scholarly journals Knockdown of STIP1 inhibits the invasion of CD133‑positive cancer stem‑like cells of the osteosarcoma MG63 cell line via the PI3K/Akt and ERK1/2 pathways

2020 ◽  
Vol 46 (6) ◽  
pp. 2251-2259
Author(s):  
Jian‑Hua Wang ◽  
Chen Gong ◽  
Feng‑Jin Guo ◽  
Xiao Zhou ◽  
Ming‑Sheng Zhang ◽  
...  
Keyword(s):  
Cell Line ◽  
Mg63 Cell

scholarly journals Effect of Aspirin on Cell Growth of Human MG-63 Osteosarcoma Line

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
E. De Luna-Bertos ◽  
J. Ramos-Torrecillas ◽  
O. García-Martínez ◽  
L. Díaz-Rodríguez ◽  
C. Ruiz
Keyword(s):  
Cell Cycle ◽  
Cell Growth ◽  
Cell Line ◽  
Bone Tissue ◽  
Tissue Repair ◽  
Mg63 Cell ◽  
Pharmacological Action ◽  
Inhibitory Effect ◽  
Cell Cycle Analysis ◽  
Inflammatory Drugs

Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used in bone tissue repair treatment for their pharmacological action. The objective of this study was to determine the effect of aspirin, on osteoblast growth, using MG63 cell line as osteoblast model. MTT spectrophotometry results showed that 20, 100, and 1000 μM aspirin doses have an inhibitory effect on growth. Cell cycle analysis revealed that aspirin doses of 100 and 1000 μM arrest the cell cycle in phase GO/G1. Parallel apoptosis/necrosis studies showed no changes in comparison to control cells after treatment with 1 or 10 μM aspirin but a significantly increased percentage of cells in apoptosis at doses of 20, 100, and 1000 μM. We highlight that treatment of osteoblast-like cells with 1000 μM aspirin increased not only the percentage of cells in apoptosis but also the percentage of necrotic cells, which was not observed in aspirin treatments at lower doses.

177Lu-DOTMP induces G2/M cell cycle arrest and apoptosis in MG63 cell line

2018 ◽  
Vol 61 (11) ◽  
pp. 837-846 ◽  
Author(s):  
Chandan Kumar ◽  
Rohit Sharma ◽  
Tapas Das ◽  
Aruna Korde ◽  
Haladhar Sarma ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Cell Line ◽  
Mg63 Cell ◽  
M Cell ◽  
Cycle Arrest

Paracrine-mediated osteoclastogenesis by the osteosarcoma MG63 cell line: is RANKL/RANK signalling really important?

2011 ◽  
Vol 28 (6) ◽  
pp. 505-514 ◽  
Author(s):  
J. Costa-Rodrigues ◽  
C. A. Teixeira ◽  
M. H. Fernandes
Keyword(s):  
Cell Line ◽  
Mg63 Cell

scholarly journals Biocompatibility and Alkaline Phosphatase Activity of Phosphorylated Chitooligosaccharides on the Osteosarcoma MG63 Cell Line

2010 ◽  
Vol 1 (1) ◽  
pp. 3-13 ◽  
Author(s):  
Jayachandran Venkatesan ◽  
Ratih Pangestuti ◽  
Zhong-Ji Qian ◽  
BoMi Ryu ◽  
Se-Kwon Kim
Keyword(s):  
Alkaline Phosphatase ◽  
Cell Line ◽  
Phosphatase Activity ◽  
Alkaline Phosphatase Activity ◽  
Mg63 Cell

Effect of tumor suppressor in lung cancer-1 on growth inhibition of MG63 cell line

2013 ◽  
Vol 12 (7) ◽  
pp. 336-338
Author(s):  
Li Qin ◽  
Yang Lin ◽  
Wenjian Chen ◽  
Wentao Zhu
Keyword(s):  
Lung Cancer ◽  
Tumor Suppressor ◽  
Growth Inhibition ◽  
Cell Line ◽  
Mg63 Cell

