (p=0,268), with pediculosis capitis incident. It can be concluded this study there was no correlation between factors with pediculosis capitis incidence, this happened maybe because of other factor like occupancy density.Keywords: pediculosis capitis, head louse, risk factor.

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Fecal Calprotectin in patients with Infantile Colic: A case-control study

10.21203/rs.3.rs-63548/v1 ◽

2020 ◽

Author(s):

Parisa Khoshnevisasl ◽

mansour sadeghzadeh ◽

Neda Mahmoudirad ◽

Nima Motamed

Keyword(s):

Case Control Study ◽

Fecal Calprotectin ◽

Case Control ◽

Control Group ◽

Case Group ◽

Infantile Colic ◽

Healthy Infants ◽

Significant Difference ◽

And Control ◽

Control Study

Abstract Back groundThe precise etiology of infantile colic has not been elucidated after many years of research. In this study, we aimed to determine the association of fecal calprotectin with infantile colic.MethodThis case control study was performed on colicky infants referred to pediatrics clinics in Zanjan over a 6-month period. Infantile colic was clinically defined based on wessel criteria. The control group consisted of healthy infants matched for age, sex, weight, and type of feeding with the case group. Fecal calprotectin levels were measured in both groups by the ELISA method.ResultsForty infants were divided equally into case and control groups. The cases consisted of 11 boys (55%) and 9 girls (45%) with a mean age of 63 days and in the control group there was 12 boys (60%) and 8 girls (40%) with mean age of 48 days. Fecal calprotectin was positive in 17 (85%) cases and 6 (30%) controls. This difference was statistically significant. There was no significant difference in fecal calprotectin regarding sex, age, weight and type of nutrition in both colicky infants and controlsConclusionFecal calprotectin levels in colicky infants were significantly higher than healthy infants.

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Study of cognitive impairment and genetic polymorphism of SLC41A1 (rs11240569 allele) in Parkinson’s disease in Upper Egypt: case-control study

The Egyptian Journal of Neurology Psychiatry and Neurosurgery ◽

10.1186/s41983-021-00341-0 ◽

2021 ◽

Vol 57 (1) ◽

Author(s):

Hamdy N. El-Tallawy ◽

Tahia H. Saleem ◽

Wafaa M. Farghaly ◽

Heba Mohamed Saad Eldien ◽

Ashraf Khodaery ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Cognitive Impairment ◽

Case Control Study ◽

Case Control ◽

Control Group ◽

Motor Symptoms ◽

And Control ◽

Non Motor Symptoms ◽

Control Study

Abstract Background Parkinson’s disease is one of the neurodegenerative disorders that is caused by genetic and environmental factors or interaction between them. Solute carrier family 41 member 1 within the PARK16 locus has been reported to be associated with Parkinson’s disease. Cognitive impairment is one of the non-motor symptoms that is considered a challenge in Parkinson’s disease patients. This study aimed to investigate the association of rs11240569 polymorphism; a synonymous coding variant in SLC41A1 in Parkinson’s disease patients in addition to the assessment of cognitive impairment in those patients. Results In a case -control study, rs11240569 single nucleotide polymorphisms in SLC41A1, genes were genotyped in 48 Parkinson’s disease patients and 48 controls. Motor and non-motor performance in Parkinson's disease patients were assessed by using the Movement Disorder Society-Sponsored Revision of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS). The genotype and allele frequencies were compared between the two groups and revealed no significant differences between case and control groups for rs11240569 in SLC41A1 gene with P value .523 and .54, respectively. Cognition was evaluated and showed the mean ± standard deviation (SD) of WAIS score of PD patients 80.4 ± 9.13 and the range was from 61 to 105, in addition to MMSE that showed mean ± SD 21.96 ± 3.8. Conclusion Genetic testing of the present study showed that rs11240569 polymorphism of SLC41A1 gene has no significant differences in distributions of alleles and genotypes between cases and control group, in addition to cognitive impairment that is present in a large proportion of PD patients and in addition to the strong correlation between cognitive impairment and motor and non-motor symptoms progression.

