scholarly journals Efficacy of Oral Low-Dose Isotretinoin in the Treatment of Acne Vulgaris in Vietnam

2019 ◽  
Vol 7 (2) ◽  
pp. 279-282 ◽  
Author(s):  
Thanh Le Thai Van ◽  
Phuong Nguyen Minh ◽  
Phuong Tran Thi Thuy ◽  
Marco Gandolfi ◽  
Francesca Satolli ◽  
...  
Keyword(s):  
Folic Acid ◽  
Acid Level ◽  
Low Dose ◽  
Homocysteine Level ◽  
Plasma Homocysteine ◽  
Plasma Homocysteine Level ◽  
Folic Acid Level ◽  
Serum Folic Acid Level ◽  
Oral Isotretinoin ◽  
Serum Folic Acid

BACKGROUND: Oral isotretinoin is an effective therapy for acne. However, isotretinoin can induce hyperhomocysteinemia and decreased serum folic acid level, which may be a risk for cardiovascular disease and thrombosis, as well as psychoses. Besides, many recent types of research emphasise the safety and effects of the low dose isotretinoin therapy. AIM: The aim of our study was to evaluate the effect of the low-dose isotretinoin on the plasma homocysteine and serum folic acid level in the Vietnamese population. METHODS: We conducted a longitudinal study to evaluate the effectiveness of the low-dose therapy on the plasma homocysteine and serum folic acid level of 52 acne patients after 6-8-week treatment at University Medical Center Ho Chi Minh City, Viet Nam. Patients had moderate-severe acne with the prolonged course, and most of them had a scar. RESULTS: With a low dose of oral isotretinoin (0.37 ± 0.11 mg/kg/day), after 6-8-week treatment, patients dropped the severity of disease, increased the plasma homocysteine level and decreased the serum folic acid level with significant differences in comparison to those before treatment. However, these changes do not exceed the normal range. CONCLUSION: In overall, low dose isotretinoin treatment had effectiveness in decrease the severity of disease and no increasing the plasma homocysteine level as well as the serum folic acid level.

scholarly journals The Measurement of Folic Acid Activity in Serum: A Diagnostic Aid in the Differentiation of the Megaloblastic Anemias

Blood ◽  
1960 ◽  
Vol 15 (2) ◽  
pp. 228-235 ◽  
Author(s):  
VICTOR HERBERT ◽  
HERMAN BAKER ◽  
OSCAR FRANK ◽  
INEZ PASHER ◽  
HARRY SOBOTKA ◽  
...  
Keyword(s):  
Folic Acid ◽  
Acid Level ◽  
Megaloblastic Anemia ◽  
Assay Method ◽  
Folic Acid Deficiency ◽  
Fasting Serum ◽  
Folic Acid Level ◽  
Acid Deficiency ◽  
Serum Folic Acid Level ◽  
Serum Folic Acid

Abstract A modified L. casei microbiologic assay for the "folic acid" content of fasting serum appears to reflect the presence or absence of folic acid deficiency in patients with megaloblastic anemia of various causes. Advantages of this assay method for fasting serum "folic acid" level over other procedures presently in use for evaluating possible folic acid deficiency are discussed.

Association between serum folic acid level and erectile dysfunction

Andrologia ◽  
2015 ◽  
Vol 48 (5) ◽  
pp. 532-535 ◽  
Author(s):  
M. Karabakan ◽  
A. E. Erkmen ◽  
O. Guzel ◽  
B. K. Aktas ◽  
A. Bozkurt ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Folic Acid ◽  
Acid Level ◽  
Folic Acid Level ◽  
Serum Folic Acid Level ◽  
Serum Folic Acid

scholarly journals A STUDY OF ASSOCIATION OF SERUM FOLIC ACID LEVEL WITH PRE ECLAMPSIA IN DEPARTMENT OF OBSTETRICS AND GYNAECOLOGY AT SMS MEDICAL COLLEGE, JAIPUR

2021 ◽  
Vol 5 (8) ◽  
Author(s):  
Archana Singh ◽  
Hetal More ◽  
B.S. Meena
Keyword(s):  
Folic Acid ◽  
Acid Level ◽  
Serum Levels ◽  
Control Group ◽  
Case Group ◽  
Medical College ◽  
Obstetrics And Gynaecology ◽  
Folic Acid Level ◽  
Serum Folic Acid Level ◽  
Serum Folic Acid

