Prospective cohort study of tea consumption and risk of digestive system cancers: results from the Shanghai Women's Health Study

ObjectiveTo examine the associations of dietary and supplemental magnesium (Mg) as assessed by a semi-quantitative food frequency questionnaire with cognitive outcomes among ageing women.DesignThis work conducts a prospective cohort study of participants enrolled in the Women’s Health Initiative Memory Study (WHIMS), which was subsequently extended and named WHIMS-Epidemiology of Cognitive Health.SettingForty clinical centres in the USA.ParticipantsPostmenopausal women aged 65–79 years without dementia on enrolment.Main outcome measuresPhysician-adjudicated mild cognitive impairment (MCI) and/or probable dementia (PD).ResultsParticipants were excluded (n=1006) if they had extreme values of dietary energy intake, had missing or extreme body mass index values, with prevalent MCI/PD at baseline, received only one cognitive assessment or had been followed up for <1 year. During >20 years of follow-up, 765 (11.8%) out of 6473 participants developed MCI/PD. For MCI/PD and MCI, the risks tended to be lower among participants in quintiles Q2–Q5 of Mg consumption compared with those in the lowest quintile. Participants in Q3 had a significantly lower risk of MCI/PD (HR 0.69, 95% CI 0.53 to 0.91) and MCI (HR 0.63, 95% CI 0.45 to 0.87) after multivariate adjustments. No significant association was observed between total Mg intake and PD. The association between total Mg intake, MCI/PD and MCI was non-linear as suggested by the likelihood test.ConclusionsTotal Mg intake between the estimated average requirement and the recommended dietary allowances may associate with a lower risk of MCI/PD and MCI.Trial registration numberNCT00685009.

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Health anxiety and risk of ischaemic heart disease: a prospective cohort study linking the Hordaland Health Study (HUSK) with the Cardiovascular Diseases in Norway (CVDNOR) project

BMJ Open ◽

10.1136/bmjopen-2016-012914 ◽

2016 ◽

Vol 6 (11) ◽

pp. e012914 ◽

Cited By ~ 14

Author(s):

Line Iden Berge ◽

Jens Christoffer Skogen ◽

Gerhard Sulo ◽

Jannicke Igland ◽

Ingvard Wilhelmsen ◽

...

Keyword(s):

Cohort Study ◽

Heart Disease ◽

Cardiovascular Diseases ◽

Ischaemic Heart Disease ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Health Anxiety ◽

Health Study

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Menstrual cycle regularity and length across the reproductive lifespan and risk of premature mortality: prospective cohort study

BMJ ◽

10.1136/bmj.m3464 ◽

2020 ◽

pp. m3464 ◽

Cited By ~ 3

Author(s):

Yi-Xin Wang ◽

Mariel Arvizu ◽

Janet W Rich-Edwards ◽

Jennifer J Stuart ◽

JoAnn E Manson ◽

...

Keyword(s):

Cardiovascular Disease ◽

Cohort Study ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Cycle Length ◽

Premature Mortality ◽

Health Study ◽

Menstrual Cycles ◽

Hazard Ratios

AbstractObjectiveTo evaluate whether irregular or long menstrual cycles throughout the life course are associated with all cause and cause specific premature mortality (age <70 years).DesignProspective cohort study.SettingNurses’ Health Study II (1993-2017).Participants79 505 premenopausal women without a history of cardiovascular disease, cancer, or diabetes and who reported the usual length and regularity of their menstrual cycles at ages 14-17 years, 18-22 years, and 29-46 years.Main outcome measuresHazard ratios and 95% confidence intervals for all cause and cause specific premature mortality (death before age 70 years) were estimated from multivariable Cox proportional hazards models.ResultsDuring 24 years of follow-up, 1975 premature deaths were documented, including 894 from cancer and 172 from cardiovascular disease. Women who reported always having irregular menstrual cycles experienced higher mortality rates during follow-up than women who reported very regular cycles in the same age ranges. The crude mortality rate per 1000 person years of follow-up for women reporting very regular cycles and women reporting always irregular cycles were 1.05 and 1.23 for cycle characteristics at ages 14-17 years, 1.00 and 1.37 for cycle characteristics at ages 18-22 years, and 1.00 and 1.68 for cycle characteristics at ages 29-46 years. The corresponding multivariable adjusted hazard ratios for premature death during follow-up were 1.18 (95% confidence interval 1.02 to 1.37), 1.37 (1.09 to 1.73), and 1.39 (1.14 to 1.70), respectively. Similarly, women who reported that their usual cycle length was 40 days or more at ages 18-22 years and 29-46 years were more likely to die prematurely than women who reported a usual cycle length of 26-31 days in the same age ranges (1.34, 1.06 to 1.69; and 1.40, 1.17 to 1.68, respectively). These relations were strongest for deaths related to cardiovascular disease. The higher mortality associated with long and irregular menstrual cycles was slightly stronger among current smokers.ConclusionsIrregular and long menstrual cycles in adolescence and adulthood are associated with a greater risk of premature mortality (age <70 years). This relation is slightly stronger among women who smoke.

