scholarly journals VEGF, Flt-1, and microvessel density in primary tumors as predictive factors of colorectal cancer prognosis

2016 ◽  
Vol 6 (2) ◽  
pp. 243-248 ◽  
Author(s):  
Justyna Zygoń ◽  
Mariusz Szajewski ◽  
Wiesław Janusz Kruszewski ◽  
Robert Rzepko
Keyword(s):  
Colorectal Cancer ◽  
Predictive Factors ◽  
Microvessel Density ◽  
Cancer Prognosis ◽  
Primary Tumors

scholarly journals Correlation of microvasculature structure with metastatic potential of localized forms of colorectal cancer

2021 ◽  
Vol 10 (4) ◽  
pp. 35-44
Author(s):  
A.S. Konstantinov ◽  
◽  
K.V. Shelekhova ◽  
◽  
◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Microvessel Density ◽  
Distant Metastases ◽  
Metastatic Potential ◽  
Structural Features ◽  
Cancer Prognosis ◽  
Metastatic Tumors ◽  
Regional Lymph Nodes ◽  
Tumor Neovascularization ◽  
The Difference

Introduction. Non-metastatic colorectal cancer can recur within five years as distant metastases in about 25% of stage II patients and 50–60% of stage III patients. It is crucial to identify the subgroup of patients with the highest risk of recurrence. Our study aimed to determine the effect of microvascular density (MVD) and pericyte impaired microvessels (PIM) on the risk of metastasis of colorectal adenocarcinomas. Materials and methods. We carried out a retrospective study of the surgical material for colorectal cancer without metastases in regional lymph nodes. The cohorts included cases with synchronous distant metasta-ses (n=53), metachronous metastases (n=45), and without distant metastases (n=53). In the last group, the follow-up period was from 64 up to 92 months. We performed triple immunohistochemical staining: ERG, α-SMA, and Podoplanin. At low magnification, we determined the areas of highest microvessel density, calculated them on an area of 1.0 mm2 with a magnification of x400. The number of microvessels without α-SMA expression was counted, and eventually the microvessel immaturity index Index-V = PIM / MVD was calculated. Results. Normal blood vessels were characterized by the expression of ERG in endothelial cells and α-SMA in pericytes, while at immature tumor microvessels, the latter were absent. The difference in MVD in the groups was statistically insignificant (p=0.414), on average 10/mm2 for non-metastatic tumors and 11/mm2 for metastatic ones. Metastatic tumors showed significantly higher PIM (mean 8/mm2 vs. 2/mm2) and Index-V (mean 0.69 vs. 0.21). Both showed a significant correlation with distant metastases (p <0.001). Conclusion. The data obtained demonstrate that imperfect tumor neovascularization correlates with metasta-sis, which leads to a worse prognosis. The density of microvessels and their structural features are important independent prognostic factors for patients with colorectal cancer. Evaluation of angiogenesis in a tumor in terms of the number and maturity of newly formed vessels enable to elucidate malignant potential of the tumor. Keywords: angiogenesis, pericytes, microvessel density, colorectal cancer, prognosis

PREDICTIVE FACTORS IN THE CHOICE OF SURGICAL TREATMENT FOR COLORECTAL CANCER WITH LAPAROSCOPIC OR "OPEN" ACCESS

2017 ◽  
Vol 63 (3) ◽  
pp. 470-474
Author(s):  
Rustem Topuzov ◽  
Georgiy Manikhas ◽  
Eskender Topuzov ◽  
Mikhail Khanevich ◽  
Magomed Abdulaev ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Surgical Treatment ◽  
Postoperative Complications ◽  
Open Access ◽  
Comparative Study ◽  
Retrospective Analysis ◽  
Predictive Factors

There are presented results of surgical treatment of 347 patients with colorectal cancer. Based on the retrospective analysis a comparative study of results of surgical treatment for colorectal cancer using laparoscopic technologies and “open” access was carried out. Predictive factors that correlate with the risk of postoperative complications with laparoscopic and “open” access at the surgical stage of treatment for colorectal cancer were determined.

Metastatic Colorectal Cancer: Prognostic and Predictive Factors

2020 ◽  
Vol 27 (17) ◽  
pp. 2779-2791 ◽  
Author(s):  
Anna Nappi ◽  
Guglielmo Nasti ◽  
Carmela Romano ◽  
Massimiliano Berretta ◽  
Alessandro Ottaiano
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Predictive Factors ◽  
Cancer Biology ◽  
Clinical Course ◽  
Molecular Signatures ◽  
Biological Drugs ◽  
The Third ◽  
Therapeutic Context ◽  
Prognostic And Predictive Factors