Background: In this study was carried out to determine the relation between serum levels of Folic Acid and preeclampsia among pregnant women. Methods: Methods- Hospital based comparative study was conducted at Department of Obstetrics and Gynaecology, SMS medical college, Jaipur. Results: In PIH group, 20.00% women folic acid level was 3.1-7.8 ng/ml, 40.00% women folic acid level was 7.9-12.6 ng/ml, 35.00% women folic acid level was 12.7-17.5 ng/ml and 5.00% women folic acid level was 17.6-20.00 ng/ml. In normotensive group, 5.00% women folic acid level was 3.1-7.8 ng/ml, 25.00% women folic acid level was 7.9-12.6 ng/ml, 50.00% women folic acid level was 12.7-17.5 ng/ml and 20.00% women folic acid level was 17.6-20.00 ng/ml. Conclusion: We conclude that folic acid is not the only element in preventing the preeclampsia, however, its serum level in case group is significantly less than control group. Keywords: Eclampsia, Folic acid, Hypertension

scholarly journals The Level of Zinc is Increasing, while the Serum Folat Level is Decreasing, after Multi-Micronutrient Supplementation in Pregnant Woman

2016 ◽  
Author(s):  
Noroyono Wibowo
Keyword(s):  
Folic Acid ◽  
Serum Iron ◽  
Acid Level ◽  
Serum Zinc ◽  
Zinc Level ◽  
Normal Serum ◽  
Micronutrient Supplementation ◽  
Folic Acid Level ◽  
Serum Folic Acid Level ◽  
Serum Folic Acid

Objective: To measure the changes of serum iron, folic acid, zinc and selenium level on pregnant woman after multi-micronutrient supplementation. Method: First trimester pregnant woman whom attended Maternal- Fetal Policlinic at Dr. Cipto Mangunkusumo Hospital from July 2011 till October 2011 was considered into the study. The intervention was consumption of multi-micronutrient tablet once a day for three months period. The outcomes were the measurements of serum level of iron, folic acid, zinc and selenium before and after supplementation. We used paired T Test and Wilcoxon test for statistical analysis. Results: Twenty-eight pregnant women in their first trimester participated in the study. The micronutrient serum level was measured before and after supplementation during the time period. Before supplementation, serum iron and zinc level were below normal. Serum selenium level was normal with higher than normal serum folic acid level. After supplementation, serum zinc level was found to be below normal. Both level of serum iron and selenium increased to normal. Serum folic level was higher than normal. We found a decrease in serum zinc level with an increase in serum folic acid level that was statistically significant (p 0.009; p 0.003 respectively). We also found a slight decrease of serum iron level and an increase of serum selenium level that were not statistically significant (p 0.295; p 0.333). Conclusion: There is a decreased level of serum zinc with an increase in serum folic acid level after multi-micronutrient supplementation. [Indones J Obstet Gynecol 2012; 36-4: 171-5] Keywords: multi-micronutrient, supplementation

MEGALOBLASTIC ANEMIA ASSOCIATED WITH THE INGESTION OF PHENOBARBITAL AND PRIMIDONE

PEDIATRICS ◽  
1963 ◽  
Vol 32 (3) ◽  
pp. 376-383
Author(s):  
Sigmund Benham Kahn ◽  
Harold Lischner ◽  
Lester Baker ◽  
William J. Williams
Keyword(s):  
Folic Acid ◽  
Acid Level ◽  
Megaloblastic Anemia ◽  
Anticonvulsant Drug ◽  
Anticonvulsant Therapy ◽  
Folic Acid Deficiency ◽  
Folic Acid Level ◽  
Acid Deficiency ◽  
Serum Folic Acid Level ◽  
Serum Folic Acid

A new case of megaloblastic anemia which occurred in a 6-year-old girl receiving anticonvulsant therapy with primidone and phenobarbital is described. Low serum folic acid activity was found on admission. A prompt clinical and hematological remission occurred following the administration of 500 µg of folic acid per day, associated with a rise in serum folic acid activity to normal. Anticonvulsant therapy with phenobarbital was continued without supplemental folic acid, and 12 months following the correction of the anemia the serum folic acid level was again found to be low. This is further evidence for a relationship between folic acid deficiency and anticonvulsant drug therapy.

scholarly journals Brief Report: Effect of Incubation Time on the L. Casei Bioassay of Folic Acid in Serum

Blood ◽  
1969 ◽  
Vol 34 (2) ◽  
pp. 216-221 ◽  
Author(s):  
A. M. STREETER ◽  
B. J. O’NEILL
Keyword(s):  
Growth Rate ◽  
Folic Acid ◽  
Incubation Period ◽  
Incubation Time ◽  
Acid Level ◽  
Normal Range ◽  
Folic Acid Level ◽  
Serum Folic Acid Level ◽  
Serum Folic Acid

Abstract It has been shown that the growth rate of L. casei differs in PGA and serum enriched media. Since the serum folic acid level is derived from a comparison of the optical densities in these media it follows that this comparison will yield changing results until growth has stopped due to exhaustion of the available folate. If the assay is terminated before this stage is reached, then nonreproducible results can be easily obtained. Variations in the number of viable organisms in the inocula from assay to assay (which are not easily avoidable) accentuate the possible error. Both these problems appear to be controlled if the usual incubation period is extended to the stage at which growth of the organism has ceased. Our normal range under these conditions is 4.5 ng./ml. to 12.4 ng./ml. with a mean of 7.1 ng./ml.

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