Limitations of the review and meta-analysis of the role of n−3 long-chain PUFA supplementation and cognitive function

The purpose of the systematic review and meta-analysis was to determine if low-ratio n-6/n-3 long-chain polyunsaturated fatty acid (PUFA) supplementation affects serum inflammation markers based on current studies.

Download Full-text

n‐3 PUFA Supplementation Alters Retinal Very‐Long‐Chain‐PUFA Levels and Ratios in Diabetic Animal Models

Molecular Nutrition & Food Research ◽

10.1002/mnfr.201801058 ◽

2019 ◽

Vol 63 (15) ◽

pp. 1801058 ◽

Cited By ~ 1

Author(s):

Aruna Gorusupudi ◽

Fu‐Yen Chang ◽

Kelly Nelson ◽

Gregory S. Hageman ◽

Paul S. Bernstein

Keyword(s):

Animal Models ◽

Diabetic Animal ◽

Pufa Supplementation ◽

Chain Pufa ◽

Long Chain

Download Full-text

Improving the survival, growth and hemolymph ion maintenance of early juvenile blue swimmer crabs, Portunus pelagicus, at hypo- and hyper-osmotic conditions through dietary long chain PUFA supplementation

Aquaculture ◽

10.1016/j.aquaculture.2012.02.013 ◽

2012 ◽

Vol 342-343 ◽

pp. 24-30 ◽

Cited By ~ 12

Author(s):

Nicholas Romano ◽

Chaoshu Zeng ◽

Noordiyana Mat Noordin ◽

Wing-Keong Ng

Keyword(s):

Portunus Pelagicus ◽

Pufa Supplementation ◽

Early Juvenile ◽

Chain Pufa ◽

Long Chain

Download Full-text

Erythrocyte DHA level as a biomarker of DHA status in specific brain regions of n-3 long-chain PUFA-supplemented aged rats

British Journal Of Nutrition ◽

10.1017/s0007114514002529 ◽

2014 ◽

Vol 112 (11) ◽

pp. 1805-1818 ◽

Cited By ~ 13

Author(s):

Anne Létondor ◽

Benjamin Buaud ◽

Carole Vaysse ◽

Laurence Fonseca ◽

Coralie Herrouin ◽

...

Keyword(s):

Fatty Acid ◽

Brain Regions ◽

Erythrocyte Membranes ◽

Aged Rats ◽

Pufa Supplementation ◽

Brain Functions ◽

Chain Pufa ◽

Brain Ageing ◽

The Relationship ◽

Long Chain

n-3 Long-chain PUFA (n-3 LC-PUFA), particularly EPA and DHA, play a key role in the maintenance of brain functions such as learning and memory that are impaired during ageing. Ageing is also associated with changes in the DHA content of brain membranes that could contribute to memory impairment. Limited studies have investigated the effects of ageing and n-3 LC-PUFA supplementation on both blood and brain fatty acid compositions. Therefore, we assessed the relationship between fatty acid contents in plasma and erythrocyte membranes and those in the hippocampus, striatum and cerebral cortex during ageing, and after a 5-month period of EPA/DHA supplementation in rats. In the blood, ageing was associated with an increase in plasma DHA content, whereas the DHA content remained stable in erythrocyte membranes. In the brain, ageing was associated with a decrease in DHA content, which was both region-specific and phospholipid class-specific. In EPA/DHA-supplemented aged rats, DHA contents were increased both in the blood and brain compared with the control rats. The present results demonstrated that n-3 LC-PUFA level in the plasma was not an accurate biomarker of brain DHA status during ageing. Moreover, we highlighted a positive relationship between the DHA levels in erythrocyte phosphatidylethanolamine (PE) and those in the hippocampus and prefrontal cortex in EPA/DHA-supplemented aged rats. Within the framework of preventive dietary supplementation to delay brain ageing, these results suggest the possibility of using erythrocyte PE DHA content as a reliable biomarker of DHA status in specific brain regions.

Download Full-text

The Role of n-3 Long Chain Polyunsaturated Fatty Acids in Cognitive Function

Latest Finding of Omega-3 Long Chain-Polyunsaturated Fatty Acids ◽

10.2174/978160805177911101010023 ◽

2012 ◽

pp. 23-38

Keyword(s):

Fatty Acids ◽

Cognitive Function ◽

Polyunsaturated Fatty Acids ◽

Long Chain

Download Full-text

Associations Between Dietary Fat Quality and Cognitive Function Among Adults: The Hispanic Community Health Study/Study of Latinos

Current Developments in Nutrition ◽

10.1093/cdn/nzaa061_052 ◽

2020 ◽

Vol 4 (Supplement_2) ◽

pp. 1424-1424

Author(s):

Nicole Karazurna ◽

Caitlin Porter ◽

Semra Aytur ◽

Tammy M Scott ◽

Josiemer Mattei ◽

...

Keyword(s):

Cognitive Function ◽

Community Health ◽

Dietary Fat ◽

Health Study ◽

Medium Chain ◽

Chain Pufa ◽

Global Cognitive Function ◽

Hispanic Community ◽

Hispanic Latinos ◽

Long Chain

Abstract Objectives Individual fatty acids (FA) within dietary fat classes [saturated (SFA), monounsaturated (MUFA), polyunsaturated (PUFA), and trans FA (TFA)] may differentially affect risk of cognitive impairment. This has received little attention by most previous studies of diet and cognitive function, and few studies are available among Hispanic/Latinos. Our objective was to quantify associations of dietary FA (DFA) patterns with cognitive function among Hispanic/Latinos residing in the US. Methods This is a cross-sectional analysis of participants of the Hispanic Community Health Study/Study of Latinos, a diverse cohort recruited from 2008–11 (n = 7842, mean age 55 y, 62% female). Dietary data are from two 24-hr recalls; the National Cancer Institute method was used to estimate usual nutrient intake. Total animal and plant MUFA variables and 26 FA were used to derive DFA patterns by principal components analysis. Global cognitive function was calculated as the average z-score from 3 cognitive tests [Word Fluency (WF), Spanish English Verbal Learning Test (B-SEVLT) sum, and Digit Symbol Substitution (DSS)]. Survey linear regression models, were adjusted for a number of confounders including, but not limited to education, depressive symptoms, ethnicity, study site, physical activity, and total energy. Results DFA patterns were characterized by greater consumption of long-chain SFA, animal MUFA, and TFA (Factor 1); short to medium-chain SFA (Factor 2); very-long-chain PUFA (Factor 3); very-long-chain SFA, plant MUFA and essential PUFA (Factor 4). Each 1-SD increase in only Factor 2 or 4 was associated with a 0.03 ± 0.01 SD or 0.02 ± 0.01 SD higher global cognitive function score, respectively (P < 0.05). Factor 2 was positiviely associated with DSS and B-SEVLT scores (P < 0.05). Factors 1 and 4 were positively associated with DSS scores (P < 0.05). Factor 3 was not significantly associated with any cognitive function measure. Conclusions Our findings suggest that intake of short to medium-chain SFA, and of plant based MUFA, SFA, and PUFA, may be associated with a small benefit on global cognitive function among Hispanic/Latino adults. Null associations were observed with a very-long-chain PUFA pattern, which may be partly due to low fish consumption. Prospective studies conducted in similar and other populations are needed to confirm our results. Funding Sources None.

Download Full-text