scholarly journals Heme- and nonheme-iron absorption and iron status 12 mo after sleeve gastrectomy and Roux-en-Y gastric bypass in morbidly obese women

2012 ◽  
Vol 96 (4) ◽  
pp. 810-817 ◽  
Author(s):  
Manuel Ruz ◽  
Fernando Carrasco ◽  
Pamela Rojas ◽  
Juana Codoceo ◽  
Jorge Inostroza ◽  
...  
Keyword(s):  
Gastric Bypass ◽  
Sleeve Gastrectomy ◽  
Iron Absorption ◽  
Iron Status ◽  
Nonheme Iron ◽  
Morbidly Obese ◽  
Obese Women

Laparoscopic Roux-En-Y Gastric Bypass Versus Sleeve Gastrectomy on Pelvic Floor Disorders in Morbidly Obese Women: a Prospective Monocentric Pilot Study

2018 ◽  
Vol 29 (2) ◽  
pp. 609-616 ◽  
Author(s):  
Clémentine Mazoyer ◽  
Patrick Treacy ◽  
Laurent Turchi ◽  
Paul Antoine Lehur ◽  
Emmanuel Benizri ◽  
...  
Keyword(s):  
Gastric Bypass ◽  
Sleeve Gastrectomy ◽  
Pilot Study ◽  
Pelvic Floor ◽  
Pelvic Floor Disorders ◽  
Morbidly Obese ◽  
Obese Women

scholarly journals Iron Deficiency in Obesity and after Bariatric Surgery

Biomolecules ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 613
Author(s):  
Geir Bjørklund ◽  
Massimiliano Peana ◽  
Lyudmila Pivina ◽  
Alexandru Dosa ◽  
Jan Aaseth ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Gastric Bypass ◽  
Sleeve Gastrectomy ◽  
Iron Deficiency ◽  
Iron Absorption ◽  
Iron Status ◽  
Gastric Bypass Surgery ◽  
Acute Phase Reactant ◽  
Obese Patients ◽  
Obese Subjects

Iron deficiency (ID) is particularly frequent in obese patients due to increased circulating levels of acute-phase reactant hepcidin and adiposity-associated inflammation. Inflammation in obese subjects is closely related to ID. It induces reduced iron absorption correlated to the inhibition of duodenal ferroportin expression, parallel to the increased concentrations of hepcidin. Obese subjects often get decreased inflammatory response after bariatric surgery, accompanied by decreased serum hepcidin and therefore improved iron absorption. Bariatric surgery can induce the mitigation or resolution of obesity-associated complications, such as hypertension, insulin resistance, diabetes mellitus, and hyperlipidemia, adjusting many parameters in the metabolism. However, gastric bypass surgery and sleeve gastrectomy can induce malabsorption and may accentuate ID. The present review explores the burden and characteristics of ID and anemia in obese patients after bariatric surgery, accounting for gastric bypass technique (Roux-en-Y gastric bypass—RYGB) and sleeve gastrectomy (SG). After bariatric surgery, obese subjects’ iron status should be monitored, and they should be motivated to use adequate and recommended iron supplementation.

scholarly journals Hepcidin and Iron Deficiency in Women One Year after Sleeve Gastrectomy: A Prospective Cohort Study

Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2516
Author(s):  
Thibaud Lefebvre ◽  
Muriel Coupaye ◽  
Marina Esposito-Farèse ◽  
Nathalie Gault ◽  
Neila Talbi ◽  
...  
Keyword(s):  
Sleeve Gastrectomy ◽  
Iron Deficiency ◽  
Iron Supplementation ◽  
Iron Homeostasis ◽  
Iron Absorption ◽  
Iron Status ◽  
Obese Women ◽  
Serum Hepcidin ◽  
One Year ◽  
The Impact

Iron deficiency with or without anemia, needing continuous iron supplementation, is very common in obese patients, particularly those requiring bariatric surgery. The aim of this study was to address the impact of weight loss on the rescue of iron balance in patients who underwent sleeve gastrectomy (SG), a procedure that preserves the duodenum, the main site of iron absorption. The cohort included 88 obese women; sampling of blood and duodenal biopsies of 35 patients were performed before and one year after SG. An analysis of the 35 patients consisted in evaluating iron homeostasis including hepcidin, markers of erythroid iron deficiency (soluble transferrin receptor (sTfR) and erythrocyte protoporphyrin (PPIX)), expression of duodenal iron transporters (DMT1 and ferroportin) and inflammatory markers. After surgery, sTfR and PPIX were decreased. Serum hepcidin levels were increased despite the significant reduction in inflammation. DMT1 abundance was negatively correlated with higher level of serum hepcidin. Ferroportin abundance was not modified. This study shed a new light in effective iron recovery pathways after SG involving suppression of inflammation, improvement of iron absorption, iron supply and efficiency of erythropoiesis, and finally beneficial control of iron homeostasis by hepcidin. Thus, recommendations for iron supplementation of patients after SG should take into account these new parameters of iron status assessment.

