Panax notoginsenoside Rb1 ameliorates Alzheimer’s disease by upregulating brain-derived neurotrophic factor and downregulating Tau protein expression

Alzheimer’s disease (AD) is associated with decreased serum levels of thyroid hormones (THs), increased levels of thyroid-stimulating hormone (TSH), and decreased protein expression of brain-derived neurotrophic factor (BDNF) and reelin in the hippocampus. In this study, we have evaluated the effect of subcutaneous administration of levothyroxine (L-T4) on levels of THs and TSH as well as protein expression of BDNF and reelin in AD rats. To make an animal model of AD, amyloid-beta peptide (Aβ) plus ibotenic acid were infused intrahippocampally, and rats were treated with L-T4 and (or) saline for 10 days. The levels of THs and TSH were measured by ELISA kits. Protein synthesis was detected by Western blotting method. Results have been shown that serum level of THs, BDNF, and reelin protein expression in the hippocampus were significantly decreased (P < 0.001) in AD animals and elevated significantly in AD rats treated with L-T4 (P < 0.01). Data showed that TSH level significantly decreased in AD rats treated with L-T4 (P < 0.05). These findings indicated that L-T4 increased BDNF and reelin protein expression by regulation of serum THs and TSH level in Aβ-induced AD rats.

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A narrative review of brain-derived neurotrophic factor (BDNF) on cognitive performance in Alzheimer’s disease

Growth Factors ◽

10.1080/08977194.2020.1864347 ◽

2021 ◽

pp. 1-17

Author(s):

Noor Azila Ismail ◽

Mohammad Farris Iman Leong Abdullah ◽

Rohayu Hami ◽

Hazwani Ahmad Yusof

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cognitive Performance ◽

Neurotrophic Factor ◽

Brain Derived Neurotrophic Factor ◽

Narrative Review

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P1-031: Age-related cerebral changes of brain-derived neurotrophic factor in a model of Alzheimer's disease in APP23 transgenic mice

Alzheimer s & Dementia ◽

10.1016/j.jalz.2006.05.406 ◽

2006 ◽

Vol 2 ◽

pp. S103-S103

Author(s):

Olaf Schulte-Herbrüggen ◽

Uwe Deicke ◽

Uwe Otten ◽

Dorothee Abramowski ◽

Matthias Staufenbiel ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Transgenic Mice ◽

Neurotrophic Factor ◽

Brain Derived Neurotrophic Factor ◽

Model Of Alzheimer’S Disease ◽

Age Related

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Polymorphism at Codon 66 of the Brain-Derived Neurotrophic Factor Gene Is Not Associated with Sporadic Alzheimer’s Disease

Dementia and Geriatric Cognitive Disorders ◽

10.1159/000077736 ◽

2004 ◽

Vol 18 (1) ◽

pp. 55-58 ◽

Cited By ~ 45

Author(s):

Onofre Combarros ◽

Jon Infante ◽

Javier Llorca ◽

José Berciano

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Neurotrophic Factor ◽

Brain Derived Neurotrophic Factor ◽

Sporadic Alzheimer’S Disease ◽

Factor Gene ◽

The Brain

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ANTINEURODEGENERATIVE ACTIVITY OF MICROALGAE DUNALIELLA SALINA IN RATS WITH ALZHEIMER’S DISEASE

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2017.v10i1.14419 ◽

2016 ◽

Vol 10 (1) ◽

pp. 134 ◽

Cited By ~ 2

Author(s):

Farouk Kamel Elbaz ◽

Hanan F Aly ◽

Wagdy Kb Khalil ◽

Hoda F Booles ◽

Gamila H Al

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Neurotrophic Factor ◽

Dunaliella Salina ◽

Brain Derived Neurotrophic Factor ◽

Male Rats ◽

Paraoxonase 1 ◽

Pon1 Activity ◽

The Brain ◽

Antioxidant Effects

ABSTRACTObjective: The present study is aimed to investigate the promising action of Dunaliella salina extract as a natural protector against Alzheimer’sdisease (AD) and reported to possess a variety of activities, including antioxidant effects due to its ability to create large amount of carotenoids.Methods: D. salina is a type of halophile green microalgae was used in the present study. 50 male rats were used in this study, where aluminumchloride was orally administered to induce AD in a dose of 100 mg/kg, daily for 6 weeks. Al-intoxicated rats treated orally daily with D. salinaethanolic extract for 6 weeks in a dose of 150 mg/kg b.wt., whereas standard anti-Alzheimer drug donepezil tartrate was administered at the doseof 10 mg/kg b.wt./day for 6 consecutive weeks. The anti-Alzheimer properties of D. salina extract were achieved through measuring the calmodulin(CaM) level, paraoxonase 1 (PON1) activity, the antiapoptotic marker (Bcl2), brain-derived neurotrophic factor (BDNF), the generation of the DNAadducts (8-hydroxy-2-deoxyguanosine [8-OHdG]/2-deoxy guanosine [2-dG]), and alteration in the expression of amyloid precursor protein, β-siteAPP-cleaving enzyme 1 (BACE1), and β-site APP-cleaving enzyme 2 (BACE2) in AD rats.Results: The current results demonstrated that supplementation of AD rats with D. salina extract-enhanced CaM level, and increased PON1 activity,upregulated Bcl2 and BDNF, decreased the levels of DNA adducts (8-OHdG/2-dG), and suppressed the alterations of the expression levels of APP,BACE1, and BACE2-m RNAs as compared with those in AD rats.Conclusion: It could be concluded that the biological activity of D. salina extract might be regulated by 9-cis b-carotene protecting the brain cells fromthe oxidative stress in AD rats.Keywords: Dunaliella salina, Calmodulin, Paraoxonase 1, Bcl2, Brain-derived neurotrophic factor, Alzheimer’s disease, DNA adduct, Amyloid precursorprotein.

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