Outcome of Pregnancy in Italian Patients with Primary Sjögren Syndrome

2013 ◽  
Vol 40 (7) ◽  
pp. 1143-1147 ◽  
Author(s):  
Roberta Priori ◽  
Angelica Gattamelata ◽  
Mariagrazia Modesti ◽  
Serena Colafrancesco ◽  
Silvia Frisenda ◽  
...  
Keyword(s):  
Case Control ◽  
Sjögren Syndrome ◽  
Sjogren Syndrome ◽  
Control Analysis ◽  
Primary Sjögren Syndrome ◽  
Multicenter Cohort ◽  
Cesarean Births ◽  
History Of ◽  
The Mean ◽  
Case Control Analysis

Objective.To investigate pregnancy and fetal outcomes in patients with primary Sjögren syndrome (pSS).Methods.An obstetric history of 36 women with established diagnosis of pSS at pregnancy was obtained from a multicenter cohort of 1075 patients. In a subgroup case-control analysis, 12 deliveries in patients with pSS were compared with 96 control deliveries.Results.Thirty-six women (31 with anti-SSA/Ro and/or anti-SSB/La antibodies) with an established diagnosis of pSS had 45 pregnancies with the delivery of 40 newborns. Two miscarriages, 2 fetal deaths, and 1 induced abortion were recorded. Mean age at the first pregnancy was 33.9 years; mean number of pregnancies was 1.25; 18/40 (45%) cesarean births were delivered; mean pregnancy length was 38.5 weeks (range 32–43), with 6 preterm deliveries. The mean Apgar score at 5 min was 8.9, mean birthweight was 2920 g (range 826–4060 g). Congenital heart block (CHB) occurred in 2/40 (5%) newborns. The reported rate of breastfeeding for at least 1 month was 60.5%. In 4/40 pregnancies (10%) a flare of disease activity was observed within a year from delivery. In the case-control subgroup analysis, 12 deliveries were compared with 96 controls and no significant differences were found.Conclusion.Patients with pSS can have successful pregnancies, which might be followed by a mild relapse. CHB was the only cause of death for offspring of mothers with pSS.

scholarly journals Case-control Analysis ofClostridium difficile—Associated Diarrhea on a Gynecologic Oncology Service

1994 ◽  
Vol 2 (4) ◽  
pp. 154-161 ◽  
Author(s):  
Steven E. Waggoner ◽  
James Barter ◽  
Gregorio Delgado ◽  
Willard Barnes
Keyword(s):  
Kansas City ◽  
Medical Center ◽  
Gynecologic Oncology ◽  
Case Control ◽  
Latex Agglutination ◽  
Control Analysis ◽  
Oncology Patients ◽  
Ofclostridium Difficile ◽  
History Of ◽  
Case Control Analysis

Objective:The incidence, morbidity, and risk factors associated withClostridium difficile-associated diarrhea (CDAD) were studied in a group of gynecologic oncology patients.Methods:A case-control analysis of gynecologic oncology patients with CDAD was carried out from August 1986 through January 1989 in a university medical center.Results:One hundred twenty-three stool samples were tested forC. difficileusing the CDT latex agglutination test (Marion Diagnostics, Kansas City, MO). Thirty episodes of CDAD developed in 23 patients. From August 1986 through July 1988, the incidence was stable at 1.5 episodes/100 admissions. From August 1988 through January 1989, the incidence increased to 9.9 episodes/100 admissions (P= 0.005). Compared with patients with nonspecific antibiotic-associated diarrhea, the study patients were hospitalized longer prior to the development of symptoms (mean 15.2 vs. 9.2 days,P= 0.006) and were admitted more frequently with diarrhea (37% vs. 11%,P= 0.015). The rates of surgery, chemotherapy, and radiation therapy were similar. Fever (57% vs. 14%,P< 0.001), abdominal pain (40% vs. 6%,P< 0.001), bloody stools (27% vs. 3%,P= 0.006), and leukocytosis (64% vs. 26%,P= 0.011) were more common among the study cases. The duration, indication, and number of antibiotics administered were similar, though once started, the mean time to symptoms was longer in the study cases (13.7 vs. 6.1 days,P= 0.004). Seven relapses, 1 death, and 1 unplanned colostomy occurred among women with CDAD.Conclusions: C. difficileis a serious cause of nosocomial morbidity in gynecologic oncology patients. Diarrhea developing after antibiotic exposure is more likely to be associated withC. difficilein patients whose symptoms develop several days after completing antibiotics and in patients with a history of CDAD.

