scholarly journals Genetic polymorphisms of melatonin receptors 1A and 1B may result in disordered lipid metabolism in obese patients with polycystic ovary syndrome

2019 ◽  
Author(s):  
Xiu‑Hua Xu ◽  
Lian‑Cui Kou ◽  
Hai‑Mei Wang ◽  
Chun‑Mei Bo ◽  
Xiao‑Cui Song
Keyword(s):  
Lipid Metabolism ◽  
Polycystic Ovary Syndrome ◽  
Genetic Polymorphisms ◽  
Polycystic Ovary ◽  
Melatonin Receptors ◽  
Obese Patients ◽  
Ovary Syndrome

scholarly journals miR-141-3p is Poorly Expressed in Polycystic Ovary Syndrome and Correlates with Glucose and Lipid Metabolism

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Lingye Fan ◽  
Chunyan Wang ◽  
Ping Zhan ◽  
Yaofang Liu
Keyword(s):  
Lipid Metabolism ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Diagnostic Value ◽  
Obese Patients ◽  
Ovary Syndrome ◽  
Glucose And Lipid Metabolism ◽  
Fat Reduction ◽  
High Prevalence ◽  
Area Under Roc Curve

Polycystic ovary syndrome (PCOS) is a common endocrinopathy with high prevalence. miR-141-3p downregulation was reported in PCOS rats. This study intended to investigate miR-141-3p expression in serum of PCOS patients and its correlation with glucose and lipid metabolism. A total of 100 PCOS patients and 100 healthy controls were enrolled in this study. Clinical parameters and glucose and lipid indexes were analyzed. A 3-month fat reduction intervention was conducted to PCOS-obese patients. Expressions of miR-141-3p and PTEN were detected. WHR and levels of TG, HDL-C, FBG, FINS, HOMA-β, and HOMA-IR showed significant differences in PCOS patients. miR-141-3p was downregulated in PCOS patients. Area under ROC curve of miR-141-3p diagnosing PCOS-obese patients was 0.985 with specificity 95.35% and flexibility 93.33%. Levels of glucose and lipid metabolism indexes were increased while HDL-C level was decreased in miR-141-3p low expression group. Indexes of PCOS-obese patients were improved and miR-141-3p was upregulated after fat reduction intervention. PTEN was upregulated in PCOS patients and negatively correlated with miR-141-3p. In conclusion, miR-141-3p was downregulated in PCOS patients and had higher diagnostic value on PCOS and associated with glucose and lipid metabolism. miR-141-3p might play a role in glucose and lipid metabolism in PCOS-obese patients by targeting PTEN.

Leptin levels and insulin sensitivity in obese and non-obese patients with polycystic ovary syndrome

1997 ◽  
Vol 11 (5) ◽  
pp. 315-320 ◽  
Author(s):  
D. Micić ◽  
Dj. Macut ◽  
V. Popović ◽  
M. Ŝumarac-Dumanović ◽  
A. Kendereŝki ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Obese Patients ◽  
Ovary Syndrome

Calpain-10 genetic polymorphisms and polycystic ovary syndrome risk: A meta-analysis and meta-regression

Gene ◽  
2013 ◽  
Vol 531 (2) ◽  
pp. 426-434 ◽  
Author(s):  
Wenjing Shen ◽  
Tianren Li ◽  
Yanjie Hu ◽  
Hongbo Liu ◽  
Min Song
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Genetic Polymorphisms ◽  
Polycystic Ovary ◽  
Meta Analysis ◽  
Ovary Syndrome ◽  
Calpain 10 ◽  
Meta Regression

scholarly journals Potential genetic polymorphisms predicting polycystic ovary syndrome

2018 ◽  
Vol 7 (5) ◽  
pp. R187-R195 ◽  
Author(s):  
Yao Chen ◽  
Shu-ying Fang
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Genetic Polymorphisms ◽  
Polycystic Ovary ◽  
Gonadal Hormones ◽  
Energy Regulation ◽  
Ovary Syndrome ◽  
Increased Risk ◽  
Number Of Genes ◽  
Hormone Biosynthesis

Polycystic ovary syndrome (PCOS) is a heterogenous endocrine disorder with typical symptoms of oligomenorrhoea, hyperandrogenism, hirsutism, obesity, insulin resistance and increased risk of type 2 diabetes mellitus. Extensive evidence indicates that PCOS is a genetic disease and numerous biochemical pathways have been linked with its pathogenesis. A number of genes from these pathways have been investigated, which include those involved with steroid hormone biosynthesis and metabolism, action of gonadotropin and gonadal hormones, folliculogenesis, obesity and energy regulation, insulin secretion and action and many others. In this review, we summarize the historical and recent findings in genetic polymorphisms of PCOS from the relevant publications and outline some genetic polymorphisms that are potentially associated with the risk of PCOS. This information could uncover candidate genes associating with PCOS, which will be valuable for the development of novel diagnostic and treatment platforms for PCOS patients.

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