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Associations between Red Blood Cell and Platelet Transfusions and Retinopathy of Prematurity

Neonatology ◽

10.1159/000512020 ◽

2020 ◽

pp. 1-7

Author(s):

Tobias Hengartner ◽

Mark Adams ◽

Riccardo E. Pfister ◽

Diane Snyers ◽

Jane McDougall ◽

...

Keyword(s):

Retinopathy Of Prematurity ◽

Odds Ratio ◽

Case Control Study ◽

Case Control ◽

Control Group ◽

Case Group ◽

Same Sex ◽

Live Births ◽

Adjusted Logistic Regression ◽

Control Study

Aim: The aim of this study is to examine possible associations between the transfusion of RBC or platelets (PLTs) and the development of retinopathy of prematurity (ROP) in infants. Methods: This retrospective, national, case-control study included all live births in Switzerland between 2013 and 2018. We investigated preterm infants at a gestational age of <28 weeks, who developed higher stage ROP (≥stage 2, n = 178). Each case infant was matched to another of the same sex who did not develop ROP (n = 178, control group). Results: When compared with the control group, we observed higher numbers of RBC transfusions per infant and higher percentages of infants receiving PLT transfusions in the case group. An adjusted logistic regression analysis revealed that both RBC (odds ratio [OR] 1.081, 95% confidence interval [CI] 1.020–1.146) and PLT transfusions (OR = 2.502, 95% CI 1.566–3.998) numbers were associated with ROP development. Conclusions: Multiple RBC and PLT transfusions are associated with higher stage ROP development. Prospective studies are required to determine their potential as risk factors.

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The role of leukotriene modifying agent treatment in neuropsychiatric events of elderly asthma patients: a nested case control study

Asthma Research and Practice ◽

10.1186/s40733-021-00070-4 ◽

2021 ◽

Vol 7 (1) ◽

Author(s):

Sang Oh Kang ◽

Kyung Hyun Min ◽

Hyun Jeong Kim ◽

Tae Hyeok Kim ◽

Woorim Kim ◽

...

Keyword(s):

Case Control Study ◽

Case Control ◽

Boxed Warning ◽

Control Group ◽

Case Group ◽

Newly Diagnosed ◽

Crude Odds Ratio ◽

Asthma Patients ◽

Nested Case Control ◽

Control Study

Abstract Background In March 2020, the US Food and Drug Administration decided that the dangers related to neuropsychiatric events (NPEs) of montelukast, one of the leukotriene modifying agents (LTMAs), should be communicated through ‘boxed warning’. In case of NPEs, the prevalence has been the highest in elderly people. Because the characteristics of the elderly such as old age itself can act as risk factors. Therefore, an investigation on safety of LTMAs related to NPEs in elderly using LTMAs is needed. Method A nested case-control study using an elderly sample cohort from the Korean National Health Insurance Service database was used. The asthma cohort included asthma patients newly diagnosed between 2003 and 2013. Within the asthma cohort, the case group was defined as patients who were diagnosed with NPEs. Among patients who had never been diagnosed with NPEs, the control group was selected by matching 1:1 by propensity score. Patients who were prescribed LTMAs for 1 year prior to index date were defined as the exposure group. The logistic regression model was used to measure the effect of LTMAs on NPEs. Results We identified 141,165 patients with newly diagnosed asthma, and selected 31,992 patients per each case and control group. Exposure to LTMAs significantly increased the risk of overall NPEs about in comparison with the absence of exposure (crude odds ratio [OR] 1.58, 95% CI 1.50–1.68). After adjusting for confounding factors, the overall NPEs risk increased (adjusted OR, 1.67, 95% CI 1.58–1.78). Conclusion This study suggests that elderly asthma patients prescribed LTMAs had a higher risk of NPEs than patients who were not treated with LTMAs. Therefore, clinicians should be aware of the potential risks of LTMAs.

