scholarly journals Association of Smoking and Obesity on the Risk of Developing Primary Sjögren Syndrome: A Population-based Cohort Study

2019 ◽  
Vol 46 (7) ◽  
pp. 727-730 ◽  
Author(s):  
Luisa Servioli ◽  
Gabriel Maciel ◽  
Carlotta Nannini ◽  
Cynthia S. Crowson ◽  
Eric L. Matteson ◽  
...  
Keyword(s):  
Smoking Status ◽  
Population Based ◽  
Case Control ◽  
Sjögren Syndrome ◽  
Sjogren Syndrome ◽  
Olmsted County ◽  
Population Based Study ◽  
Primary Sjögren Syndrome ◽  
Never Smokers

Objective.To explore the role of smoking and obesity in primary Sjögren syndrome (pSS).Methods.Olmsted County (Minnesota, USA) residents (n = 106) diagnosed with pSS from 2000 to 2015 were compared to 3 controls without pSS and matched for age and sex who were randomly selected from Olmsted County residents.Results.Current smokers were less likely to be pSS cases (OR 0.34, 95% CI 0.14–0.85), while there was no association between former smoking and case/control status (OR 1.27, 95% CI 0.80–2.03) compared to never smokers. Smoking status was not associated with antinuclear antibody, anti-SSA, anti-SSB, or rheumatoid factor positivity (p > 0.05). OR for obesity was 0.79 (95% CI 0.48–1.30).Conclusion.In this population-based study, current smoking was inversely associated with case/control status, while body mass index lacked any association.

scholarly journals Smoking, Obesity, and Risk of Primary Sjögren Syndrome

2021 ◽  
pp. jrheum.210808
Author(s):  
Tomoyuki Kawada
Keyword(s):  
Antinuclear Antibody ◽  
Case Control Study ◽  
Smoking Status ◽  
Case Control ◽  
Sjögren Syndrome ◽  
Sjogren Syndrome ◽  
Primary Sjögren Syndrome ◽  
Former Smokers ◽  
Never Smokers ◽  
Control Study

I read the paper by Servioli et al1 conducting a 1:3 case-control study to evaluate the association between smoking status and primary (p-) Sjögren syndrome (SS). ORs (95% CIs) of current and former smokers compared to never smokers for pSS were 0.34 (0.14–0.85) and 1.27 (0.80–2.03), respectively. In contrast, there was no significant association of smoking status with antinuclear antibody, anti-SSA, anti-SSB, or rheumatoid factor positivity.

scholarly journals Questions on the Bidirectional Relationship Between Primary Sjögren Syndrome and Non-Hodgkin Lymphoma

2020 ◽  
pp. jrheum.201352
Author(s):  
Yun-Tzu Liang ◽  
Pui-Ying Leong ◽  
James Cheng-Chung Wei
Keyword(s):  
Hodgkin Lymphoma ◽  
Population Based ◽  
Sjögren Syndrome ◽  
Sjogren Syndrome ◽  
Population Based Study ◽  
Bilateral Relationship ◽  
Non Hodgkin Lymphoma ◽  
Primary Sjögren Syndrome ◽  
Bidirectional Relationship

We have read with great interest in the article by Wang, et al on the higher incidence of non-Hodgkin lymphoma (NHL) in patients with primary Sjögren syndrome (pSS) and the higher incidence of pSS in patients with NHL1. Thank you for the discovery of the bilateral relationship between pSS and NHL in this nationwide population-based study1.

Bidirectional Relationship Between Primary Sjögren Syndrome and Non-Hodgkin Lymphoma: A Nationwide Taiwanese Population-based Study

2020 ◽  
Vol 47 (9) ◽  
pp. 1374-1378
Author(s):  
Li-Hui Wang ◽  
Wei-Ming Wang ◽  
Chun-Yu Lin ◽  
Sheng-Hsiang Lin ◽  
Chi-Chang Shieh
Keyword(s):  
Hodgkin Lymphoma ◽  
Population Based ◽  
Sjögren Syndrome ◽  
Sjogren Syndrome ◽  
Research Database ◽  
Population Based Study ◽  
Non Hodgkin Lymphoma ◽  
Primary Sjögren Syndrome ◽  
Bidirectional Relationship ◽  
New Onset

