Factors associated with dropout in a lung cancer high-risk cohort - the Liverpool lung project

To investigate the risk factors of complications in lung cancer patients after CT image-guided percutaneous lung biopsy (PTNB), in this study, 110 patients admitted to Xixi Hospital from January 30, 2017 to June 30, 2019 were selected for PTNB, and the basic characteristic information, lesion diameter, number of needle penetration, depth of needle penetration, physiological results of biopsy, postoperative concurrent symptoms, and success rate of biopsy were recorded. In addition, multivariate Logistic regression model (MLRM) was adopted to explore the correlation between various correlated characters and concurrent symptoms. The results showed that the biopsy pathological results were 53 cases of adenocarcinoma, 31 patients with squamous cell carcinoma, 8 patients with thymic carcinoma, 7 patients with small cell carcinoma and 11 patients with lymph carcinoma, and the success rate of needle biopsy was 100% by comparison with the final diagnosis. Among them, 35 patients developed pneumothorax symptoms postoperatively with a complication rate of 31.82%, 22 patients developed hemoptysis postoperatively with a complication rate of 20%, and 6 patients developed infection with a complication rate of 5.45%. The results of regression analysis showed that pneumothorax and hemoptysis were positively correlated with the number of de needles (P < 0.05), and negatively correlated with lesion diameter (P < 0.05). In addition, pneumothorax was also significantly positively correlated with age (P < 0.05), and infection was significantly positively correlated with the number of puncture needles (P < 0.05). Therefore, the main complications after PTNB are pneumothorax and hemoptysis, the high risk factors associated with pneumothorax include lesion diameter, number of puncture needles and age, the high risk factors associated with hemoptysis include lesion diameter and number of puncture needles, and the risk factors associated with infection are number of puncture needles.

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S38 Fourier transform infra-red (FTIR) spectroscopy on sputum from lung cancer patients, healthy controls and a high-risk cohort

Thorax ◽

10.1136/thx.2010.150912.38 ◽

2010 ◽

Vol 65 (Suppl 4) ◽

pp. A19-A20 ◽

Cited By ~ 2

Author(s):

R. Ghosal ◽

K. E. Lewis ◽

P. Kloer ◽

S. Bayliss ◽

L. Mur ◽

...

Keyword(s):

Lung Cancer ◽

Fourier Transform ◽

High Risk ◽

Ftir Spectroscopy ◽

Cancer Patients ◽

Healthy Controls ◽

Lung Cancer Patients ◽

Infra Red ◽

High Risk Cohort

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Performance of the EarlyCDT® Lung test in detection of lung cancer and pulmonary metastases in a high-risk cohort

Lung Cancer ◽

10.1016/j.lungcan.2021.06.010 ◽

2021 ◽

Author(s):

Morten Borg ◽

Sara W.C. Wen ◽

Line Nederby ◽

Torben Frøstrup Hansen ◽

Anders Jakobsen ◽

...

Keyword(s):

Lung Cancer ◽

High Risk ◽

Pulmonary Metastases ◽

High Risk Cohort

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The adenocarcinoma-specific stage shift: Closely-repeated low-dose helical CT screening in a high-risk cohort for 10 years

Journal of Clinical Oncology ◽

10.1200/jco.2006.24.18_suppl.1006 ◽

2006 ◽

Vol 24 (18_suppl) ◽

pp. 1006-1006

Author(s):

N. Seki ◽

K. Eguchi ◽

M. Kaneko ◽

H. Ohmatsu ◽

R. Kakinuma ◽

...

Keyword(s):