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Analisis Faktor Fetus dan Tali Pusat terhadap Risiko Asphyxia Perinatal di Surakarta

Jurnal Ilmu Keperawatan Anak ◽

10.32584/jika.v3i1.521 ◽

2020 ◽

Vol 3 (1) ◽

pp. 16

Author(s):

Siti Lestari ◽

Dyah Dwi Astuti ◽

Fachriza Malika Ramadhani

Keyword(s):

Risk Factors ◽

Case Control Study ◽

Perinatal Asphyxia ◽

Case Control ◽

Control Group ◽

Case Group ◽

Retrospective Case ◽

Chi Square ◽

Fetal Position ◽

Control Study

Asfiksia perinatal merujuk pada kekurangan oksigen selama persalinan, sehingga berpotensi menyebabkan kematian dan kecacatan. WHO memperkirakan 4 juta anak terlahir dengan asfiksia setiap tahun, dimana 1 juta di antaranya meninggal dan 1 juta anak bertahan hidup dengan gejala sisa neurologis yang parah. Penelitian ini bertujuan untuk menganalisis faktor risiko fetal dan tali pusat pada asfiksia neonatal.Penelitian dilakukan di lakukan di RS Dr Moewardi Surakarta dengan pendekatan quantitative retrospective case control study. Data diambil dari rekam medis antara tahun 2013-2018. Penelitan ini melibatkan 264 neonatal yang terdiri dari 88 kelompok kasus dan 176 kelompok control. Kelompok kasus adalah bayi dengan diagnosa asfiksia yang dilakukan analisis terhadap faktor risiko fetal, sedangkan bayi yang tidak mengalami asfiksia dijadikan kelompok kontrol. Hasil analisis statistik uji Chi-Square dan Fisher Exact ditemukan bahwa kelahiran prematur (OR 2,07 CI 95% P 0,02), persalinan dengan tindakan (OR 3,61 CI 95% P 0,00), berat bayi (OR 2,85 CI 95% P 0,00), posisi janin (OR 2,37 CI 95% P 0,05), tali pusat ( QR 3,071 CI 95% P 0,01) berisiko terhadap insiden asfiksia perinatal. Air ketuban yang bercampur meconium (OR 1,51 CI 95% P 0,16) tidak memiliki risiko dengan Asfiksia perinatal. Kesimpulan: Risiko terhadap insiden asfiksia perinatal meliputi kelahiran prematur, persalinan dengan tindakan, berat bayi, posisi janin, dan tali pusat.Perinatal asphyxia refers to a lack of oxygen during labor, which has the potential to cause death and disability. WHO estimates 4 million children born with asphyxia each year, in which 1 million dies and 1 million survive with severe neurological sequelae. This study aims to analyze fetal and umbilical risk factors in neonatal asphyxia.This research is a quantitative retrospective case-control study, which was conducted at The Dr. Moewardi hospital, Surakarta. Data was taken from medical records from 2013-2018. The case group was patients diagnosed asphyxia, while those who did not experience asphyxia were treated as a control group. A total of 264 samples, consisting of 88 case group respondents and 176 control group respondents. Statistical analysis Chi- Square and Fisher Exact found that preterm birth (OR 2.07 CI 95% P 0.02), labor with instrument or complication (OR 3.61 CI 95% P 0.00), infant weight (OR 2.85 CI 95% P 0, 00), fetal position (OR 2.37 CI 95% P 0.05), umbilical cord (QR 3.071 CI 95% P 0.01) are at risk for the incidence of perinatal Asphyxia. The amniotic fluid mixed with meconium (OR 1.51 CI 95% P 0.16) has no risk with perinatal asphyxia.The risk factors of incidences of perinatal asphyxia were preterm birth, labor with instrument or complication, baby weight, fetal position and umbilical cord.

