Smoking, Obesity, and Risk of Primary Sjögren Syndrome

Former Smokers ◽

Never Smokers ◽

I read the paper by Servioli et al1 conducting a 1:3 case-control study to evaluate the association between smoking status and primary (p-) Sjögren syndrome (SS). ORs (95% CIs) of current and former smokers compared to never smokers for pSS were 0.34 (0.14–0.85) and 1.27 (0.80–2.03), respectively. In contrast, there was no significant association of smoking status with antinuclear antibody, anti-SSA, anti-SSB, or rheumatoid factor positivity.

Intracranial hemodynamic changes in primary Sjögren syndrome: a transcranial Doppler case–control study

Neurological Sciences ◽

10.1007/s10072-015-2204-3 ◽

2015 ◽

Vol 36 (9) ◽

pp. 1589-1595 ◽

Cited By ~ 4

Author(s):

Manuela Morreale ◽

Ada Francia ◽

Pasquale Marchione ◽

Federica Manuppella ◽

Patrizia Giacomini

Keyword(s):

Transcranial Doppler ◽

Case Control Study ◽

Case Control ◽

Sjögren Syndrome ◽

Sjogren Syndrome ◽

Hemodynamic Changes ◽

Salivary 1H-NMR Metabolomics in Primary Sjögren Syndrome. Preliminary Results of a Pilot Case-Control Study

Proceedings ◽

10.3390/proceedings2019035039 ◽

2019 ◽

Vol 35 (1) ◽

pp. 39

Author(s):

Setti ◽

Sandri ◽

Tarentini ◽

Panari ◽

Mucci ◽

...

Keyword(s):

Autoimmune Disease ◽

1H Nmr ◽

Case Control Study ◽

Case Control ◽

Sjögren Syndrome ◽

Sjogren Syndrome ◽

Exocrine Glands ◽

Preliminary Results ◽

Primary Sjögren Syndrome (pSS) is a multisystem autoimmune disease which mainly involves exocrine glands, such as salivary and lacrimal. [...]

Association of Smoking and Obesity on the Risk of Developing Primary Sjögren Syndrome: A Population-based Cohort Study

The Journal of Rheumatology ◽

10.3899/jrheum.180481 ◽

2019 ◽

Vol 46 (7) ◽

pp. 727-730 ◽

Cited By ~ 1

Author(s):

Luisa Servioli ◽

Gabriel Maciel ◽

Carlotta Nannini ◽

Cynthia S. Crowson ◽

Eric L. Matteson ◽

...

Keyword(s):

Smoking Status ◽

Population Based ◽

Case Control ◽

Sjögren Syndrome ◽

Sjogren Syndrome ◽

Olmsted County ◽

Population Based Study ◽

Never Smokers

Objective.To explore the role of smoking and obesity in primary Sjögren syndrome (pSS).Methods.Olmsted County (Minnesota, USA) residents (n = 106) diagnosed with pSS from 2000 to 2015 were compared to 3 controls without pSS and matched for age and sex who were randomly selected from Olmsted County residents.Results.Current smokers were less likely to be pSS cases (OR 0.34, 95% CI 0.14–0.85), while there was no association between former smoking and case/control status (OR 1.27, 95% CI 0.80–2.03) compared to never smokers. Smoking status was not associated with antinuclear antibody, anti-SSA, anti-SSB, or rheumatoid factor positivity (p > 0.05). OR for obesity was 0.79 (95% CI 0.48–1.30).Conclusion.In this population-based study, current smoking was inversely associated with case/control status, while body mass index lacked any association.

SAT0399 Chronic Antigenic Stimulation and Activity of the Disease Are Predictive of Lymphoma Development in Primary SjÖgren Syndrome: A Case Control Study of 64 Cases

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2015-eular.6116 ◽

2015 ◽

Vol 74 (Suppl 2) ◽

pp. 803.2-804

Author(s):

G. Nocturne ◽

A. Virone ◽

V. Le Guern ◽

E. Hachulla ◽

C. Daien ◽

...

Keyword(s):

Case Control Study ◽

Case Control ◽

Sjögren Syndrome ◽

Antigenic Stimulation ◽

Sjogren Syndrome ◽

Chronic Antigenic Stimulation ◽

Associations between serum carotenoid levels and the risk of non-Hodgkin lymphoma: a case–control study

British Journal Of Nutrition ◽

10.1017/s000711452000152x ◽

2020 ◽

Vol 124 (12) ◽

pp. 1311-1319

Author(s):

Shan Li ◽

Xianglu Zhu ◽

Lin Zhu ◽

Xin Hu ◽

Shujuan Wen

Keyword(s):