Objective.Bidirectional relationships between some autoimmune diseases and non-Hodgkin lymphoma (NHL) may exist. We conducted this nationwide population-based study in Taiwan to investigate whether there is a bidirectional relationship between primary Sjögren syndrome (pSS) and NHL.Methods.Using the National Health Insurance Research Database of Taiwan, we identified 15,636 patients with new-onset pSS without previous cancer and 25,074 patients with new-onset NHL without previous pSS as 2 non-overlapping cohorts from 1998 to 2012, and followed them until 2013. Standardized incidence ratios (SIR) for NHL in the patients with pSS and SIR for pSS in the patients with NHL were compared with the general population.Results.Among the 15,636 patients with pSS, 741 developed cancers, including 51 with NHL. The highest SIR of specific cancer risk in patients with pSS was that for NHL (SIR 4.6, 95% CI 3.4–6.0). Among the 25,074 patients with NHL, 49 developed pSS; the SIR was also increased (SIR 3.2, 95% CI 2.4–4.2). The risk was highest within 1 year after the diagnosis of each disease.Conclusion.This nationwide population-based study is the first to report a bidirectional relationship between pSS and NHL. Our findings suggest being alert for patients with pSS or NHL who have early signs of the other disease in clinical care. The underlying mechanisms of the bidirectional relationship merit further investigation.

scholarly journals Lymphoma and Sjögren Syndrome: A Common Overlapping Syndrome?

2021 ◽  
pp. jrheum.201537
Author(s):  
Yu-Wen Chen ◽  
Po-Yu Tsai ◽  
James Cheng-Chung Wei
Keyword(s):  
Hodgkin Lymphoma ◽  
Population Based ◽  
Sjögren Syndrome ◽  
Sjogren Syndrome ◽  
Population Based Study ◽  
Non Hodgkin Lymphoma ◽  
Primary Sjögren Syndrome ◽  
Research Article ◽  
Bidirectional Relationship

We read with interest the research article entitled, “Bidirectional Relationship Between Primary Sjögren Syndrome and Non-Hodgkin Lymphoma: A Nationwide Population-based Study” by Wang, et al published in The Journal of Rheumatology.1 The authors conducted research revealing that primary Sjögren syndrome (SS) and non-Hodgkin lymphoma (NHL) are bidirectionally associated with each other.

Intracranial hemodynamic changes in primary Sjögren syndrome: a transcranial Doppler case–control study

2015 ◽  
Vol 36 (9) ◽  
pp. 1589-1595 ◽  
Author(s):  
Manuela Morreale ◽  
Ada Francia ◽  
Pasquale Marchione ◽  
Federica Manuppella ◽  
Patrizia Giacomini
Keyword(s):  
Transcranial Doppler ◽  
Case Control Study ◽  
Case Control ◽  
Sjögren Syndrome ◽  
Sjogren Syndrome ◽  
Hemodynamic Changes ◽  
Primary Sjögren Syndrome ◽  
Control Study

Outcome of Pregnancy in Italian Patients with Primary Sjögren Syndrome

2013 ◽  
Vol 40 (7) ◽  
pp. 1143-1147 ◽  
Author(s):  
Roberta Priori ◽  
Angelica Gattamelata ◽  
Mariagrazia Modesti ◽  
Serena Colafrancesco ◽  
Silvia Frisenda ◽  
...  
Keyword(s):  
Case Control ◽  
Sjögren Syndrome ◽  
Sjogren Syndrome ◽  
Control Analysis ◽  
Primary Sjögren Syndrome ◽  
Multicenter Cohort ◽  
Cesarean Births ◽  
History Of ◽  
The Mean ◽  
Case Control Analysis

Objective.To investigate pregnancy and fetal outcomes in patients with primary Sjögren syndrome (pSS).Methods.An obstetric history of 36 women with established diagnosis of pSS at pregnancy was obtained from a multicenter cohort of 1075 patients. In a subgroup case-control analysis, 12 deliveries in patients with pSS were compared with 96 control deliveries.Results.Thirty-six women (31 with anti-SSA/Ro and/or anti-SSB/La antibodies) with an established diagnosis of pSS had 45 pregnancies with the delivery of 40 newborns. Two miscarriages, 2 fetal deaths, and 1 induced abortion were recorded. Mean age at the first pregnancy was 33.9 years; mean number of pregnancies was 1.25; 18/40 (45%) cesarean births were delivered; mean pregnancy length was 38.5 weeks (range 32–43), with 6 preterm deliveries. The mean Apgar score at 5 min was 8.9, mean birthweight was 2920 g (range 826–4060 g). Congenital heart block (CHB) occurred in 2/40 (5%) newborns. The reported rate of breastfeeding for at least 1 month was 60.5%. In 4/40 pregnancies (10%) a flare of disease activity was observed within a year from delivery. In the case-control subgroup analysis, 12 deliveries were compared with 96 controls and no significant differences were found.Conclusion.Patients with pSS can have successful pregnancies, which might be followed by a mild relapse. CHB was the only cause of death for offspring of mothers with pSS.