Lung Cancer ◽

High Risk ◽

Tumor Size ◽

Detection Rate ◽

Low Dose ◽

Helical Ct ◽

Ct Screening ◽

Specific Stage ◽

High Risk Cohort

1006 Background: Trials of CT screening for lung cancer have not yet proven the presence of a stage shift, to say nothing of a mortality benefit. On the basis of an update from Anti-Lung Cancer Association project, we investigated whether the stage shift did occur during the long-term closely-repeated low-dose helical CT screening in a high-risk cohort. Methods: A total of2,120 participants (mean age 63 yrs, 87% male, and 83% smoker) underwent low-dose helical CT screening semiannually from 1993 to 2004 (median, 3.5 years). Results: Nineteen prevalence and 57 incidence lung cancers were detected. In comparison between baseline and repeated screening, the detection rate was 0.90% vs. 0.32% (P < 0.001) and the tumor size was 24mm vs. 17mm (P = 0.018). Adenocarcinoma (74% and 63%) and stage IA (58% and 79%) were observed most commonly in both screen-groups, respectively, but their proportions showed no significant difference between groups, respectively. Regarding the survival of lung cancer patients, screening type was not a significant prognostic factor. In repeated screening,the detection rate oflung cancer except bronchioloalveolar carcinoma increased significantly depending on CT repeating times (r = 0.50, P = 0.020). Moreover, the proportion of stage II-IV and the tumor size decreased significantly only in invasive adenocarcinoma (r = -0.77, P = 0.007 and r = -0.60, P = 0.029, respectively). Conclusions: The adenocarcinoma-specific stage shift did occur in a high-risk cohort. Considering larger proportion of adenocarcinoma in this population, smokers might benefit from the long-term closely-repeated low-dose helical CT screening. No significant financial relationships to disclose.

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O-296 Aberrant DNA methylation and sputum atypia predict lung cancer — Preliminary report from the University of Colorado SPORE high risk cohort study

Lung Cancer ◽

10.1016/s0169-5002(03)91954-4 ◽

2003 ◽

Vol 41 ◽

pp. S86 ◽

Cited By ~ 1

Author(s):

Fred R. Hirsch ◽

Steven A. Belinski ◽

Timothy C. Kennedy ◽

York E. Miller ◽

Wilbur A. Franklin ◽

...

Keyword(s):

Lung Cancer ◽

Dna Methylation ◽

Cohort Study ◽

High Risk ◽

Preliminary Report ◽

University Of Colorado ◽

Aberrant Dna Methylation ◽

The University ◽

High Risk Cohort

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Chest Radiographic Findings in High-risk Covid-19 Pneumonia Patients

10.21203/rs.3.rs-1210242/v1 ◽

2022 ◽

Author(s):

Iroshani Kodikara ◽

Buddhi Anjani Galabada ◽

Aruni Manjula Kurupparachchi

Keyword(s):

High Risk ◽

Patient Outcomes ◽

Left Lung ◽

Positive Association ◽

Exact Nature ◽

X Rays ◽

Lung Involvement ◽

Radiographic Findings ◽

Factors Associated ◽

High Risk Cohort

Abstract Background/ objectivesThe severity of Covid-19 pneumonia has shown a positive association with co-existing risk factors. However, the exact nature of lung involvement in high-risk Covid-19 patients is yet to be resolved. Therefore, we evaluated the CXR features, temporal progression, and the factors associated with CXR severity in high-risk patients.MethodsChest X-rays (n=289) of Covid-19 infected high-risk adults (n=228) treated at the Base Hospital Homagama were evaluated to record CXR features, their temporal progression, CXR severity score and the patient outcomes. ResultsThe studies patients (48.2% men) were in mean age(SD) of 59(15) years. The most frequent CXR features were patchy ground-glass opacities (49%; GG) and patchy consolidations (42%; CON). They showed bilateral (100%) involvement, superoinferior gradient (100%) and diffuse (27%), peripheral (18%) or perihilar (10%) distribution. CON was the predominant opacity among the non-survivors and GG among the survivors (χ2=14.73; p=0.001). Right lung predominant (28%) asymmetrical lung involvement was more frequent than bilateral symmetrical (16%) or left lung predominance (7%). Progression into fatal disease was significantly higher when the lung involvement is asymmetrical: right predominance: ODDs:0.502; p=0.023; left predominance: ODDs:0.268; p=0.002. The CXRs were frequently normal in early (66%) and progressive (56%; χ2=36.64; p<0.001) stages than in peak or resolving stages. The predictors of CXR severity included age (β:0.140; 95% CI:0.041–0.233; p=0.004), male gender (β:4.140; 95% CI:1.452–6.481; p=0.003), and disease day (β:0.622; 95% CI:0.301–0.942; p<0.001). ConclusionThis study decoded the CXR features of Covid-19 pneumonia in a high-risk cohort while describing their associations.

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