MAZZUCO Stefan, KEILMAN Nico (eds.), 2020, Developments in Demographic Forecasting, Springer Nature, Switzerland AG, The Springer Series on Demographic Methods and Population Analysis, VIII + 258 p.

Population ◽  
2021 ◽  
Vol Vol. 75 (4) ◽  
pp. 621-623
Author(s):  
Daniel Courgeau
Author(s):  
Hakan Ancin

This paper presents methods for performing detailed quantitative automated three dimensional (3-D) analysis of cell populations in thick tissue sections while preserving the relative 3-D locations of cells. Specifically, the method disambiguates overlapping clusters of cells, and accurately measures the volume, 3-D location, and shape parameters for each cell. Finally, the entire population of cells is analyzed to detect patterns and groupings with respect to various combinations of cell properties. All of the above is accomplished with zero subjective bias.In this method, a laser-scanning confocal light microscope (LSCM) is used to collect optical sections through the entire thickness (100 - 500μm) of fluorescently-labelled tissue slices. The acquired stack of optical slices is first subjected to axial deblurring using the expectation maximization (EM) algorithm. The resulting isotropic 3-D image is segmented using a spatially-adaptive Poisson based image segmentation algorithm with region-dependent smoothing parameters. Extracting the voxels that were labelled as "foreground" into an active voxel data structure results in a large data reduction.


1985 ◽  
Vol 61 (1) ◽  
pp. 44-54 ◽  
Author(s):  
D. Schons ◽  
W. D. Hohenboken ◽  
J. D. Hall

2020 ◽  
Author(s):  
Jose De-Sola ◽  
Gabriel Rubio ◽  
Hernan Talledo ◽  
Carmen Jaudenes ◽  
Andrea DÁgostino ◽  
...  

BACKGROUND Problem phone use is a growing concern in most societies, being associated to social and health problems in a similar way to other behavioral addictions. However, both, its prevalence and its nature as a behavioral disorder are not well described nor understood. More over it is not universally recognized yet as a clinical entity that deserves health-oriented interventions. OBJECTIVE In this study, both, an evaluation of cell phone craving and problematic cell phone use among the Spanish population was carried out. Our initial hypothesis is that both problematic cell phone use and cravings have increased in the last 5 years. METHODS Methods We used our adaptation of the original Mobile Phone Problematic Use Scale (MPPUS) as well as the Mobile Phone Addiction Craving Scale (MPACS) A total of 1,612 online interviews were conducted in 17 autonomous communities in the Spanish territory, with a global and specific analysis by gender, age, profession, education level and population center size. RESULTS The results indicate that the prevalence of problematic cell phone use in Spain is currently 4.8%, with 14.8% of users who abuse and are at risk of dependence and lack of control. In total, 19.6% of the population currently has mobile device use issues. These results do not differ significantly from those obtained in our previous investigation; in contrast, the level of craving increased significant. Both in the prevalence of problematic cell phone use and in craving, the highest incidence is observed for people between 16 and 35 years old, students, and users without education or basic education and in urban centers. There are no differences between genders. CONCLUSIONS Therefore, the present study confirms that prevalence of problem phone use remained high in the Spanish Population, despite the rising concerns around its unhealthy consequences. In addition, we confirmed an increase in cell phone craving scores, indicating that technological dependence and need is increasing every day. CLINICALTRIAL The present study is not an intervention study so no Trial Registration was requested


Molecules ◽  
2020 ◽  
Vol 25 (24) ◽  
pp. 5970
Author(s):  
Nabil Al-Zaqri ◽  
Mohammed Suleiman ◽  
Anas Al-Ali ◽  
Khaled Alkanad ◽  
Karthik Kumara ◽  
...  

The exo⇔endo isomerization of 2,5-dimethoxybenzaldehyde was theoretically studied by density functional theory (DFT) to examine its favored conformers via sp2–sp2 single rotation. Both isomers were docked against 1BNA DNA to elucidate their binding ability, and the DFT-computed structural parameters results were matched with the X-ray diffraction (XRD) crystallographic parameters. XRD analysis showed that the exo-isomer was structurally favored and was also considered as the kinetically preferred isomer, while several hydrogen-bonding interactions detected in the crystal lattice by XRD were in good agreement with the Hirshfeld surface analysis calculations. The molecular electrostatic potential, Mulliken and natural population analysis charges, frontier molecular orbitals (HOMO/LUMO), and global reactivity descriptors quantum parameters were also determined at the B3LYP/6-311G(d,p) level of theory. The computed electronic calculations, i.e., TD-SCF/DFT, B3LYP-IR, NMR-DB, and GIAO-NMR, were compared to the experimental UV–Vis., optical energy gap, FTIR, and 1H-NMR, respectively. The thermal behavior of 2,5-dimethoxybenzaldehyde was also evaluated in an open atmosphere by a thermogravimetric–derivative thermogravimetric analysis, indicating its stability up to 95 °C.


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