Anti-proliferative effects of Euphorbia hirta L on the activity of cytotoxicity in bone cancer MG-63 cells

2021 ◽  
pp. 2221-2223
Author(s):  
Subhashini Rajakumaran ◽  
Ruth Christiya C
Keyword(s):  
Cell Line ◽  
Methanolic Extract ◽  
Bone Cancer ◽  
Mg63 Cell ◽  
Dependent Manner ◽  
Antiproliferative Effects ◽  
Euphorbia Hirta ◽  
Potential Source ◽  
Cause Of Deaths ◽  
Dose Dependent

Medicinal plants maintain the health and vitality of individuals, and also have potential curative effect on various diseases, including cancer. Bone cancer is the foremost cause of deaths among women worldwide. In this present study, the antiproliferative effects of methanol extracts of Euphorbia hirta L leaves was investigated on MG 63 cell line. The methanolic extract of plant exhibited significant dose dependent antiproliferative activity against MG63 cell line which was ranged between 89.43% and 20.63% at concentrations of 50µg/ml and 350µg/ml correspondingly (24 hours). Moreover, the plant found to decrease the cell viability in dose dependent manner. The results of this study show that Euphorbia hirta L is a potential source of compounds that may serve as leads for anticancer property.

Ultrastructure of NPC/HK1 cells heterotransplanted in athymic nude mice

1982 ◽  
Vol 40 ◽  
pp. 236-237
Author(s):  
E.C. Chew ◽  
C.L. Li ◽  
D.P. Huang ◽  
H.C. Ho ◽  
L.S. Mak ◽  
...  
Keyword(s):  
Cell Line ◽  
Nude Mice ◽  
Biopsy Specimen ◽  
Epithelial Cell Line ◽  
Present Communication ◽  
Recurrent Tumour ◽  
Athymic Nude Mice ◽  
Cell Line Establishment ◽  
Fine Structures ◽  
Well Differentiated

An epithelial cell line, NPC/HK1, has recently been established from a biopsy specimen of a recurrent tumour of the nasopharynx which was histologically diagnosed as a moderately to well differentiated squamous cell carcinoma. A definite decrease in the amount of tonofilaments and desmosomes in the NPC/HK1 cells during the cell line establishment was observed. The present communication reports on the fine structures of the NPC/HK1 cells heterotraneplanted in athymic nude mice.

Ultrastructure of Choriocarcinoma in Vitro

1969 ◽  
Vol 27 ◽  
pp. 362-363
Author(s):  
John C. Garancis ◽  
R. A. Pattillo
Keyword(s):  
Cell Line ◽  
Physiological Function ◽  
Cell System ◽  
Bewo Cell ◽  
Bewo Cells ◽  
Gestational Choriocarcinoma ◽  
Bewo Cell Line

Growth of cell system (BeWo-cell line) derived from human gestational choriocarcinoma has been established and continuously maintained in-vitro. Furthermore, it is evident from the previous studies that this cell line has retained the physiological function of the placental trophoblasts, namely the synthesis of human chorionic gonadotrophil(HCG).The BeWo cells were relatively small and possessed single nuclei, thus indicating that this cell line consists exclusively of cytotrophoblasts. In some instances cells appeared widely separated and their lateral surfaces were provided with numerous microvilli (Fig.1).

An Established Epithelial Cell Line (NPC/HK1) from a Nasopharyngeal Carcinoma - II. A Sem Study

1982 ◽  
Vol 40 ◽  
pp. 224-225
Author(s):  
Li C.L. ◽  
Chew E.C. ◽  
Huang D.P. ◽  
Ho H.C. ◽  
Mak L.S. ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Epithelial Cell ◽  
Surface Morphology ◽  
Cell Line ◽  
Epithelial Cell Line ◽  
Present Communication ◽  
Cells In Culture ◽  
Sem Study ◽  
Well Differentiated

An epithelial cell line, NPC/HK1, has recently been successfully established from a nasopharyngeal carcinoma of the moderately to well differentiated squamous type. The present communication reports on the surface morphology of the NPC/HK1 cells in culture.

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