The molecular effects of oncogenesis on cell-extracellular matrix adhesion (Review)

2001 ◽  
Author(s):  
Liat Nadav ◽  
Ben-Zion Katz
Keyword(s):  
Extracellular Matrix ◽  
Matrix Adhesion ◽  
Molecular Effects

Pancreatic Cancer Cells Invasiveness is Mainly Affected by Interleukin-1β not by Transforming Growth Factor-β1

2005 ◽  
Vol 20 (4) ◽  
pp. 235-241 ◽  
Author(s):  
E. Greco ◽  
D. Basso ◽  
P. Fogar ◽  
S. Mazza ◽  
F. Navaglia ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Extracellular Matrix ◽  
Cancer Cells ◽  
Cell Lines ◽  
Cancer Cell ◽  
Pancreatic Cancer Cell ◽  
Matrigel Invasion ◽  
Matrix Adhesion ◽  
Pancreatic Cancer Cells ◽  
Tgf Β1

Background We investigated in vitro whether IL-1β and TGF-β1 affect pancreatic cancer cell growth, adhesion to the extracellular matrix and Matrigel invasion. Materials and methods Adhesion to fibronectin, laminin and type I collagen, and Matrigel invasion after stimulation with saline, IL-1β and TGF-β1 were evaluated using three primary and three metastatic pancreatic cancer cell lines. Results Extracellular matrix adhesion of control cells varied independently of the metastatic characteristics of the studied cell lines, whereas Matrigel invasion of control cells was partly correlated with the in vivo metastatic potential. IL-1β did not influence extracellular matrix adhesion, whereas it significantly enhanced the invasiveness of three of the six cell lines. TGF-β1 affected the adhesion of one cell line, and exerted contrasting effects on Matrigel invasion of different cell lines. Conclusions IL-1β enhances the invasive capacity of pancreatic cancer cells, whereas TGF-β1 has paradoxical effects on pancreatic cancer cells; this makes it difficult to interfere with TGF-β1 signaling in pancreatic cancer treatment.

Ets-1 Upregulates Matrix Metalloproteinase-1 Expression through Extracellular Matrix Adhesion in Vascular Endothelial Cells

2002 ◽  
Vol 291 (1) ◽  
pp. 130-138 ◽  
Author(s):  
Shinji Naito ◽  
Shunichi Shimizu ◽  
Mutsumi Matsuu ◽  
Masahiro Nakashima ◽  
Toshiyuki Nakayama ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Endothelial Cells ◽  
Matrix Metalloproteinase ◽  
Vascular Endothelial Cells ◽  
Vascular Endothelial ◽  
Matrix Adhesion ◽  
Matrix Metalloproteinase 1
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