A Thorough Presentation of Autism Diagnostic Observation Schedule (ADOS-2)

2022 ◽  
pp. 21-38
Author(s):  
Elpis Papaefstathiou
Keyword(s):  
Psychometric Properties ◽  
Direct Observation ◽  
Diagnostic Tool ◽  
Gold Standard ◽  
Autism Diagnostic Observation Schedule ◽  
Autism Diagnostic Observation

ADOS-2 is considered the gold standard observational instrument for use in the diagnosis and/or classification of autism and ASD. In this chapter, the process of assessment will be described, which involves direct observation and engagement of children and adults for whom an ASD is suspected. Specifically, an emphasis will be put on ADOS structure, namely the five different modules for the assessment. Then, the advantages of ADOS-2 will be elaborated as a diagnostic tool and a brief review of studies concerning its psychometric properties will be reported.

scholarly journals The Brief Observation of Symptoms of Autism (BOSA): Development of a New Adapted Assessment Measure for Remote Telehealth Administration through COVID-19 and Beyond

2021 ◽  
Author(s):  
Deanna Dow ◽  
Alison Holbrook ◽  
Christina Toolan ◽  
Nicole McDonald ◽  
Kyle Sterrett ◽  
...  
Keyword(s):  
Social Context ◽  
Psychometric Properties ◽  
Autism Diagnostic Observation Schedule ◽  
Psychological Services ◽  
Assessment Measure ◽  
Sensitivity Specificity ◽  
Autism Diagnostic Observation

Interest in telehealth assessment for autism has increased due to COVID-19 and subsequent expansion of remote psychological services, though options that are easy for clinicians to adopt and available through the lifespan are limited. The Brief Observation of Symptoms of Autism (BOSA) provides a social context with standardized materials and activities that can be coded by clinicians trained in the Autism Diagnostic Observation Schedule (ADOS). The current project examined psychometric properties to determine optimal use for each BOSA version. Three hundred and seven participants with 453 BOSAs were included to determine best performing items for algorithms, validity, sensitivity, specificity, recommended cut-offs, and proposed ranges of concern. While preliminary, the BOSA provides a promising new option for telehealth-administered assessment for autism.

scholarly journals School-age social behavior and pragmatic language ability in children with prenatal serotonin reuptake inhibitor exposure

2019 ◽  
Vol 32 (1) ◽  
pp. 21-30 ◽  
Author(s):  
Erica L. Smearman ◽  
Cassandra L. Hendrix ◽  
Dominika A. Winiarski ◽  
Katrina C. Johnson ◽  
Alicia K. Smith ◽  
...  
Keyword(s):  
Reuptake Inhibitor ◽  
Gold Standard ◽  
Serotonin Reuptake ◽  
Autism Diagnostic Observation Schedule ◽  
Autism Spectrum ◽  
Pragmatic Language ◽  
Social Responsiveness ◽  
Serotonin Reuptake Inhibitor ◽  
Early Elementary School ◽  
Autism Diagnostic Observation

AbstractStudies examining associations between fetal serotonin reuptake inhibitor (SRI) exposure and child autism spectrum disorder (ASD) diagnoses or delayed language remain mixed and rarely prospectively follow children or employ gold-standard assessments. We prospectively followed a cohort of mother–child dyads from pregnancy through early elementary school (N = 178), and obtained maternal and alternate–caregiver ratings of behaviors related to ASD (N = 137), as well as direct, gold-standard assessments of child ASD symptoms and pragmatic language among dyads who experienced prenatal depression and either took SRIs or were medication free during pregnancy (N = 44). Prenatal SRI exposure was related to maternal ratings of ASD-related behaviors (β = 0.24 95% confidence interval; CI [0.07, 0.48]), and, among boys, alternative caregiver ratings (males-only β = 0.28 95% CI [0.02, 0.55], females-only β = −0.21 95% CI [–0.63, 0.08]). However, results of our direct assessments suggest an association between SRI exposure and reduced pragmatic language scores (β = –0.27, 95% CI [–0.53, –0.01], but not ASD (Autism Diagnostic Observation Schedule β = 0.14 95% CI [–0.15, 0.41]; Social Responsiveness Scale β = 0.08 95% CI [–0.25, 0.40]). These discrepancies point to issues regarding how ASD is assessed, and the possibility that SRIs may be more strongly associated with language or other broader behaviors that coincide with ASD. Larger prospective studies that incorporate thorough, gold-standard assessments of ASD, language, and other ASD-related behaviors are needed.