: Colorectal cancer represents the third most frequently occurring cancer worldwide. In the last decade, the survival of patients affected by metastatic colorectal cancer (mCRC) has improved through the introduction of biological drugs. However, in this new and dynamic therapeutic context, research about prognostic and predictive factors is important to guide the oncologists to effective therapies as well as to improve the understanding of colorectal cancer biology. Their identification is an intensive area of research and our future goal will be to depict tumour-specific "molecular signatures" in order to predict the clinical course of the disease and the best treatments. : In this report, we describe clinical, pathological and molecular biomarkers that can play a role as prognostic or predictive factors in mCRC.

scholarly journals The Role of the CpG Island Methylator Phenotype in Colorectal Cancer Prognosis Depends on Microsatellite Instability Screening Status

2010 ◽  
Vol 16 (6) ◽  
pp. 1845-1855 ◽  
Author(s):  
Anna M. Dahlin ◽  
Richard Palmqvist ◽  
Maria L. Henriksson ◽  
Maria Jacobsson ◽  
Vincy Eklöf ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Microsatellite Instability ◽  
Cpg Island ◽  
Cancer Prognosis ◽  
Cpg Island Methylator Phenotype ◽  
Methylator Phenotype

scholarly journals Metastatic heterogeneity of the consensus molecular subtypes of colorectal cancer

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Peter W. Eide ◽  
Seyed H. Moosavi ◽  
Ina A. Eilertsen ◽  
Tuva H. Brunsell ◽  
Jonas Langerud ◽  
...  
Keyword(s):  
Gene Expression ◽  
Colorectal Cancer ◽  
Principal Components ◽  
Prognostic Value ◽  
Tumor Heterogeneity ◽  
Molecular Subtypes ◽  
R Package ◽  
Data Set ◽  
Primary Tumors ◽  
External Data

AbstractGene expression-based subtypes of colorectal cancer have clinical relevance, but the representativeness of primary tumors and the consensus molecular subtypes (CMS) for metastatic cancers is not well known. We investigated the metastatic heterogeneity of CMS. The best approach to subtype translation was delineated by comparisons of transcriptomic profiles from 317 primary tumors and 295 liver metastases, including multi-metastatic samples from 45 patients and 14 primary-metastasis sets. Associations were validated in an external data set (n = 618). Projection of metastases onto principal components of primary tumors showed that metastases were depleted of CMS1-immune/CMS3-metabolic signals, enriched for CMS4-mesenchymal/stromal signals, and heavily influenced by the microenvironment. The tailored CMS classifier (available in an updated version of the R package CMScaller) therefore implemented an approach to regress out the liver tissue background. The majority of classified metastases were either CMS2 or CMS4. Nonetheless, subtype switching and inter-metastatic CMS heterogeneity were frequent and increased with sampling intensity. Poor-prognostic value of CMS1/3 metastases was consistent in the context of intra-patient tumor heterogeneity.

Double-edged sword of inflammasome genetics in colorectal cancer prognosis

2020 ◽  
Vol 213 ◽  
pp. 108373
Author(s):  
Raylane Adrielle Gonçalves Cambui ◽  
Gilmar Ferreira do Espírito Santo ◽  
Fernanda Pereira Fernandes ◽  
Vinicius Nunes Cordeiro Leal ◽  
Bianca Borsatto Galera ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Prognosis

scholarly journals Discordance of KRAS Mutational Status between Primary Tumors and Liver Metastases in Colorectal Cancer: Impact on Long-Term Survival Following Radical Resection

Cancers ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 2148
Author(s):  
Francesco Ardito ◽  
Francesco Razionale ◽  
Lisa Salvatore ◽  
Tonia Cenci ◽  
Maria Vellone ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastases ◽  
Primary Tumor ◽  
Kras Mutation ◽  
Colorectal Tumor ◽  
Term Survival ◽  
Primary Tumors ◽  
Mutation Status ◽  
Primary Colorectal Tumor ◽  
Kras Mutation Status

If KRAS mutation status of primary colorectal tumor is representative of corresponding colorectal liver metastases (CRLM) mutational pattern, is controversial. Several studies have reported different rates of KRAS discordance, ranging from 4 to 32%. Aim of this study is to assess the incidence of discordance and its impact on overall survival (OS) in a homogenous group of patients. KRAS mutation status was evaluated in 107 patients resected for both primary colorectal tumor and corresponding CRLM at the same institution, between 2007 and 2018. Discordance rate was 15.9%. Its incidence varied according to the time interval between the two mutation analyses (p = 0.025; Pearson correlation = 0.2) and it was significantly higher during the first 6 months from the time of primary tumor evaluation. On multivariable analysis, type of discordance (wild-type in primary tumor, mutation in CRLM) was the strongest predictor of poor OS (p < 0.001). At multivariable logistic regression analysis, the number of CRLM >3 was an independent risk factor for the risk of KRAS discordance associated with the worst prognosis (OR = 4.600; p = 0.047). Results of our study suggested that, in the era of precision medicine, possibility of KRAS discordance should be taken into account within multidisciplinary management of patients with metastatic colorectal cancer.

Sign in / Sign up

Export Citation Format

Share Document