Food iron absorption in idiopathic hemochromatosis

Blood ◽  
1989 ◽  
Vol 74 (6) ◽  
pp. 2187-2193 ◽  
Author(s):  
SR Lynch ◽  
BS Skikne ◽  
JD Cook
Keyword(s):  
Serum Ferritin ◽  
Iron Absorption ◽  
Iron Status ◽  
Normal Subjects ◽  
Heme Iron ◽  
Nonheme Iron ◽  
Ferritin Concentration ◽  
Normal Volunteers ◽  
Idiopathic Hemochromatosis ◽  
The Relationship

Abstract The relationship between iron status and food iron absorption was evaluated in 75 normal volunteers, 15 patients with idiopathic hemochromatosis, and 22 heterozygotes by using double extrinsic radioiron tags to label independently the nonheme and heme iron components of a hamburger meal. In normal subjects, absorption from each of these pools was inversely correlated with storage iron, as measured by the serum ferritin concentration. In patients with hemochromatosis, absorption of both forms of iron was far greater than would be predicted from the relationship between absorption and serum ferritin observed in normal volunteers. Nevertheless, there was still a modest but statistically significant reduction in absorption of nonheme iron with increasing serum ferritin. This relationship could not be demonstrated in the case of heme iron absorption. In heterozygotes, nonheme iron absorption from a hamburger meal containing no supplementary iron did not differ significantly from that observed in normal volunteers. However, when this meal was both modified to promote bioavailability and supplemented with iron, absorption of nonheme iron was significantly elevated. These studies confirm the presence of excessive nonheme iron absorption even from unfortified meals in patients with idiopathic hemochromatosis and suggest in addition that they are particularly susceptible to iron loading from diets containing a high proportion of heme iron. Impaired regulation of nonheme iron absorption was also observed in heterozygous individuals, but a statistically significant abnormality was demonstrable only when the test meal contained a large highly bioavailable iron supplement.

High specific activity heme-Fe and its application for studying heme-Fe metabolism in Caco-2 cell monolayers

2002 ◽  
Vol 283 (5) ◽  
pp. G1125-G1131 ◽  
Author(s):  
Jennifer R. Follett ◽  
Yasushi A. Suzuki ◽  
Bo Lönnerdal
Keyword(s):  
Iron Absorption ◽  
Specific Activity ◽  
Iron Status ◽  
Basolateral Membrane ◽  
High Specific Activity ◽  
Heme Iron ◽  
Nonheme Iron ◽  
Serum Free Medium ◽  
Factors Affecting ◽  
Cell Monolayers

Heme-Fe is an important source of dietary iron in humans. Caco-2 cells have been used extensively to study human iron absorption with an emphasis on factors affecting nonheme iron absorption. Therefore, we examined several factors known to affect heme iron absorption. Cells grown in bicameral chambers were incubated with high specific activity [59Fe]heme alone or with 1% globin, BSA, or fatty acid-free BSA (BSA-FA) to examine the effect of protein source on absorption. Heme iron absorption was enhanced by globin and inhibited by BSA and BSA-FA. Absorption of heme iron in cells pretreated for 7 days with serum-free medium containing 1, 25, 50, or 100 μM Fe was higher in the 1-μM-Fe pretreatment group than in all other groups ( P < 0.05), showing an effect of iron status. Increased heme concentrations resulted in decreased percent absorbed but increased total heme iron absorption and increased transport rate across the basolateral membrane. Finally, cells treated with 10 μM CdCl2, which induces heme oxygenase, demonstrated higher absorption of [59Fe]heme than control cells ( P < 0.05). Our results from Caco-2 cells are in agreement with human studies and make this a promising model for examining intestinal heme iron absorption.

PL-27: The effect of laparoscopic Roux-en-Y gastric bypass on urinary incontinence in morbidly obese women

2008 ◽  
Vol 4 (3) ◽  
pp. 298-299
Author(s):  
Rajesh Laungani ◽  
Arthur M. Carlin ◽  
Nicole Seleno ◽  
Todd Hoffman
Keyword(s):  
Gastric Bypass ◽  
Urinary Incontinence ◽  
Morbidly Obese ◽  
Obese Women
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