scholarly journals The Brief Observation of Symptoms of Autism (BOSA): Development of a New Adapted Assessment Measure for Remote Telehealth Administration Through COVID-19 and Beyond

2021 ◽  
Author(s):  
Deanna Dow ◽  
Alison Holbrook ◽  
Christina Toolan ◽  
Nicole McDonald ◽  
Kyle Sterrett ◽  
...  
Keyword(s):  
Social Context ◽  
Psychometric Properties ◽  
Autism Diagnostic Observation Schedule ◽  
Psychological Services ◽  
Assessment Measure ◽  
Sensitivity Specificity ◽  
Autism Diagnostic Observation

AbstractInterest in telehealth assessment for autism has increased due to COVID-19 and subsequent expansion of remote psychological services, though options that are easy for clinicians to adopt and available through the lifespan are limited. The Brief Observation of Symptoms of Autism (BOSA) provides a social context with standardized materials and activities that can be coded by clinicians trained in the Autism Diagnostic Observation Schedule. The current project examined psychometric properties to determine optimal use for each BOSA version. Three hundred and seven participants with 453 BOSAs were included to determine best performing items for algorithms, validity, sensitivity, specificity, recommended cut-offs, and proposed ranges of concern. While preliminary, the BOSA provides a promising new option for telehealth-administered assessment for autism.

Sex differences in social communication behaviors in toddlers with suspected autism spectrum disorder as assessed by the ADOS-2 toddler module

Autism ◽  
2021 ◽  
pp. 136236132110470
Author(s):  
Emily Ronkin ◽  
Erin C Tully ◽  
Lee Branum-Martin ◽  
Lindsey L Cohen ◽  
Christine Hall ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Sex Differences ◽  
Social Communication ◽  
Gold Standard ◽  
Autism Diagnostic Observation Schedule ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Future Research ◽  
Communication Behaviors ◽  
Autism Diagnostic Observation

The Autism Diagnostic Observation Schedule, 2nd-edition (ADOS-2) Toddler Module is the current gold-standard measure of autism spectrum disorder (ASD), a neurodevelopmental condition more frequently diagnosed in toddler boys than girls. Some evidence suggests that behaviors assessed by the Toddler Module may capture an ASD phenotype that is more common among boys than girls. Focus on these behaviors may contribute to sex differences in ASD diagnoses. Particularly, the ADOS-2 may equivalently weight social communication behaviors on which boys and girls are expected to look similar and behaviors that which girls may, due to early socialization, perform differently than boys. As a consequence, the Toddler Module may fail to identify ASD in girls who should qualify for the diagnosis. The current study examined the possibility that some ADOS-2 items may function differently for boys and girls by testing the degree to which eight items equivalently related to a social communication latent factor across sexes in toddlers with suspected ASD. Inconsistent with hypotheses, tests of differential item functioning revealed no evidence of sex differences, suggesting that the Toddler Module assesses these eight items similarly for boys and girls. Examination of factor loadings point to Creativity/Imagination as an area of interest for future research. Lay Abstract When toddlers are suspected of autism spectrum disorder (ASD), the gold-standard assessment technique is with the Autism Diagnostic Observation Schedule, 2nd edition (ADOS-2) Toddler Module, a behavioral observation system. ASD is a neurodevelopmental condition more frequently diagnosed in toddler boys than in toddler girls. There is some evidence that the ADOS-2 assesses behaviors that are more characteristic of boys with ASD than girls. Thus, it is possible that focusing on these behaviors contributes at least in part to why more boys are diagnosed than girls. Specifically, girls may show more social skills than boys during the ADOS-2 assessment due to their socialization histories, which may lead to missed diagnoses of ASD in toddler girls. The current study examined eight social behaviors assessed by the ADOS-2 in a sample of toddlers with suspected ASD to see if they contributed differently to the total score of those items. Examination of those items suggested that those social communication behaviors work the same for boys and girls with suspected ASD, which was inconsistent with hypotheses. However, examination of particular items raises the possibility of examining creative/imaginative play as an area for future research.