Intracranial hemodynamic changes in primary Sjögren syndrome: a transcranial Doppler case–control study

2015 ◽  
Vol 36 (9) ◽  
pp. 1589-1595 ◽  
Author(s):  
Manuela Morreale ◽  
Ada Francia ◽  
Pasquale Marchione ◽  
Federica Manuppella ◽  
Patrizia Giacomini
Keyword(s):  
Transcranial Doppler ◽  
Case Control Study ◽  
Case Control ◽  
Sjögren Syndrome ◽  
Sjogren Syndrome ◽  
Hemodynamic Changes ◽  
Primary Sjögren Syndrome ◽  
Control Study

scholarly journals Hypokalaemic paralysis and metabolic alkalosis in a patient with Sjögren syndrome: a case report and literature review

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Rasika Ranaweerage ◽  
Shehan Perera ◽  
Aruna Gunapala
Keyword(s):  
Lower Limb ◽  
Metabolic Alkalosis ◽  
Muscle Power ◽  
Autoimmune Disorders ◽  
Sjögren Syndrome ◽  
Gitelman Syndrome ◽  
Sjogren Syndrome ◽  
Limb Weakness ◽  
Primary Sjögren Syndrome ◽  
History Of

Abstract Background Acquired Gitelman syndrome is a very rare disorder reported in association with autoimmune disorders, mostly Sjögren syndrome. It is characterized by the presence of hypokalaemic metabolic alkalosis, hypocalciuria, hypomagnesaemia and hyper-reninaemia, in the absence of typical genetic mutations associated with inherited Gitelman syndrome. Case presentation A 20 year old woman who was previously diagnosed with primary Sjögren syndrome and autoimmune thyroiditis presented with two week history of lower limb weakness and salt craving. Examination revealed upper limb and lower limb muscle weakness with muscle power of 3/5 on MRC scale and diminished deep tendon reflexes. On evaluation, she had hypokalaemia with high trans-tubular potassium gradient, metabolic alkalosis and hypocalciuria, features suggestive of Gitelman syndrome. New onset hypokalaemic alkalosis in a previously normokalaemic patient with Sjögren syndrome strongly favored a diagnosis of acquired Gitelman syndrome. Daily potassium supplementation and spironolactone resulted in complete clinical recovery. Conclusions Acquired Gitelman syndrome associated with Sjögren syndrome is rare. It should be considered as a differential diagnosis during evaluation of acute paralysis and hypokalaemic metabolic alkalosis in patients with autoimmune disorders, especially Sjögren syndrome.

Abstract 87: Selective Serotonin Reuptake Inhibitors and Risk of Intracerebral Hemorrhage

Stroke ◽  
2016 ◽  
Vol 47 (suppl_1) ◽  
Author(s):  
Ahmed Z Obeidat ◽  
Padmini Sekar ◽  
Charles J Moomaw ◽  
Sharyl R Martini ◽  
Jennifer Osborne ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Ischemic Stroke ◽  
Intracerebral Hemorrhage ◽  
Serotonin Reuptake ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Bleeding Risk ◽  
Case Control ◽  
Control Analysis ◽  
History Of ◽  
Case Control Analysis

Background: Selective serotonin reuptake inhibitors (SSRI) are widely used in the treatment of psychiatric disorders such as post-stroke depression. Some studies have reported an association between SSRI use and increased bleeding risk, including intracerebral hemorrhage (ICH). We evaluated this association in two large ICH case control studies. We also tested to see whether SSRI use potentiates the bleeding risk associated with warfarin use and prior ischemic stroke. Methods: ICH cases and controls from the Genetic and Environmental Risk Factors for Hemorrhagic Stroke (GERFHS) and Ethnic Racial Variations in ICH (ERICH) studies were combined in an unmatched case-control analysis. SSRI use and variables previously associated with ICH risk were tested in univariate and multivariate analyses. Interaction terms for SSRI use plus warfarin use and SSRI use plus prior ischemic stroke were included. Results: There were 4134 ICH cases with 303 pre-stroke SSRI users (7.3%) and 4945 controls with 419 SSRI users (8.5%). Results of the multivariate analysis are presented in the table. In univariate analysis, SSRI use was protective (OR 0.85, CI 0.73-1.00, p = .05), however in multivariate analysis this became non-significant. Although the combination of an SSRI and warfarin produced a higher point estimate for ICH risk than warfarin alone, the interaction term did not reach significance (p = .09). There was no interaction found for SSRI use plus history of ischemic stroke. Conclusions: In this large case control analysis, SSRI use was not associated with increased risk of ICH. We also failed to confirm an interaction between SSRI use, warfarin use, and ICH risk, although a modest effect cannot be excluded. While a history of ischemic stroke is a risk factor for ICH, SSRI use did not increase that risk.

scholarly journals Salivary 1H-NMR Metabolomics in Primary Sjögren Syndrome. Preliminary Results of a Pilot Case-Control Study

Proceedings ◽  
2019 ◽  
Vol 35 (1) ◽  
pp. 39
Author(s):  
Setti ◽  
Sandri ◽  
Tarentini ◽  
Panari ◽  
Mucci ◽  
...  
Keyword(s):  
Autoimmune Disease ◽  
1H Nmr ◽  
Case Control Study ◽  
Case Control ◽  
Sjögren Syndrome ◽  
Sjogren Syndrome ◽  
Exocrine Glands ◽  
Preliminary Results ◽  
Primary Sjögren Syndrome ◽  
Control Study