Hodgkin Lymphoma ◽

Case Control Study ◽

Smoking Status ◽

Conditional Logistic Regression ◽

Case Control ◽

Total Carotenoids ◽

Non Hodgkin Lymphoma ◽

Never Smokers ◽

Serum Carotenoids ◽

AbstractLimited studies have investigated the effects of serum carotenoids on the risk of non-Hodgkin lymphoma (NHL), and the findings have been inconclusive. This study aims to assess the association between serum total or specific carotenoid levels and NHL risk. This 1:1 matched, hospital-based case–control study enrolled 512 newly diagnosed (within 1 month) NHL patients and 512 healthy controls who were matched by age (±5 years) and sex in Urumqi, China. Serum carotenoid levels were measured by HPLC. Conditional logistic regression showed that higher serum total carotenoid levels and their subtypes (e.g. α-carotene, β-carotene, β-cryptoxanthin and lycopene) were dose-dependently associated with decreased NHL risk. The multivariable-adjusted OR and their 95 % CI for NHL risk for quartile 4 (v. quartile 1) were 0·31 (95 % CI 0·22, 0·48; Pfor trend < 0·001) for total carotenoids, 0·52 (95 % CI 0·33, 0·79; Pfor trend: 0·003) for α-carotene, 0·63 (95 % CI 0·42, 0·94; Pfor trend: 0·031) for β-carotene, 0·73 (95 % CI 0·49, 1·05; Pfor trend: 0·034) for β-cryptoxanthin and 0·51 (95 % CI 0·34, 0·75; Pfor trend: 0·001) for lycopene. A null association was observed between serum lutein + zeaxanthin and NHL risk (OR 0·89, 95 % CI 0·57, 1·38; Pfor trend: 0·556). Significant interactions were observed after stratifying according to smoking status, and inverse associations were more evident among current smokers than past or never smokers for total carotenoids, α-carotene and lycopene (Pfor heterogeneity: 0·047, 0·042 and 0·046). This study indicates that higher serum carotenoid levels might be inversely associated with NHL risk, especially among current smokers.

Neighbourhood deprivation and lung cancer risk: a nested case–control study in the USA

BMJ Open ◽

10.1136/bmjopen-2017-021059 ◽

2018 ◽

Vol 8 (9) ◽

pp. e021059 ◽

Cited By ~ 3

Author(s):

Maureen Sanderson ◽

Melinda C Aldrich ◽

Robert S Levine ◽

Barbara Kilbourne ◽

Qiuyin Cai ◽

...

Keyword(s):

Lung Cancer ◽

Cancer Risk ◽

Case Control Study ◽

Lung Cancer Risk ◽

Smoking Status ◽

Case Control ◽

Neighbourhood Deprivation ◽

Former Smokers ◽

Nested Case Control ◽

ObjectivesTo examine the association between neighbourhood deprivation and lung cancer risk.DesignNested case–control study.SettingSouthern Community Cohort Study of persons residing in 12 states in the southeastern USA.Participants1334 cases of lung cancer and 5315 controls.Primary outcome measureRisk of lung cancer.ResultsAfter adjustment for smoking status and other confounders, and additional adjustment for individual-level measures of socioeconomic status (SES), there was no monotonic increase in risk with worsening deprivation score overall or within sex and race groups. There was an increase among current and shorter term former smokers (p=0.04) but not among never and longer term former smokers. There was evidence of statistically significant interaction by sex among whites, but not blacks, in which the effect of worsening deprivation on lung cancer existed in males but not in females.ConclusionsArea-level measures of SES were associated with lung cancer risk in current and shorter term former smokers only in this population.

Evaluating the efficacy of topical vancomycin powder in the treatment of open lower extremity fractures

Trauma ◽

10.1177/1460408620978142 ◽

2020 ◽

pp. 146040862097814

Author(s):

Justin Vaida ◽

Alexander DB Conti ◽

Justin J Ray ◽

Daniel A Bravin ◽

Michelle A Bramer

Keyword(s):

Lower Extremity ◽

Case Control Study ◽

Smoking Status ◽

Case Control ◽

Wound Complications ◽

Control Group ◽

Retrospective Case ◽

Vancomycin Powder ◽

Introduction Optimal management of lower extremity fractures includes early antibiotics administration, thorough irrigation and debridement, consideration of soft tissue injury, and definitive skeletal management. The purpose of this study was to evaluate the efficacy of topical vancomycin powder in the treatment of open lower extremity fractures. Methods This was a retrospective case control study in which open lower extremity fractures at our institution were reviewed for development of infection (including species and sensitivity if present) and the development of unanticipated wound complications requiring intervention. Patients from 2010-2015 were treated with standard of care consistent with evidence-based literature (IV antibiotics with external fixator, intramedullary nail, etc.). Patients from 2016–18 were additionally treated with vancomycin powder applied directly to the wound before closure. All patients were monitored per the treating surgeon’s standard follow-up protocol and had follow-up of at least two months. Results This retrospective case control study comprised 434 patients. The historical control group (n = 388 patients) and treatment group (n = 46 patients) were similar for age, sex, BMI (body mass index), diabetes, smoking status, and Injury Severity Score (ISS). There were 36 infections (9.28%) in the control group compared to four infections (8.70%) in the vancomycin powder group (p = 0.901). No significant difference was seen after adjusting for age, sex, BMI, diabetes, smoking status, and ISS. The vancomycin powder group experienced significantly more wound complications (15.2%) compared to the control group (6.4%; p = 0.039), which remained significant when adjusting for multiple covariates. Conclusions Topical vancomycin powder did not reduce the infection rate when applied in the surgical site of open lower extremity fractures. Instead, the addition of topical vancomycin powder resulted in significantly more wound complications in patients with open lower extremity fractures.