Full assessment: direct observation and the signs of autism

2018 ◽  
Author(s):  
Traolach S. Brugha
Keyword(s):  
Direct Observation ◽  
Autism Diagnostic Observation Schedule ◽  
Interview Question ◽  
Question And Answer ◽  
Answer Format ◽  
Autism Diagnostic Observation

This chapter focuses on direct observation and examination, moving consciously from the traditional interview, question, and answer format, to the observational format. Observing 1:1, with a carer present—for example, does the patient engage, both verbally and non-verbally, or is (s)he aloof, unless directly asked to join in? The Autism Diagnostic Observation Schedule (ADOS) is mentioned with an outline description. The limitations of observation, if comorbidity is present, are pointed out, indicating how comorbidity can be distinguished (and then referring on to Chapter 10). Methods used by psychopathologists in psychiatry to observe signs of autism are also refreshed.

scholarly journals Validity of classification of distal radial fractures in the Swedish fracture register

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Malena Bergvall ◽  
Carl Bergdahl ◽  
Carl Ekholm ◽  
David Wennergren
Keyword(s):  
Gold Standard ◽  
Reference Group ◽  
Observer Agreement ◽  
Distal Radial Fractures ◽  
Young Males ◽  
Small Peak ◽  
National Quality ◽  
Fracture Register ◽  
Standard Classification

Abstract Background Distal radial fractures (DRF) are one of the most common fractures with a small peak in incidence among young males and an increasing incidence with age among women. The reliable classification of fractures is important, as classification provides a framework for communicating effectively on clinical cases. Fracture classification is also a prerequisite for data collection in national quality registers and for clinical research. Since its inception in 2011, the Swedish Fracture Register (SFR) has collected data on more than 490,000 fractures. The attending physician classifies the fracture according to the AO/OTA classification upon registration in the SFR. Previous studies regarding the classification of distal radial fractures (DRF) have shown difficulties in inter- and intra-observer agreement. This study aims to assess the accuracy of the registration of DRF in adults in the SFR as it is carried out in clinical practice. Methods A reference group of three experienced orthopaedic trauma surgeons classified 128 DRFs, randomly retrieved from the SFR, at two classification sessions 6 weeks apart. The classification the reference group agreed on was regarded as the gold standard classification for each fracture. The accuracy of the classification in the SFR was defined as the agreement between the gold standard classification and the classification in the SFR. Inter- and intra-observer agreement was evaluated and the degree of agreement was calculated as Cohen’s kappa. Results The accuracy of the classification of DRF in the SFR was kappa = 0.41 (0.31–0.51) for the AO/OTA subgroup/group and kappa = 0.48 (0.36–0.61) for the AO/OTA type. This corresponds to moderate agreement. Inter-observer agreement ranged from kappa 0.22–0.48 for the AO/OTA subgroup/group and kappa 0.48–0.76 for the AO/OTA type. Intra-observer agreement ranged from kappa 0.52–0.70 for the AO/OTA subgroup/group and kappa 0.71–0.76 for the AO/OTA type. Conclusions The study shows moderate accuracy in the classification of DRF in the SFR. Although the degree of accuracy for DRF appears to be lower than for other fracture locations, the accuracy shown in the current study is similar to that in previous studies of DRF.

scholarly journals KLASIFIKASI LEKSIKOSTATISTIK BAHASA BANGGOI DAN BAHASA HOTI DI KABUPATEN SERAM BAGIAN TIMUR [Lexicostatistic Classification Of Banggai And Hoti Language In East Seram District]