scholarly journals Primary Sjogren Syndrome: Focus on Innate Immune Cells and Inflammation

Vaccines ◽  
2020 ◽  
Vol 8 (2) ◽  
pp. 272
Author(s):  
Chiara Rizzo ◽  
Giulia Grasso ◽  
Giulia Maria Destro Castaniti ◽  
Francesco Ciccia ◽  
Giuliana Guggino
Keyword(s):  
Sjögren Syndrome ◽  
Innate Immune ◽  
Lymphoid Cells ◽  
Sjogren Syndrome ◽  
Innate Immune Cells ◽  
Complex Interplay ◽  
Innate And Adaptive Immunity ◽  
Primary Sjögren Syndrome ◽  
Long Time

Primary Sjogren Syndrome (pSS) is a complex, multifactorial rheumatic disease that mainly targets salivary and lacrimal glands, inducing epithelitis. The cause behind the autoimmunity outbreak in pSS is still elusive; however, it seems related to an aberrant reaction to exogenous triggers such as viruses, combined with individual genetic pre-disposition. For a long time, autoantibodies were considered as the hallmarks of this disease; however, more recently the complex interplay between innate and adaptive immunity as well as the consequent inflammatory process have emerged as the main mechanisms of pSS pathogenesis. The present review will focus on innate cells and on the principal mechanisms of inflammation connected. In the first part, an overview of innate cells involved in pSS pathogenesis is provided, stressing in particular the role of Innate Lymphoid Cells (ILCs). Subsequently we have highlighted the main inflammatory pathways, including intra- and extra-cellular players. A better knowledge of such processes could determine the detection of new therapeutic targets that are a major need for pSS.

scholarly journals The Risk of Deep Venous Thrombosis and Pulmonary Embolism in Primary Sjögren Syndrome: A General Population-based Study

2017 ◽  
Vol 44 (8) ◽  
pp. 1184-1189 ◽  
Author(s):  
J. Antonio Aviña-Zubieta ◽  
Michael Jansz ◽  
Eric C. Sayre ◽  
Hyon K. Choi
Keyword(s):  
Pulmonary Embolism ◽  
General Population ◽  
Population Based ◽  
Sjögren Syndrome ◽  
First Year ◽  
Study Cohort ◽  
Sjogren Syndrome ◽  
Primary Sjögren Syndrome ◽  
Entry Time ◽  
Increased Risk

Objective.To estimate the future risk and time trends of venous thromboembolism (VTE) in individuals with newly diagnosed primary Sjögren syndrome (pSS) in the general population.Methods.Using a population database that includes all residents of British Columbia, Canada, we created a study cohort of all patients with incident SS and up to 10 controls from the general population matched for age, sex, and entry time. We compared incidence rates (IR) of pulmonary embolism (PE), deep vein thrombosis (DVT), and VTE between the 2 groups according to SS disease duration. We calculated HR, adjusting for confounders.Results.Among 1175 incident pSS cases (mean age 56.7 yrs, 87.6% women), the IR of PE, DVT, and VTE were 3.9, 2.8, and 5.2 per 1000 person-years (PY), respectively; the corresponding rates in the comparison cohort were 0.9, 0.8, and 1.4 per 1000 PY. Compared with non-SS individuals, the multivariable HR for PE, DVT, and VTE among SS cases were 4.07 (95% CI 2.04–8.09), 2.80 (95% CI 1.27–6.17), and 2.92 (95% CI 1.66–5.16), respectively. The HR matched for age, sex, and entry time for VTE, PE, and DVT were highest during the first year after SS diagnosis (8.29, 95% CI 2.57–26.77; 4.72, 95% CI 1.13–19.73; and 7.34, 95% CI 2.80–19.25, respectively).Conclusion.These findings provide population-based evidence that patients with pSS have a substantially increased risk of VTE, especially within the first year after SS diagnosis. Further research into the involvement of monitoring and prevention of VTE in SS may be warranted.

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