Neurological Disorders, Rehabilitation, and Associated Technologies

Author(s):  
Sateesh Reddy Avutu ◽  
Dinesh Bhatia

Patients with neurological disorders are increasing globally due to various factors such as change in lifestyle patterns, professional and personal stress, small nuclear families, etc. Neurological rehabilitation is an area focused by the several research and development organizations and scientists from different disciplines to invent new and advanced rehabilitation devices. This chapter starts with the classification of different neurological disorders and their potential causes. The rehabilitation devices available globally for neurological patients with their underlying associated technologies are explained in the chapter. Towards the end of the chapter, the reader can acquire the fundamental knowledge about the different neurological disorders and the mal-functionality associated with the corresponding organs. The utilization of advanced technologies such as artificial intelligence, machine learning, and deep learning by researchers to fabricate neuro rehabilitation devices to improve patients' quality of life (QOL) are discussed in concluding section of the chapter.

Author(s):  
Sateesh Reddy Avutu ◽  
Dinesh Bhatia

Patients with neurological disorders are increasing globally due to various factors such as change in lifestyle patterns, professional and personal stress, small nuclear families, etc. Neurological rehabilitation is an area focused by the several research and development organizations and scientists from different disciplines to invent new and advanced rehabilitation devices. This chapter starts with the classification of different neurological disorders and their potential causes. The rehabilitation devices available globally for neurological patients with their underlying associated technologies are explained in the chapter. Towards the end of the chapter, the reader can acquire the fundamental knowledge about the different neurological disorders and the mal-functionality associated with the corresponding organs. The utilization of advanced technologies such as artificial intelligence, machine learning, and deep learning by researchers to fabricate neuro rehabilitation devices to improve patients' quality of life (QOL) are discussed in concluding section of the chapter.


Author(s):  
Jessee Moirangthem ◽  
Sateesh Reddy Avutu ◽  
Meena Gupta ◽  
Dinesh Bhatia

Rehabilitation is an area of focus by experts and researchers from different disciplines owing to the increase in number of various types of disabilities. This chapter covers information relating to causes and need for rehabilitation devices for differently abled people with motor, vision, or hearing impairment. The chapter begins with a brief on the disability population worldwide and in India, and progresses towards presenting available devices in global market and possible improvement that can be made to improve the functionality of the device and in turn improve the quality of life (QoL) of the users. Towards the end of the chapter, a reader can acquire the fundamental knowledge about the different types of disability, suitable aids, and working.


Author(s):  
Jessee Moirangthem ◽  
Sateesh Reddy Avutu ◽  
Meena Gupta ◽  
Dinesh Bhatia

Rehabilitation is an area of focus by experts and researchers from different disciplines owing to the increase in number of various types of disabilities. This chapter covers information relating to causes and need for rehabilitation devices for differently abled people with motor, vision, or hearing impairment. The chapter begins with a brief on the disability population worldwide and in India, and progresses towards presenting available devices in global market and possible improvement that can be made to improve the functionality of the device and in turn improve the quality of life (QoL) of the users. Towards the end of the chapter, a reader can acquire the fundamental knowledge about the different types of disability, suitable aids, and working.


2021 ◽  
Vol 5 (3) ◽  
pp. 019-023
Author(s):  
Nusrat Aziz

Botulinum toxin is produced by Clostridium botulini bacteria. It has been increasingly used as a boon in medical practice for chemodenervation in conditions like skeletal muscle spasticity, glandular hypersecretion, neuropathic pain and smooth muscle hyperactivity. The action of Botulinum neurotoxin (BoNT) is by blocking the neurotransmission at the cholinergic nerve endings, by inhibiting the docking and fusion of Acetyl Choline (Ach) vesicles for exocytosis into the synaptic area.Botulinum toxin has been used for management of neurological disorders with great patient satisfaction and appreciation. The effect of botulinum toxin wears off in 3-6 months and may require another dose. Frequent dosing may lead to production of antibodies against BoNT with consequent irresponsiveness to therapy in a few cases. Scrupulous use of botulinum toxin in the hands of experts may help a long way in giving much needed relief and respite to neurological patients and increase their quality of life. Its use in cosmetic dermatology in reducing wrinkles, by relaxing the facial muscles is very popular


Author(s):  
Paolo Martelletti ◽  
E. Bentivegna ◽  
V. Spuntarelli ◽  
M. Luciani

AbstractThe so-called long COVID-19 is a set of symptoms that accompanies the patient even for months after discharge from the hospital. These symptoms include easy muscle fatigue, moderate breathlessness, persistent headache, the feeling of a foggy head, and the development of psychiatric disorders. In general, the quality of life of at least half of the patients who come out of the COVID-19 syndrome, both mild and severe, shows a markedly worsening despite having passed a difficult physical and psychological test. Among all the neurological disorders that can most frequently be found in the long COVID-19, it is important to consider the persistent headache symptomatology as a possible chronic sequela of the infection. Since there is not a definition in the International Headache Society classification of this type of headache, we must focus our attention on this long-COVID-19 headache especially because clinical studies are being planned to collect big data for the International Headache Society Classification Committee.