TOTOBUANG ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 239-255
Author(s):  
Erniati Erniati
Keyword(s):  
Data Collection ◽  
Qualitative Methods ◽  
Direct Observation ◽  
Geographical Proximity ◽  
Note Taking ◽  
The People ◽  
Quantitative And Qualitative Methods

This study is a lexicostatistical study that aims to classify words that are related statistically to classify similarities. This research is focused on Banggoi and Hoti languages spoken by the people in West Bula District, East Seram Regency, Maluku Province. The aim is to determine the kinship classification of Banggoi and Hoti languages and determine the time of separation between the two languages. The method used is quantitative and qualitative methods with data collection techniques using direct observation, listening, note-taking, and recording methods. The results showed that Banggoi language and Hoti language have kinship with percentage of 31.5%. Based on this percentage, the two languages are at the stok/family kinship level. The existence of this kinship is influenced by geographical proximity, while the time of separation of the two languages is estimated at 1,170 years ago. Kajian ini merupakan kajian leksikostatistik yang bertujuan mengelompokkan kata-kata yang berkerabat dengan mengelompokkan persamaan secara statistik. Peneltian ini difokuskan pada bahasa Banggoi dan bahasa Hoti yang ditutukan oleh masyarakat yang ada di Kecamatan Bula Barat, Kabupaten Seram Bagian Timur, Provinsi Maluku. Tujuan kajian adalah untuk mengetahui klasifikasi kekerabatan bahasa Banggoi dan bahasa Hoti dan menentukan waktu pisah dari kedua bahasa tersebut. Penelitian ini menggunakan  metode kuantitatif dan kualitatif dengan teknik pengambilan data dilakukan dengan menggunakan teknik  observasi langsung, simak, catat, dan perekaman. Hasil penelitian menunjukkan bahwa antara bahasa Banggoi dan bahasa Hoti memilki kekerabatan dengan persentase 31,5%. Berdasarkan persentase tersebut maka kedua bahasa tersebut berada pada tingkat kekerabatan stok/rumpun.  Adanya kekerabatan bahasa Banggoi dan bahasa Hoti karena dipengaruhi oleh letak geografi yang berdekatan dan  waktu pisah kedua bahasa tersebut diperkirakan pada 1.170 tahun  yang lalu.

scholarly journals Towards a better understanding of the low recall of insertion variants with short-read based variant callers

2020 ◽  
Author(s):  
Wesley Delage ◽  
Julien Thevenon ◽  
Claire Lemaitre
Keyword(s):  
Gold Standard ◽  
Insertion Site ◽  
Structural Variants ◽  
Genomic Context ◽  
Breakpoint Junction ◽  
Short Read ◽  
Depth Analysis ◽  
Long Read ◽  
The Impact

AbstractSince 2009, numerous tools have been developed to detect structural variants (SVs) using short read technologies. Insertions >50 bp are one of the hardest type to discover and are drastically underrepresented in gold standard variant callsets. The advent of long read technologies has completely changed the situation. In 2019, two independent cross technologies studies have published the most complete variant callsets with sequence resolved insertions in human individuals. Among the reported insertions, only 17 to 37% could be discovered with short-read based tools. In this work, we performed an in-depth analysis of these unprecedented insertion callsets in order to investigate the causes of such failures. We have first established a precise classification of insertion variants according to four layers of characterization: the nature and size of the inserted sequence, the genomic context of the insertion site and the breakpoint junction complexity. Because these levels are intertwined, we then used simulations to characterize the impact of each complexity factor on the recall of several SV callers. Simulations showed that the most impacting factor was the insertion type rather than the genomic context, with various difficulties being handled differently among the tested SV callers, and they highlighted the lack of sequence resolution for most insertion calls. Our results explain the low recall by pointing out several difficulty factors among the observed insertion features and provide avenues for improving SV caller algorithms and their [email protected]

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