Primary Sjögren Syndrome (pSS) is a multisystem autoimmune disease which mainly involves exocrine glands, such as salivary and lacrimal. [...]

scholarly journals Association of Smoking and Obesity on the Risk of Developing Primary Sjögren Syndrome: A Population-based Cohort Study

2019 ◽  
Vol 46 (7) ◽  
pp. 727-730 ◽  
Author(s):  
Luisa Servioli ◽  
Gabriel Maciel ◽  
Carlotta Nannini ◽  
Cynthia S. Crowson ◽  
Eric L. Matteson ◽  
...  
Keyword(s):  
Smoking Status ◽  
Population Based ◽  
Case Control ◽  
Sjögren Syndrome ◽  
Sjogren Syndrome ◽  
Olmsted County ◽  
Population Based Study ◽  
Primary Sjögren Syndrome ◽  
Never Smokers

Objective.To explore the role of smoking and obesity in primary Sjögren syndrome (pSS).Methods.Olmsted County (Minnesota, USA) residents (n = 106) diagnosed with pSS from 2000 to 2015 were compared to 3 controls without pSS and matched for age and sex who were randomly selected from Olmsted County residents.Results.Current smokers were less likely to be pSS cases (OR 0.34, 95% CI 0.14–0.85), while there was no association between former smoking and case/control status (OR 1.27, 95% CI 0.80–2.03) compared to never smokers. Smoking status was not associated with antinuclear antibody, anti-SSA, anti-SSB, or rheumatoid factor positivity (p > 0.05). OR for obesity was 0.79 (95% CI 0.48–1.30).Conclusion.In this population-based study, current smoking was inversely associated with case/control status, while body mass index lacked any association.

Increased Frequency of Hand Osteoarthritis in Patients with Primary Sjögren Syndrome Compared with Systemic Lupus Erythematosus

2016 ◽  
Vol 43 (6) ◽  
pp. 1068-1071 ◽  
Author(s):  
Adem Aksoy ◽  
Dilek Solmaz ◽  
Gercek Can ◽  
Pinar Cetin ◽  
Ali Balci ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Daily Practice ◽  
Sjögren Syndrome ◽  
Controlled Study ◽  
Hand Osteoarthritis ◽  
Sjogren Syndrome ◽  
Systemic Lupus ◽  
Primary Sjögren Syndrome ◽  
The Mean

Objective.In daily practice, we noticed that hand osteoarthritis (OA) was commonly associated with primary Sjögren syndrome (pSS). Therefore, we aimed to investigate its prevalence in patients with pSS in a controlled study.Methods.The study included patients with pSS and controls with systemic lupus erythematosus (SLE). Standard hand/wrist radiographs were obtained and classified according to the Kellgren-Lawrence system. “Erosive hand OA” was defined according to the Verbruggen-Veys classification.Results.There were 114 patients with pSS (110 women, 51.0 yrs) and 34 patients with SLE (33 women, 42.4 yrs). Among 114 patients with pSS, 42.7% had radiographic, 30.3% symptomatic, and 16.0% erosive hand OA. The prevalences of radiographic (45.5%) and erosive hand OA (14.4%) in 90 patients with pSS with age- and sex-matched patients with SLE were significantly higher than those in patients with SLE (14.7% and 0.0%, p = 0.007 and p = 0.012, respectively). Interobserver reliabilities for diagnosing radiographic and erosive OA were found to be good (ĸ = 0.780 and ĸ = 0.788, respectively). Intraobserver reliabilities for diagnosing radiographic and erosive OA were also good (ĸ = 0.784 and ĸ = 0.825 for FO, and ĸ = 0.722 and ĸ = 0.800 for AB, respectively). The frequency of hand OA in patients with pSS was found to be increased with increasing age (r = 0.513). The mean age of those with erosive hand OA was significantly higher than those without erosive OA (p < 0.001).Conclusion.This study suggests that pSS, conversely to SLE, is more frequently associated with hand OA.

scholarly journals Smoking, Obesity, and Risk of Primary Sjögren Syndrome

2021 ◽  
pp. jrheum.210808
Author(s):  
Tomoyuki Kawada
Keyword(s):  
Antinuclear Antibody ◽  
Case Control Study ◽  
Smoking Status ◽  
Case Control ◽  
Sjögren Syndrome ◽  
Sjogren Syndrome ◽  
Primary Sjögren Syndrome ◽  
Former Smokers ◽  
Never Smokers ◽  
Control Study

I read the paper by Servioli et al1 conducting a 1:3 case-control study to evaluate the association between smoking status and primary (p-) Sjögren syndrome (SS). ORs (95% CIs) of current and former smokers compared to never smokers for pSS were 0.34 (0.14–0.85) and 1.27 (0.80–2.03), respectively. In contrast, there was no significant association of smoking status with antinuclear antibody, anti-SSA, anti-SSB, or rheumatoid factor positivity.

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