Dysbiosis in Microbiome Leading to Colitis-Associated Cancer

Risk Factor ◽

Bowel Disease ◽

Gut Microbiome ◽

The Body ◽

Physiological Processes ◽

Microbiome Diversity ◽

The World ◽

Colitis-associated cancers are a metastatic form of inflammatory bowel disease considered a vital health associated risk factor causing the death of approximately five lacs people every year throughout the world. There are trillions of bacteria that are associated with our gut as a part of our healthy microbiome. The microbiota plays a plethora of important role in determining the normal physiological processes of the cells and, subsequently, the body. The imbalance in microbiome diversity (dysbiosis) due to abnormal dietary habitats, hectic lifestyle, and other factors thus alters the normal physiological processes of the body, thereby causing several chronic diseases. Therefore, it is essential to maintain the homeostasis between the host and their gut microbiome. So, based on the facts mentioned above, this chapter is entirely devoted to providing an overview of colitis-associated cancer and their relation with the dysbiosis of a healthy microbiome. Moreover, the mechanism involved in the development of colorectal cancer and its preventive insights has also been addressed.

Clustering co-abundant genes identifies components of the gut microbiome that are reproducibly associated with colorectal cancer and inflammatory bowel disease

Microbiome ◽

10.1186/s40168-019-0722-6 ◽

2019 ◽

Vol 7 (1) ◽

Cited By ~ 7

Author(s):

Samuel S. Minot ◽

Amy D. Willis

Keyword(s):

Colorectal Cancer ◽

Bowel Disease ◽

Gut Microbiome ◽

Family history as a risk factor for colorectal cancer in inflammatory bowel disease

Gastroenterology ◽

10.1053/gast.2001.24052 ◽

2001 ◽

Vol 120 (6) ◽

pp. 1356-1362 ◽

Cited By ~ 272

Author(s):

Johan Askling ◽

Paul W. Dickman ◽

Anders Ekbom ◽

Per Karlén ◽

Olle Broström ◽

...

Keyword(s):

Colorectal Cancer ◽

Risk Factor ◽

Family History ◽

Bowel Disease ◽

Pathophysiological Roles of PPARγin Gastrointestinal Epithelial Cells

PPAR Research ◽

10.1155/2008/148687 ◽

2008 ◽

Vol 2008 ◽

pp. 1-8 ◽

Cited By ~ 2

Author(s):

Brian M. Necela ◽

E. Aubrey Thompson

Keyword(s):

Colorectal Cancer ◽

Epithelial Cells ◽

Bowel Disease ◽

The Body ◽

Published Data ◽

Physiological Functions ◽

Considerable Controversy ◽

Inflammatory Bowel ◽

Gastrointestinal Epithelium

Although the highest levels of PPARγexpression in the body have been reported in the gastrointestinal epithelium, little is known about the physiological functions of that receptor in the gut. Moreover, there is considerable controversy concerning the effects of thiazolidinedione PPARγagonists on the two major diseases of the gastrointestinal track: colorectal cancer and inflammatory bowel disease. We will undertake to review both historical and recently published data with a view toward summarizing what is presently known about the roles of PPARγin both physiological and pathological processes in the gastrointestinal epithelium.

A Guide to the Gut Microbiome and its Relevance to Critical Care

British Journal of Nursing ◽

10.12968/bjon.2020.29.19.1106 ◽

2020 ◽

Vol 29 (19) ◽

pp. 1106-1112

Author(s):

James L Alexander ◽

Benjamin H Mullish

Keyword(s):

Critical Care ◽

Gastrointestinal Tract ◽

Bowel Disease ◽

Gut Microbiome ◽

Chronic Conditions ◽

The Body ◽

Huge Number ◽

Novel Approach ◽

Although it is well-established that particular bacteria may cause gastroenteritis and other infections when present in the gut, it is only recently that scientists have made significant inroads into understanding the huge number of other bacteria and additional microbes that live within the gastrointestinal tract, referred to as the gut microbiome. In particular, it is now recognised that bacteria within the gut microbiome have a wide variety of roles in maintaining different aspects of human health, and that disturbances of these bacteria may potentially cause or contribute to a number of different medical conditions, including particular infections, certain cancers, and chronic conditions, including inflammatory bowel disease. Moreover, there is increasing awareness that these bacteria help determine how the body responds to medication, including antibiotics and chemotherapy. There has been growing interest in different approaches to alter the gut microbiome as a novel approach to medical therapy. This article provides an overview of the importance of the gut microbiome, with a particular focus on critical care.