Plasma Magnesium Concentrations and Risk of Incident Cancer in Adults with Hypertension: A Nested Case-Control Study

Annals of Nutrition and Metabolism ◽

10.1159/000510214 ◽

2020 ◽

Vol 76 (5) ◽

pp. 304-312

Author(s):

Tengfei Lin ◽

Chonglei Bi ◽

Yun Song ◽

Huiyuan Guo ◽

Lishun Liu ◽

...

Keyword(s):

Case Control Study ◽

Smoking Status ◽

Controlled Trial ◽

Case Control ◽

Cancer Site ◽

Incident Cancer ◽

Plasma Magnesium ◽

Nested Case Control ◽

Risk Of Cancer ◽

Objective: The association between plasma magnesium and risk of incident cancer remains inconclusive in previous studies. We aimed to investigate the prospective relationship of baseline plasma magnesium concentrations with the risk of incident cancer and to examine possible effect modifiers. Methods: A nested case-control study with 228 incident cancer cases and 228 matched controls was conducted using data from the China Stroke Primary Prevention Trial (CSPPT), a randomized, double-blind, controlled trial, conducted from May 2008 to August 2013. Study outcomes included incident cancer and its subtypes. Results: When plasma magnesium concentrations were assessed as quartiles, a significantly higher incident risk of total cancer was found in participants in quartile 1 (<0.76 mmol/L; odds ratio [OR] = 2.70; 95% CI: 1.33–5.49) and quartile 4 (≥0.89 mmol/L; OR = 2.05; 95% CI: 1.12–3.76), compared with those in quartile 3 (0.83 to <0.89 mmol/L). In cancer site-specific analyses, similar trends were found for gastrointestinal cancer, esophageal cancer, gastric cancer, breast cancer, lung cancer, and other cancers. Furthermore, none of the variables, including age, sex, current smoking status, current alcohol intake, BMI, systolic blood pressure, and total cholesterol levels at baseline significantly modified the association between plasma magnesium and cancer risk. Conclusions: Both low and high plasma magnesium concentrations were significantly associated with an increased incident risk of cancer, compared with the reference concentrations of 0.83 to <0.89 mmol/L among hypertensive adults.

1009 Sleep Apnea and Colorectal Adenoma in the Veteran Population: A Case-Control Study

SLEEP ◽

10.1093/sleep/zsaa056.1005 ◽

2020 ◽

Vol 43 (Supplement_1) ◽

pp. A383-A384

Author(s):

L Guan ◽

L Jiao ◽

S Malhotra

Keyword(s):

Sleep Apnea ◽

Sleep Duration ◽

Colorectal Adenoma ◽

Case Control Study ◽

Smoking Status ◽

Medical Center ◽

The United States ◽

Case Control ◽

Sleep Study ◽

Abstract Introduction Colorectal cancer is the third most common cancer in the United States, with over half of colorectal cancers estimated to be the result of modifiable risk factors. Studies relating sleep apnea (SA) and colorectal adenoma (CRA) are limited and the findings are equivocal. The objective of this study was to examine the association between SA and risk of CRA. Methods This was a retrospective cross-sectional case-control study of data collected from 460 veterans, ages 50-79, seen in the colonoscopy clinic at the Michael E. DeBakey VA Medical Center between 2014 and 2018. Information on demographics, sleep history, and co-morbidities were obtained through lifestyle questionnaire. Self-reported SA was diagnosed by a prior sleep study. Cases consisted of 297 participants had pathologically confirmed adenoma (including 117 participants having advanced CRA with villous component or diameter of polyp > 1 cm). Controls consisted of 173 polyp-free participants. The distribution of demographics and lifestyle factors were compared between CRA and non-CRA using the Student’s t or chi-square tests. Odds ratios (OR) and 95% confidence intervals (CI) of CRA in association with CRA were calculated using univariate and multivariate unconditional logistic regression models. The confounding factors included age, sex, ethnicity, obesity, smoking status, alcohol use, hypertension, and sleep duration. Results Compared with non-SA, the multivariable OR (95% CI) for CRA was 0.92 (0.58-1.48); for non-advanced CRA was 1.14 (0.68-1.91), and for advanced CRA was 0.61 (0.32-1.17) in SA participants. Adjustment of sleep duration in the model did not change the risk estimates. Conclusion Sleep-study diagnosed SA was not associated with development of CRA in this veteran population. Further studies are needed to confirm this observation and incorporate the severity and treatment of SA, and undiagnosed SA in risk assessment. Support This research is supported in part by the Gillson Longenbaugh Foundation, and Golfers Against Cancer organization (to LJ), the Cancer Prevention Research Institute of Texas (CPRIT) (RP#140767, to LJ).