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The Relationship between Serum Levels of Vitamin C, Uric Acid and Antioxidant Condition with Coronary Artery Diseases: a Case-Control Study

10.21203/rs.2.15439/v1 ◽

2019 ◽

Author(s):

Aida Torkzaban ◽

Seyed Amir Mansour Alavi Naeini ◽

Akbar Hassanzadeh ◽

Mehrdad Namdari

Keyword(s):

Uric Acid ◽

Vitamin C ◽

Case Control Study ◽

Demographic Data ◽

Systolic Pressure ◽

Case Control ◽

Control Group ◽

Case Group ◽

Significant Difference ◽

Control Study

Abstract Background Coronary hearth diseases are among the main causes of death in adults. Increase of oxidative stress and defects in antioxidant defense play a major role in endothelium performance and are an effective factor in progress of atherosclerosis. Some studies have also reported different malondialdehyde and total antioxidant capacity among the atherosclerosis patients.Methods In this case-control study, 44 atherosclerosis patients referring to Shahid Madani treatment-education center were considered as the case group; while 44 healthy peoples were placed in the control group. Demographic data and anthropometric indices were measured. Food frequency questionnaire and international physical activity questionnaires were also completed. After 12 hours of fasting, 10 ml blood was sampled from the participants. Uric acid, vitamin C, TAC and MDA were also measured. The data were finally analyzed by SPSS Ver 22 software.Results A significant difference was observed between the two groups in terms of uric acid (P<0.001) and vitamin C (P<0.03). However, mean MDA and TAC showed no significant difference between the two groups. The two groups’ difference in terms of vitamin A, E and beta carotene, zinc and selenium intake was not significant. A significant difference was however detected between the two groups in terms of vitamin C (P<0.047). A significant relationship was also observed between the systolic pressure and CHD (P<0.028).Conclusion Results of this study indicated that the uric acid and vitamin C levels of atherosclerosis patients had significant increase and decrease in comparison with the healthy subjects, respectively. Mean TAC and antioxidant levels of their diets (except for vitamin C) showed no significant difference. Systolic blood pressure of the patients was significantly higher than the controls.

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Job stress and resilience in Iranian nurses during the COVID-19 pandemic: A case-control study

Work ◽

10.3233/wor-210476 ◽

2021 ◽

pp. 1-10

Author(s):

Gholam-Abbas Shirali ◽

Arman Amiri ◽

Khalil Taherzadeh Chanani ◽

Maryam Silavi ◽

Sanaz Mohipoor ◽

...

Keyword(s):

Job Stress ◽

Negative Correlation ◽

Case Control Study ◽

Case Control ◽

Target Group ◽

Control Group ◽

Wide Range ◽

The Face ◽

And Control ◽

Control Study

BACKGROUND: The COVID-19 pandemic has created a wide range of sociocultural pressures on nurses. Resilience is defined as one’s ability to adapt to an unpredictable situation and it can be a factor in accepting an undesirable psychosocial situation. OBJECTIVE: The aim of the present study was to examine resilience in nurses in the face of job stress during the COVID-19 pandemic. METHODS: The study was carried out as a case-control study with participation of 400 nurses as the target group (nurses exposed to COVID-19 patients) and the control group (nurses not exposed to COVID-19 patients). To examine resilience and job stress, Conor and Davidson’s questionnaire and OSIPOW questionnaire were used respectively. RESULTS: The mean scores of job stress and resilience were significantly different between the target and control groups (p < 0.05). So that resilience in the target group was less than that in the control group. In addition, job stress in the target group was higher than that of the control group (p < 0.05). There was a significant and negative correlation between resilience and job stress and the correlation was stronger in the target group (p < 0.05). CONCLUSIONS: Given the high job stress score in the participants and its negative correlation with resilience, there is need to provide the health personnel with efficient preventive and treatment approaches, improve and educate the principles of resilience, improve mental health services system, and introduce programs to control some of demographical factors in job stress such as physical activity, and employment status of nurses.

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