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Cancer Incidence Among Paraquat Exposed Applicators in the Agricultural Health Study: A Prospective Cohort Study

International Journal of Occupational and Environmental Health ◽

10.1179/oeh.2009.15.3.274 ◽

2009 ◽

Vol 15 (3) ◽

pp. 274-281 ◽

Cited By ~ 12

Author(s):

Sue K. Park ◽

Daehee Kang ◽

Laura Beane-Freeman ◽

Aaron Blair ◽

Jane A. Hoppin ◽

...

Keyword(s):

Cohort Study ◽

Prospective Cohort Study ◽

Cancer Incidence ◽

Prospective Cohort ◽

Health Study ◽

Agricultural Health ◽

Agricultural Health Study

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Qingdao Port Cardiovascular Health Study: a prospective cohort study

BMJ Open ◽

10.1136/bmjopen-2015-008403 ◽

2015 ◽

Vol 5 (12) ◽

pp. e008403 ◽

Cited By ~ 2

Author(s):

Erica S Spatz ◽

Xianyan Jiang ◽

Jiapeng Lu ◽

Frederick A Masoudi ◽

John A Spertus ◽

...

Keyword(s):

Cohort Study ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Cardiovascular Health ◽

Health Study ◽

Cardiovascular Health Study

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A Prospective Cohort Study of Vitamins B, C, E, and Multivitamin Intake and Endometriosis

Journal of Endometriosis and Pelvic Pain Disorders ◽

10.5301/je.5000151 ◽

2013 ◽

Vol 5 (1) ◽

pp. 17-26 ◽

Cited By ~ 16

Author(s):

Anne Marie Darling ◽

Jorge E. Chavarro ◽

Susan Malspeis ◽

Holly R. Harris ◽

Stacey A. Missmer

Keyword(s):

Cohort Study ◽

Vitamin E ◽

Vitamin C ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

B Vitamins ◽

Food Sources ◽

Health Study ◽

Protective Mechanism ◽

Incident Cases

Purpose Diet is a potentially modifiable risk factor for endometriosis. It has been hypothesized that vitamins C, E, and the B vitamins may influence factors involved in the pathogenesis of endometriosis, such as oxidative stress and steroid hormone metabolism. In this large, prospective cohort study, we examined the relation between intake of vitamins C, E, the B vitamins, and the use of multivitamin supplements and diagnosis of endometriosis. Methods Data were collected from women in the Nurses' Health Study II between 1991 and 2005. Diet was assessed via food frequency questionnaire. Incidence rate ratios (RR) and 95% confidence intervals (CI) were estimated using time-varying Cox proportional hazards models. Results A total of 1383 incident cases of laparoscopically-confirmed endometriosis were observed among 70,617 women during 735,286 person years of follow-up. Intakes of thiamine (B1) (RR = 0.84, CI = 0.72-0.99; P-value, test for linear trend[P] = 0.04), folate (B9) (RR = 0.79, CI = 0.66-0.93; P = 0.003), vitamin C (RR = 0.81, CI = 0.68-0.95; P = 0.02), and vitamin E (RR = 0.70, CI = 0.59-0.83; P<0.0001) solely from food sources were inversely related to endometriosis diagnosis. However, intakes of these nutrients from supplements alone were unrelated to endometriosis. Conclusion Thiamine, folate, vitamin C, and vitamin E from food sources are inversely related to endometriosis risk. Our results suggest that the protective mechanism may not be related to the nutrients themselves but rather other components of foods rich in these micronutrients or factors correlated with diets high in these vitamin-rich foods.

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