Molecular Interactions of α-Synuclein, Mitochondria, and Cellular Degradation Pathways in Parkinson's Disease
Keyword(s):
Parkinson's disease (PD) has been reported to be the most common neurodegenerative diseases all over the world. Several proteins are associated and responsible for causing PD. One such protein is α-synuclein. This chapter discusses the role of α-synuclein in PD. Various genetic and epigenetic factors, which cause structural and functional changes for α-synuclein, have been described. Several molecular mechanisms, which are involved in regulating mitochondrial and lysosomal related pathways and are linked to α-synuclein, have been discussed in detail. The knowledge gathered is further discussed in terms of using α-synuclein as a diagnostic marker for PD and as a novel therapeutic target for the same.
2019 ◽
Vol 66
◽
pp. 265-266
◽
Keyword(s):
2013 ◽
Vol 2013
◽
pp. 1-9
◽
Keyword(s):
Ghrelin is neuroprotective in Parkinson’s disease: molecular mechanisms of metabolic neuroprotection
2013 ◽
Vol 4
(1)
◽
pp. 25-36
◽