2020 ◽  
Vol 31 (2) ◽  
pp. 62-68
Author(s):  
Sara E. Holm ◽  
Alexander Schmidt ◽  
Christoph J. Ploner

Abstract. Some people, although they are perfectly healthy and happy, cannot enjoy music. These individuals have musical anhedonia, a condition which can be congenital or may occur after focal brain damage. To date, only a few cases of acquired musical anhedonia have been reported in the literature with lesions of the temporo-parietal cortex being particularly important. Even less literature exists on congenital musical anhedonia, in which impaired connectivity of temporal brain regions with the Nucleus accumbens is implicated. Nonetheless, there is no precise information on the prevalence, causes or exact localization of both congenital and acquired musical anhedonia. However, the frequent involvement of temporo-parietal brain regions in neurological disorders such as stroke suggest the possibility of a high prevalence of this disorder, which leads to a considerable reduction in the quality of life.


2021 ◽  
Vol 16 (1) ◽  
Author(s):  
F. Haubner ◽  
A. Schneider ◽  
H. Schinke ◽  
M. Bertlich ◽  
B. G. Weiss ◽  
...  

Abstract Background Recurrent spontaneous epistaxis is the most common clinical manifestation and the most debilitating symptom in hereditary haemorrhagic telangiectasia (HHT) patients. To this date, there exist only a classification of HHT patients by different genetic mutations. There is no standard classification for the mucocutaneous endonasal manifestations of HHT. The aim of the present study was to document the variety of endonasal HHT lesions using digital microscopy and to propose a clinical classification. Methods We recorded the endonasal HHT lesions of 28 patients using a digital microscope. We reconstructed the 3D images und videos recorded by digital microscope afterwards and classified the endonasal lesions of HHT in two classes: Grade A, presence of only flat telangiectasias in the mucosa level and Grade B, (additional) presence of raised berry or wart-like telangiectasia spots. We investigated also Haemoglobin level by routine laboratory procedures, plasma VEGF level by ELISA, Severity of epistaxis by epistaxis severity score (ESS) and quality of life by a linear visual analogue scale (VAS). Results We found a higher quality of life and a lower severity of epistaxis in Grade A patients in comparison to Grade B patients. No difference in plasma VEGF level and in Haemoglobin between Grad A patients and Grade B patients could be detected. Plasma VEGF levels showed no gender specific differences. It could also not be correlated to the extranasal manifestation. Conclusion The classification for endonasal manifestation of HHT proposed in this study indicates severity of epistaxis und quality of life. Digital microscopy with the ability of 3D reconstruction of images presents a useful tool for such classifications. The classification of endonasal HHT lesions using digital microscopy allows to evaluate the dynamic of HHT lesions in the course of time independent of examiner. This allows also to evaluate the efficacy of the different treatment modalities by dynamic of HHT lesions. Moreover digital microscopy is very beneficial in academic teaching of rare diseases.


2021 ◽  
Vol 3 (2) ◽  
Author(s):  
Roheela Yasmeen ◽  
Nida Mobeen ◽  
Muhammad Amjad Khan ◽  
Irfan Aslam ◽  
Samia Chaudhry

Epilepsy which is also called seizures disorder is an uncontrolled action of the central nervous system. Itis not a single disease but a set of neurological disorders. Actually in this situation, the brain does notreceive a precise signal and as a result an abnormal condition is produced that is usually involuntary inaction. In this review, we aimed to focus on the relationship of anti-epileptic drugs with sexual dysfunctionand adaptation of better remedies that improve a patient’s family life. Sexual dysfunction is a commoncomorbidity in people with epilepsy which badly affects their quality of life. Sexual dysfunction is causedby different factors like psychiatric problems, anti-epileptic drugs (AEDs) and social factors etc. Sexualdysfunctions include ejaculatory failure, lessen libido, penile erection in men and irregular menstrual cyclein women. Common drugs such as Topiramate, Gabapentin (GBP), Valproate (VA), Carbamazepine (CBZ),Olanzapine (OL) and Risperidone (RTG) that are in practice to treat epilepsy usually produced adverseeffect on sexual dysfunction. Even though a lot of studies have been carried out to control sexualdysfunction in epilepsy’s patient, but still research is going on. Medicine such as Cyproheptadine,Mianserin, Buspirone, Yohimbine were found better to treat epilepsy with minimum side effects of sexualdysfunction. Moreover, it is also seen that certain vasodilators, folate , and vitamin supplements areeffective in improving the quality of life.


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